Introducing Epigenetics

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Introducing Epigenetics

Cath Ennis
Introducing Epigenetics Book PDF

Author : Cath Ennis
Publisher : Icon Books Ltd
Page : 285 pages
File Size : 51,8 Mb
Release : 2017-02-02
Category : Science
ISBN : 9781848319035

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Introducing Epigenetics by Cath Ennis Pdf

Epigenetics is the most exciting field in biology today, developing our understanding of how and why we inherit certain traits, develop diseases and age, and evolve as a species. This non-fiction comic book introduces us to genetics, cell biology and the fascinating science of epigenetics, which is rapidly filling in the gaps in our knowledge, allowing us to make huge advances in medicine. We'll look at what identical twins can teach us about the epigenetic effects of our environment and experiences, why certain genes are 'switched on' or off at various stages of embryonic development, and how scientists have reversed the specialization of cells to clone frogs from a single gut cell. In Introducing Epigenetics, Cath Ennis and Oliver Pugh pull apart the double helix, examining how the epigenetic building blocks and messengers that interpret and edit our genes help to make us, well, us.

Introduction to Epigenetics

Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Introduction to Epigenetics Book PDF

Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Publisher : Springer Nature
Page : 215 pages
File Size : 53,7 Mb
Release : 2021-03-23
Category : Science
ISBN : 9783030686703

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Introduction to Epigenetics by Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz Pdf

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

The Epigenetics Revolution

Nessa Carey
The Epigenetics Revolution Book PDF

Author : Nessa Carey
Publisher : Columbia University Press
Page : 353 pages
File Size : 52,6 Mb
Release : 2012-03-06
Category : Science
ISBN : 9780231530712

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The Epigenetics Revolution by Nessa Carey Pdf

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Epigenetics and Dermatology

Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Epigenetics and Dermatology Book PDF

Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publisher : Academic Press
Page : 520 pages
File Size : 53,5 Mb
Release : 2015-02-16
Category : Science
ISBN : 9780128012727

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Epigenetics and Dermatology by Qianjin Lu,Christopher C. Chang,Bruce C. Richardson Pdf

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

The Developing Genome

David Scott Moore
The Developing Genome Book PDF

Author : David Scott Moore
Publisher : Oxford University Press, USA
Page : 321 pages
File Size : 43,6 Mb
Release : 2015
Category : Medical
ISBN : 9780199922345

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The Developing Genome by David Scott Moore Pdf

Includes bibliographical references (pages 275-300) and index

Epigenetics and Systems Biology

Leonie Ringrose
Epigenetics and Systems Biology Book PDF

Author : Leonie Ringrose
Publisher : Academic Press
Page : 286 pages
File Size : 54,5 Mb
Release : 2017-04-25
Category : Medical
ISBN : 9780128030769

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Epigenetics and Systems Biology by Leonie Ringrose Pdf

Epigenetics and Systems Biology highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology in epigenetics studies. This book breaks down the obstacles which exist between systems biology and epigenetics researchers due to information barriers and segmented research, giving real-life examples of successful combinations of systems biology and epigenetics experiments. Each section covers one type of modeling and one set of epigenetic questions on which said models have been successfully applied. In addition, the book highlights how modeling and systems biology relate to studies of RNA, DNA, and genome instability, mechanisms of DNA damage signaling and repair, and the effect of the environment on genome stability. Presents original research in a wider perspective to reveal potential for synergies between the two fields of study Provides the latest experiments in primary literature for the modeling audience Includes chapters written by experts in systems biology and epigenetics who have vast experience studying clinical applications

Computational Epigenetics and Diseases

Anonim
Computational Epigenetics and Diseases Book PDF

Author : Anonim
Publisher : Academic Press
Page : 450 pages
File Size : 45,5 Mb
Release : 2019-02-06
Category : Business & Economics
ISBN : 9780128145142

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Computational Epigenetics and Diseases by Anonim Pdf

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Epigenetic Gene Expression and Regulation

Suming Huang,Michael D Litt,C. Ann Blakey
Epigenetic Gene Expression and Regulation Book PDF

Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Page : 482 pages
File Size : 45,9 Mb
Release : 2015-10-19
Category : Science
ISBN : 9780128004715

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Epigenetic Gene Expression and Regulation by Suming Huang,Michael D Litt,C. Ann Blakey Pdf

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Drug Discovery in Cancer Epigenetics

