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Author : Anonim
Publisher : Unknown
Page : 412 pages
File Size : 40,5 Mb
Release : 1854
Category : Electronic
ISBN : DMM:057002562635
Author : Bin Yu,Ning Li,Caiyun Fu
Publisher : Elsevier
Page : 988 pages
File Size : 51,9 Mb
Release : 2023-07-19
Category : Medical
ISBN : 9780443186127
Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. Provides wide coverage of privileged scaffolds in new drug discovery Includes complex and diverse natural product scaffolds Covers applications to peptides and peptide-based drugs
Author : David B. Quinn
Publisher : Taylor & Francis
Page : 559 pages
File Size : 55,6 Mb
Release : 2023-08-18
Category : History
ISBN : 9781000963809
First published in 1974, England and the Discovery of America places the early explorations of the English in North America in the broad context of 15th and 16th century history. Marshalling evidence that cannot be pushed aside and sifting a mass of fascinating detail (including problems of cartography and the Vinland Map controversy), Professor Quinn presents circumstantial indications pointing to 1481 as the date or the discovery of America by Bristol voyagers – fishermen seeking new sources of cod, and merchant sailors with maps carrying promise of unexploited Atlantic islands. Whereas England did little to follow up her early lead, Quinn demonstrates that English initiatives from the 1580s onward, though slow, were of great importance. He brings to life the men involved in a variety of rash and heroic experiments in colonization and casts new light on their fates. He makes it clear that it was this very profusion of trial and error and trail again, as well as the conviction that settlement in temperate latitudes in North America could be effective if tenaciously enough sought, that enabled the English to strike and maintain routes in their new American world. This book will be of interest to students of English history, American history, colonial history and naval history.
Author : Willem Cornelis Unnik
Publisher : Unknown
Page : 124 pages
File Size : 42,6 Mb
Release : 1960
Category : Coptic manuscripts (Papyri)
ISBN : UOM:39015002785064
Author : Robert Stroud,Janet Finer-Moore
Publisher : Royal Society of Chemistry
Page : 400 pages
File Size : 41,6 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847557964
Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with: * A rich understanding of modern approaches to docking * A comparison and critical evaluation of state-of-the-art methods * Details on harnessing computational methods for both analysis and prediction * An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms * Critical reviews of current fragment based methods with perceptive applications to kinases Addressing a wide range of uses of protein structures for drug discovery the Editors have created and essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery.
Author : Arthur Henry Joel,Charles Calvert Smoot,Charles Knesal Cooperrider,Clarence Sheldon Slater,Cyril Oliver Bratley,Eugenia Cuvillier,George Henry Hepting,George Luther Schnur,George W. Barber,George Wallace Musgrave,Harold Blaisdell Shepard,Herbert George Barott,James Stewart Wiant,James William Park,Lawrence Zeleny,Lewis Bertie Olmstead,Margaret Blanche Hays,Norman Julian Wall,Paul Lewis Harding,R. L. Piemeisel,R. W. Leukel,Stephen Harold Hastings,Stuart Bevier Show,William Henry Black,Barnard Andrew Hendricks,Dan Hansen,David Augustus Coleman,E. I. Kotok,Edwin Alfonso Trowbridge,F. F. Dicke,Francis Raymond Lawson,George Grant Hedgcock,Jacob Martin Lutz,Oscar Roland Mathews,R. S. Holmes,Ralph Wylie Frey,Robert Arthur Norton,J. I. Hardy,Dean Humboldt Rose,Horace Greeley Byers
Publisher : Unknown
Page : 1406 pages
File Size : 41,5 Mb
Release : 1937
Category : Agricultural credit
ISBN : OSU:32435027441104
Author : Anonim
Publisher : Unknown
Page : 566 pages
File Size : 55,5 Mb
Release : 1870
Category : Electronic
ISBN : ONB:+Z229464100
Author : Anonim
Publisher : Unknown
Page : 730 pages
File Size : 47,8 Mb
Release : 1895
Category : Electronic
ISBN : BSB:BSB11799706
Author : Anonim
Publisher : Unknown
Page : 996 pages
File Size : 47,6 Mb
Release : 1895
Category : Encyclopedias and dictionaries
ISBN : STANFORD:36105119900236
Author : Anton E. Lawson
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 53,7 Mb
Release : 2006-04-11
Category : Science
ISBN : 9780306482069
A goal of mine ever since becoming an educational researcher has been to help construct a sound theory to guide instructional practice. For far too long, educational practice has suffered because we have lacked firm instructional guidelines, which in my view should be based on sound psychological theory, which in turn should be based on sound neurological theory. In other words, teachers need to know how to teach and that "how-to-teach" should be based solidly on how people learn and how their brains function. As you will see in this book, my answer to the question of how people learn is that we all learn by spontaneously generating and testing ideas. Idea generating involves analogies and testing requires comparing predicted consequences with actual consequences. We learn this way because the brain is essentially an idea generating and testing machine. But there is more to it than this. The very process ofgenerating and testing ideas results not only in the construction of ideas that work (i. e. , the learning of useful declarative knowledge), but also in improved skill in learning (i. e. , the development of improved procedural knowledge).
