Molecular Diagnostics

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Molecular Diagnostics

George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson
Molecular Diagnostics Book PDF

Author : George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson
Publisher : Academic Press
Page : 520 pages
File Size : 52,8 Mb
Release : 2016-10-27
Category : Medical
ISBN : 9780128029886

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Molecular Diagnostics by George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson Pdf

Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Molecular Diagnostics

Wayne W. Grody,Robert M. Nakamura,Frederick L. Kiechle,Charles Strom
Molecular Diagnostics Book PDF

Author : Wayne W. Grody,Robert M. Nakamura,Frederick L. Kiechle,Charles Strom
Publisher : Academic Press
Page : 736 pages
File Size : 42,8 Mb
Release : 2009-11-06
Category : Science
ISBN : 0080919049

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Molecular Diagnostics by Wayne W. Grody,Robert M. Nakamura,Frederick L. Kiechle,Charles Strom Pdf

Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. Molecular Diagnostics provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting. Serves as the definitivereference for molecular pathologists worldwide Covers a variety of molecular techniques including next generation sequencing, tumor somatic cell genotyping, infectious and genetic disease tecting, and pharmacogenetics Discusses in the detail issues concerning quality assurance, regulation, ethics, and future directions for the science

Molecular Diagnostics: Promises and Possibilities

Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Molecular Diagnostics Promises and Possibilities Book PDF

Author : Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Publisher : Springer Science & Business Media
Page : 520 pages
File Size : 40,6 Mb
Release : 2010-01-29
Category : Medical
ISBN : 9789048132614

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Molecular Diagnostics: Promises and Possibilities by Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen Pdf

A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

Clinical Molecular Diagnostics

Shiyang Pan,Jinhai Tang
Clinical Molecular Diagnostics Book PDF

Author : Shiyang Pan,Jinhai Tang
Publisher : Springer Nature
Page : 889 pages
File Size : 50,9 Mb
Release : 2021-07-08
Category : Medical
ISBN : 9789811610370

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Clinical Molecular Diagnostics by Shiyang Pan,Jinhai Tang Pdf

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Molecular Diagnostics

E. van Pelt-Verkuil,W.B. van Leeuwen,R. te Witt
Molecular Diagnostics Book PDF

Author : E. van Pelt-Verkuil,W.B. van Leeuwen,R. te Witt
Publisher : Springer
Page : 457 pages
File Size : 42,9 Mb
Release : 2019-06-03
Category : Medical
ISBN : 9789811316043

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Molecular Diagnostics by E. van Pelt-Verkuil,W.B. van Leeuwen,R. te Witt Pdf

The books Molecular Diagnostics Part 1 and 2 provide a comprehensive and practical overview of the state-of-the-art molecular biological diagnostic strategies that are being used in a wide variety of disciplines. The editors and experts in their respective fields have combined their knowledge to write these two books. Many years of experience in the development, application and quality control of molecular diagnostic methods is reflected herewith. Molecular Diagnostics Part 1 is dedicated to the theoretical backgrounds of the technologies often applied in molecular diagnostics, in which nucleic acid amplification methods (such as real-time PCR), sequencing and bioinformatics are the basic tools. The assay design and -development, combined with items of trouble-shooting are described in detail. As a foundation of reliable molecular diagnostic assays, the quality control required for validation, implementation and performance of molecular diagnostic assays is thoroughly discussed. This book also provides extensive information for those working with molecular techniques in a wide variety of research applications using conventional and real-time PCR technology, Sanger and high throughput sequencing techniques, and bioinformatics. Molecular Diagnostics Part 2 highlights the applications of the molecular diagnostic methods in the various diagnostic laboratories, comprising: - Clinical microbiology - Clinical chemistry - Clinical genetics - Clinical pathology - Molecular hematopathology - Veterinary health - Plant health - Food safety Both full-colour and well-illustrated books are particularly valuable for students, clinicians, scientists and other professionals who are interested in (designing) molecular diagnostic methods and for those who wish to broaden their knowledge on the current molecular biological revolution. The information in the books highlights the trend of the integration of multiple (clinical) disciplines into one universal molecular laboratory.

