Ten Drugs

Author : Thomas Hager
Publisher : Abrams
Page : 342 pages
File Size : 50,7 Mb
Release : 2019-03-05
Category : Medical
ISBN : 9781683355311

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Ten Drugs by Thomas Hager Pdf

“The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History

Author : Thomas Hager
Publisher : Harry N. Abrams
Page : 0 pages
File Size : 42,7 Mb
Release : 2019-03-05
Category : Science
ISBN : 1419734407

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Ten Drugs by Thomas Hager Pdf

Beginning with opium, the "joy plant," which has been used for 10,000 years, Hager's subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain; the infamous knockout drops; the first antibiotic, which saved countless lives; the first antipsychotic, which helped empty public mental hospitals; Viagra, statins; and the new frontier of monoclonal antibodies.

Author : Thomas Hager
Publisher : Crown
Page : 354 pages
File Size : 54,5 Mb
Release : 2007-08-28
Category : Science
ISBN : 9781400082148

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The Demon Under the Microscope by Thomas Hager Pdf

In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of sulfa, the first antibiotic and the drug that shaped modern medicine. The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel.

Author : Adrian Nicole LeBlanc
Publisher : Simon and Schuster
Page : 432 pages
File Size : 50,6 Mb
Release : 2012-10-23
Category : Biography & Autobiography
ISBN : 9781439124895

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Random Family by Adrian Nicole LeBlanc Pdf

This New York Times bestseller intimately depicts urban life in a gripping book that slips behind cold statistics and sensationalism to reveal the true sagas lurking behind the headlines of gangsta glamour. In her extraordinary bestseller, Adrian Nicole LeBlanc immerses readers in the intricacies of the ghetto, revealing the true sagas lurking behind the headlines of gangsta glamour, gold-drenched drug dealers, and street-corner society. Focusing on two romances—Jessica’s dizzying infatuation with a hugely successful young heroin dealer, Boy George, and Coco’s first love with Jessica's little brother, Cesar—Random Family is the story of young people trying to outrun their destinies. Jessica and Boy George ride the wild adventure between riches and ruin, while Coco and Cesar stick closer to the street, all four caught in a precarious dance between survival and death. Friends get murdered; the DEA and FBI investigate Boy George; Cesar becomes a fugitive; Jessica and Coco endure homelessness, betrayal, the heartbreaking separation of prison, and, throughout it all, the insidious damage of poverty. Charting the tumultuous cycle of the generations—as girls become mothers, boys become criminals, and hope struggles against deprivation—LeBlanc slips behind the cold statistics and sensationalism and comes back with a riveting, haunting, and true story.

Author : Janet Bond Brill, PhD, RD, LDN
Publisher : Harmony
Page : 352 pages
File Size : 45,8 Mb
Release : 2013-05-07
Category : Health & Fitness
ISBN : 9780307986368

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Blood Pressure Down by Janet Bond Brill, PhD, RD, LDN Pdf

For the nearly 78 million Americans with hypertension, a safe, effective lifestyle plan—incorporating the DASH diet principles and much more—for lowering blood pressure naturally If you have high blood pressure, you're not alone: nearly a third of adult Americans have been diagnosed with hypertension, and another quarter are well on their way. Yet a whopping 56 percent of diagnosed patients do not have it under control. The good news? Hypertension is easily treatable (and preventable), and you can take action today to bring your blood pressure down in just four weeks—without the potential dangers and side effects of prescription medications. In Blood Pressure Down, Janet Bond Brill distills what she's learned over decades of helping her patients lower their blood pressure into a ten-step lifestyle plan that's manageable for anyone. You'll: • harness the power of blood pressure power foods like bananas, spinach, and yogurt • start a simple regimen of exercise and stress reduction • stay on track with checklists, meal plans, and more than fifty simple recipes Easy, effective, safe—and delicious—Blood Pressure Down is the encouraging resource that empowers you, or your loved ones, to lower your blood pressure and live a longer, heart-healthy life.

Author : Janet Bond Brill, PhD, RD, LDN
Publisher : Harmony
Page : 338 pages
File Size : 51,8 Mb
Release : 2009-01-21
Category : Health & Fitness
ISBN : 9780307494467

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Cholesterol Down by Janet Bond Brill, PhD, RD, LDN Pdf

