Download Full eBooks in PDF
A Doubly Adaptive Biased Coin Design Biased Coin Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of A Doubly Adaptive Biased Coin Design Biased Coin book. This book definitely worth reading, it is an incredibly well-written.
Author : JEFFREY ROBERT EISELE
Publisher : Unknown
Page : 184 pages
File Size : 47,8 Mb
Release : 1991
Category : Electronic
ISBN : UOM:39015018967599
normally distributed is considered.
Author : Feifang Hu,William F. Rosenberger
Publisher : John Wiley & Sons
Page : 240 pages
File Size : 47,8 Mb
Release : 2006-09-29
Category : Mathematics
ISBN : 9780470055878
Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including: How does response-adaptive randomization affect power? Can standard inferential tests be applied following response-adaptive randomization? What is the effect of delayed response? Which procedure is most appropriate and how can "most appropriate" be quantified? How can heterogeneity of the patient population be incorporated? Can response-adaptive randomization be performed with more than two treatments or with continuous responses? The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes: The relationship between power and response-adaptive randomization The general result for determining asymptotically best procedures Procedures based on urn models Procedures based on sequential estimation Implications for the practice of clinical trials Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.
Author : Siu Pang Yung,Tze Leung Lai,Hailiang Yang
Publisher : World Scientific
Page : 252 pages
File Size : 46,7 Mb
Release : 2004-06-28
Category : Mathematics
ISBN : 9789814482615
This workshop was the first of its kind in bringing together researchers in probability theory, stochastic processes, insurance and finance from mainland China, Taiwan, Hong Kong, Singapore, Australia and the United States. In particular, as China has joined the WTO, there is a growing demand for expertise in actuarial sciences and quantitative finance. The strong probability research and graduate education programs in many of China's universities can be enriched by their outreach in fields that are of growing importance to the country's expanding economy, and the workshop and its proceedings can be regarded as the first step in this direction.This book presents the most recent developments in probability, finance and actuarial sciences, especially in Chinese probability research. It focuses on the integration of probability theory with applications in finance and insurance. It also brings together academic researchers and those in industry and government. With contributions by leading authorities on probability theory — particularly limit theory and large derivations, valuation of credit derivatives, portfolio selection, dynamic protection and ruin theory — it is an essential source of ideas and information for graduate students and researchers in probability theory, mathematical finance and actuarial sciences, and thus every university should acquire a copy.The proceedings have been selected for coverage in:• Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)• Index to Social Sciences & Humanities Proceedings® (ISSHP® / ISI Proceedings)• Index to Social Sciences & Humanities Proceedings (ISSHP CDROM version / ISI Proceedings)• CC Proceedings — Engineering & Physical Sciences
Author : T. L. Lai,Hailiang Yang,Siu Pang Yung
Publisher : World Scientific
Page : 253 pages
File Size : 52,8 Mb
Release : 2004
Category : Mathematics
ISBN : 9789812388537
This workshop was the first of its kind in bringing together researchers in probability theory, stochastic processes, insurance and finance from mainland China, Taiwan, Hong Kong, Singapore, Australia and the United States. In particular, as China has joined the WTO, there is a growing demand for expertise in actuarial sciences and quantitative finance. The strong probability research and graduate education programs in many of China's universities can be enriched by their outreach in fields that are of growing importance to the country's expanding economy, and the workshop and its proceedings can be regarded as the first step in this direction.This book presents the most recent developments in probability, finance and actuarial sciences, especially in Chinese probability research. It focuses on the integration of probability theory with applications in finance and insurance. It also brings together academic researchers and those in industry and government. With contributions by leading authorities on probability theory ? particularly limit theory and large derivations, valuation of credit derivatives, portfolio selection, dynamic protection and ruin theory ? it is an essential source of ideas and information for graduate students and researchers in probability theory, mathematical finance and actuarial sciences, and thus every university should acquire a copy.The proceedings have been selected for coverage in: ? Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)? Index to Social Sciences & Humanities Proceedings? (ISSHP? / ISI Proceedings)? Index to Social Sciences & Humanities Proceedings (ISSHP CDROM version / ISI Proceedings)? CC Proceedings ? Engineering & Physical Sciences
Author : Alessandro Baldi Antognini,Alessandra Giovagnoli
Publisher : CRC Press
Page : 216 pages
File Size : 48,9 Mb
Release : 2015-04-06
Category : Mathematics
ISBN : 9781466505766
