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Author : Johng S. Rhim,Richard Kremer
Publisher : Springer Science & Business Media
Page : 239 pages
File Size : 54,5 Mb
Release : 2011-09-15
Category : Science
ISBN : 9781461402541

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Human Cell Transformation by Johng S. Rhim,Richard Kremer Pdf

Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: · Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems · Oncogenes · Tumor suppressor genes · Viral transformation · In vitro model systems for viral, chemical and radiation carcinogenesis · Cell aging · The multistep nature of human carcinogenesis · The role of stem cells and the microenvironment in tumorigenesis · The genes involved in multistep carcinogenesis Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area! Features ؠ Multistep models ؠ Breast cancer/Stem cells ؠ Prostate cancer/Stem cells ؠ Multistep / Genes

Author : V. M. Zhdanov
Publisher : CRC Press
Page : 344 pages
File Size : 50,8 Mb
Release : 1987
Category : Medical
ISBN : 3718603144

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Virology Reviews by V. M. Zhdanov Pdf

Author : Anonim
Publisher : Unknown
Page : 1026 pages
File Size : 47,6 Mb
Release : 2007
Category : Cancer
ISBN : RUTGERS:44008000277773

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Journal of the National Cancer Institute by Anonim Pdf

Author : E. J. Steele
Publisher : CRC Press
Page : 200 pages
File Size : 52,7 Mb
Release : 1991-01-03
Category : Medical
ISBN : 0849353483

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Somatic Hypermutation in V-Regions by E. J. Steele Pdf

This book provides critical reviews regarding the process of somatic hypermutation in antibody V genes. Topics covered include the in vivo kinetics of antigen-driven somatic hypermutation in a number of well-studied systems in mice; the instability of lg genes in cultured cells; the key role played in vivo by germinal centers in providing the appropriate "mutational" microenvironment; the types of nucleotide sequence errors generated; the process of hypermutation in pre-arranged V regions expressed in transgenic mice; and a critical evaluation of the status of molecular models proposed to explain hypermutation. Other topics include a detailed review of data from hypervariable retroviral systems, as well as precise studies on the mutagenic potential of various DNA polymerases in vitro. The book will provide indispensable information for immunologists, geneticists, molecular biologists, biochemists, and cell biologists.

Author : A.K. Kanellis,C. Chang,H. Klee,A.B. Bleecker,J.C. Pech,Donald Grierson
Publisher : Springer Science & Business Media
Page : 451 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401144537

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Biology and Biotechnology of the Plant Hormone Ethylene II by A.K. Kanellis,C. Chang,H. Klee,A.B. Bleecker,J.C. Pech,Donald Grierson Pdf

The inflorescence of the monoecious maize plant is unique among the Gramineae in the sharp separation of the male and female structures. The male tassel at the terminus of the plant most often sheds pollen before the visual appearance of the receptive silks of th the female ear at a lateral bud, normally at the 10 leaf [I]. Earlier studies examined the ontogeny of the growing tissues beginning with the embryo in the kernel through to the obvious protuberances of the growing point as the kernel germinates. The differentiated developing soon-to-become tassel and the lateral bulges that develop into the ears on the lateral buds become apparent very early in the germinating kernel [2, 3, 46]. A certain number of cells are destined for tassel and ear development [8]. As the plant develops, there is a phase transition [\3, 16] from the vegetative lateral buds to the reproductive lateral buds. This change in phase has been ascribed to genotypic control as evidenced in the differences among different genotypes in the initiation of the reproductive [I]. The genetic control of tassel and ear initiation has been gleaned from anatomical observations. Lejeune and Bernier [I2] found that maize plants terminate the initiation of additional axillary meristems at the time of tassel initiation. This would indicate that the top-most ear shoot is initiated on the same day as the initiation of tassel development and this event signals the end of the undifferentiated growing point.

Author : Hans J Stauss,Yutaka Kawakami,Giorgio Parmiani
Publisher : CRC Press
Page : 220 pages
File Size : 44,8 Mb
Release : 2003-01-23
Category : Medical
ISBN : 9780203217658

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Tumor Antigens Recognized by T Cells and Antibodies by Hans J Stauss,Yutaka Kawakami,Giorgio Parmiani Pdf

Recent progress in fundamental tumor immunology has led to immunotherapy trials in patients with solid tumors and hematological malignancies. In the past, immunotherapy approaches were primarily based on enhancement of tumor immunity with cytokines and adjuvant therapy, without knowledge of relevant tumor antigens. The discovery of tumor antigens c

Author : R. J. C. Harris
Publisher : Academic Press
Page : 326 pages
File Size : 48,8 Mb
Release : 2014-07-18
Category : Science
ISBN : 9781483281995

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Cytogenetics of Cells in Culture by R. J. C. Harris Pdf

Cytogenetics of Cells in Culture is a compendium of papers that deals with techniques to detect patterns of DNA replication, cellular control mechanisms, and chromosome analyses with automated instrumentation. Some papers discuss the effects of cell hybridization and of noxious substances such as radiation, chemical agents, and viruses on chromosomal patterns. Other papers focus on the influence of altered chromosomal complement on the survival of cells to long-term tissue culture or to ionizing radiation treatment. A couple of papers points out that naturally occurring chromosomal abnormalities in mammalian populations are relatively rare and are not necessarily associated with physical defects or disease. One paper notes that chromosomes in cells with different functions have different patterns of replication in which the changes are small and hidden. The chromosomes will usually be neutralized showing little of the characteristic pattern of replication or condensation during the early cleavage stages, that will later change into differentiated characteristic ways for each tissue type. Another paper describes chromosome breakage associated with viruses and DNA inhibitors. The compendium can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or physiology.

