Shock Factor

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Shock Factor

Sgt. Jack Coughlin,John R. Bruning
Shock Factor Book PDF

Author : Sgt. Jack Coughlin,John R. Bruning
Publisher : St. Martin's Press
Page : 336 pages
File Size : 54,8 Mb
Release : 2014-10-28
Category : History
ISBN : 9781250038371

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Shock Factor by Sgt. Jack Coughlin,John R. Bruning Pdf

From the author of the New York Times bestselling memoir Shooter, comes a riveting narrative of how snipers have changed the course of America's war on al Qaida in the Middle East and Africa. Retired Marine sniper Jack Coughlin (Shooter) and John Bruning pull back the curtain of secrecy to take an insider's look at the dark and misunderstood world of America's sniper force. Long considered the redheaded stepchildren of the infantry, snipers have been loathed by their fellow warriors, called "ten cent killers" by our media, and portrayed as unbalanced psychopaths by Hollywood. Coughlin and Bruning explore the lives and careers of some of America's most effective snipers during key missions, moments and campaigns in the War on Terror. Part page-turning thriller, part deeply human drama, Shock Factor takes you from the streets of the modern day "Stalingrad" of Ramadi to the skyscrapers of Baghdad as America's one-shot warriors fight desperate battles against all odds, find themselves at the heart of tense international incidents, stalk key enemy leaders, and discover horrific human rights abuses perpetrated by our own allies. Based on extensive interviews with snipers currently on active duty, Shock Factor's gripping accounts of harrowing combat, buried truths and secrets revealed could only be told by snipers to a trusted member of their own elite and cloistered brotherhood.

The Shock Doctrine

Naomi Klein
The Shock Doctrine Book PDF

Author : Naomi Klein
Publisher : Vintage Canada
Page : 674 pages
File Size : 46,5 Mb
Release : 2009-03-18
Category : Political Science
ISBN : 9780307371300

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The Shock Doctrine by Naomi Klein Pdf

From the bestselling author of No Logo—the gripping story of how America’s “free market” polices exploited crises and shock for three decades from Pinochet’s coup in Chile in 1973 to the "War on Terror." In her groundbreaking reporting, Naomi Klein introduced the term "disaster capitalism." Whether covering Baghdad after the U.S. occupation, Sri Lanka in the wake of the tsunami, or New Orleans post-Katrina, she witnessed something remarkably similar. People still reeling from catastrophe were being hit again, this time with economic "shock treatment," losing their land and homes to rapid-fire corporate makeovers. The Shock Doctrine retells the story of one the most dominant ideologies of our time: Milton Friedman's free market economic revolution. In contrast to the popular myth of this movement's peaceful global victory, Klein shows how it has exploited moments of shock and extreme violence in order to implement its economic policies in so many parts of the world from Latin America and Eastern Europe to South Africa, Russia, and Iraq. At the core of disaster capitalism is the use of cataclysmic events to advance radical privatization combined with the privatization of the disaster response itself. Klein argues that by capitalizing on crises, created by nature or war, the disaster capitalism complex now exists as a booming new economy, and is the violent culmination of a radical economic project that has been incubating for fifty years.

Shock Value

Jason Zinoman
Shock Value Book PDF

Author : Jason Zinoman
Publisher : Penguin
Page : 267 pages
File Size : 49,9 Mb
Release : 2011-07-07
Category : Performing Arts
ISBN : 9781101516966

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Shock Value by Jason Zinoman Pdf

An enormously entertaining account of the gifted and eccentric directors who gave us the golden age of modern horror in the 1970s, bringing a new brand of politics and gritty realism to the genre. Much has been written about the storied New Hollywood of the 1970s, but at the same time as Martin Scorsese, Steven Spielberg, and Francis Ford Coppola were making their first classic movies, a parallel universe of directors gave birth to the modern horror film-aggressive, raw, and utterly original. Based on unprecedented access to the genre's major players, The New York Times's critic Jason Zinoman's Shock Value delivers the first definitive account of horror's golden age. By the late 1960s, horror was stuck in the past, confined mostly to drive-in theaters and exploitation houses, and shunned by critics. Shock Value tells the unlikely story of how the much-disparaged horror film became an ambitious art form while also conquering the multiplex. Directors such as Wes Craven, Roman Polanski, John Carpenter, and Brian De Palma- counterculture types operating largely outside the confines of Hollywood-revolutionized the genre, exploding taboos and bringing a gritty aesthetic, confrontational style, and political edge to horror. Zinoman recounts how these directors produced such classics as Rosemary's Baby, Carrie, The Texas Chainsaw Massacre, and Halloween, creating a template for horror that has been imitated relentlessly but whose originality has rarely been matched. This new kind of film dispensed with the old vampires and werewolves and instead assaulted audiences with portraits of serial killers, the dark side of suburbia, and a brand of nihilistic violence that had never been seen before. Shock Value tells the improbable stories behind the making of these movies, which were often directed by obsessive and insecure young men working on shoestring budgets, were funded by sketchy investors, and starred porn stars. But once The Exorcist became the highest grossing film in America, Hollywood took notice. The classic horror films of the 1970s have now spawned a billion-dollar industry, but they have also penetrated deep into the American consciousness. Quite literally, Zinoman reveals, these movies have taught us what to be afraid of. Drawing on interviews with hundreds of the most important artists in horror, Shock Value is an enthralling and personality-driven account of an overlooked but hugely influential golden age in American film.

Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Peter Csermely,László Vígh
Molecular Aspects of the Stress Response Chaperones Membranes and Networks Book PDF

Author : Peter Csermely,László Vígh
Publisher : Springer Science & Business Media
Page : 218 pages
File Size : 45,7 Mb
Release : 2007-08-09
Category : Science
ISBN : 9780387399751

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Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks by Peter Csermely,László Vígh Pdf

This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.

Shock Value

John Waters
Shock Value Book PDF

Author : John Waters
Publisher : Unknown
Page : 243 pages
File Size : 46,9 Mb
Release : 1995
Category : Biography & Autobiography
ISBN : 1560250925

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Shock Value by John Waters Pdf

"Beware, if your sensibilities are delicate, if you see yourself as a person of taste, if 'outrageous' is not your adjective of choice. Because this is a story about filmmaker John Waters, whose early career is marked by such startling cult raves as Multiple Maniacs, in which its heroine is raped by a 15-foot broiled lobster; Polyester, which featured scratch-and-sniff cards; and, most notorious, Pink Flamingos, in which its transvestite star Divine eats fresh dog feces." -Tampa Tribune In Shock Value, the autobiography of notorious filmmaker John Waters, "the Sultan of Sleaze" recounts his career & explains the inspiration behind his movies. Through pictures, anecdotes, & interviews, get to know the stars of Waters' films-like Divine, Kitten, & Edith Massey-in ways that should make you queasy, or at least uncomfortable. Along the way, Waters explains what his filmmaking philosophies are & attempts to justify what he's done to American movies. "Shock Value is shocking. Any honest account of human experience must be shocking. For it is the function of art to make the reader or viewer aware of what he knows & in most cases doesn't know that he knows & doesn't want to know." -William S. Burroughs

Plant Promoters and Transcription Factors

Lutz Nover
Plant Promoters and Transcription Factors Book PDF

Author : Lutz Nover
Publisher : Springer Science & Business Media
Page : 279 pages
File Size : 48,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783540480372

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Plant Promoters and Transcription Factors by Lutz Nover Pdf

The control of plant gene expression at the transcriptional level is the main subject of this volume. Genetics, molecular biology and gene technology have dramatically improved our knowledge of this event. The functional analysis of promoters and transcription factors provides more and more insights into the molecular anatomy of initiation complexes assembled from RNA polymerase and the multiplicity of helper and control proteins. Formation of specific DNA-protein complexes - activating or repressing transcription - is the crux of developmental or environmental control of gene expression. The book presents an up-to-date, critical overview of this rapidly advancing field.

Regulation of Organelle and Cell Compartment Signaling

Ralph A. Bradshaw,Edward A. Dennis
Regulation of Organelle and Cell Compartment Signaling Book PDF

Author : Ralph A. Bradshaw,Edward A. Dennis
Publisher : Academic Press
Page : 550 pages
File Size : 45,9 Mb
Release : 2011-04-05
Category : Science
ISBN : 9780123822147

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Regulation of Organelle and Cell Compartment Signaling by Ralph A. Bradshaw,Edward A. Dennis Pdf

This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles. Articles written and edited by experts in the field Thematic volume covering regulation of endoplasmic reticulum function, regulation of cell cycle progression, and quality control and assurance in mitochondrion events Up-to-date research on events in membrane proteins and proteins of intracellular matrix

Exploring Pancreatic Metabolism and Malignancy

Ganji Purnachandra Nagaraju,Aramati BM Reddy
Exploring Pancreatic Metabolism and Malignancy Book PDF

Author : Ganji Purnachandra Nagaraju,Aramati BM Reddy
Publisher : Springer Nature
Page : 268 pages
File Size : 43,9 Mb
Release : 2019-11-23
Category : Medical
ISBN : 9789813293939

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Exploring Pancreatic Metabolism and Malignancy by Ganji Purnachandra Nagaraju,Aramati BM Reddy Pdf

This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.

