How Not To Be A Dck

Author : Meghan Doherty
Publisher : Zest Books ™
Page : 218 pages
File Size : 54,8 Mb
Release : 2019-08-01
Category : Young Adult Nonfiction
ISBN : 9781541581876

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How Not to Be a Dick by Meghan Doherty Pdf

On the one hand, nobody wants to be a dick. On the other hand, dicks are everywhere! They cut in line, talk behind our backs, recline into our seats, and even have the power to morph into trolls online. Their powers are impressive, but with a little foresight and thoughtfulness, we can take a stand against dickishness today. How Not to Be a Dick is packed with honest and straightforward advice, but it also includes playful illustrations showing two well-meaning (but not always well behaved) young people as they confront moments of potential dickishness in their everyday lives. Sometimes they falter, sometimes they triumph, but they always seek to find a better way. And with their help, you can too. Just see the agreement at the beginning of the book: I pledge to use the tools and techniques provided in this book to help make the world a less dickish place. "Doherty fires absurd twenty-first-century zingers that happen to be really, really, really funny."—starred, Booklist

Author : Wolfgang Hiddemann,T. Haferlach,Thomas Büchner,J. Ritter,M. Unterhalt
Publisher : Springer Science & Business Media
Page : 606 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642593581

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Acute Leukemias IX by Wolfgang Hiddemann,T. Haferlach,Thomas Büchner,J. Ritter,M. Unterhalt Pdf

Acute Leukemias IX provides an extended and thorough overview of recent developments in cell biology and experimental therapy for acute leukemias. Following the tradition of the Acute Leukemias series since 1987, this book bridges the gap between basic research and clinical studies and emphasizes that both aspects are equally necessary to achieve improvements, not only in understanding the disease but also in providing better therapy. As a forum for world-wide activities in the field of acute leukemias the volume contains invaluable contributions that provide the reader with new, previously unpublished information.

Author : Jie Yan,Jianfeng Liu,Qian Ren,Qi Wang
Publisher : Frontiers Media SA
Page : 215 pages
File Size : 45,6 Mb
Release : 2023-01-13
Category : Science
ISBN : 9782832511411

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Molecular mechanisms of substance abuse and its neurotoxicity by Jie Yan,Jianfeng Liu,Qian Ren,Qi Wang Pdf

Author : Ganji Purnachandra Nagaraju
Publisher : Academic Press
Page : 223 pages
File Size : 44,7 Mb
Release : 2019-02-26
Category : Science
ISBN : 9780128176627

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Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy by Ganji Purnachandra Nagaraju Pdf

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Author : Thomas Büchner,Wolfgang Hiddemann,Bernhard Wörmann,Günter Schellong,Jörg Ritter,Ursula Creutzig
Publisher : Springer Science & Business Media
Page : 1005 pages
File Size : 49,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642603778

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Acute Leukemias VI by Thomas Büchner,Wolfgang Hiddemann,Bernhard Wörmann,Günter Schellong,Jörg Ritter,Ursula Creutzig Pdf

For 10 years the book series Acute Leukemias has been providing updates on the rapid progress being made internationally concerning this group of diseases. The fifth volume mainly addressed experimental approaches, but the present issue presents both therapeutic and prognostic aspects of the most recent results from major multicenter clinical trials. Additional chapters report new trends in leukemia cell biology,the monitoring of minimal residual disease, and secondary leukemias, as well as new antileukemic drugs, antimicrobial strategies, and the use of cytokines. The combined efforts against acute leukemias described in this book explain the recent improvements in the outcome of patients suffering from acute leukemias.