Adaptive Designs for Sequential Treatment Allocation presents a rigorous theoretical treatment of the results and mathematical foundation of adaptive design theory. The book focuses on designing sequential randomized experiments to compare two or more treatments incorporating information accrued along the way. The authors first introduce the termin
Author : Sandeep Menon,Richard C. Zink
Publisher : SAS Institute
Page : 364 pages
File Size : 49,5 Mb
Release : 2015-12-09
Category : Computers
ISBN : 9781629600840
This book covers domains of modern clinical trial design: classical, group sequential, adaptive, and Bayesian methods applicable to and used in various phases of pharmaceutical development. Written for biostatisticians, pharmacometricians, clinical developers, and statistical programmers involved in the design, analysis, and interpretation of clinical trials, as well as students in graduate and postgraduate programs in statistics or biostatistics, it covers topics including: dose-response and dose-escalation designs; sequential methods to stop trials early for overwhelming efficacy, safety, or futility; Bayesian designs incorporating historical data; adaptive sample size re-estimation and randomization to allocate subjects to effective treatments; population enrichment designs. Methods are illustrated using clinical trials from diverse therapeutic areas, including dermatology, endocrinology, infectious disease, neurology, oncology and rheumatology. --
Author : Yaoting Zhang
Publisher : World Scientific
Page : 304 pages
File Size : 42,5 Mb
Release : 2003
Category : Mathematics
ISBN : 9812796703
An interview with Professor Yaoting Zhang / Qiwei Yao and Zhaohai Li -- Significance level in interval mapping / David O. Siegmund and Benny Yakir -- An asymptotic Pythagorean identity / Zhiliang Ying -- A Monte Carlo gap test in computing HPD regions / Ming-Hui Chen [und weitere] -- Estimating restricted normal means using the EM-type algorithms and IBF sampling / Ming Tan, Guo-Liang Tian and Hong-Bin Fang -- An example of algorithm mining: covariance adjustment to accelerate EM and Gibbs / Chuanhai Liu -- Large deviations and deviation inequality for kernel density estimator in L[symbol]-distance / Liangzhen Lei, Liming Wu and Bin Xie -- Local sensitivity analysis of model misspecification / Guobing Lu -- Empirical likelihood confidence intervals for the difference of two quantiles of a population / Yongsong Qin and Yuehua Wu -- Exponential inequalities for spatial processes and uniform convergence rates for density estimation / Qiwei Yao -- A skew regression model for inference of stock volatility / Tuhao J. Chen and Hanfeng Chen -- Explicit transitional dynamics in growth models / Danyang Xie -- A fiscal federalism approach to optimal taxation and intergovernmental transfers in a dynamic model / Liutang Gong and Heng-Fu Zou -- Sharing catastrophe risk under model uncertainty / Xiaodong Zhu -- Ranked set sampling: a methodology for observational economy / Zehua Chen -- Some recent advances on response-adaptive randomized designs / Feifang Hu -- A childhood epidemic model with birthrate-dependent transmission / Yingcun Xia -- Linear regression analysis with observations subject to interval censoring / Linxiong Li -- When can the Haseman-Elston procedure for quantitative trait loci be improved? Insights from optimal design theory / Zhaohai Li, Minyu Xie and Joseph L. Gastwirth -- A semiparametric method for mapping quantitative trait loci / Jian Huang and Kai Wang -- Structure mixture regression models / Hongtu Zhu and Heping Zhang
Author : Oleksandr Sverdlov
Publisher : CRC Press
Page : 536 pages
File Size : 50,5 Mb
Release : 2015-06-30
Category : Mathematics
ISBN : 9781482239898
Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and unbiased treatment comparisons following adaptive random
Author : Shein-Chung Chow
Publisher : CRC Press
Page : 2434 pages
File Size : 46,5 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9781351110266
Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a well-balanced summary of current regulatory requirements, and (3) describes recently developed statistical methods in the pharmaceutical sciences. Features of the Fourth Edition: 1. 78 new and revised entries have been added for a total of 308 chapters and a fourth volume has been added to encompass the increased number of chapters. 2. Revised and updated entries reflect changes and recent developments in regulatory requirements for the drug review/approval process and statistical designs and methodologies. 3. Additional topics include multiple-stage adaptive trial design in clinical research, translational medicine, design and analysis of biosimilar drug development, big data analytics, and real world evidence for clinical research and development. 4. A table of contents organized by stages of biopharmaceutical development provides easy access to relevant topics. About the Editor: Shein-Chung Chow, Ph.D. is currently an Associate Director, Office of Biostatistics, U.S. Food and Drug Administration (FDA). Dr. Chow is an Adjunct Professor at Duke University School of Medicine, as well as Adjunct Professor at Duke-NUS, Singapore and North Carolina State University. Dr. Chow is the Editor-in-Chief of the Journal of Biopharmaceutical Statistics and the Chapman & Hall/CRC Biostatistics Book Series and the author of 28 books and over 300 methodology papers. He was elected Fellow of the American Statistical Association in 1995.
Author : Anthony C Atkinson,Atanu Biswas
Publisher : CRC Press
Page : 341 pages
File Size : 43,6 Mb
Release : 2013-12-26
Category : Mathematics
ISBN : 9781584886938
Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.
