Autophagy And Cardiometabolic Diseases

Author : Jun Ren,James R. Sowers,Yingmei Zhang
Publisher : Academic Press
Page : 340 pages
File Size : 50,7 Mb
Release : 2018-04-12
Category : Medical
ISBN : 9780128054420

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Autophagy and Cardiometabolic Diseases by Jun Ren,James R. Sowers,Yingmei Zhang Pdf

Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Author : Sebastiano Sciarretta,Richard N. Kitsis,Junichi Sadoshima
Publisher : Frontiers Media SA
Page : 111 pages
File Size : 50,6 Mb
Release : 2021-03-04
Category : Medical
ISBN : 9782889665563

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Mitochondrial Dysfunction and Cardiovascular Diseases by Sebastiano Sciarretta,Richard N. Kitsis,Junichi Sadoshima Pdf

Author : Ning Chen
Publisher : Springer Nature
Page : 267 pages
File Size : 42,7 Mb
Release : 2021-09-30
Category : Medical
ISBN : 9789811645259

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Exercise, Autophagy and Chronic Diseases by Ning Chen Pdf

This book establishes a bridge between exercise-mediated functional status of autophagy and non-communicable chronic diseases for elucidating and clarifying the corresponding signal pathways and underlying mechanisms. The book consists of 13 chapters focusing on the in-depth discussion on signal pathways for regulating the functional status of autophagy for the prevention, treatment and rehabilitation of chronic diseases, the optimization of exercise intervention strategies for common and frequently-occurring chronic diseases, and the development of exercise mimetic pills for the persons with disability for exercise performance, or the persons without willing to exercise. This book is interesting and will be useful to a wide readership in the various fields of exercise science, exercise fitness, sports medicine, preventive medicine, and functional foods.

Author : H. Böhles,A. C. Sewell
Publisher : CRC Press
Page : 188 pages
File Size : 54,9 Mb
Release : 2004
Category : Cardiomyopathy
ISBN : 3887631048

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Metabolic Cardiomyopathy by H. Böhles,A. C. Sewell Pdf

During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.

Author : Weidong Le
Publisher : Springer Nature
Page : 734 pages
File Size : 48,6 Mb
Release : 2020-07-15
Category : Medical
ISBN : 9789811542725

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Autophagy: Biology and Diseases by Weidong Le Pdf

This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine

Author : Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit
Publisher : Springer Nature
Page : 596 pages
File Size : 54,8 Mb
Release : 2019-11-06
Category : Science
ISBN : 9789811382734

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Oxidative Stress in Heart Diseases by Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit Pdf

This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Author : Lorrie A. Kirshenbaum
Publisher : Springer Nature
Page : 293 pages
File Size : 41,5 Mb
Release : 2021-11-29
Category : Science
ISBN : 9783030787998

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Biochemistry of Apoptosis and Autophagy by Lorrie A. Kirshenbaum Pdf

One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis. While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death is merely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event. Autophagy is another cellular process that has received considerable attention over the past two decades and its remarkable involvement in the processes of cell survival, death and tumorigenesis. Macro autophagy is a catabolic process that involves the selective and targeted removal of oxidized proteins, macromolecular structures and organelles through an elaborate cellular process involving a lysosome mediated pathway. Other forms of autophagy involving adapter proteins, commonly referred to as chaperone mediated autophagy, involves the selective removal of cellular cargo by the ubiquitin-proteasome pathway. The book will serve as a reference guide for basic and clinical scientists who are interested in understanding how these critical cellular processes impact the pathogenesis of human disease.

Author : Jun Ren,Xin Wang,Ying Mei Zhang
Publisher : Frontiers Media SA
Page : 310 pages
File Size : 55,5 Mb
Release : 2021-11-02
Category : Science
ISBN : 9782889715831

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New Drug Targets for Proteotoxicity in Cardiometabolic Diseases by Jun Ren,Xin Wang,Ying Mei Zhang Pdf

Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Page : 89 pages
File Size : 47,8 Mb
Release : 2019-08-08
Category : Electronic
ISBN : 9782889459384

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Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease by Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Paul Holvoet
Publisher : Springer Nature
Page : 289 pages
File Size : 40,7 Mb
Release : 2021-03-26
Category : Medical
ISBN : 9783030688448

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Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer by Paul Holvoet Pdf

This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.

