Protein Physics

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Protein Physics

Author : Alexei V. Finkelstein,Oleg Ptitsyn
Publisher : Elsevier
Page : 528 pages
File Size : 46,7 Mb
Release : 2016-06-22
Category : Science
ISBN : 9780081012369

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Protein Physics by Alexei V. Finkelstein,Oleg Ptitsyn Pdf

Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era

The Physics of Proteins

Author : Hans Frauenfelder
Publisher : Springer Science & Business Media
Page : 448 pages
File Size : 49,7 Mb
Release : 2010-05-30
Category : Science
ISBN : 9781441910448

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The Physics of Proteins by Hans Frauenfelder Pdf

Provides an introduction to the structure and function of biomolecules --- especially proteins --- and the physical tools used to investigate them The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully New tools appear regularly - synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding

Lectures on Statistical Physics and Protein Folding

Author : Kerson Huang
Publisher : World Scientific
Page : 160 pages
File Size : 40,9 Mb
Release : 2005-05-30
Category : Science
ISBN : 9789814481069

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Lectures on Statistical Physics and Protein Folding by Kerson Huang Pdf

' This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix. Contents:EntropyMaxwell–Boltzmann DistributionFree EnergyChemical PotentialPhase TransitionsKinetics of Phase TransitionsThe Order ParameterCorrelation FunctionStochastic ProcessesLangevin EquationThe Life ProcessSelf-AssemblyKinetics of Protein FoldingPower Laws in Protein FoldingSelf-Avoiding Walk and TurbulenceConvergent Evolution in Protein Folding Readership: Graduate students, researchers and academics interested in statistical physics and molecular biology. Keywords:Statistical Physics;Protein Folding;BiophysicsReviews:“My particularly favorite is the chapter on order parameters, explaining with simplicity and clarity this subject so frequently difficult and confusing for the beginning students … the book makes a strong attempt to place the protein folding problem where it really belongs — in the context of fundamental statistical mechanics. Whether the attempt is successful or not is a matter of a reader's opinion, but the very direction is both timely and welcome.”Professor Alexander Grosberg University of Minnesota '

Computational Methods for Protein Structure Prediction and Modeling

Author : Ying Xu,Dong Xu,Jie Liang
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 48,6 Mb
Release : 2007-08-24
Category : Science
ISBN : 9780387683720

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Computational Methods for Protein Structure Prediction and Modeling by Ying Xu,Dong Xu,Jie Liang Pdf

Volume One of this two-volume sequence focuses on the basic characterization of known protein structures, and structure prediction from protein sequence information. Eleven chapters survey of the field, covering key topics in modeling, force fields, classification, computational methods, and structure prediction. Each chapter is a self contained review covering definition of the problem and historical perspective; mathematical formulation; computational methods and algorithms; performance results; existing software; strengths, pitfalls, challenges, and future research.

Physics of Bio-Molecules and Cells

Author : Henrik Flyvbjerg,Frank Jülicher,Pal Ormos,Francois David
Publisher : Springer Science & Business Media
Page : 580 pages
File Size : 47,6 Mb
Release : 2003-07-01
Category : Science
ISBN : 9783540457015

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Physics of Bio-Molecules and Cells by Henrik Flyvbjerg,Frank Jülicher,Pal Ormos,Francois David Pdf

Aimed at those working to enter this rapidly developing field, this volume on biological physics is written in a pedagogical style by leading scientists giving explanations that take their starting point where any physicist can follow and end at the frontier of research in biological physics. These lectures describe the state-of-the-art physics of biomolecules and cells. In biological systems ranging from single biomolecules to entire cells and larger biological systems, it focuses on aspects that require concepts and methods from physics for their analysis and understanding, such as the mechanics of motor proteins; how the genetic code is physically read and managed; the machinery of protein--DNA interactions; force spectroscopy of biomolecules' velopes, cytoskeletons, and cytoplasms; polymerization forces; listeria propulsion; cell motility; lab-on-a-chip nanotechnology for single-molecule analysis of biomolecules; bioinformatics; and coding and computational strategies of the brain.

Monte Carlo Methods in Chemical Physics

Author : David M. Ferguson,J. Ilja Siepmann,Donald G. Truhlar
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 49,7 Mb
Release : 2009-09-09
Category : Science
ISBN : 9780470142172

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Monte Carlo Methods in Chemical Physics by David M. Ferguson,J. Ilja Siepmann,Donald G. Truhlar Pdf

In Monte Carlo Methods in Chemical Physics: An Introduction to the Monte Carlo Method for Particle Simulations J. Ilja Siepmann Random Number Generators for Parallel Applications Ashok Srinivasan, David M. Ceperley and Michael Mascagni Between Classical and Quantum Monte Carlo Methods: "Variational" QMC Dario Bressanini and Peter J. Reynolds Monte Carlo Eigenvalue Methods in Quantum Mechanics and Statistical Mechanics M. P. Nightingale and C.J. Umrigar Adaptive Path-Integral Monte Carlo Methods for Accurate Computation of Molecular Thermodynamic Properties Robert Q. Topper Monte Carlo Sampling for Classical Trajectory Simulations Gilles H. Peslherbe Haobin Wang and William L. Hase Monte Carlo Approaches to the Protein Folding Problem Jeffrey Skolnick and Andrzej Kolinski Entropy Sampling Monte Carlo for Polypeptides and Proteins Harold A. Scheraga and Minh-Hong Hao Macrostate Dissection of Thermodynamic Monte Carlo Integrals Bruce W. Church, Alex Ulitsky, and David Shalloway Simulated Annealing-Optimal Histogram Methods David M. Ferguson and David G. Garrett Monte Carlo Methods for Polymeric Systems Juan J. de Pablo and Fernando A. Escobedo Thermodynamic-Scaling Methods in Monte Carlo and Their Application to Phase Equilibria John Valleau Semigrand Canonical Monte Carlo Simulation: Integration Along Coexistence Lines David A. Kofke Monte Carlo Methods for Simulating Phase Equilibria of Complex Fluids J. Ilja Siepmann Reactive Canonical Monte Carlo J. Karl Johnson New Monte Carlo Algorithms for Classical Spin Systems G. T. Barkema and M.E.J. Newman