Author : Àngels Massip-Bonet,Gemma Bel-Enguix,Albert Bastardas-Boada
Publisher : Springer
Page : 331 pages
File Size : 47,5 Mb
Release : 2019-01-11
Category : Language Arts & Disciplines
ISBN : 9783030045982

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Complexity Applications in Language and Communication Sciences by Àngels Massip-Bonet,Gemma Bel-Enguix,Albert Bastardas-Boada Pdf

This book offers insights on the study of natural language as a complex adaptive system. It discusses a new way to tackle the problem of language modeling, and provides clues on how the close relation between natural language and some biological structures can be very fruitful for science. The book examines the theoretical framework and then applies its main principles to various areas of linguistics. It discusses applications in language contact, language change, diachronic linguistics, and the potential enhancement of classical approaches to historical linguistics by means of new methodologies used in physics, biology, and agent systems theory. It shows how studying language evolution and change using computational simulations enables to integrate social structures in the evolution of language, and how this can give rise to a new way to approach sociolinguistics. Finally, it explores applications for discourse analysis, semantics and cognition.

Author : Anonim
Publisher : ScholarlyEditions
Page : 80 pages
File Size : 54,9 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464933219

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Phosphoproteins: Advances in Research and Application: 2011 Edition by Anonim Pdf

Phosphoproteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Phosphoproteins in a concise format. The editors have built Phosphoproteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phosphoproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phosphoproteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Amrik Sahota,Milton W. Taylor
Publisher : Springer Science & Business Media
Page : 814 pages
File Size : 51,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781461525844

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Purine and Pyrimidine Metabolism in Man VIII by Amrik Sahota,Milton W. Taylor Pdf

These volumes record the presentations made at the VIII International Symposium on Purine and Pyrimidine Metabolism in Manheld at Indiana University, Bloomington, USA from May 22- May 27, 1994. This was a continuation of meetings held every three years with the idea of bringing clinicians and basic scientists together, which we hope results in cross-fertilization of ideas. Some of the papers presented in this volume represent oral contributions and others are from posters, but we emphasize that both are considered of equal merit. As is obvious from a perusal of the titles of the papers there has been a shift in the focus of this meeting, which reflects a general shift in the area of purine and pyrimidine metabolism. The emphasis has definitely shifted to gene structure and molecular genetics, with the beginnings we hope of gene therapy as an important branch of this area of science. Although many of the inherited diseases discussed in this text can be treated with drugs, the major thrust in the futurewill be in gene therapy, where the gene (or cDNA) will be used to treat the patient with enzyme deficiency, particularly if the patient is young. As can be seen from the Iist of authors there is a remarkable degree of international cooperation in this area across countries and continents. We thank the many participants who have attended these symposia many times, and we welcome the large group of scientists from Eastern Europe who are attending this meeting for the first time.

Author : Leung Ka Yin
Publisher : World Scientific Publishing Company
Page : 432 pages
File Size : 52,7 Mb
Release : 2004-10-04
Category : Science
ISBN : 9789813106239

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Current Trends in the Study of Bacterial and Viral Fish and Shrimp Diseases by Leung Ka Yin Pdf

The important volume summarizes the current trends and developments in the study of bacterial and viral fish diseases. Books on these subjects are few and relevant review articles are mostly outdated. This volume will thus serve as a platform for scientists and aquaculturists to understand the current limitations as well as new developments so that fish health and disease control can advance to new heights. The first section provides readers with an overview of the bacterial and viral diseases and the current understanding of innate immunity and interactions with pathogens. Section II includes case studies, where three pathogens are presented, namely two bacteria (Aeromonas hydrophila and Vibrio anguillarum, the common causes of bacterial diseases in freshwater and marine aquaculture, respectively) and the white spot syndrome virus (an important viral disease in shrimp). These case studies serve as models for the study of various bacterial and viral diseases. Section III presents new platform technologies that are widely used in the study of human pathogens. It aims to spur fish biologists to use modern and cutting edge technologies for their studies so that the study of fish disease can move into the mainstream and focus on the basics. The final section is on marine biotechnology, discussing biotechnology products that are urgently needed for the aquaculture industry — spin-offs from basic research, including diagnostics, immunotherapy and vaccine development, and the use of probiotics.

