Metabolic Autophagy

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Metabolic Autophagy

Author : Siim Land
Publisher : Metabolic Autophagy Diet
Page : 534 pages
File Size : 54,6 Mb
Release : 2019-02-09
Category : Science
ISBN : 1790686393

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Metabolic Autophagy by Siim Land Pdf

Intermittent Fasting for Longevity and Performance Your cells are constantly monitoring the nutrient status of the cells to determine whether or not to conserve energy or to promote growth. **One of the few known ways of increasing lifespan in almost all species is caloric restriction and energy deprivation.** This triggers many metabolic pathways and processes that make the organism more adaptable to environmental stressors and thus live longer. **The metabolism has two sub-categories or sub-processes called anabolism and catabolism. ** * Anabolism, meaning 'upward' in Greek, describes the synthesis of biological molecules to build up new physical matter in the body. * Catabolism, meaning 'downward' in Greek, describes the breaking down of biological molecules to release energy. This can apply to the breakdown of bodily tissue as well as the digestion of food that then gets assimilated into the body through anabolic processes. In addition to 'Metabolic', you can also find another word in the title - 'Autophagy', which translates from Ancient Greek into 'self-devouring' or 'eating of self'. This is central to the main practice of this book. By maintaining a balance between anabolism and catabolism, you can effectively extend your lifespan. The process of autophagy entails your healthy cells devouring the old, worn-out, weak ones and converting them back into energy. It's literally your body eating itself and using that to maintain homeostasis. There are many longevity-boosting benefits to this as illustrated in virtually all other species. This book is a collection of guidelines about the principles of the anabolic-catabolic cycles in regards to nutrition and exercise. It's definitely not a panacea - a solution or remedy for all conditions and circumstances. Instead, it's a very specific protocol that's not supposed to apply for all situations. **Metabolic Autophagy will teach you:** * What increases lifespan in humans and other species * Why there's so much disease and obesity in society * How to promote health and longevity with intermittent fasting * What is Autophagy and how it works * How to age slower and be vigorous throughout your life * Which foods make you live longer and build muscle * How the nutrient regulators of mTOR, AMPK, sirtuins, FOXO proteins, hormesis and others affect longevity * What are circadian rhythms and how they affect your health * Metabolic Autophagy Foods list and their anabolic-catabolic score * Supplements that support muscle growth and longevity * Many extras and bonuses in regards to food and exerciseSiim Land is a best-selling author, anthropologist, entrepreneur, high-performance coach and a biohacker who writes about optimizing health and human performance.This book incorporates daily lifestyle and dietary practices that help to cross the chasm between longevity and high performance.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author : M. A. Hayat
Publisher : Academic Press
Page : 430 pages
File Size : 52,9 Mb
Release : 2016-12-28
Category : Medical
ISBN : 9780128094273

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by M. A. Hayat Pdf

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Summary of Siim Land's Metabolic Autophagy

Author : Everest Media,
Publisher : Everest Media LLC
Page : 88 pages
File Size : 45,7 Mb
Release : 2022-05-28T22:59:00Z
Category : Medical
ISBN : 9798822501362

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Summary of Siim Land's Metabolic Autophagy by Everest Media, Pdf

Please note: This is a companion version & not the original book. Sample Book Insights: #1 There are many things that determine the lifespan of an organism, such as its genetics, phylogeny, mutations, and life history. However, the biggest role probably has to do with the ecological niche. #2 Free radicals are atoms or molecules with an unpaired electron in their outer layer. They are very reactive and cause oxidative damage. Antioxidants and other reducing agents can lower this oxidation. #3 The ability to cope with oxidative stress and other stressors is compromised in aging, which makes you more vulnerable to free radicals as you get older. Taking lots of antioxidants and reducing oxidative stress with supplements has failed to be effective in fighting disease. #4 The mitochondria are the most important organelles in your body as they govern everything related to energy metabolism and cellular homeostasis. If your mitochondria are dysfunctional, you will not only speed up aging but also feel more tired, exhausted, and lethargic.

Autophagy in Health and Disease

Author : Beverly Rothermel,Abhinav Diwan
Publisher : Elsevier
Page : 456 pages
File Size : 43,5 Mb
Release : 2021-09-22
Category : Science
ISBN : 9780128220047

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Autophagy in Health and Disease by Beverly Rothermel,Abhinav Diwan Pdf

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study. Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathology Offers extended coverage of the mechanisms that mediate autophagy Covers the role of autophagy in stem cells and induced pluripotent stem cells, as well as the regenerative process of paligenosis Highlights important questions that remain to be addressed

Autophagy in tumor and tumor microenvironment

Author : Sujit Kumar Bhutia
Publisher : Springer Nature
Page : 284 pages
File Size : 54,7 Mb
Release : 2020-10-24
Category : Medical
ISBN : 9789811569302

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Autophagy in tumor and tumor microenvironment by Sujit Kumar Bhutia Pdf