Author : Loredana Moro
Publisher : Unknown
Page : 322 pages
File Size : 51,7 Mb
Release : 2020-09-04
Category : Electronic
ISBN : 3039369180

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The Rise of Mitochondria in Medicine by Loredana Moro Pdf

Mitochondria are critical bioenergetic and biosynthetic machines that are essential for normal cell function. Traditionally, mitochondria have been considered the powerhouse of the cell, as they supply most of the cellular energy through oxidative phosphorylation. In addition, they supply the building blocks needed for the synthesis of cellular biomass. More recently, mitochondria have been recognized as signaling hubs that receive and transmit signals throughout the cell, thereby affecting cell functionality and fate. The signals generated by mitochondria include changes in metabolites, the NAD+/NADH ratio, ATP/ADP ratio, Ca2+, and reactive oxygen species (ROS), but our understanding of their nature, dynamics, targets, and roles in different physiopathological contexts is still under development. Mitochondrial dysfunction, which may originate from primary defects within the organelles or from stress conditions in the microenvironment, is a hallmark of many common diseases, including ischaemia-reperfusion injury, cancer, metabolic disease, and neurodegenerative disorders, and has become a major research focus in medicine. Understanding the biology of mitochondrial signaling and the role of mitochondrial dysfunction in the pathogenesis of many metabolic, degenerative, cardiovascular, and neoplastic diseases is crucial for the development of strategies aimed at therapeutically restoring mitochondrial functionality. This Special Issue presents current knowledge in the field of mitochondrial signaling in health and disease, and recent advances in mitochondrial pharmacology.

Author : Beverly Rothermel,Abhinav Diwan
Publisher : Elsevier
Page : 456 pages
File Size : 51,9 Mb
Release : 2021-09-22
Category : Science
ISBN : 9780128220047

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Autophagy in Health and Disease by Beverly Rothermel,Abhinav Diwan Pdf

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study. Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathology Offers extended coverage of the mechanisms that mediate autophagy Covers the role of autophagy in stem cells and induced pluripotent stem cells, as well as the regenerative process of paligenosis Highlights important questions that remain to be addressed

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 45,9 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Author : Alaeddin Abukabda,Maria Suciu,Minodora Andor
Publisher : BoD – Books on Demand
Page : 144 pages
File Size : 53,5 Mb
Release : 2021-04-21
Category : Medical
ISBN : 9781838819491

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Cardiovascular Risk Factors in Pathology by Alaeddin Abukabda,Maria Suciu,Minodora Andor Pdf

This book provides a broad overview of the molecular mechanisms associated with relevant and significant cardiovascular conditions that continue to plague humanity. It also discusses potential and promising therapeutic avenues targeted at addressing these conditions. The overarching goal of this multifaceted work is to entice future and current members of the scientific community to direct their endeavors towards improving our current knowledge of cardiovascular disease conditions and curb their impact on our everyday lives.

Author : Sushil Sharma
Publisher : CRC Press
Page : 608 pages
File Size : 48,6 Mb
Release : 2021-09-03
Category : Technology & Engineering
ISBN : 9781000298413

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Charnolophagy in Health and Disease by Sushil Sharma Pdf

This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies implicated in early morbidity and mortality and disease-specific spatiotemporal, targeted, safe, and effective evidence-based personalized theranostic charnolopharmacotherapeutics to cure them. Basic DRESS and GELS principles, nanoparticles to cure chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers to curb CB molecular pathogenesis (CBMP) are described for better quality of life and longevity. Specific guidelines for environmental protection and preservation of zoological and botanical species at the verge of extinction, Triple "I" Hypothesis for mitochondrial quality control, and transcriptional regulation of CSexR and CSendoR to cure chronic diseases are presented. Novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, aging population, toxicologists, environmental protectionists, pharmaceutical industry, biomedical scientists, researchers, medical students, physicians, nurses, paramedical professionals, and global audience will be interested in this interesting book to prevent pandemics and raise healthcare awareness.