Cancer Informatics

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Cancer Informatics

Author : John S. Silva,Marion J. Ball,Christopher G. Chute,Judith V. Douglas,Curtis P. Langlotz,Joyce C. Niland,William L. Scherlis
Publisher : Springer Science & Business Media
Page : 377 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461300632

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Cancer Informatics by John S. Silva,Marion J. Ball,Christopher G. Chute,Judith V. Douglas,Curtis P. Langlotz,Joyce C. Niland,William L. Scherlis Pdf

Cancer Informatics chronicles the development of the National Cancer Institute's new Cancer Informatics Infrastructure (CII) - an information management system infrastructure designed to faciliate clinical trials, provide for reliable, secure information exchange, and improve patient care. The book details the challenges involved in creating and managing such a knowledge base, including technologies, standards, and current, state-of-the-art applications. The ultimate goal of CII is to function as an enabler of clinical trials, expediting the clinical trials lifecycle, faciliating faster and safer drug development and more appropriate treatment choices for cancer patients. Contributors address the role the CII must play in converting the growing knowledge of genes, proteins, and pathways into appropriate preventative, diagnostic, and therapeutic measures. Presented in four sections, the first provides an overview of the processes involved in moving the infrastructure for cancer from theory into practice. Sections two through four offer the latest work done in the areas of technology, cancer-specific and national standards, and applications to faciliate clinical trials.

Oncology Informatics

Author : Bradford W. Hesse,David Ahern,Ellen Beckjord
Publisher : Academic Press
Page : 448 pages
File Size : 44,5 Mb
Release : 2016-03-17
Category : Computers
ISBN : 9780128022009

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Oncology Informatics by Bradford W. Hesse,David Ahern,Ellen Beckjord Pdf

Oncology Informatics: Using Health Information Technology to Improve Processes and Outcomes in Cancer Care encapsulates National Cancer Institute-collected evidence into a format that is optimally useful for hospital planners, physicians, researcher, and informaticians alike as they collectively strive to accelerate progress against cancer using informatics tools. This book is a formational guide for turning clinical systems into engines of discovery as well as a translational guide for moving evidence into practice. It meets recommendations from the National Academies of Science to "reorient the research portfolio" toward providing greater "cognitive support for physicians, patients, and their caregivers" to "improve patient outcomes." Data from systems studies have suggested that oncology and primary care systems are prone to errors of omission, which can lead to fatal consequences downstream. By infusing the best science across disciplines, this book creates new environments of "Smart and Connected Health." Oncology Informatics is also a policy guide in an era of extensive reform in healthcare settings, including new incentives for healthcare providers to demonstrate "meaningful use" of these technologies to improve system safety, engage patients, ensure continuity of care, enable population health, and protect privacy. Oncology Informatics acknowledges this extraordinary turn of events and offers practical guidance for meeting meaningful use requirements in the service of improved cancer care. Anyone who wishes to take full advantage of the health information revolution in oncology to accelerate successes against cancer will find the information in this book valuable. Presents a pragmatic perspective for practitioners and allied health care professionals on how to implement Health I.T. solutions in a way that will minimize disruption while optimizing practice goals Proposes evidence-based guidelines for designers on how to create system interfaces that are easy to use, efficacious, and timesaving Offers insight for researchers into the ways in which informatics tools in oncology can be utilized to shorten the distance between discovery and practice

Cancer Informatics in the Post Genomic Era

Author : Igor Jurisica,Dennis A. Wigle,Bill Wong
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 54,8 Mb
Release : 2007-05-04
Category : Medical
ISBN : 9780387693217

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Cancer Informatics in the Post Genomic Era by Igor Jurisica,Dennis A. Wigle,Bill Wong Pdf

Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science. This, of course, requires analytic tools. Those tools are garnered by developing and assessing methods and systems for the acquisition, processing, and interpretation of patient data, aided by scientific discovery. Key challenges in this field include integrating research and clinical care, sharing data, and establishing partnerships within and across sectors of patient diagnosis and treatment.

