Molecular Biology Of Assemblies And Machines

Author : Alasdair C. Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham
Publisher : Garland Science
Page : 888 pages
File Size : 42,6 Mb
Release : 2016-02-18
Category : Science
ISBN : 9781134982820

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Molecular Biology of Assemblies and Machines by Alasdair C. Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham Pdf

Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine. Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.

Author : Alasdair Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham
Publisher : Garland Science
Page : 881 pages
File Size : 44,8 Mb
Release : 2016-02-18
Category : Medical
ISBN : 9781000064902

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Molecular Biology of Assemblies and Machines by Alasdair Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham Pdf

Molecular Biology of Assemblies and Machines provides a comprehensive narrative of the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell. Richly illustrated in full color, the text is written for advanced undergraduates, graduate students, and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.

Author : Bruce Alberts
Publisher : Garland Science
Page : 1465 pages
File Size : 45,5 Mb
Release : 2017-08-07
Category : Science
ISBN : 9781317563754

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Molecular Biology of the Cell by Bruce Alberts Pdf

As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Author : Joachim Frank
Publisher : Cambridge University Press
Page : 287 pages
File Size : 45,7 Mb
Release : 2011-12-19
Category : Science
ISBN : 9781139499903

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Molecular Machines in Biology by Joachim Frank Pdf

The concept of molecular machines in biology has transformed the medical field in a profound way. Many essential processes that occur in the cell, including transcription, translation, protein folding and protein degradation, are all carried out by molecular machines. This volume focuses on important molecular machines whose architecture is known and whose functional principles have been established by tools of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited volume includes contributions from prominent scientists and researchers who understand and have explored the structure and functions of these machines. This book is essential for students and professionals in the medical field who want to learn more about molecular machines.

Author : Giovanni Zocchi
Publisher : Princeton University Press
Page : 188 pages
File Size : 44,6 Mb
Release : 2018-07-10
Category : Science
ISBN : 9780691173863

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Molecular Machines by Giovanni Zocchi Pdf

Molecular Machines presents a dynamic new approach to the physics of enzymes and DNA from the perspective of materials science. Unified around the concept of molecular deformability—how proteins and DNA stretch, fold, and change shape—this book describes the complex molecules of life from the innovative perspective of materials properties and dynamics, in contrast to structural or purely chemical approaches. It covers a wealth of topics, including nonlinear deformability of enzymes and DNA; the chemo-dynamic cycle of enzymes; supra-molecular constructions with internal stress; nano-rheology and viscoelasticity; and chemical kinetics, Brownian motion, and barrier crossing. Essential reading for researchers in materials science, engineering, and nanotechnology, the book also describes the landmark experiments that have established the materials properties and energy landscape of large biological molecules. Molecular Machines is also ideal for the classroom. It gives graduate students a working knowledge of model building in statistical mechanics, making it an essential resource for tomorrow's experimentalists in this cutting-edge field. In addition, mathematical methods are introduced in the bio-molecular context—for example, DNA conformational transitions are used to illustrate the transfer matrix formalism. The result is a generalized approach to mathematical problem solving that enables students to apply their findings more broadly. Molecular Machines represents the next leap forward in nanoscience, as researchers strive to harness proteins, enzymes, and DNA as veritable machines in medicine, technology, and beyond.

Author : Anonim
Publisher : Academic Press
Page : 414 pages
File Size : 44,7 Mb
Release : 2011-10-12
Category : Science
ISBN : 9780124159297

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Molecular Assembly in Natural and Engineered Systems by Anonim Pdf

This volume explores some of the most exciting recent advances in basic research on molecular assembly in natural and engineered systems and how this knowledge is leading to advances in the various fields. This series provides a forum for discussion of new discoveries, approaches, and idea Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 54,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : David S Goodsell
Publisher : Unknown
Page : 196 pages
File Size : 47,6 Mb
Release : 1996-04-19
Category : Electronic
ISBN : 1461223377

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Our Molecular Nature by David S Goodsell Pdf

Author : Peter M Hoffmann
Publisher : Basic Books
Page : 288 pages
File Size : 48,5 Mb
Release : 2012-10-30
Category : Science
ISBN : 9780465033362

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Life's Ratchet by Peter M Hoffmann Pdf

Life is an enduring mystery. Yet, science tells us that living beings are merely sophisticated structures of lifeless molecules. If this view is correct, where do the seemingly purposeful motions of cells and organisms originate? In Life's Ratchet, physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale. Below the calm, ordered exterior of a living organism lies microscopic chaos, or what Hoffmann calls the molecular storm -- specialized molecules immersed in a whirlwind of colliding water molecules. Our cells are filled with molecular machines, which, like tiny ratchets, transform random motion into ordered activity, and create the "purpose" that is the hallmark of life. Tiny electrical motors turn electrical voltage into motion, nanoscale factories custom-build other molecular machines, and mechanical machines twist, untwist, separate and package strands of DNA. The cell is like a city -- an unfathomable, complex collection of molecular workers working together to create something greater than themselves. Life, Hoffman argues, emerges from the random motions of atoms filtered through these sophisticated structures of our evolved machinery. We are agglomerations of interacting nanoscale machines more amazing than anything in science fiction. Rather than relying on some mysterious "life force" to drive them -- as people believed for centuries -- life's ratchets harness instead the second law of thermodynamics and the disorder of the molecular storm. Grounded in Hoffmann's own cutting-edge research, Life's Ratchet reveals the incredible findings of modern nanotechnology to tell the story of how the noisy world of atoms gives rise to life itself.

