Discovery

Author : Teresa Torres
Publisher : Product Talk LLC
Page : 201 pages
File Size : 45,9 Mb
Release : 2021-05-19
Category : Design
ISBN : 9781736633311

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Continuous Discovery Habits by Teresa Torres Pdf

"If you haven't had the good fortune to be coached by a strong leader or product coach, this book can help fill that gap and set you on the path to success." - Marty Cagan How do you know that you are making a product or service that your customers want? How do you ensure that you are improving it over time? How do you guarantee that your team is creating value for your customers in a way that creates value for your business? In this book, you'll learn a structured and sustainable approach to continuous discovery that will help you answer each of these questions, giving you the confidence to act while also preparing you to be wrong. You'll learn to balance action with doubt so that you can get started without being blindsided by what you don't get right. If you want to discover products that customers love-that also deliver business results-this book is for you.

Author : Susan Wortzman
Publisher : Unknown
Page : 317 pages
File Size : 52,9 Mb
Release : 2017
Category : Electronic discovery (Law)
ISBN : 0433488182

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E-discovery in Canada by Susan Wortzman Pdf

Author : John Muir
Publisher : Hodder & Stoughton
Page : 0 pages
File Size : 48,5 Mb
Release : 1992
Category : Alaska
ISBN : 0906371341

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John Muir by John Muir Pdf

Features the eight influential books in which John Muir reflects on the beauty of America's wilderness and fights for their protection.

Author : Bin Yu,Ning Li,Caiyun Fu
Publisher : Elsevier
Page : 988 pages
File Size : 44,8 Mb
Release : 2023-07-19
Category : Medical
ISBN : 9780443186127

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Privileged Scaffolds in Drug Discovery by Bin Yu,Ning Li,Caiyun Fu Pdf

Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. Provides wide coverage of privileged scaffolds in new drug discovery Includes complex and diverse natural product scaffolds Covers applications to peptides and peptide-based drugs

Author : David C Blakemore,Paul M Doyle,Yvette M Fobian
Publisher : Royal Society of Chemistry
Page : 517 pages
File Size : 51,8 Mb
Release : 2016-07-15
Category : Science
ISBN : 9781782627913

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Synthetic Methods in Drug Discovery by David C Blakemore,Paul M Doyle,Yvette M Fobian Pdf

Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods to access novel motifs and monomers. This book provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Moreover, key opportunities in expanding chemical space are presented, including the increasingly important syntheses that introduce three-dimensional molecular shape. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Author : Robert Stroud,Janet Finer-Moore
Publisher : Royal Society of Chemistry
Page : 400 pages
File Size : 55,5 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847557964

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Computational and Structural Approaches to Drug Discovery by Robert Stroud,Janet Finer-Moore Pdf

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with: * A rich understanding of modern approaches to docking * A comparison and critical evaluation of state-of-the-art methods * Details on harnessing computational methods for both analysis and prediction * An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms * Critical reviews of current fragment based methods with perceptive applications to kinases Addressing a wide range of uses of protein structures for drug discovery the Editors have created and essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery.

Author : Howard M. Fillit, MD,Alan W. O'Connell, PhD
Publisher : Springer Publishing Company
Page : 297 pages
File Size : 44,7 Mb
Release : 2002-01-03
Category : Medical
ISBN : 9780826115348

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Drug Discovery and Development for Alzheimer's Disease, 2000 by Howard M. Fillit, MD,Alan W. O'Connell, PhD Pdf

This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

Author : Charles Rathbone Low
Publisher : Unknown
Page : 374 pages
File Size : 54,6 Mb
Release : 1881
Category : Discoveries in geography
ISBN : HARVARD:32044058184649

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Maritime Discovery by Charles Rathbone Low Pdf

Author : H. Gerhard Vogel,Jochen Maas
Publisher : Springer Science & Business Media
Page : 896 pages
File Size : 41,6 Mb
Release : 2006
Category : Medical
ISBN : 9783540256380

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Drug Discovery and Evaluation by H. Gerhard Vogel,Jochen Maas Pdf

This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.

Author : Anton E. Lawson
Publisher : Springer Science & Business Media
Page : 285 pages
File Size : 42,7 Mb
Release : 2006-04-11
Category : Science
ISBN : 9780306482069

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The Neurological Basis of Learning, Development and Discovery by Anton E. Lawson Pdf

A goal of mine ever since becoming an educational researcher has been to help construct a sound theory to guide instructional practice. For far too long, educational practice has suffered because we have lacked firm instructional guidelines, which in my view should be based on sound psychological theory, which in turn should be based on sound neurological theory. In other words, teachers need to know how to teach and that "how-to-teach" should be based solidly on how people learn and how their brains function. As you will see in this book, my answer to the question of how people learn is that we all learn by spontaneously generating and testing ideas. Idea generating involves analogies and testing requires comparing predicted consequences with actual consequences. We learn this way because the brain is essentially an idea generating and testing machine. But there is more to it than this. The very process ofgenerating and testing ideas results not only in the construction of ideas that work (i. e. , the learning of useful declarative knowledge), but also in improved skill in learning (i. e. , the development of improved procedural knowledge).