Gerda Egger,Paola Arimondo
Drug Discovery in Cancer Epigenetics Book PDF

Author : Gerda Egger,Paola Arimondo
Publisher : Academic Press
Page : 498 pages
File Size : 40,8 Mb
Release : 2015-11-19
Category : Medical
ISBN : 9780128024928

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Drug Discovery in Cancer Epigenetics by Gerda Egger,Paola Arimondo Pdf

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

Clinical Epigenetics

Luke B. Hesson,Antonia L. Pritchard
Clinical Epigenetics Book PDF

Author : Luke B. Hesson,Antonia L. Pritchard
Publisher : Springer Nature
Page : 265 pages
File Size : 44,5 Mb
Release : 2019-08-31
Category : Medical
ISBN : 9789811389580

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Clinical Epigenetics by Luke B. Hesson,Antonia L. Pritchard Pdf

In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.

Epigenetics

C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Epigenetics Book PDF

Author : C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
Publisher : CSHL Press
Page : 503 pages
File Size : 47,6 Mb
Release : 2007
Category : Epigenesis, Genetic
ISBN : 9780879697242

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Epigenetics by C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros Pdf

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Epigenetics of the Immune System

Dieter Kabelitz,Jaydeep Bhat
Epigenetics of the Immune System Book PDF

Author : Dieter Kabelitz,Jaydeep Bhat
Publisher : Academic Press
Page : 386 pages
File Size : 43,8 Mb
Release : 2020-06-04
Category : Medical
ISBN : 9780128179659

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Epigenetics of the Immune System by Dieter Kabelitz,Jaydeep Bhat Pdf

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

Epigenetics

Lyle Armstrong
Epigenetics Book PDF

Author : Lyle Armstrong
Publisher : Garland Science
Page : 474 pages
File Size : 48,7 Mb
Release : 2020-09-10
Category : Science
ISBN : 9781000319736

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Epigenetics by Lyle Armstrong Pdf

The concept of epigenetics has been known about since the 1940s, but it is only in the last 10 years that research has shown just how wide ranging its effects are. It is now a very widely-used term, but there is still a lot of confusion surrounding what it actually is and does.Epigenetics is a new textbook that brings together the structure and mac

Neuropsychiatric Disorders and Epigenetics

Jacob Peedicayil,Dennis R. Grayson
Neuropsychiatric Disorders and Epigenetics Book PDF

Author : Jacob Peedicayil,Dennis R. Grayson
Publisher : Elsevier
Page : 418 pages
File Size : 50,9 Mb
Release : 2023-09-29
Category : Science
ISBN : 9780443185175

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Neuropsychiatric Disorders and Epigenetics by Jacob Peedicayil,Dennis R. Grayson Pdf

Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding Includes chapter contributions from leading global experts

Epigenetic Principles of Evolution

Nelson Çabej
Epigenetic Principles of Evolution Book PDF

Author : Nelson Çabej
Publisher : Elsevier
Page : 847 pages
File Size : 40,6 Mb
Release : 2012
Category : Science
ISBN : 9780124158313

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Epigenetic Principles of Evolution by Nelson Çabej Pdf

Cabej (biology, U. of Tirana, Albania) explains the epigenetic principles of evolution (as opposed to the theory of evolution as determined by changes in genes) and reconstructs the developmental mechanisms of evolutionary changes in metazoans, based on empirical evidence. He focuses on the mechanisms of the generation of the evolutionary innovations from the influence of environment on heredity rather than the role of natural selection. He discusses control systems and determination of phenotypic traits in metazoans, neural manipulation of gene expression, epigenetic control of reproduction and early development, neural control of postphylotypic development, and the epigenetic system of inheritance. He follows with description of neural-developmental premises of evolutionary adaptation, including evolution and stress responses and behavioral adaptation to changes in environment, ontogeny, and intragenerational developmental plasticity; epigenetics of circumevolutionary phenomena and the mechanism of evolutionary change, including transgenerational developmental plasticity and the evolution of metazoans and their control system; and the origins of evolutionary novelty, evolution by loss or by reverting to ancestral characters, neural crest-determined evolutionary novelties, evolutionary convergences, species and allopatric speciation, and sympatric speciation. He presents the available evidence for his theory, rather than illustrating an established theory, and includes a comparative presentation of the neo-Darwinian view to his epigenetic explanation. There is no index. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com).