Biophysics Of Computation

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Biophysics of Computation

Author : Christof Koch
Publisher : Oxford University Press
Page : 588 pages
File Size : 40,8 Mb
Release : 2004-10-28
Category : Medical
ISBN : 9780190292850

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Biophysics of Computation by Christof Koch Pdf

Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes. Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation. Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.

Biophysics of Computation

Author : Christof Koch
Publisher : Oxford University Press
Page : 587 pages
File Size : 40,7 Mb
Release : 2004-10-28
Category : Medical
ISBN : 9780195181999

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Biophysics of Computation by Christof Koch Pdf

Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation.Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.

Single Neuron Computation

Author : Thomas M. McKenna,Joel L. Davis,Steven F. Zornetzer
Publisher : Academic Press
Page : 644 pages
File Size : 47,6 Mb
Release : 2014-05-19
Category : Computers
ISBN : 9781483296067

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Single Neuron Computation by Thomas M. McKenna,Joel L. Davis,Steven F. Zornetzer Pdf

This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs. The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods.

Computational Neuroscience

Author : Hanspeter A Mallot
Publisher : Springer Science & Business Media
Page : 135 pages
File Size : 48,7 Mb
Release : 2013-05-23
Category : Technology & Engineering
ISBN : 9783319008615

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Computational Neuroscience by Hanspeter A Mallot Pdf

Computational Neuroscience - A First Course provides an essential introduction to computational neuroscience and equips readers with a fundamental understanding of modeling the nervous system at the membrane, cellular, and network level. The book, which grew out of a lecture series held regularly for more than ten years to graduate students in neuroscience with backgrounds in biology, psychology and medicine, takes its readers on a journey through three fundamental domains of computational neuroscience: membrane biophysics, systems theory and artificial neural networks. The required mathematical concepts are kept as intuitive and simple as possible throughout the book, making it fully accessible to readers who are less familiar with mathematics. Overall, Computational Neuroscience - A First Course represents an essential reference guide for all neuroscientists who use computational methods in their daily work, as well as for any theoretical scientist approaching the field of computational neuroscience.

Computational Neuroscience

Author : Eric L. Schwartz
Publisher : MIT Press
Page : 468 pages
File Size : 55,6 Mb
Release : 1993-08-26
Category : Computational neuroscience
ISBN : 0262691647

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Computational Neuroscience by Eric L. Schwartz Pdf

The thirty original contributions in this book provide a working definition of"computational neuroscience" as the area in which problems lie simultaneously within computerscience and neuroscience. They review this emerging field in historical and philosophical overviewsand in stimulating summaries of recent results. Leading researchers address the structure of thebrain and the computational problems associated with describing and understanding this structure atthe synaptic, neural, map, and system levels.The overview chapters discuss the early days of thefield, provide a philosophical analysis of the problems associated with confusion between brainmetaphor and brain theory, and take up the scope and structure of computationalneuroscience.Synaptic-level structure is addressed in chapters that relate the properties ofdendritic branches, spines, and synapses to the biophysics of computation and provide a connectionbetween real neuron architectures and neural network simulations.The network-level chapters take upthe preattentive perception of 3-D forms, oscillation in neural networks, the neurobiologicalsignificance of new learning models, and the analysis of neural assemblies and local learningrides.Map-level structure is explored in chapters on the bat echolocation system, cat orientationmaps, primate stereo vision cortical cognitive maps, dynamic remapping in primate visual cortex, andcomputer-aided reconstruction of topographic and columnar maps in primates.The system-level chaptersfocus on the oculomotor system VLSI models of early vision, schemas for high-level vision,goal-directed movements, modular learning, effects of applied electric current fields on corticalneural activity neuropsychological studies of brain and mind, and an information-theoretic view ofanalog representation in striate cortex.Eric L. Schwartz is Professor of Brain Research and ResearchProfessor of Computer Science, Courant Institute of Mathematical Sciences, New York UniversityMedical Center. Computational Neuroscience is included in the System Development FoundationBenchmark Series.