Author : Nancy Flournoy,William F. Rosenberger
Publisher : IMS
Page : 304 pages
File Size : 42,9 Mb
Release : 1995
Category : Mathematics
ISBN : 0940600366
Author : Atanu Biswas,Sujay Datta,Jason P. Fine,Mark R. Segal
Publisher : John Wiley & Sons
Page : 616 pages
File Size : 54,9 Mb
Release : 2007-12-14
Category : Mathematics
ISBN : 0470181192
The Most Comprehensive and Cutting-Edge Guide to Statistical Applications in Biomedical Research With the increasing use of biotechnology in medical research and the sophisticated advances in computing, it has become essential for practitioners in the biomedical sciences to be fully educated on the role statistics plays in ensuring the accurate analysis of research findings. Statistical Advances in the Biomedical Sciences explores the growing value of statistical knowledge in the management and comprehension of medical research and, more specifically, provides an accessible introduction to the contemporary methodologies used to understand complex problems in the four major areas of modern-day biomedical science: clinical trials, epidemiology, survival analysis, and bioinformatics. Composed of contributions from eminent researchers in the field, this volume discusses the application of statistical techniques to various aspects of modern medical research and illustrates how these methods ultimately prove to be an indispensable part of proper data collection and analysis. A structural uniformity is maintained across all chapters, each beginning with an introduction that discusses general concepts and the biomedical problem under focus and is followed by specific details on the associated methods, algorithms, and applications. In addition, each chapter provides a summary of the main ideas and offers a concluding remarks section that presents novel ideas, approaches, and challenges for future research. Complete with detailed references and insight on the future directions of biomedical research, Statistical Advances in the Biomedical Sciences provides vital statistical guidance to practitioners in the biomedical sciences while also introducing statisticians to new, multidisciplinary frontiers of application. This text is an excellent reference for graduate- and PhD-level courses in various areas of biostatistics and the medical sciences and also serves as a valuable tool for medical researchers, statisticians, public health professionals, and biostatisticians.
Author : William F. Rosenberger,John M. Lachin
Publisher : John Wiley & Sons
Page : 284 pages
File Size : 47,9 Mb
Release : 2015-10-28
Category : Mathematics
ISBN : 9781118742372
Praise for the First Edition “All medical statisticians involved in clinical trials should read this book...” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive randomization, including minimization techniques and inference New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Plenty of problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, simplify the mathematics, and ease readers’ understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics. William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles, as well as The Theory of Response-Adaptive Randomization in Clinical Trials, also published by Wiley. John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as in the Department of Statistics at The George Washington University. A Fellow of the American Statistical Association and the Society for Clinical Trials, Dr. Lachin is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.
Author : Guosheng Yin
Publisher : John Wiley & Sons
Page : 364 pages
File Size : 52,5 Mb
Release : 2013-06-07
Category : Medical
ISBN : 9781118183328
A balanced treatment of the theories, methodologies, and designissues involved in clinical trials using statisticalmethods There has been enormous interest and development in Bayesianadaptive designs, especially for early phases of clinical trials.However, for phase III trials, frequentist methods still play adominant role through controlling type I and type II errors in thehypothesis testing framework. From practical perspectives, ClinicalTrial Design: Bayesian and Frequentist Adaptive Methods providescomprehensive coverage of both Bayesian and frequentist approachesto all phases of clinical trial design. Before underpinning variousadaptive methods, the book establishes an overview of thefundamentals of clinical trials as well as a comparison of Bayesianand frequentist statistics. Recognizing that clinical trial design is one of the mostimportant and useful skills in the pharmaceutical industry, thisbook provides detailed discussions on a variety of statisticaldesigns, their properties, and operating characteristics for phaseI, II, and III clinical trials as well as an introduction to phaseIV trials. Many practical issues and challenges arising in clinicaltrials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacytrade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs andstatistical methods that have been employed at the world's leadingmedical centers as well as in the pharmaceutical industry. Thesoftware used throughout the book is freely available on the book'srelated website, equipping readers with the necessary tools fordesigning clinical trials. Clinical Trial Design is an excellent book for courses on thetopic at the graduate level. The book also serves as a valuablereference for statisticians and biostatisticians in thepharmaceutical industry as well as for researchers andpractitioners who design, conduct, and monitor clinical trials intheir everyday work.
Author : Anonim
Publisher : ScholarlyEditions
Page : 67 pages
File Size : 44,9 Mb
Release : 2013-01-10
Category : Medical
ISBN : 9781481648752
Issues in Healthcare Communication and Information Technology: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Medical Informatics and Decision Making in a concise format. The editors have built Issues in Healthcare Communication and Information Technology: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Medical Informatics and Decision Making in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Healthcare Communication and Information Technology: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.