Biomedical Informatics for Cancer Research

Author : Michael F. Ochs,John T. Casagrande,Ramana V. Davuluri
Publisher : Springer Science & Business Media
Page : 354 pages
File Size : 54,6 Mb
Release : 2010-04-06
Category : Medical
ISBN : 9781441957146

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Biomedical Informatics for Cancer Research by Michael F. Ochs,John T. Casagrande,Ramana V. Davuluri Pdf

view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant proteins, since any tre- ment must aim to improve health to justify its potential side effects. Treatment for cancer must become highly individualized, focusing on the specific aberrant driver proteins in an individual. This drives a need for informatics in cancer far beyond the need in other diseases. For instance, routine treatment with statins has become widespread for minimizing heart disease, with most patients responding to standard doses (Wilt et al. 2004). In contrast, standard treatment for cancer must become tailored to the molecular phenotype of an individual tumor, with each patient receiving a different combination of therapeutics aimed at the specific aberrant proteins driving the cancer. Tracking the aberrations that drive cancers, identifying biomarkers unique to each individual for molecular-level di- nosis and treatment response, monitoring adverse events and complex dosing schedules, and providing annotated molecular data for ongoing research to improve treatments comprise a major biomedical informatics need.

Informatics Needs and Challenges in Cancer Research

Author : Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Page : 146 pages
File Size : 50,5 Mb
Release : 2012-11-02
Category : Medical
ISBN : 9780309259484

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Informatics Needs and Challenges in Cancer Research by Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum Pdf

As information technology becomes an integral part of health care, it is important to collect and analyze data in a way that makes the information understandable and useful. Informatics tools-which help collect, organize, and analyze data-are essential to biomedical and health research and development. The field of cancer research is facing an overwhelming deluge of data, heightening the national urgency to find solutions to support and sustain the cancer informatics ecosystem. There is a particular need to integrate research and clinical data to facilitate personalized medicine approaches to cancer prevention and treatment-for example, tailoring treatment based on an individual patient's genetic makeup as well as that of the tumor-and to allow for more rapid learning from patient experiences. To further examine informatics needs and challenges for 21st century biomedical research, the IOM's National Cancer Policy Forum held a workshop February 27-28, 2012. The workshop was designed to raise awareness of the critical and urgent importance of the challenges, gaps and opportunities in informatics; to frame the issues surrounding the development of an integrated system of cancer informatics for acceleration of research; and to discuss solutions for transformation of the cancer informatics enterprise. Informatics Needs and Challenges in Cancer Research: Workshop Summary summarizes the workshop.

Medical Statistics for Cancer Studies

Author : Trevor F. Cox
Publisher : CRC Press
Page : 407 pages
File Size : 53,6 Mb
Release : 2022-06-23
Category : Mathematics
ISBN : 9781000601152

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Medical Statistics for Cancer Studies by Trevor F. Cox Pdf

Cancer is a dreaded disease. One in two people will be diagnosed with cancer within their lifetime. Medical Statistics for Cancer Studies shows how cancer data can be analysed in a variety of ways, covering cancer clinical trial data, epidemiological data, biological data, and genetic data. It gives some background in cancer biology and genetics, followed by detailed overviews of survival analysis, clinical trials, regression analysis, epidemiology, meta-analysis, biomarkers, and cancer informatics. It includes lots of examples using real data from the author’s many years of experience working in a cancer clinical trials unit. Features: A broad and accessible overview of statistical methods in cancer research Necessary background in cancer biology and genetics Details of statistical methodology with minimal algebra Many examples using real data from cancer clinical trials Appendix giving statistics revision.