Author : Isaac Witz
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 43,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468436778

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In Situ Expression of Tumor Immunity by Isaac Witz Pdf

Because of several valid (and some invalid) reasons, the research field of tumor immunology has been declining in popularity. The Simplistic dogmas, articles of faith, and theories of the late 1960s and early 1970s on the immuno logical mechanisms of the host-tumor interrelationships have frequently been refuted by some of the new developments in cancer biology, cancer biochem istry, and immunology. Furthermore, some of the conventional assays used to monitor "tumor-host immune relations" did not always reflect the host's true clinical situation or his prognosis. Several approaches to immunological interven tion were less successful than expected. In addition, the concept of "immune surveillance," which was basic to many researchers in the field of cancer im munology, seemed to fall apart. Much of the criticism was based on results from solid, well-performed, and well-controlled experiments, but there was also un just criticism based on ill-conceived and badly performed studies, and on misin terpretations of experimental data. There are many misconceptions about the tumor-host relationship. It is very often assumed that tumor immunity, as expressed systemically, is truly reflected at the tumor site. Several studies reported in this volume and elsewhere indicate that such is not always the case. Certain immune effectors may be selectively prevented from reaching the tumor site or the close vicinity of the tumor cells because of mechanical or chemical barriers, whereas others may be selectively attracted to the site by chemotaxis or other mechanisms.

Author : Bernhard Schink
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 47,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461541875

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Advances in Microbial Ecology by Bernhard Schink Pdf

Volume 16 of Advances in Microbial Ecology has a difficult history. Nearly halfway through its completion, Gwynfryn Jones had to resign as managing edi tor for health reasons, and he asked me to take over. I want to thank Gwyn for his dedicated work in this publication series, and wish him all the best for the future. After the change in editorship, some authors had to be encouraged on rather short notice to provide their chapters in order to make appearance of this volume possible within a reasonable period of time. Nonetheless, I think that the articles we present with this volume represent an enjoyable collection of up-to-date con tributions to microbial ecology. In my own understanding, microbial ecology com prises the elucidation of microbial activities in natural or semi natural environ ments, including physiology, biochemistry, population dynamics, and interactions with all the biotic and abiotic environmental conditions microbes encounter. This comprises studies on single organisms in defined cultures in an ecological per spective, the analysis of microbial activities in complex environments, as well as the development of concepts for the interactions of microorganisms with the world in which they live. Last but not least, microbial ecology is not an exotic science studied exclusively in remote places untouched by human beings.

Author : Donald R. Kirsch,Rosemarie Kelly,Myra B. Kurtz
Publisher : CRC Press
Page : 232 pages
File Size : 46,5 Mb
Release : 1990-05-29
Category : Medical
ISBN : 0849355702

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The Genetics of Candida by Donald R. Kirsch,Rosemarie Kelly,Myra B. Kurtz Pdf

The objective of this volume is to provide a preliminary data base for Candida albicans plus serve as a reference for the genetic methods now available for the manipulation of several species in the genus Candida. This comprehensive review focuses primarily on C. albicans and includes reference data on the types and complementation status of mutations isolated in C. albicans, preliminary recombination mapping, chromosome analysis, physical measurements of DNA content and complexity, mitochondrial genome mapping, and analyses of restriction fragment length polymorphisms. It discusses a variety of genetic techniques in relation to current research questions aimed at virulence factors, dimorphism, and the potential use of Candida strains in biotechnology processes. This up-to-date publication is an indispensable resource for everyone who is involved with microbiology, genetics, and molecular and cellular biology.

Author : Anonim
Publisher : Academic Press
Page : 344 pages
File Size : 50,5 Mb
Release : 1999-03-18
Category : Science
ISBN : 9780080580890

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Advances in Parasitology by Anonim Pdf

Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomeiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

Author : Phycological Society of America
Publisher : CUP Archive
Page : 160 pages
File Size : 43,7 Mb
Release : 1983-03-31
Category : Science
ISBN : 9780521250672

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Survival Strategies of the Algae by Phycological Society of America Pdf

This 1983 book provides information regarding ecological conditions and population dynamics of both marine and freshwater algae form diverse habitats.

Author : Chandralata Raghukumar
Publisher : Springer Science & Business Media
Page : 343 pages
File Size : 43,6 Mb
Release : 2012-01-06
Category : Science
ISBN : 9783642233425

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Biology of Marine Fungi by Chandralata Raghukumar Pdf

The diversity, ecological role and biotechnological applications of marine fungi have been addressed in numerous scientific publications in the last few years. This enormous spurt of information has led to a dire need among students and professionals alike for a source, which contains comprehensive reviews of various aspects of marine fungi. This book addresses this need, especially since it is written by reputed marine mycologists. The latest information on topics including molecular taxonomy and phylogeny, ecology of fungi in different marine habitats such as deep sea, corals, dead- sea, fungi in extreme marine environments and their biotechnological applications is reviewed. The book presents a comprehensive source of information and analysis aimed at marine fungi for researchers, teachers and students of marine mycology.

Author : National Cancer Institute (U.S.)
Publisher : Unknown
Page : 900 pages
File Size : 47,8 Mb
Release : 1963
Category : Cancer
ISBN : UOM:39015008107040

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Journal by National Cancer Institute (U.S.) Pdf

Author : Roy G. Smith,Michael O. Thorner
Publisher : Springer Science & Business Media
Page : 345 pages
File Size : 51,8 Mb
Release : 2000-01-28
Category : Medical
ISBN : 9781592590155

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Human Growth Hormone by Roy G. Smith,Michael O. Thorner Pdf

In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.