Advances in Cell and Molecular Diagnostics

Pongali Raghavendra,Thammineni Pullaiah
Advances in Cell and Molecular Diagnostics Book PDF

Author : Pongali Raghavendra,Thammineni Pullaiah
Publisher : Academic Press
Page : 298 pages
File Size : 54,5 Mb
Release : 2018-01-10
Category : Medical
ISBN : 9780128136805

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Advances in Cell and Molecular Diagnostics by Pongali Raghavendra,Thammineni Pullaiah Pdf

Advances in Cell and Molecular Diagnostics brings the scientific advances in the translation and validation of cellular and molecular discoveries in medicine into the clinical diagnostic setting. It enumerates the description and application of technological advances in the field of cellular and molecular diagnostic medicine, providing an overview of specialized fields, such as biomarker, genetic marker, screening, DNA-profiling, NGS, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, and biomarker toxicologies. In addition, it presents novel discoveries and clinical pathologic correlations, including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, and the description or polymorphisms linked to disease states. This book is a valuable resource for oncologists, practitioners and several members of the biomedical field who are interested in understanding how to apply cutting-edge technologies into diagnostics and healthcare. Encompasses the current scientific advances in the translation and validation of cellular and molecular discoveries into the clinical diagnostic setting Explains the application of cellular and molecular diagnostics methodologies in clinical trials Focuses on translating preclinical tests to the bedside in order to help readers apply the most recent technologies to healthcare

Molecular Allergy Diagnostics

Jörg Kleine-Tebbe,Thilo Jakob
Molecular Allergy Diagnostics Book PDF

Author : Jörg Kleine-Tebbe,Thilo Jakob
Publisher : Springer
Page : 531 pages
File Size : 42,6 Mb
Release : 2017-05-08
Category : Medical
ISBN : 9783319424996

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Molecular Allergy Diagnostics by Jörg Kleine-Tebbe,Thilo Jakob Pdf

This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a “must read” for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.

Molecular Diagnostics and Treatment of Pancreatic Cancer

Asfar Azmi
Molecular Diagnostics and Treatment of Pancreatic Cancer Book PDF

Author : Asfar Azmi
Publisher : Elsevier
Page : 458 pages
File Size : 41,9 Mb
Release : 2014-04-14
Category : Medical
ISBN : 9780124079465

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Molecular Diagnostics and Treatment of Pancreatic Cancer by Asfar Azmi Pdf

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Fundamentals of Molecular Diagnostics

David E. Bruns,Edward R. Ashwood,Carl A. Burtis
Fundamentals of Molecular Diagnostics Book PDF

Author : David E. Bruns,Edward R. Ashwood,Carl A. Burtis
Publisher : Elsevier Health Sciences
Page : 298 pages
File Size : 53,5 Mb
Release : 2007-05-25
Category : Medical
ISBN : 9781416037378

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Fundamentals of Molecular Diagnostics by David E. Bruns,Edward R. Ashwood,Carl A. Burtis Pdf

This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, including Patrick Bossuyt, Angela Caliendo, Rossa W.K. Chiu, Kojo S.J. Elenitoba-Johnson, Andrea Ferreira-Gonzalez, Amy Groszbach, Sultan Habeebu, Doris Haverstick, Malek Kamoun, Anthony Killeen, Noriko Kusukawa, Y.M. Dennis Lo, Elaine Lyon, Gwendolyn McMillin, Christopher Price, James Versalovic, Cindy Vnencak-Jones, Victor Weedn, Peter Wilding, Thomas Williams, and Carl Wittwer, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use. A full-color, 4-page insert shows realistic images of the output for many molecular tests. Learning Objectives open each chapter with an overview of what you should achieve. Key Words are listed and defined at the beginning of each chapter, and are bolded in the text. Review Questions at the end of every chapter let you measure your comprehension. Advanced Concepts are included, but set apart from the rest of the text, for students who want a higher level of learning. Ethics boxes address ethical issues, allowing you to apply your knowledge to real-life scenarios. A glossary of all key words may be easily accessed in the back of the book.

Molecular Diagnostics

Lela Buckingham
Molecular Diagnostics Book PDF

Author : Lela Buckingham
Publisher : F. A. Davis Company
Page : 0 pages
File Size : 55,5 Mb
Release : 2012
Category : Medical
ISBN : 0803626770

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Molecular Diagnostics by Lela Buckingham Pdf

The first text on molecular diagnostics specifically designed for clinical laboratory science programs is back! This exceptional resource introduces the fundamentals of nucleic acid, as well as more advanced concepts. With a focus on the application of molecular concepts in the clinical laboratory to diagnosis diseases, the 2nd Edition includes important updates and improvements to keep up with the rapidly developing field. Inside youll find in-depth explanations of the principles of molecular-based assays as well as reference material, trouble-shooting tips for the laboratory, and discussions that emphasize the continuing emergence of new diagnostic technologies.