Biomedical Informatics for Cancer Research

Author : Michael F. Ochs,John T. Casagrande,Ramana V. Davuluri
Publisher : Springer
Page : 354 pages
File Size : 54,9 Mb
Release : 2011-07-21
Category : Medical
ISBN : 1441957138

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Biomedical Informatics for Cancer Research by Michael F. Ochs,John T. Casagrande,Ramana V. Davuluri Pdf

view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant proteins, since any tre- ment must aim to improve health to justify its potential side effects. Treatment for cancer must become highly individualized, focusing on the specific aberrant driver proteins in an individual. This drives a need for informatics in cancer far beyond the need in other diseases. For instance, routine treatment with statins has become widespread for minimizing heart disease, with most patients responding to standard doses (Wilt et al. 2004). In contrast, standard treatment for cancer must become tailored to the molecular phenotype of an individual tumor, with each patient receiving a different combination of therapeutics aimed at the specific aberrant proteins driving the cancer. Tracking the aberrations that drive cancers, identifying biomarkers unique to each individual for molecular-level di- nosis and treatment response, monitoring adverse events and complex dosing schedules, and providing annotated molecular data for ongoing research to improve treatments comprise a major biomedical informatics need.

Statistics and Informatics in Molecular Cancer Research

Author : Carsten Wiuf,Claus L. Andersen
Publisher : Oxford University Press
Page : 217 pages
File Size : 42,7 Mb
Release : 2009-06-18
Category : Mathematics
ISBN : 9780199532872

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Statistics and Informatics in Molecular Cancer Research by Carsten Wiuf,Claus L. Andersen Pdf

A collection of chapters from carefully chosen experts covering the theory behind the complex mathematical, statistical, and bioinformatics tools needed to extract, handle, and process data and their application to real data.

Oncology Informatics

Author : Bradford W. Hesse,David Ahern,Ellen Beckjord
Publisher : Academic Press
Page : 400 pages
File Size : 40,7 Mb
Release : 2016-03-01
Category : Electronic
ISBN : 0128021152

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Oncology Informatics by Bradford W. Hesse,David Ahern,Ellen Beckjord Pdf

Oncology Informatics: Using Health Information Technology to Improve Processes and Outcomes in Cancer Care encapsulates NCI-collected evidence into a format that is optimally useful for hospital planners, physicians, researchers, and informaticians alike as they collectively strive to accelerate progress against cancer using informatics tools. Anyone who wishes to take full advantage of the health information revolution in oncology to accelerate successes against cancer will find the information in this book valuable. It is a translational guide for moving evidence into practice, and meets recommendations from the national Academies of Science to reorient the research portfolio toward providing greater cognitive support for physicians, patients, and their caregivers to improve patient outcomes. Data from systems studies have suggested that oncology and primary care systems are prone to errors of omission that can lead to fatal consequences downstream. By infusing the best science across disciplines, this book creates new environments of smart and connected health and acts as a formational guide for turning clinical systems into engines of discovery. Following recommendations from the IOM's Roundtable on Evidence-Based Medicine, the authors encapsulate best practice for creating a Learning Healthcare System in oncology. Presents a pragmatic perspective for practitioners and allied health care professionals on how to implement Health I.T. solutions in a way that will minimize disruption while optimizing practice goals Proposes evidence-based guidelines for designers on how to create system interfaces that are easy to use, efficacious, and timesaving Offers insight for researchers into the ways in which informatics tools in oncology can be utilized to shorten the distance between discovery and practice

Personalized and Precision Medicine Informatics

Author : Terrence Adam,Constantin Aliferis
Publisher : Springer Nature
Page : 349 pages
File Size : 43,5 Mb
Release : 2019-09-17
Category : Medical
ISBN : 9783030186265

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Personalized and Precision Medicine Informatics by Terrence Adam,Constantin Aliferis Pdf

This book adopts an integrated and workflow-based treatment of the field of personalized and precision medicine (PPM). Outlined within are established, proven and mature workflows as well as emerging and highly-promising opportunities for development. Each workflow is reviewed in terms of its operation and how they are enabled by a multitude of informatics methods and infrastructures. The book goes on to describe which parts are crucial to discovery and which are essential to delivery and how each of these interface and feed into one-another. Personalized and Precision Medicine Informatics provides a comprehensive review of the integrative as well as interpretive nature of the topic and brings together a large body of literature to define the topic and ensure that this is the key reference for the topic. It is an unique contribution that is positioned to be an essential guide for both PPM experts and non-experts, and for both informatics and non-informatics professionals.

