Molecular Genetic Pathology

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Molecular Genetic Pathology

Liang Cheng,David Y. Zhang,John N. Eble
Molecular Genetic Pathology Book PDF

Author : Liang Cheng,David Y. Zhang,John N. Eble
Publisher : Springer
Page : 1136 pages
File Size : 49,7 Mb
Release : 2013-03-05
Category : Medical
ISBN : 1461447992

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Molecular Genetic Pathology by Liang Cheng,David Y. Zhang,John N. Eble Pdf

Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.

Molecular Genetic Testing in Surgical Pathology

John D. Pfeifer
Molecular Genetic Testing in Surgical Pathology Book PDF

Author : John D. Pfeifer
Publisher : Lippincott Williams & Wilkins
Page : 530 pages
File Size : 55,8 Mb
Release : 2006
Category : Medical
ISBN : 0781747481

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Molecular Genetic Testing in Surgical Pathology by John D. Pfeifer Pdf

Written by experts from Washington University School of Medicine, this text is a thorough review of the specific molecular genetic techniques that can provide diagnostically useful molecular genetic information on tissue samples—including cytogenetics, fluorescence in situ hybridization (FISH), PCR, electrophoresis and hybridization analysis, DNA sequence analysis, and microarrays. The first part of the book describes each technique, indicates its advantages, disadvantages, capabilities, and limitations, and systematically addresses sensitivity and specificity issues. Subsequent chapters, organized by organ system, detail the specific applications of these tests in surgical pathology. More than 150 full-color and black-and-white illustrations complement the text.

Essential Concepts in Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Essential Concepts in Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 634 pages
File Size : 53,7 Mb
Release : 2019-11-23
Category : Medical
ISBN : 9780128132586

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Essential Concepts in Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Diagnostic Molecular Pathology in Practice

Iris Schrijver
Diagnostic Molecular Pathology in Practice Book PDF

Author : Iris Schrijver
Publisher : Springer Science & Business Media
Page : 339 pages
File Size : 51,7 Mb
Release : 2011-09-09
Category : Medical
ISBN : 3642196772

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Diagnostic Molecular Pathology in Practice by Iris Schrijver Pdf

This entirely case-based book covers a broad cross-section of the practical issues frequently encountered in the day-to-day activities of a molecular genetic pathologist. The book is divided into four sections on the principal areas addressed in molecular genetic pathology (MGP): inherited diseases, hematopathology, solid tumors, and infectious diseases. The topics covered by the cases in each section include test selection, qualitative and quantitative laboratory techniques, test interpretation, prognostic and therapeutic considerations, ethical considerations, technical troubleshooting, and result reporting. This book will be ideal for trainees in MGP and clinical molecular genetics who require a practice-based preparation for board examinations. It will also be very useful for residents and fellows in medical specialties to which MGP is pertinent, and for practicing pathologists who want to learn more about the current practice of molecular diagnostics.

Molecular Pathology in Clinical Practice

Debra G.B. Leonard
Molecular Pathology in Clinical Practice Book PDF

Author : Debra G.B. Leonard
Publisher : Springer Science & Business Media
Page : 600 pages
File Size : 53,8 Mb
Release : 2007-11-25
Category : Medical
ISBN : 9780387332277

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Molecular Pathology in Clinical Practice by Debra G.B. Leonard Pdf

This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

Cell and Tissue Based Molecular Pathology E-Book

Raymond R. Tubbs,Mark H. Stoler
Cell and Tissue Based Molecular Pathology E Book Book PDF

Author : Raymond R. Tubbs,Mark H. Stoler
Publisher : Elsevier Health Sciences
Page : 452 pages
File Size : 45,6 Mb
Release : 2008-09-22
Category : Medical
ISBN : 9781437719482

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Cell and Tissue Based Molecular Pathology E-Book by Raymond R. Tubbs,Mark H. Stoler Pdf

This volume in the Foundations in Diagnostic Pathology Series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! It focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. With an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you’re getting the most up-to-date, authoritative coverage available. Its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice! Offers detailed discussions on today’s technologies to help you select the best test for case evaluation. Presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field. Features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.

Molecular Genetic Pathology

Liang Cheng,David Y. Zhang
Molecular Genetic Pathology Book PDF

Author : Liang Cheng,David Y. Zhang
Publisher : Springer Science & Business Media
Page : 784 pages
File Size : 51,9 Mb
Release : 2010-01-01
Category : Medical
ISBN : 9781597454056

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Molecular Genetic Pathology by Liang Cheng,David Y. Zhang Pdf

This volume presents a useful and up-to-date handbook containing information relevant to the clinical practice of molecular genetic pathology. It features organized, detailed text on specific molecular genetic techniques. The volume provides a unique reference for the practicing pathologist and medical geneticist, as well as a review book for residents and fellows in training in pathology, medical genetics and molecular genetic pathology.

Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 40,5 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Molecular Pathology in Clinical Practice

Debra G.B. Leonard
Molecular Pathology in Clinical Practice Book PDF

Author : Debra G.B. Leonard
Publisher : Springer
Page : 1001 pages
File Size : 50,6 Mb
Release : 2016-02-02
Category : Medical
ISBN : 9783319196749

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Molecular Pathology in Clinical Practice by Debra G.B. Leonard Pdf

This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, laboratory management, genomics and proteomics. Throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests and important clinical and laboratory issues. The second edition of Molecular Pathology in Clinical Practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleagues and trainees.