This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Autophagy

Author : Thomas Hawthorn
Publisher : scott m ecommerce
Page : 136 pages
File Size : 42,8 Mb
Release : 2019-06-24
Category : Health & Fitness
ISBN : 8210379456XXX

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Autophagy by Thomas Hawthorn Pdf

Discover how a one day starvation secret won the nobel prize. And how you can use it to lose weight and promote long-term health. In 2016, Yoshinori Ohsumi won the Nobel Prize for his research on Autophagy. Now, not only does autophagy have lifechanging weight loss benefits… It may help treat cancer and neurodegenerative diseases like Alzheimer’s. Why has this unique type of fasting only become established in the past couple of years? It’s simple, the fat cats of our food industry establishment have billions riding on the outdated “3 square meals a day” lifestyle. And not only is this typical American lifestyle outdated, it’s downright dangerous! However, there is another way. And inside this breakthrough book you’ll discover: How to lose weight faster while intermittent fasting IBS pain? You can blame this common food 5 superfoods you can find at your local supermarket How inflamed is your body right now? Exactly what to ask your doctor to find out the truth. How to increase autophagy without fasting for several days in a row 7 best foods for nurturing gut health Eat this “forgotten food” to reverse plaque build up in your arteries How to properly do a water fast without feeling weak or getting hungry. A handful of this food cuts risk of heart disease by 24% 1 in 4 supplements failed quality tests at a leading independent lab. Discover which ones to throw out How to lose weight without working out every day 3 beginner mistakes which actually prevent autophagy, and how to avoid them Do you get autophagy during 16/8 fasting? The surprising truth …and much, much more. Plus countless other health secrets… Including this “miracle beverage” which researchers at the University of Minnesota found lowered diabetes risk by 33%... drinking this also boosts the effectiveness of your fast… plus one drink to avoid which sneakily breaks your fast You’ll also discover How to avoid starvation mode while fasting The raw truth about extended water fasting Is too much autophagy bad? Get the answer from the world’s leading expert Why do dogs who eat 1 meal a day live 20% longer than dogs who eat 3 meals a day? The 3 benefits of autophagy you probably didn’t know about Autophagy success stories – how one obese Mom lost 90lbs in less than 6 months and cured her diabetes All written in plain English. So you don’t need a medical degree to understand and apply what’s inside. This is not just a diet fad. This is a long-term gamechanger in the health and longevity space. Here’s the deal. The traditional “calories in, calories out” weight loss method no longer works. And restrictive low-fat or vegan diets often leave you hungry and irritable. However, when you combine the keto diet with a 2016 Nobel Prize winning breakthrough known as autophagy – you get the keto diet on steroids So take control of your life and show your friends and family that there is a simple way to lose weight and be happy – scroll up and click “add to cart”

Autophagy

Author : Alaina W. Bolton
Publisher : Unknown
Page : 132 pages
File Size : 45,9 Mb
Release : 2020-07-26
Category : Health & Fitness
ISBN : 1989655831

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Autophagy by Alaina W. Bolton Pdf

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 55,5 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Sirtuin Biology in Cancer and Metabolic Disease

Author : Kenneth Maiese
Publisher : Elsevier
Page : 300 pages
File Size : 45,9 Mb
Release : 2021-02-20
Category : Medical
ISBN : 9780128224847

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Sirtuin Biology in Cancer and Metabolic Disease by Kenneth Maiese Pdf

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author : M. A. Hayat
Publisher : Academic Press
Page : 622 pages
File Size : 43,8 Mb
Release : 2017-09-07
Category : Medical
ISBN : 9780128121474

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by M. A. Hayat Pdf

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms. Presents the most advanced information regarding the role of the autophagic system in life and death States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease Authored by global leaders in the field, bringing the broadest, most expert coverage available

The Immunity Fix

Author : Siim Land,James Dinicolantonio
Publisher : Unknown
Page : 482 pages
File Size : 47,7 Mb
Release : 2020-10-27
Category : Electronic
ISBN : 9798551508717

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The Immunity Fix by Siim Land,James Dinicolantonio Pdf