Take control of your cholesterol with this 10-point plan from nutrition and fitness expert Dr. Janet Brill—without using drugs. If you are one of the nearly 100 million Americans struggling with high cholesterol, then Dr. Janet Brill offers you a revolutionary new plan for taking control of your health—without the risks of statin drugs. With Dr. Brill’s breakthrough Cholesterol Down Plan, you simply add nine “miracle foods” to your regular diet and thirty minutes of walking to your daily routine. That’s all. This straightforward and easy-to-follow program can lower your LDL (“bad”) cholesterol by as much as 47 percent in just four weeks. Cholesterol Down explains Dr. Brill’s ten-point plan as well as the science behind it. You’ll learn how each miracle food affects LDL cholesterol and how the foods work together for maximum effect, as well as: • How eating whole grains helps reduce LDL cholesterol in your bloodstream • Why antioxidants keep plaque from building up in your arteries • How certain steps change the structure of LDL cholesterol particles (and why it’s best for them to be large and fluffy) • Why walking just thirty minutes a day lowers “bad” cholesterol and cuts dangerous belly fat With everything you need to stay focused on the plan, including a daily checklist, a six-month chart for racking LDL cholesterol changes, tools for assessing your risk level for cardiovascular disease, sample weekly menus, and even heart-healthy recipes, Cholesterol Down is the safe and effective alternative or complement to statin drugs.

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 41,8 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Author : United States. General Accounting Office
Publisher : Unknown
Page : 12 pages
File Size : 47,9 Mb
Release : 2001
Category : Drugs
ISBN : UCBK:C079752088

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Drug Safety by United States. General Accounting Office Pdf

Author : Dr. Carl L. Hart
Publisher : Penguin
Page : 304 pages
File Size : 43,7 Mb
Release : 2021-01-12
Category : Social Science
ISBN : 9781101981658

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Drug Use for Grown-Ups by Dr. Carl L. Hart Pdf

“Hart’s argument that we need to drastically revise our current view of illegal drugs is both powerful and timely . . . when it comes to the legacy of this country’s war on drugs, we should all share his outrage.” —The New York Times Book Review From one of the world's foremost experts on the subject, a powerful argument that the greatest damage from drugs flows from their being illegal, and a hopeful reckoning with the possibility of their use as part of a responsible and happy life Dr. Carl L. Hart, Ziff Professor at Columbia University and former chair of the Department of Psychology, is one of the world's preeminent experts on the effects of so-called recreational drugs on the human mind and body. Dr. Hart is open about the fact that he uses drugs himself, in a happy balance with the rest of his full and productive life as a researcher and professor, husband, father, and friend. In Drug Use for Grown-Ups, he draws on decades of research and his own personal experience to argue definitively that the criminalization and demonization of drug use--not drugs themselves--have been a tremendous scourge on America, not least in reinforcing this country's enduring structural racism. Dr. Hart did not always have this view. He came of age in one of Miami's most troubled neighborhoods at a time when many ills were being laid at the door of crack cocaine. His initial work as a researcher was aimed at proving that drug use caused bad outcomes. But one problem kept cropping up: the evidence from his research did not support his hypothesis. From inside the massively well-funded research arm of the American war on drugs, he saw how the facts did not support the ideology. The truth was dismissed and distorted in order to keep fear and outrage stoked, the funds rolling in, and Black and brown bodies behind bars. Drug Use for Grown-Ups will be controversial, to be sure: the propaganda war, Dr. Hart argues, has been tremendously effective. Imagine if the only subject of any discussion about driving automobiles was fatal car crashes. Drug Use for Grown-Ups offers a radically different vision: when used responsibly, drugs can enrich and enhance our lives. We have a long way to go, but the vital conversation this book will generate is an extraordinarily important step.

Author : Anonim
Publisher : Unknown
Page : 76 pages
File Size : 52,9 Mb
Release : 2007
Category : Brain
ISBN : MINN:31951D025861296

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Drugs, Brains, and Behavior by Anonim Pdf

"Drugs, Brains, and Behavior" is an online textbook written by C. Robin Timmons and Leonard W. Hamilton. The book was previously published by Prentice Hall, Inc. in 1990 as "Principles of Behavioral Pharmacology." The authors attempt to develop an understanding of the interpenetration of brain, behavior and environment. They discuss the chemistry of behavior in both the literal sense of neurochemistry and the figurative sense of an analysis of the reactions with the environment.

Author : Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 172 pages
File Size : 48,7 Mb
Release : 2002-01-07
Category : Medical
ISBN : 9780309082587

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Caffeine for the Sustainment of Mental Task Performance by Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research Pdf

This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

Author : Michelle Alexander
Publisher : The New Press
Page : 434 pages
File Size : 49,8 Mb
Release : 2020-01-07
Category : Law
ISBN : 9781620971949

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The New Jim Crow by Michelle Alexander Pdf