Diagnostic Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Diagnostic Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 846 pages
File Size : 42,5 Mb
Release : 2023-10-27
Category : Science
ISBN : 9780128229934

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Diagnostic Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Diagnostic Pathology and Molecular Genetics of the Thyroid

Yuri E. Nikiforov,Paul W. Biddinger,Lester D. R. Thompson
Diagnostic Pathology and Molecular Genetics of the Thyroid Book PDF

Author : Yuri E. Nikiforov,Paul W. Biddinger,Lester D. R. Thompson
Publisher : Lippincott Williams & Wilkins
Page : 451 pages
File Size : 45,7 Mb
Release : 2012-04-20
Category : Medical
ISBN : 9781451114553

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Diagnostic Pathology and Molecular Genetics of the Thyroid by Yuri E. Nikiforov,Paul W. Biddinger,Lester D. R. Thompson Pdf

Diagnostic Pathology and Molecular Genetics of the Thyroid, Second Edition, offers a comprehensive overview of the diagnostic surgical pathology, cytopathology, immunohistochemistry and molecular genetics of the thyroid diseases, including neoplastic and non-neoplastic conditions. The book provides a detailed description of the surgical pathology of thyroid diseases side by side with major advances in immunohistochemistry and molecular genetics that can be used in evaluating thyroid tumors and non-neoplastic diseases.

Gestational Trophoblastic Disease

Pei Hui
Gestational Trophoblastic Disease Book PDF

Author : Pei Hui
Publisher : Springer Science & Business Media
Page : 205 pages
File Size : 55,8 Mb
Release : 2011-12-15
Category : Medical
ISBN : 9781617793943

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Gestational Trophoblastic Disease by Pei Hui Pdf

In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations. Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.

Practical Oncologic Molecular Pathology

Yi Ding,Linsheng Zhang
Practical Oncologic Molecular Pathology Book PDF

Author : Yi Ding,Linsheng Zhang
Publisher : Springer Nature
Page : 449 pages
File Size : 40,6 Mb
Release : 2021-07-10
Category : Medical
ISBN : 9783030732271

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Practical Oncologic Molecular Pathology by Yi Ding,Linsheng Zhang Pdf

This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology. Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals.

Principles of Molecular Pathology

Anthony Killeen
Principles of Molecular Pathology Book PDF

Author : Anthony Killeen
Publisher : Springer Science & Business Media
Page : 354 pages
File Size : 55,7 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015058713168

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Principles of Molecular Pathology by Anthony Killeen Pdf

This text offers a review of the genetic basis of common diseases, discusses relevant laboratory studies, shows how molecular genetic studies can be used in pathology, and emphasizes how molecular genetics are essential to contemporary pathology practice. It presents the foundations needed in order to understand molecular genetic principles as they relate to pathology and will benefit medical students, pathology residents, physicians, pathologists, laboratory scientists, medical technologists, and other scientists.

Diagnostic Pathology: Molecular Oncology E-Book

Mohammad A. Vasef,Aaron Auerbach
Diagnostic Pathology Molecular Oncology E Book Book PDF

Author : Mohammad A. Vasef,Aaron Auerbach
Publisher : Elsevier Health Sciences
Page : 1050 pages
File Size : 41,9 Mb
Release : 2023-12-04
Category : Medical
ISBN : 9780443112805

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Diagnostic Pathology: Molecular Oncology E-Book by Mohammad A. Vasef,Aaron Auerbach Pdf

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Providing a clear understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer in an era of personalized medicine, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Molecular Oncology is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, molecular pathologist, oncologist, or pathologist in training as an ideal day-to-day reference or as a reliable learning resource. Provides up-to-date, comprehensive coverage of relevant molecular tests and their clinical applications, along with organ-based chapters on the molecular genetic data relevant to individual disease entities Contains new chapters and substantial revisions to existing content that include updates from the 2022 International Consensus Classification and the WHO Classification of Haematolymphoid Tumours, fifth edition Provides expert guidance on selecting the right test(s) at the right time, as well as comparisons of molecular testing methods (e.g., FISH vs. cytogenetics) Includes current information for new actionable mutations and targeted therapies Covers ultrasensitive molecular techniques for minimal residual disease detection and disease monitoring Discusses circulating cell-free DNA analysis for detection of resistance-associated mutations and disease monitoring, and provides usage details Features an image-rich layout with more than 2,400 print and online-only images, including high-resolution H&E stains, immunostains, FISH images, gross pathology and clinical photographs, detailed full-color medical illustrations, and informative diagrams, charts, and schematics Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care Any additional digital ancillary content may publish up to 6 weeks following the publication date Molecular oncology is a rapidly evolving field with tremendous amounts of information that is new since the 2e published in March 2019. There is new molecular genetic data linked to either new targeted therapies or that serves as diagnostic or prognostic indicators. The 3e will include 8-10 new chapters and substantial updates and rewrites to existing contents to make sure ongoing edits and revisions to the upcoming WHO Classification of Hematopoietic Tumors are included in the 3e. The authors provide guidance on selecting the right test(s) at the right time for the right patient and comparisons of molecular testing methods (i.e., FSH testing vs. cytogenetics) are included. The market lacks a definitive source of all the recent changes, and DP3 Molecular Oncology will provide a comprehensive information source.