Informatics in Radiation Oncology

Author : George Starkschall,R. Alfredo C. Siochi
Publisher : CRC Press
Page : 329 pages
File Size : 44,6 Mb
Release : 2013-09-05
Category : Science
ISBN : 9781439825839

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Informatics in Radiation Oncology by George Starkschall,R. Alfredo C. Siochi Pdf

Reflecting the increased importance of the collaborations between radiation oncology and informatics professionals, Informatics in Radiation Oncology discusses the benefits of applying informatics principles to the processes within radiotherapy. It explores how treatment and imaging information is represented, stored, and retrieved as well as how this information relates to other patient data. The book deepens your knowledge of current and emerging information technology and informatics principles applied to radiation oncology so that all the data gathered—from laboratory results to medical images—can be fully exploited to make treatments more effective and processes more efficient. After introducing the basics of informatics and its connection to radiation oncology, the book examines the process of healthcare delivery in radiation oncology, the challenges of managing images in radiotherapy, and the burgeoning field of radiogenomics. It then presents teaching, clinical trials, and research tools and describes open access clinical imaging archives in radiotherapy, techniques for maximizing information from multimodality imaging, and the roles of images in treatment planning. It also looks at how informatics can improve treatment planning, the safety and efficiency of delivery systems, image-guided patient positioning, and patient assessment. The book concludes with discussions on how outcomes modeling evaluates the effectiveness of treatments, how quality control informatics improves the reliability of processes, and how to perform quality assurance on the informatics tools. With contributions from a host of top international experts in radiation oncology, medical physics, and informatics, this book leads the way in moving the field forward. It encourages you to find new ways of applying informatics to radiation oncology and help your patients in their fight against cancer.

Cancer Bioinformatics

Author : Ying Xu,Juan Cui,David Puett
Publisher : Springer
Page : 368 pages
File Size : 40,7 Mb
Release : 2014-08-30
Category : Computers
ISBN : 9781493913817

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Cancer Bioinformatics by Ying Xu,Juan Cui,David Puett Pdf

This book provides a framework for computational researchers studying the basics of cancer through comparative analyses of omic data. It discusses how key cancer pathways can be analyzed and discovered to derive new insights into the disease and identifies diagnostic and prognostic markers for cancer. Chapters explain the basic cancer biology and how cancer develops, including the many potential survival routes. The examination of gene-expression patterns uncovers commonalities across multiple cancers and specific characteristics of individual cancer types. The authors also treat cancer as an evolving complex system, explore future case studies, and summarize the essential online data sources. Cancer Bioinformatics is designed for practitioners and researchers working in cancer research and bioinformatics. It is also suitable as a secondary textbook for advanced-level students studying computer science, biostatistics or biomedicine.

Cancer Registry Management

Author : Herman R. Menck
Publisher : Unknown
Page : 0 pages
File Size : 54,5 Mb
Release : 2011
Category : Cancer
ISBN : 0757569005

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Cancer Registry Management by Herman R. Menck Pdf

Cancer Diagnostics and Therapeutics

Author : S. K. Basu,Chinmay Kumar Panda,Subrata Goswami
Publisher : Springer Nature
Page : 525 pages
File Size : 50,8 Mb
Release : 2022-04-15
Category : Medical
ISBN : 9789811647529

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Cancer Diagnostics and Therapeutics by S. K. Basu,Chinmay Kumar Panda,Subrata Goswami Pdf

This book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.

Cancer Bioinformatics

Author : Alexander Krasnitz
Publisher : Humana
Page : 280 pages
File Size : 40,6 Mb
Release : 2019-12-10
Category : Medical
ISBN : 1493994042

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Cancer Bioinformatics by Alexander Krasnitz Pdf

This volume covers a wide variety of state of the art cancer-related methods and tools for data analysis and interpretation. Chapters were designed to attract a broad readership, ranging from active researchers in computational biology and bioinformatics developers, clinical oncologists, and anti-cancer drug developers wishing to rationalize their search for new compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, installation instructions for computational tools discussed, explanations of the input and output formats, and illustrative examples of applications. Authoritative and cutting-edge, Cancer Bioinformatics: Methods and Protocols aims to support researchers performing computational analysis of cancer-related data.