Author : Kirsty Hughes
Publisher : CUP Archive
Page : 236 pages
File Size : 48,5 Mb
Release : 1986-08-14
Category : Business & Economics
ISBN : 0521320364

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Exports and Technology by Kirsty Hughes Pdf

This book analyses the relationships between technological advancement and innovation, and trade performance. It concentrates, in particular, on the contribution of research and development expenditures, and skilled labour, to exports. It examines what determines expenditure on R & D, and whether there is a chain of causation from exports to R & D. The book reviews and develops the existing literature both on the relationship between technology, skill and trade flows, and on the determinants of research and development. It also looks at relative technological competitiveness and export performance in the USA, Japan, West Germany, the UK and France. It examines empirical evidence for the theories analysed on the basis of cross-section studies of UK manufactured exports, imports, and net trade; of changes in the trade variables, and of R & D spending. A comparative study of the UK and West Germany is also provided.

Author : Godefridus J Peters
Publisher : Springer Science & Business Media
Page : 476 pages
File Size : 43,6 Mb
Release : 2007-11-07
Category : Medical
ISBN : 9781597451482

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Deoxynucleoside Analogs in Cancer Therapy by Godefridus J Peters Pdf

Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.

Author : Anonim
Publisher : Academic Press
Page : 373 pages
File Size : 55,9 Mb
Release : 1998-02-09
Category : Science
ISBN : 0080863477

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Progress in Nucleic Acid Research and Molecular Biology by Anonim Pdf

Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology Contributions from leaders in their fields Abundant references

Author : Aneurin Owen
Publisher : Unknown
Page : 1044 pages
File Size : 46,6 Mb
Release : 1841
Category : Law
ISBN : GENT:900000118910

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Ancient Laws and Institutes of Wales by Aneurin Owen Pdf

Author : Andrea Griesmacher,Peter Chiba,Mathias M. Müller
Publisher : Springer Science & Business Media
Page : 816 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461553816

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Purine and Pyrimidine Metabolism in Man IX by Andrea Griesmacher,Peter Chiba,Mathias M. Müller Pdf

th th This volume comprizes articles presented at the joint IX International and 6 Euro pean Symposium on Purine and Pyrimidine Metabolism in Man held in Gmunden, Austria, June 1 through 7, 1997. Since the first of this series of meetings was held in Israel in 1973, conventions were organized every three years in different parts of the world including the USA, Japan, and Europe. The different aspects of purine and pyrimidine metabolism bring together re searchers working in molecular genetics, biochemical pharmacology, biochemistry, devel opmental biology, immunology, epidemiology and the clinics. Oriented research in the field has been seminal for the development of potent anticancer and antiviral drugs. As the number of genes which are cloned, grows, the understanding of metabolism is increas ingly enlarged and might provide leads to further improve therapeutic concepts and to bet ter understand mechanisms responsible for the development of resistance against these drugs. In certain diseases purine and pyrimidine analogs represent not only the drugs of choice but in fact are the sole therapeutic alternative at present. The field has also taken an early lead in attempting to correct inborn errors of purine and pyrimidine metabolism by gene therapy. The organization of this meeting involved a large number of people who dedicated their time in an effort to make this symposium a success. We thank the Abstract Review Committee, the International Advisory Board and in particular the Symposium Secretariat for doing a wonderful job.

Author : Mauro Vallati,Diane Kitchin
Publisher : Springer Nature
Page : 277 pages
File Size : 46,5 Mb
Release : 2020-03-25
Category : Computers
ISBN : 9783030385613

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Knowledge Engineering Tools and Techniques for AI Planning by Mauro Vallati,Diane Kitchin Pdf

This book presents a comprehensive review for Knowledge Engineering tools and techniques that can be used in Artificial Intelligence Planning and Scheduling. KE tools can be used to aid in the acquisition of knowledge and in the construction of domain models, which this book will illustrate. AI planning engines require a domain model which captures knowledge about how a particular domain works - e.g. the objects it contains and the available actions that can be used. However, encoding a planning domain model is not a straightforward task - a domain expert may be needed for their insight into the domain but this information must then be encoded in a suitable representation language. The development of such domain models is both time-consuming and error-prone. Due to these challenges, researchers have developed a number of automated tools and techniques to aid in the capture and representation of knowledge. This book targets researchers and professionals working in knowledge engineering, artificial intelligence and software engineering. Advanced-level students studying AI will also be interested in this book.