Author : David P. Clark,Nanette J. Pazdernik,Michelle R. McGehee
Publisher : Elsevier
Page : 1006 pages
File Size : 47,6 Mb
Release : 2018-11-02
Category : Science
ISBN : 9780128132890

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Molecular Biology by David P. Clark,Nanette J. Pazdernik,Michelle R. McGehee Pdf

Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves. Moreover, as part of the Academic Cell line of textbooks, this book contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles form the basis of case studies found in the associated online study guide that is designed to tie current topics to the scientific community. Contains new chapters on non-coding RNA, genome defense, epigenetics and epigenomics Features new and expanded coverage of RNAi, CRISPR, genome editing, giant viruses and proteomics Includes an Academic Cell Study Guide that ties all articles from the text with concurrent case studies Provides an updated, ancillary package with flashcards, online self-quizzing, references with links to outside content, and PowerPoint slides with images

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 52,5 Mb
Release : 1990
Category : Electronic
ISBN : OCLC:632911225

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The Eukaryotic Nucleus by Anonim Pdf

Author : R.E. Dalbey
Publisher : Elsevier
Page : 276 pages
File Size : 55,6 Mb
Release : 1995-08-31
Category : Science
ISBN : 0080526098

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Protein Export and Membrane Biogenesis by R.E. Dalbey Pdf

The incentive for putting together Volume 4 of this series was to review the wealth of new information that has become available in prokaryotic organisms in protein export and membrane biogenesis. Just in the last several years, protein translocation has now been efficiently reconstituted using defined components and the mechanism by which proteins are moved across membrane bilayers is now being examined at a higher resolution. In addition, because of a new technical breakthrough using osmolytes, it is now possible to reconstitute a number of channel proteins, ATPase, receptors, and transporters. In many cases, it is possible to successfully predict the membrane topology of these types of proteins using both "hydrophobicity analysis" and the "positive inside" rule. In this volume, two chapters focus on protein translocation across membranes (Biochemical Analyses of Components Comprising the Protein Translocation Machinery of E. Coli; Protein Translocation Genetics), while several others on how proteins assemble into the ineer membrane of E. Coli (Membrane Protein Assembly; Membrane Insertion of Small Proteins: Evolutionary and Functional Aspects; Pigment-Protein Complex Assembly in Rhodobacter sphaeroides and Rhodobacter Capsulatus). Other sections review recent progress on transporters (Identification and Reconstitution of Anion Exchange Mechanisms in Bacteria; Helic Packing in the C-Terminal Half of Lactose Permease) and signal transduction (Mechanism of Transmembrane Signaling in Osmoregulation) as well as the assembly of prints into the outer membrane (Export and Assembly of Outer Membrane Proteins in E. coli). Although the emphasis of the book is on proteins, the role of phospholipids in controlling various cell surface processes is reviewed (Role of Phospholipids in coli Cell Function). I should point out the reason for the rapid progress in bacteria research is because of the possibility to apply biochemistry and genetics in this organism.

Author : Kenneth W. Adolph
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461236528

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Molecular Biology of Chromosome Function by Kenneth W. Adolph Pdf

Chromosomes have structure, determined by the interactions of proteins with DNA, and chromosomes have functions, in particular, replication of DNA and transcription of messenger RNA. Chromosome structure and function are not separate topics, since chromosome organization pro foundly influences the activity of the genome in replication and transcrip tion. This is especially clear for higher cells, including human cells, in which chromatin fibers are created by the binding of histone proteins to the DNA, and folding of the fibers produces mitotic chromosomes and interphase nuclei. The intricate organization of DNA in higher cells is now recognized as being closely involved with genome activity. Many fundamental results have originated from studies of bacterial and viral systems, which have been systems of choice because of their less complex life cycles. The processes of replication and transcription show differences between the higher and simpler systems (e. g. , different enzymes and protein factors are involved). But the parallels are as striking as the differences in detail. Even for bacteria and viruses, a full understanding of these processes will require integrating the results of molecular biology with those of structural biology and cell biology. Three important subjects are covered in this volume: DNA replication and recombination, gene transcription, and chromosome organization. The sections dealing with replication and transcription examine recent results obtained by applying the techniques of molecular biology and biochemistry. Eukaryotic, prokaryotic, and viral systems are discussed.

Author : P. Michael Conn
Publisher : Academic Press
Page : 288 pages
File Size : 47,6 Mb
Release : 2009-01-09
Category : Science
ISBN : 0080923399

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Molecular Biology of Protein Folding by P. Michael Conn Pdf

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume. *Follow the new editor-in-chief, P. Michael Conn, as he introduces this second thematic volume in the series – an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding *Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer’s and diabetes *Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science

Author : Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard
Publisher : World Scientific
Page : 128 pages
File Size : 48,5 Mb
Release : 2016-08-08
Category : Science
ISBN : 9789814749343

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Structure and Action of Molecular Chaperones by Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard Pdf

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.