Celiac Disease

Peter Kruzliak,Govind Bhagat
Celiac Disease Book PDF

Author : Peter Kruzliak,Govind Bhagat
Publisher : BoD – Books on Demand
Page : 200 pages
File Size : 48,8 Mb
Release : 2012-07-19
Category : Medical
ISBN : 9789535106845

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Celiac Disease by Peter Kruzliak,Govind Bhagat Pdf

Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye and barley) in genetically susceptible individuals. CD can manifest itself with a previously unappreciated range of clinical presentations, including the typical malabsorption syndrome and a spectrum of symptoms potentially affecting any organ system. Since CD often presents in an atypical or even silent manner, many cases remain undiagnosed and carry the risk of long-term complications, including anemia and other hematological complications, osteoporosis, neurological complications or cancer. The high prevalence of the disease and its variety of clinical outcomes raise several interesting questions. This book covers most of the aforementioned controversial and yet unresolved topics by including the contributions of experts in CD.What the reader will surely find stimulating about this book is not only its exhaustive coverage of our current knowledge of CD, but also provocative new concepts in disease pathogenesis and treatment.

Chaperones

Stuart K. Calderwood,Thomas L. Prince
Chaperones Book PDF

Author : Stuart K. Calderwood,Thomas L. Prince
Publisher : Springer Nature
Page : 328 pages
File Size : 50,7 Mb
Release : 2023-08-04
Category : Science
ISBN : 9781071633427

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Chaperones by Stuart K. Calderwood,Thomas L. Prince Pdf

This second edition volume expands on the previous edition with new discussions on the latest techniques used to study molecular chaperones and the stress response. The chapters in this book cover such as analysis of the initiation and regulation of the stress response; the role of heat shock protein 90 (Hsp90) in gene expression through chromosome-immunoprecipitation; features of chaperone function and biology; the emerging role of the extracellular HSPs; and the use of chaperones as biomarkers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chaperones: Methods and Protocols, Second Edition is a valuable resource for all researchers who want to learn more about this interesting and developing field.

The Science of Hormesis in Health and Longevity

Suresh I. S. Rattan,Marios Kyriazi
The Science of Hormesis in Health and Longevity Book PDF

Author : Suresh I. S. Rattan,Marios Kyriazi
Publisher : Academic Press
Page : 326 pages
File Size : 44,6 Mb
Release : 2018-10-23
Category : Medical
ISBN : 9780128142547

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The Science of Hormesis in Health and Longevity by Suresh I. S. Rattan,Marios Kyriazi Pdf

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work. Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more

Immunity, Tumors and Aging: The Role of HSP70

Igor Malyshev
Immunity Tumors and Aging The Role of HSP70 Book PDF

Author : Igor Malyshev
Publisher : Springer Science & Business Media
Page : 141 pages
File Size : 54,9 Mb
Release : 2013-01-08
Category : Medical
ISBN : 9789400759435

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Immunity, Tumors and Aging: The Role of HSP70 by Igor Malyshev Pdf

The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiac surgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.

Investigations in Yeast Functional Genomics and Molecular Biology

Matthew Eckwahl
Investigations in Yeast Functional Genomics and Molecular Biology Book PDF

Author : Matthew Eckwahl
Publisher : CRC Press
Page : 414 pages
File Size : 55,6 Mb
Release : 2014-02-24
Category : Medical
ISBN : 9781771880107

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Investigations in Yeast Functional Genomics and Molecular Biology by Matthew Eckwahl Pdf

This book examines conserved pathways mediating cell cycle progression and cell polarity establishment. It includes examples of yeast, regulatory circuits, and feedback regulation, with emphasis on system-wide approaches. It also covers protein interaction networks and trait locus analysis and presents methods and challenges in comparative genomics analysis and evolutionary genetics.

Molecular Chaperones in Health and Disease

Matthias Gaestel
Molecular Chaperones in Health and Disease Book PDF

Author : Matthias Gaestel
Publisher : Springer Science & Business Media
Page : 464 pages
File Size : 53,8 Mb
Release : 2005-09-27
Category : Science
ISBN : 3540258752

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Molecular Chaperones in Health and Disease by Matthias Gaestel Pdf

Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.

Stress-Inducible Cellular Responses

U. Feige,R.I. Morimoto,Barbara Polla
Stress Inducible Cellular Responses Book PDF

Author : U. Feige,R.I. Morimoto,Barbara Polla
Publisher : Birkhäuser
Page : 487 pages
File Size : 47,8 Mb
Release : 2013-03-11
Category : Science
ISBN : 9783034890885

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Stress-Inducible Cellular Responses by U. Feige,R.I. Morimoto,Barbara Polla Pdf

This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimetal approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. The book will be invaluable for all those working on stress and is intended for every "stress laboratory" as a source of knowledge and perspectives.