Named one of the most important nonfiction books of the 21st century by Entertainment Weekly‚ Slate‚ Chronicle of Higher Education‚ Literary Hub, Book Riot‚ and Zora A tenth-anniversary edition of the iconic bestseller—"one of the most influential books of the past 20 years," according to the Chronicle of Higher Education—with a new preface by the author "It is in no small part thanks to Alexander's account that civil rights organizations such as Black Lives Matter have focused so much of their energy on the criminal justice system." —Adam Shatz, London Review of Books Seldom does a book have the impact of Michelle Alexander's The New Jim Crow. Since it was first published in 2010, it has been cited in judicial decisions and has been adopted in campus-wide and community-wide reads; it helped inspire the creation of the Marshall Project and the new $100 million Art for Justice Fund; it has been the winner of numerous prizes, including the prestigious NAACP Image Award; and it has spent nearly 250 weeks on the New York Times bestseller list. Most important of all, it has spawned a whole generation of criminal justice reform activists and organizations motivated by Michelle Alexander's unforgettable argument that "we have not ended racial caste in America; we have merely redesigned it." As the Birmingham News proclaimed, it is "undoubtedly the most important book published in this century about the U.S." Now, ten years after it was first published, The New Press is proud to issue a tenth-anniversary edition with a new preface by Michelle Alexander that discusses the impact the book has had and the state of the criminal justice reform movement today.

Author : Hans-Christoph Diener,Marcia Wilkinson
Publisher : Springer Science & Business Media
Page : 173 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642733277

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Drug-Induced Headache by Hans-Christoph Diener,Marcia Wilkinson Pdf

M. WILKINSON Patients with frequent or daily headaches pose a very difficult problem for the physician who has to treat them, particularly as many patients think that there should be a medicine or medicines which give them instant relief. In the search for the compound which would meet this very natural desire, many drugs have been manufactured and the temptation for the physician is either to increase the dose of a drug which seems to be, at any rate, partially effective, or to add one or more drugs to those which the patient is already taking. Although there have been some references to the dangers of overdosage of drugs for migraine in the past, it was not until relatively recently that it was recognized that drugs given for the relief of headache, if taken injudiciously, may themselves cause headache. The first drugs to be implicated in this way were ergotamine and phenazone. In the case of ergotamine tartrate, the dangers of ergotism were well known as this was a disorder which had been known and written about for many years. In the treatment of headache, fully blown ergotism is rare and in recent years has usually been due to self-medication in doses much greater than those prescribed although there are a few recorded cases where toxic amounts have been given.

Author : Ruben Vardanyan,Victor Hruby
Publisher : Elsevier
Page : 634 pages
File Size : 54,8 Mb
Release : 2006-03-10
Category : Medical
ISBN : 008046212X

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Synthesis of Essential Drugs by Ruben Vardanyan,Victor Hruby Pdf

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references

Author : Patrick Radden Keefe
Publisher : Bond Street Books
Page : 480 pages
File Size : 49,7 Mb
Release : 2021-04-13
Category : Business & Economics
ISBN : 9780385697552

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Empire of Pain by Patrick Radden Keefe Pdf

A grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin, by the prize-winning, bestselling author of Say Nothing The Sackler name adorns the walls of many storied institutions—Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and the sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing a blockbuster painkiller that was the catalyst for the opioid crisis. Empire of Pain begins with the story of three doctor brothers, Raymond, Mortimer and the incalculably energetic Arthur, who weathered the poverty of the Great Depression and appalling anti-Semitism. Working at a barbaric mental institution, Arthur saw a better way and conducted groundbreaking research into drug treatments. He also had a genius for marketing, especially for pharmaceuticals, and bought a small ad firm. Arthur devised the marketing for Valium, and built the first great Sackler fortune. He purchased a drug manufacturer, Purdue Frederick, which would be run by Raymond and Mortimer. The brothers began collecting art, and wives, and grand residences in exotic locales. Their children and grandchildren grew up in luxury. Forty years later, Raymond’s son Richard ran the family-owned Purdue. The template Arthur Sackler created to sell Valium—co-opting doctors, influencing the FDA, downplaying the drug’s addictiveness—was employed to launch a far more potent product: OxyContin. The drug went on to generate some thirty-five billion dollars in revenue, and to launch a public health crisis in which hundreds of thousands would die. This is the saga of three generations of a single family and the mark they would leave on the world, a tale that moves from the bustling streets of early twentieth-century Brooklyn to the seaside palaces of Greenwich, Connecticut, and Cap d’Antibes to the corridors of power in Washington, D.C. Empire of Pain chronicles the multiple investigations of the Sacklers and their company, and the scorched-earth legal tactics that the family has used to evade accountability. The history of the Sackler dynasty is rife with drama—baroque personal lives; bitter disputes over estates; fistfights in boardrooms; glittering art collections; Machiavellian courtroom maneuvers; and the calculated use of money to burnish reputations and crush the less powerful. Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling. It is a portrait of the excesses of America’s second Gilded Age, a study of impunity among the super elite and a relentless investigation of the naked greed and indifference to human suffering that built one of the world’s great fortunes.