Biological Computation

Author : Ehud Lamm,Ron Unger
Publisher : CRC Press
Page : 332 pages
File Size : 49,7 Mb
Release : 2011-05-25
Category : Mathematics
ISBN : 9781420087963

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Biological Computation by Ehud Lamm,Ron Unger Pdf

The area of biologically inspired computing, or biological computation, involves the development of new, biologically based techniques for solving difficult computational problems. A unified overview of computer science ideas inspired by biology, Biological Computation presents the most fundamental and significant concepts in this area. In the book

Computation in Science

Author : Konrad Hinsen
Publisher : Morgan & Claypool Publishers
Page : 140 pages
File Size : 48,5 Mb
Release : 2015-12-01
Category : Science
ISBN : 9781681741574

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Computation in Science by Konrad Hinsen Pdf

This book provides a theoretical background in computation to scientists who use computational methods. It explains how computing is used in the natural sciences, and provides a high-level overview of those aspects of computer science and software engineering that are most relevant for computational science. The focus is on concepts, results, and applications, rather than on proofs and derivations. The unique feature of this book is that it “connects the dots between computational science, the theory of computation and information, and software engineering. The book should help scientists to better understand how they use computers in their work, and to better understand how computers work. It is meant to compensate a bit for the general lack of any formal training in computer science and information theory. Readers will learn something they can use throughout their careers.

Computational Models of Brain and Behavior

Author : Ahmed A. Moustafa
Publisher : John Wiley & Sons
Page : 584 pages
File Size : 45,8 Mb
Release : 2017-09-11
Category : Psychology
ISBN : 9781119159070

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Computational Models of Brain and Behavior by Ahmed A. Moustafa Pdf

A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.

Retinal Computation

Author : Greg Schwartz
Publisher : Academic Press
Page : 342 pages
File Size : 42,7 Mb
Release : 2021-08-07
Category : Medical
ISBN : 9780128231777

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Retinal Computation by Greg Schwartz Pdf

Retinal Computation summarizes current progress in defining the computations performed by the retina, also including the synaptic and circuit mechanisms by which they are implemented. Each chapter focuses on a single retinal computation that includes the definition of the computation and its neuroethological purpose, along with the available information on its known and unknown neuronal mechanisms. All chapters contain end-of-chapter questions associated with a landmark paper, as well as programming exercises. This book is written for advanced graduate students, researchers and ophthalmologists interested in vision science or computational neuroscience of sensory systems. While the typical textbook's description of the retina is akin to a biological video camera, the real retina is actually the world’s most complex image processing machine. As part of the central nervous system, the retina converts patterns of light at the input into a rich palette of representations at the output. The parallel streams of information in the optic nerve encode features like color, contrast, orientation of edges, and direction of motion. Image processing in the retina is undeniably complex, but as one of the most accessible parts of the central nervous system, the tools to study retinal circuits with unprecedented precision are up to the task. This book provides a practical guide and resource about the current state of the field of retinal computation. Provides a practical guide on the field of retinal computation Summarizes and clearly explains important topics such as luminance, contrast, spatial features, motion and other computations Contains discussion questions, a landmark paper, and programming exercises within each chapter

The Feeling of Life Itself

Author : Christof Koch
Publisher : MIT Press
Page : 277 pages
File Size : 53,6 Mb
Release : 2019-09-24
Category : Science
ISBN : 9780262042819

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The Feeling of Life Itself by Christof Koch Pdf

A thought-provoking argument that consciousness—more widespread than previously assumed—is the feeling of being alive, not a type of computation or a clever hack In The Feeling of Life Itself, Christof Koch offers a straightforward definition of consciousness as any subjective experience, from the most mundane to the most exalted—the feeling of being alive. Psychologists study which cognitive operations underpin a given conscious perception. Neuroscientists track the neural correlates of consciousness in the brain, the organ of the mind. But why the brain and not, say, the liver? How can the brain—three pounds of highly excitable matter, a piece of furniture in the universe, subject to the same laws of physics as any other piece—give rise to subjective experience? Koch argues that what is needed to answer these questions is a quantitative theory that starts with experience and proceeds to the brain. In The Feeling of Life Itself, Koch outlines such a theory, based on integrated information. Koch describes how the theory explains many facts about the neurology of consciousness and how it has been used to build a clinically useful consciousness meter. The theory predicts that many, and perhaps all, animals experience the sights and sounds of life; consciousness is much more widespread than conventionally assumed. Contrary to received wisdom, however, Koch argues that programmable computers will not have consciousness. Even a perfect software model of the brain is not conscious. Its simulation is fake consciousness. Consciousness is not a special type of computation—it is not a clever hack. Consciousness is about being.

