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A Book of Discovery. The History of the World's Exploration, From the Earliest Times to the Finding of the South Pole by Mb Synge Pdf
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Real World Drug Discovery by Robert M. Rydzewski Pdf
Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.
Sorenson tells the story of a young married man and expectant father just starting graduate school. With a beautifully written storyline, an emotional climax, and a surprise ending, the story leaves readers uplifted and pondering on its message of human potential.
The Adventure of Self-Discovery by Stanislav Grof Pdf
Here Grof presents a useful model of the psychea model extended by his thirty years of studying non-ordinary states of consciousness. It is useful for understanding such phenomena as shamanism, mysticism, psychedelic states, spontaneous visionary experiences, and psychotic episodes. The model is also useful in explaining the dynamics of experiential psychotherapies and a variety of sociopolitical manifestations such as war and revolution. This book might have been entitled Beyond Drugs. The second part describes the principles and process of the non-pharmacological technique developed by the author and his wife, Christina, for self-exploration and for psychotherapy. Grof explores in detail the components of this technique. He describes its method, its effective mechanisms, as well as its goals and potential. Its practice is simple, since it utilizes the natural healing capacity of the psyche.
Author : Stephen J. Pyne Publisher : University of Arizona Press Page : 337 pages File Size : 45,5 Mb Release : 2021-02-23 Category : History ISBN : 9780816541119
The Great Ages of Discovery by Stephen J. Pyne Pdf
For more than 600 years, Western civilization has relied on exploration to learn about a wider world and universe. The Great Ages of Discovery details the different eras of Western exploration in terms of its locations, its intellectual contexts, the characteristic moral conflicts that underwrote encounters, and the grand gestures that distill an age into its essence. Historian and MacArthur Fellow Stephen J. Pyne identifies three great ages of discovery in his fascinating new book. The first age of discovery ranged from the early 15th to the early 18th century, sketched out the contours of the globe, aligned with the Renaissance, and had for its grandest expression the circumnavigation of the world ocean. The second age launched in the latter half of the 18th century, spanning into the early 20th century, carrying the Enlightenment along with it, pairing especially with settler societies, and had as its prize achievement the crossing of a continent. The third age began after World War II, and, pivoting from Antarctica, pushed into the deep oceans and interplanetary space. Its grand gesture is Voyager’s passage across the solar system. Each age had in common a galvanic rivalry: Spain and Portugal in the first age, Britain and France—followed by others—in the second, and the USSR and USA in the third. With a deep and passionate knowledge of the history of Western exploration, Pyne takes us on a journey across hundreds of years of geographic trekking. The Great Ages of Discovery is an interpretive companion to what became Western civilization’s quest narrative, with the triumphs and tragedies that grand journey brought, the legacies of which are still very much with us.
Privileged Scaffolds in Drug Discovery by Bin Yu,Ning Li,Caiyun Fu Pdf
Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. Provides wide coverage of privileged scaffolds in new drug discovery Includes complex and diverse natural product scaffolds Covers applications to peptides and peptide-based drugs
Quantum Mechanics in Drug Discovery by N.B. Singh Pdf
"Quantum Mechanics in Drug Discovery" is an illuminating guide that navigates the intersection of quantum mechanics and pharmaceutical research. Designed for scientists, researchers, and professionals in the field of drug discovery, this book explores the crucial role of quantum mechanics in understanding molecular interactions, electronic structures, and the behavior of chemical compounds. Covering principles such as quantum molecular modeling and computational chemistry, the book provides valuable insights into predicting and optimizing drug properties with precision. With clarity and practical relevance, it serves as an indispensable resource for those seeking a deeper understanding of how quantum mechanics contributes to the advancement of drug development and innovation.
Safari Stanley's Reptile Discovery by Christopher Biggs Pdf
Your child will have fun whilst developing recognition, memory and vocabulary skills. Join Safari Stanley on his latest adventure. This time he's off to discover the world of reptiles! Your child will want to meet Stanley and his new friends again and again.
The Entrepreneurial Discovery Process and Regional Development by Åge Mariussen,Seija Virkkala,Håkon Finne,Tone Merethe Aasen Pdf
There is a broad and long-standing debate on possible solutions to the regional vulnerabilities of globalisation. In 2014, the European Commission began implementing Smart Specialisation Strategy, a place-based strategy of growth, regional transformation and new industrial policy with collective entrepreneurial discovery processes (EDP) at its core. This volume approaches the mystery of entrepreneurial discovery; that is, how relevant knowledge is created, converted and shared in a process of discovery. These essays bring together scholars from economics, geography, sociology, organisation studies, innovation studies, and complexity theory, offering new approaches to overcome the limitations of place-based development and suggesting improved methods leading to growth.
Discovery and Exploration of the Mississippi Valley by John Gilmary Shea,John Shea Pdf
This is an OCR edition without illustrations or index. It may have numerous typos or missing text. However, purchasers can download a free scanned copy of the original rare book from GeneralBooksClub.com. You can also preview excerpts from the book there. Purchasers are also entitled to a free trial membership in the General Books Club where they can select from more than a million books without charge. Original Published by: Redfield in 1852 in 366 pages; Subjects: Mississippi River; Mississippi river; History / United States / General; History / United States / State & Local / General; History / United States / State & Local / Midwest; History / United States / State & Local / South; Travel / United States / General; Travel / United States / Midwest / General;