Diagnostic Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Diagnostic Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 846 pages
File Size : 52,7 Mb
Release : 2023-10-27
Category : Science
ISBN : 9780128229934

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Diagnostic Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Molecular Diagnostics

William B. Coleman,Gregory J. Tsongalis
Molecular Diagnostics Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Springer Science & Business Media
Page : 387 pages
File Size : 52,6 Mb
Release : 2013-04-18
Category : Medical
ISBN : 9781475725889

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Molecular Diagnostics by William B. Coleman,Gregory J. Tsongalis Pdf

Notable practitioners describe how laboratory medicine is practiced today and illuminate how it will function tomorrow as the revolutionary advances afforded by molecular diagnostics become increasingly central to effective analysis. Proceeding from a discussion of elementary nucleic acid technology to a review of the more advanced techniques, the distinguished contributors lay the groundwork for a comprehensive understanding of their applications throughout clinical medicine. The result is a detailed description of those molecular technologies currently used in diagnostic laboratories, as well as those that seem particularly promising. Detailed discussions of specific clinical applications include those for cancer, hematological malignancies, cardiovascular disease, and neuromuscular, endocrine, and infectious diseases.

Principles and Applications of Molecular Diagnostics

Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park
Principles and Applications of Molecular Diagnostics Book PDF

Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park
Publisher : Elsevier
Page : 422 pages
File Size : 52,8 Mb
Release : 2018-06-13
Category : Science
ISBN : 9780128160626

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Principles and Applications of Molecular Diagnostics by Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park Pdf

Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments. Explains the principles and tools of molecular biology Describes standard and state-of-the-art molecular techniques for obtaining qualitative and quantitative results Provides a detailed description of current molecular applications used to solve diagnostics tasks

Molecular and Diagnostic Procedures in Mycoplasmology

Anonim
Molecular and Diagnostic Procedures in Mycoplasmology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 466 pages
File Size : 48,6 Mb
Release : 1996-02-21
Category : Science
ISBN : 9780080536798

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Molecular and Diagnostic Procedures in Mycoplasmology by Anonim Pdf

This book and its companion, Volume I, concentrate on new procedures--especially those based on the new molecular methodology--developed within the past decade. This volume deals with the new genetic and immunological tools applied to the diagnosis of mycoplasma infections of humans, animals, plants, insects, and all cultures. Volume I outlines the approaches, techniques, and procedures applied to cell and molecular biology studies of mycoplasmas. Key Features * Diagnostic genetic probes * Immunological tools * Antibiotic sensitivity testing * Diagnosis of specific diseases * Experimental infections * Diagnosis of mycoplasma infections of cell cultures

Molecular Diagnostic PCR Handbook

Gerrit J. Viljoen,Louis H. Nel,John R. Crowther
Molecular Diagnostic PCR Handbook Book PDF

Author : Gerrit J. Viljoen,Louis H. Nel,John R. Crowther
Publisher : Springer Science & Business Media
Page : 342 pages
File Size : 49,8 Mb
Release : 2005-07-19
Category : Medical
ISBN : 1402034032

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Molecular Diagnostic PCR Handbook by Gerrit J. Viljoen,Louis H. Nel,John R. Crowther Pdf

PREFACE The Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture is involved in agricultural research and development and assists Member States of FAO and IAEA in improving strategies to ensure food security through the use of nuclear techniques and related biotechnologies, where such techniques have a valuable and often unique role. In particular, molecular diagnostic methods have rapidly evolved in the past twenty years, since the advent of the Polymerase Chain Reaction (PCR). They are used in a wide range of agricultural areas such as, improving soil and water management; producing better crop varieties; diagnosing plant and animal diseases; controlling insect pests and improving food quality and safety. The uses of nucleic acid-directed methods have increased significantly in the past five years and have made important contributions to disease control country programmes for improving national and international trade. These developments include the more routine use of PCR as a diagnostic tool in veterinary diagnostic laboratories. However, there are many problems associated with the transfer and particularly, the application of this technology. These include lack of consideration of: the establishment of quality-assured procedures, the required set-up of the laboratory and the proper training of staff. This can lead to a situation where results are not assured. This book gives a comprehensive account of the practical aspects of PCR and strong consideration is given to ensure its optimal use in a laboratory environment. This includes the setting-up of a PCR laboratory; Good Laboratory Practice and standardised of PCR protocols.