Effective Computation in Physics

Author : Anthony Scopatz,Kathryn D. Huff
Publisher : "O'Reilly Media, Inc."
Page : 552 pages
File Size : 50,7 Mb
Release : 2015-06-25
Category : Science
ISBN : 9781491901588

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Effective Computation in Physics by Anthony Scopatz,Kathryn D. Huff Pdf

More physicists today are taking on the role of software developer as part of their research, but software development isn’t always easy or obvious, even for physicists. This practical book teaches essential software development skills to help you automate and accomplish nearly any aspect of research in a physics-based field. Written by two PhDs in nuclear engineering, this book includes practical examples drawn from a working knowledge of physics concepts. You’ll learn how to use the Python programming language to perform everything from collecting and analyzing data to building software and publishing your results. In four parts, this book includes: Getting Started: Jump into Python, the command line, data containers, functions, flow control and logic, and classes and objects Getting It Done: Learn about regular expressions, analysis and visualization, NumPy, storing data in files and HDF5, important data structures in physics, computing in parallel, and deploying software Getting It Right: Build pipelines and software, learn to use local and remote version control, and debug and test your code Getting It Out There: Document your code, process and publish your findings, and collaborate efficiently; dive into software licenses, ownership, and copyright procedures

Computational Neuroscience

Author : Wanpracha Chaovalitwongse,Panos M. Pardalos,Petros Xanthopoulos
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 52,7 Mb
Release : 2010-07-03
Category : Medical
ISBN : 0387886303

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Computational Neuroscience by Wanpracha Chaovalitwongse,Panos M. Pardalos,Petros Xanthopoulos Pdf

This volume includes contributions from diverse disciplines including electrical engineering, biomedical engineering, industrial engineering, and medicine, bridging a vital gap between the mathematical sciences and neuroscience research. Covering a wide range of research topics, this volume demonstrates how various methods from data mining, signal processing, optimization and cutting-edge medical techniques can be used to tackle the most challenging problems in modern neuroscience.

Alzheimer's Disease: Biology, Biophysics And Computational Models

Author : Don Kulasiri,Jingyi Liang
Publisher : World Scientific
Page : 416 pages
File Size : 49,8 Mb
Release : 2022-01-06
Category : Medical
ISBN : 9781800610132

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Alzheimer's Disease: Biology, Biophysics And Computational Models by Don Kulasiri,Jingyi Liang Pdf

Alzheimer's disease (AD) is the leading cause of dementia and, unfortunately, remains incurable. The social, emotional and financial implications of AD are immeasurable, and about 47 million people worldwide are affected by AD or other forms of dementia. As lifespans are improved by healthcare systems worldwide, age-associated neurodegenerative diseases are imposing an increasing challenge to science. It is becoming imperative for us to understand the causes of these diseases, AD in particular, at molecular and cellular levels. Starting with the broader picture from a biological perspective, this book takes the reader through fascinating dynamics within and outside of neurons in the brain.Alzheimer's Disease: Biology, Biophysics and Computational Models helps the reader to understand AD from mechanistic and biochemical perspectives at intra- and inter-cellular levels. It focuses on biochemical pathways and modeling associated with AD. Some of the recent research on biophysics and computational models related to AD are explained using context-driven computational and mathematical modeling and essential biology is discussed to understand the modeling research.

Neural Computation and Self-organizing Maps

Author : Helge Ritter,Thomas Martinetz,Klaus Schulten
Publisher : Addison Wesley Publishing Company
Page : 328 pages
File Size : 50,9 Mb
Release : 1992
Category : Neural circuitry
ISBN : UOM:39015024997929

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Neural Computation and Self-organizing Maps by Helge Ritter,Thomas Martinetz,Klaus Schulten Pdf

Mathematical Biophysics

Author : Andrew Rubin,Galina Riznichenko
Publisher : Springer Science & Business Media
Page : 273 pages
File Size : 41,5 Mb
Release : 2013-11-26
Category : Science
ISBN : 9781461487029

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Mathematical Biophysics by Andrew Rubin,Galina Riznichenko Pdf

This book presents concise descriptions and analysis of the classical and modern models used in mathematical biophysics. The authors ask the question "what new information can be provided by the models that cannot be obtained directly from experimental data?" Actively developing fields such as regulatory mechanisms in cells and subcellular systems and electron transport and energy transport in membranes are addressed together with more classical topics such as metabolic processes, nerve conduction and heart activity, chemical kinetics, population dynamics, and photosynthesis. The main approach is to describe biological processes using different mathematical approaches necessary to reveal characteristic features and properties of simulated systems. With the emergence of powerful mathematics software packages such as MAPLE, Mathematica, Mathcad, and MatLab, these methodologies are now accessible to a wide audience.