Author : Elizabeth Fee
Publisher : Johns Hopkins University Press+ORM
Page : 480 pages
File Size : 54,5 Mb
Release : 2016-06-12
Category : Medical
ISBN : 9781421421124
The story of a world-renowned institution and “a broad investigation of early twentieth-century public health ideology in America” (Journal of the American Medical Association). At the end of the nineteenth century, public health was the province of part-time political appointees and volunteer groups of every variety. Public health officers were usually physicians, but they could also be sanitary engineers, lawyers, or chemists—there was little agreement about the skills and knowledge necessary for practice. In Disease and Discovery, Elizabeth Fee examines the conflicting ideas about public health’s proper subject and scope and its search for a coherent professional unity and identity. She draws on the debates and decisions surrounding the establishment of what was initially known as the Johns Hopkins School of Hygiene and Public Health, the first independent institution for public health research and education, to crystallize the fundamental questions of the field. Many of the issues of public health education in the early twentieth century are still debated today. What is the proper relationship of public health to medicine? What is the relative importance of biomedical, environmental, and sociopolitical approaches to public health? Should schools of public health emphasize research skills over practical training? Should they provide advanced training and credentials for the few or simpler educational courses for the many? Fee explores the many dimensions of these issues in the context of the founding of the Johns Hopkins school. She details the efforts to define the school’s structure and purpose, select faculty and students, and organize the curriculum, and she follows the school’s growth and adaptation to the changing social environment through the beginning of World War II. As Fee demonstrates, not simply in its formation but throughout its history, the School of Hygiene served as a crucible for the forces shaping the public health profession as a whole.
Author : Karuppusamy Arunachalam,Xuefei Yang,Sreeja Puthanpura Sasidharan
Publisher : Springer Nature
Page : 569 pages
File Size : 55,5 Mb
Release : 2022-09-20
Category : Science
ISBN : 9781071626832
This detailed volume explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.
Author : David C Blakemore,Paul M Doyle,Yvette M Fobian
Publisher : Royal Society of Chemistry
Page : 517 pages
File Size : 54,9 Mb
Release : 2016-07-15
Category : Science
ISBN : 9781782627913
Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods to access novel motifs and monomers. This book provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Moreover, key opportunities in expanding chemical space are presented, including the increasingly important syntheses that introduce three-dimensional molecular shape. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.
Author : Dominique Side
Publisher : Troubador Publishing Ltd
Page : 424 pages
File Size : 47,6 Mb
Release : 2022-03-04
Category : Religion
ISBN : 9781803138626
Discovering Buddhism introduces Buddhism as a culture and civilization, a system of thought and a religion. It presents the views and practices of all the main Buddhist traditions without bias and addresses the history of Buddhism, the key topics taught by the Buddha, and a selection of contemporary issues.
Author : sir Walter Ralegh
Publisher : Unknown
Page : 342 pages
File Size : 46,7 Mb
Release : 1848
Category : Electronic
ISBN : OXFORD:590823634