The Immunity Fix is a comprehensive guide to how the immune system works, how different viruses and infections affect our health and offers strategies that have been shown to enhance the immune system. It includes the most up-to-date scientific information about the most important factors related to staying healthy during viral outbreaks as well as in everyday life. There's also practical tips and tools that improve stress resilience, speed of recovery, metabolic health, cardiovascular function and quality of life. Here are the topics discussed in the book: * Lessons From Past Pandemics * Fundamentals of the Immune System and Immunosenescence * Immunity and Cancer: What's the Link? * Magnesium Deficiency and Immunodeficiencies * How an Overactive Immune System Drives Chronic Inflammation and Autoimmune Diseases * COVID-19 and an Overactive Immune System * Insulin Resistance and Immunity * Balancing Our Omega 6/3 Ratio to Calm an Overactive Immune System * Hot and Cold Therapy to Prime the Immune System * Eating for a Healthy Immune System * The Power of Nutrients and Nutraceuticals for Boosting Immunity * Intermittent Fasting, Autophagy and Immunosenescence * Exercise and Immunity * Sleep, Circadian Rhythms, and the Immune SystemCompared to other books about the same topic, The Immunity Fix takes an objective view about the pros and cons of every known intervention and lays out the most research-backed protocols to follow. This book will teach you how to support your immune system, what to do when you actually get sick and how to improve your overall health and vitality. As a cardiovascular research scientist and doctor of pharmacy Dr. James J. DiNicolantonio has spent years researching nutrition. A well-respected and internationally known scientist and expert on health and nutrition, he has contributed extensively to health policy and medical literature. Dr. DiNicolantonio is the author of 3 best-selling health books, The Salt Fix, Superfuel and The Longevity Solution. Siim Land is an author, speaker, content creator and renown biohacker from Estonia. Despite his young age, he is considered one of the top people in the biohacking and health optimization community. Siim Land has written books like Metabolic Autophagy and Stronger by Stress.

Metabolic Cardiomyopathy

Author : H. Böhles,A. C. Sewell
Publisher : CRC Press
Page : 188 pages
File Size : 49,5 Mb
Release : 2004
Category : Cardiomyopathy
ISBN : 3887631048

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Metabolic Cardiomyopathy by H. Böhles,A. C. Sewell Pdf

During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.

The Power Of Autophagy

Author : Douglas Tieman
Publisher : Unknown
Page : 156 pages
File Size : 44,5 Mb
Release : 2019-10-31
Category : Health & Fitness
ISBN : 1646960025

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The Power Of Autophagy by Douglas Tieman Pdf

Have you also heard of this trendy new term "Autophagy" but just cannot really get behind it? Are you looking for a scientifically accurate, but easy to understand guide to use the new concept to your advantage? Or are you simply interested in a healthy lifestyle, a sustainable diet form or detoxification of your body? If you answered yes to at least one of the questions above, this guide is specifically written for you. Currently, there are not many Autophagy-books out there and the ones who often lack scientific accuracy, the density of information or are simply too confusing and hard to understand for a layman. But what exactly is Autophagy, you might ask? Great question! Autophagos is greek and stands for "self-devouring". It is a natural regeneration process that occurs at a cellular level in the body, reducing the likelihood of contracting some diseases as well as prolonging lifespan. In 2016, Yoshinori Ohsumi won the Nobel Prize for his discoveries into the mechanisms of autophagy. These have led to a better understanding of diseases such as Parkinson's and dementia. In this guide you'll discover: The 5 little-known lifestyle-changes to induce autophagy easily (even if you are already living "healthy" and exercising regularly!) What exactly is Autophagy step by step and how to regulate it? Does Autophagy have any downsides? And if yes, what are the best ways to deal with them effectively? Why the importance of autophagy has been underestimated for years - with dramatic consequences! The 7 magical ways to activate the hidden power - in a natural and healthy way The biggest myths busted: a comprehensive faq to understand all the relevant vocabulary, mechanisms and complex relationships that concern autophagy The absolute worst 3 things you might be doing to hinder autophagy (avoid these mistakes at all costs if you want to reap the full benefits!) ...and much, much more! By relying on the latest scientific research from international experts, this guide is able to identify the exact dietary and non-dietary actions to induce autophagy and jumpstart your health, well-being, weight loss and much more. So if you want to finally take advantage of the revolutionary new process to boost health, lose weight and much more, click "Add to Cart" now!

The Switch

Author : James W. Clement
Publisher : Simon and Schuster
Page : 320 pages
File Size : 42,8 Mb
Release : 2021-04-27
Category : Health & Fitness
ISBN : 9781982115401

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The Switch by James W. Clement Pdf

"How can you lose dramatic weight, reverse chronic conditions, and stay healthier longer? Flip the switch on your metabolism with intermittent fasting, protein restriction, and ketosis! Lose weight. Reverse Chronic Conditions. Live Healthier Longer. Within each of us is an ancient mechanism that eliminates toxic materials, initiates fat burning, and protects cells against stress. It's called autophagy, and when it's turned on, the complex operation can not only slow down the aging process, but can optimize biological function as a whole, helping to stave off all manner of disease-from diabetes to dementia-and affording us the healthy lifespan we never thought possible. So how can we activate this switch through diet? How frequently should we fast and for how long? Must we abstain from all foods or just specific macronutrients? What's the sweet spot between intermittent fasting, protein restriction, and ketogenic eating? Backed by a wealth of data, and with a practical program anyone can follow for lasting results, The Switch not only decodes the science of autophagy, but also teaches you how to control it and benefit from its profound impact"--

Autophagy: Biology and Diseases

Author : Zheng-Hong Qin
Publisher : Springer Nature
Page : 727 pages
File Size : 51,9 Mb
Release : 2019-11-27
Category : Science
ISBN : 9789811506024

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Autophagy: Biology and Diseases by Zheng-Hong Qin Pdf

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.