Protein Actions: Principles and Modeling

Author : Ivet Bahar,Robert L. Jernigan,Ken A. Dill
Publisher : Garland Science
Page : 336 pages
File Size : 54,7 Mb
Release : 2017-02-14
Category : Science
ISBN : 9781351815017

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Protein Actions: Principles and Modeling by Ivet Bahar,Robert L. Jernigan,Ken A. Dill Pdf

Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.

Soft Condensed Matter Physics in Molecular and Cell Biology

Author : W.C.K. Poon,David Andelman
Publisher : CRC Press
Page : 344 pages
File Size : 50,6 Mb
Release : 2006-01-13
Category : Science
ISBN : 9781420003338

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Soft Condensed Matter Physics in Molecular and Cell Biology by W.C.K. Poon,David Andelman Pdf

Soft condensed matter physics, which emerged as a distinct branch of physics in the 1990s, studies complex fluids: liquids in which structures with length scale between the molecular and the macroscopic exist. Polymers, liquid crystals, surfactant solutions, and colloids fall into this category. Physicists deal with properties of soft matter system

Physics in Molecular Biology

Author : Kim Sneppen,Giovanni Zocchi
Publisher : Cambridge University Press
Page : 328 pages
File Size : 51,9 Mb
Release : 2005-08-25
Category : Science
ISBN : 0521844193

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Physics in Molecular Biology by Kim Sneppen,Giovanni Zocchi Pdf

This book, first published in 2005, is a discussion for advanced physics students of how to use physics to model biological systems.

Physics of Charged Macromolecules

Author : Murugappan Muthukumar
Publisher : Cambridge University Press
Page : 523 pages
File Size : 44,9 Mb
Release : 2023-02-28
Category : Science
ISBN : 9780521864879

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Physics of Charged Macromolecules by Murugappan Muthukumar Pdf

A clear and intuitive introduction to the physics of charged macromolecules, from fundamentals to the latest research developments.


Author : Charles L. Brooks,Martin Karplus,B. Montgomery Pettitt
Publisher : John Wiley & Sons
Page : 278 pages
File Size : 51,5 Mb
Release : 2009-09-08
Category : Science
ISBN : 9780470141816

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Proteins by Charles L. Brooks,Martin Karplus,B. Montgomery Pettitt Pdf

Presenting a wide-ranging view of current developments in protein research, the papers in this collection, each written by highly regarded experts in the field, examine various aspects of protein structure, functions, dynamics, and experimentation. Topics include dynamical simulation methods, the biological role of atom fluctuations, protein folding, influences on protein dynamics, and a variety of analytical techniques, such as X-ray diffraction, vibrational spectroscopy, photodissociation and rebinding kinetics. This is part of a series devoted to providing general information on a wide variety of topics in chemical physics in order to stimulate new research and to serve as a text for beginners in a particular area of chemical physics.

Principles of Protein-Protein Association

Author : Harold P. Erickson
Publisher : IOP Publishing Limited
Page : 100 pages
File Size : 50,9 Mb
Release : 2019-06-19
Category : Physical biochemistry
ISBN : 0750324104

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Principles of Protein-Protein Association by Harold P. Erickson Pdf

Protein-protein associations are fundamental to biological mechanisms. This book, created from lecture notes and classroom sessions, covers the general principles of protein-protein association. It should be of considerable value to cell biologists with a limited understanding of proteins, as well as to biochemists with a deeper background in protein structure. Developed from lectures given to beginning graduate students in cell and molecular biology, Principles of Protein-Protein Association presents general principles of thermodynamics and kinetics, and structural principles of protein-protein interface. An important feature is guided reading of informative classic papers. Faculties organizing similar classes, and students and researchers wishing to learn on their own, will also find this book of use. Book jacket.

Computational Protein Design

Author : Ilan Samish
Publisher : Humana
Page : 0 pages
File Size : 51,6 Mb
Release : 2016-12-03
Category : Science
ISBN : 1493966359

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Computational Protein Design by Ilan Samish Pdf

The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.

A Century of Physics

Author : D. Allan Bromley
Publisher : Springer Science & Business Media
Page : 123 pages
File Size : 46,5 Mb
Release : 2013-03-14
Category : Science
ISBN : 9781475736892

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A Century of Physics by D. Allan Bromley Pdf

In this "Cook’s Tour" of developments in physics and realted fields, D. Allan Bromley, Science Advisor to President Bush during 1989-1983 and past president of the American Physical Society, conveys much of the excitement and wonder that research in physics generated in the 20th century and asks what new things are in store in the next century.

Statistical Physics of Biomolecules

Author : Daniel M. Zuckerman
Publisher : CRC Press
Page : 356 pages
File Size : 43,5 Mb
Release : 2010-06-02
Category : Mathematics
ISBN : 9781420073799

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Statistical Physics of Biomolecules by Daniel M. Zuckerman Pdf

From the hydrophobic effect to protein-ligand binding, statistical physics is relevant in almost all areas of molecular biophysics and biochemistry, making it essential for modern students of molecular behavior. But traditional presentations of this material are often difficult to penetrate. Statistical Physics of Biomolecules: An Introduction brin