Caveolae

Author : Christopher J. Fielding
Publisher : John Wiley & Sons
Page : 294 pages
File Size : 54,9 Mb
Release : 2006-12-13
Category : Science
ISBN : 9783527607501

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Lipid Rafts and Caveolae by Christopher J. Fielding Pdf

This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail. Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background Distinct structures and functions Structural basis Signaling Viral entry and virion budding Cholesterol transport Caveolins Lipid shells Cell polarity and intracellular trafficking Cancer cells Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.

Author : Jean-François Jasmin,Philippe Frank,Michael P. Lisanti
Publisher : Springer Science & Business Media
Page : 199 pages
File Size : 54,7 Mb
Release : 2012-03-12
Category : Medical
ISBN : 9781461412229

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Caveolins and Caveolae by Jean-François Jasmin,Philippe Frank,Michael P. Lisanti Pdf

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

Author : Jean-François Jasmin,Philippe Frank,Michael P. Lisanti
Publisher : Springer
Page : 0 pages
File Size : 42,9 Mb
Release : 2012-01-30
Category : Medical
ISBN : 1461412218

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Caveolins and Caveolae by Jean-François Jasmin,Philippe Frank,Michael P. Lisanti Pdf

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

Author : Margit Pavelka,Jürgen Roth
Publisher : Springer Science & Business Media
Page : 366 pages
File Size : 54,8 Mb
Release : 2010-07-16
Category : Science
ISBN : 9783211993903

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Functional Ultrastructure by Margit Pavelka,Jürgen Roth Pdf

The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.

Author : T.Y. Chang,Dale A. Freeman
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 44,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461551133

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Intracellular Cholesterol Trafficking by T.Y. Chang,Dale A. Freeman Pdf

INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol trafficking also appeared to have reached the point where it would start to rapidly expand beyond these few laboratories. Understanding of cholesterol trafficking was moving from a largely descriptive science into the molecular age. It seemed a good time to get together and see how much we agreed upon up to this point. More authors contributed to this volume than attended the St. Louis meeting. That meeting was generously funded by grants from Bristol-Myers Squibb, Merck and Company and Parke-Davis, however, the total funding available limited the size of the meeting. For the book, we are not so limited and have tried to be as inclusive as possible and pretty much invited everyone who is presently active in this area. We were quite fortunate to successfully recruit the authors we sought for each of these chapters. The authors and their contributions can be organized by particular interests and particular areas of expertise.

Author : Carlos M. Guardia,David Charles Gershlick,Aitor Hierro
Publisher : Frontiers Media SA
Page : 142 pages
File Size : 52,7 Mb
Release : 2021-12-07
Category : Science
ISBN : 9782889718269

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Energy Requirements in Membrane Trafficking by Carlos M. Guardia,David Charles Gershlick,Aitor Hierro Pdf

Author : Alessandra Cambi,Diane S. Lidke
Publisher : CRC Press
Page : 496 pages
File Size : 50,7 Mb
Release : 2014-10-27
Category : Medical
ISBN : 9781482209914

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Cell Membrane Nanodomains by Alessandra Cambi,Diane S. Lidke Pdf

Cell Membrane Nanodomains: From Biochemistry to Nanoscopy describes recent advances in our understanding of membrane organization, with a particular focus on the cutting-edge imaging techniques that are making these new discoveries possible. With contributions from pioneers in the field, the book explores areas where the application of these novel

Author : Sabyasachi Maiti,Kalyan Kumar Sen
Publisher : CRC Press
Page : 432 pages
File Size : 48,7 Mb
Release : 2016-11-03
Category : Medical
ISBN : 9781315353074

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Bio-Targets and Drug Delivery Approaches by Sabyasachi Maiti,Kalyan Kumar Sen Pdf

The advances in drug delivery systems over recent years have resulted in a large number of novel delivery systems with the potential to revolutionize the treatment and prevention of diseases. Bio-Targets and Drug Delivery Approaches is an easy-to-read book for students, researchers and pharmaceutical scientists providing a comprehensive introduction to the principles of advanced drug delivery and targeting their current applications and potential future developments.

Author : Shiro Suetsugu
Publisher : Academic Press
Page : 469 pages
File Size : 41,8 Mb
Release : 2022-09-08
Category : Science
ISBN : 9780323899192

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Plasma Membrane Shaping by Shiro Suetsugu Pdf

Plasma Membrane Shaping summarizes current knowledge on how cells shape their membrane. Organized in four sections, the book opens with a broad overview of the plasma membrane, its composition, usual shapes and substructures, Actin/WASP/arp2/3 structures, BAR domains, and Ankyrin repeat domains, dynamin, and phospholipid signaling. Other sections cover the shaping of the plasma membrane for transport processes, discussions on exosomes, microvesicles, and endosomes, clathrin-coated pits, caveolae, and other endocytic pits, membrane deformation for cell movement, and some of the most current dry and wet lab research techniques to investigate cellular membrane shaping. This is an ideal resource for new researchers coming into this area as well as for graduate students. The methods section will be of interest to both microscopists and computer scientists dedicated to the visualization, data collection, and analysis of plasma membrane shaping experiments. Covers membrane shaping for both cytosis and cell movement Includes dry and wet lab research methods of plasma membrane shaping Describes the molecular machinery involved with protein and lipid balance in the plasma membrane Presents the coordination of cellular structures involved in cell deformation and motion

Author : Peter Kohl,Frederick Sachs,Michael R. Franz
Publisher : OUP Oxford
Page : 512 pages
File Size : 45,6 Mb
Release : 2011-08-25
Category : Medical
ISBN : 9780191636233

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Cardiac Mechano-Electric Coupling and Arrhythmias by Peter Kohl,Frederick Sachs,Michael R. Franz Pdf

Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information provided carefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with the practising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.

Author : M.P. Mattson
Publisher : Elsevier
Page : 236 pages
File Size : 46,7 Mb
Release : 2003-05-06
Category : Science
ISBN : 0080522505

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Membrane Lipid Signaling in Aging and Age-Related Disease by M.P. Mattson Pdf

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

Author : Lorenza González-Mariscal
Publisher : Springer Nature
Page : 340 pages
File Size : 43,8 Mb
Release : 2022-05-31
Category : Science
ISBN : 9783030972042

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Tight Junctions by Lorenza González-Mariscal Pdf

This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.

Author : Felix Kratz,Peter Senter,Henning Steinhagen
Publisher : John Wiley & Sons
Page : 1828 pages
File Size : 46,8 Mb
Release : 2013-09-30
Category : Medical
ISBN : 9783527647750

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Drug Delivery in Oncology by Felix Kratz,Peter Senter,Henning Steinhagen Pdf

In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.

Author : Edward Bittar
Publisher : Elsevier
Page : 264 pages
File Size : 52,5 Mb
Release : 2005-10-07
Category : Science
ISBN : 0080458602

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Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease by Edward Bittar Pdf

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Author : Rüdiger Liersch,Wolfgang E. Berdel,Torsten Kessler
Publisher : Springer Science & Business Media
Page : 238 pages
File Size : 46,9 Mb
Release : 2009-12-24
Category : Medical
ISBN : 9783540782810

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Angiogenesis Inhibition by Rüdiger Liersch,Wolfgang E. Berdel,Torsten Kessler Pdf

Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.