Author : O. Maimon,M. Last
Publisher : Springer Science & Business Media
Page : 169 pages
File Size : 53,7 Mb
Release : 2013-03-09
Category : Computers
ISBN : 9781475732962

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Knowledge Discovery and Data Mining by O. Maimon,M. Last Pdf

This book presents a specific and unified approach to Knowledge Discovery and Data Mining, termed IFN for Information Fuzzy Network methodology. Data Mining (DM) is the science of modelling and generalizing common patterns from large sets of multi-type data. DM is a part of KDD, which is the overall process for Knowledge Discovery in Databases. The accessibility and abundance of information today makes this a topic of particular importance and need. The book has three main parts complemented by appendices as well as software and project data that are accessible from the book's web site (http://www.eng.tau.ac.iV-maimonlifn-kdg£). Part I (Chapters 1-4) starts with the topic of KDD and DM in general and makes reference to other works in the field, especially those related to the information theoretic approach. The remainder of the book presents our work, starting with the IFN theory and algorithms. Part II (Chapters 5-6) discusses the methodology of application and includes case studies. Then in Part III (Chapters 7-9) a comparative study is presented, concluding with some advanced methods and open problems. The IFN, being a generic methodology, applies to a variety of fields, such as manufacturing, finance, health care, medicine, insurance, and human resources. The appendices expand on the relevant theoretical background and present descriptions of sample projects (including detailed results).

Author : David B. Quinn
Publisher : Taylor & Francis
Page : 559 pages
File Size : 51,7 Mb
Release : 2023-08-18
Category : History
ISBN : 9781000963809

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England and the Discovery of America, 1481-1620 by David B. Quinn Pdf

First published in 1974, England and the Discovery of America places the early explorations of the English in North America in the broad context of 15th and 16th century history. Marshalling evidence that cannot be pushed aside and sifting a mass of fascinating detail (including problems of cartography and the Vinland Map controversy), Professor Quinn presents circumstantial indications pointing to 1481 as the date or the discovery of America by Bristol voyagers – fishermen seeking new sources of cod, and merchant sailors with maps carrying promise of unexploited Atlantic islands. Whereas England did little to follow up her early lead, Quinn demonstrates that English initiatives from the 1580s onward, though slow, were of great importance. He brings to life the men involved in a variety of rash and heroic experiments in colonization and casts new light on their fates. He makes it clear that it was this very profusion of trial and error and trail again, as well as the conviction that settlement in temperate latitudes in North America could be effective if tenaciously enough sought, that enabled the English to strike and maintain routes in their new American world. This book will be of interest to students of English history, American history, colonial history and naval history.

Author : Fabrice Guillet,Gilbert Ritschard,Djamel A. Zighed
Publisher : Springer
Page : 335 pages
File Size : 54,6 Mb
Release : 2010-09-07
Category : Technology & Engineering
ISBN : 9783642005800

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Advances in Knowledge Discovery and Management by Fabrice Guillet,Gilbert Ritschard,Djamel A. Zighed Pdf

During the last decade, the French-speaking scientific community developed a very strong research activity in the field of Knowledge Discovery and Management (KDM or EGC for “Extraction et Gestion des Connaissances” in French), which is concerned with, among others, Data Mining, Knowledge Discovery, Business Intelligence, Knowledge Engineering and SemanticWeb. The recent and novel research contributions collected in this book are extended and reworked versions of a selection of the best papers that were originally presented in French at the EGC 2009 Conference held in Strasbourg, France on January 2009. The volume is organized in four parts. Part I includes five papers concerned by various aspects of supervised learning or information retrieval. Part II presents five papers concerned with unsupervised learning issues. Part III includes two papers on data streaming and two on security while in Part IV the last four papers are concerned with ontologies and semantic.

Author : Karuppusamy Arunachalam,Xuefei Yang,Sreeja Puthanpura Sasidharan
Publisher : Springer Nature
Page : 569 pages
File Size : 54,8 Mb
Release : 2022-09-20
Category : Science
ISBN : 9781071626832

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Natural Product Experiments in Drug Discovery by Karuppusamy Arunachalam,Xuefei Yang,Sreeja Puthanpura Sasidharan Pdf

This detailed volume explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.

Author : James Braid
Publisher : UKCHH Ltd
Page : 403 pages
File Size : 51,5 Mb
Release : 2008
Category : Hypnotism
ISBN : 9780956057006

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The Discovery of Hypnosis by James Braid Pdf