Drug Resistance In Cancer

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Drug Resistance in Cancer Cells

Kapil Mehta,Zahid H. Siddik
Drug Resistance in Cancer Cells Book PDF

Author : Kapil Mehta,Zahid H. Siddik
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 40,8 Mb
Release : 2009-06-12
Category : Medical
ISBN : 9780387894454

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Drug Resistance in Cancer Cells by Kapil Mehta,Zahid H. Siddik Pdf

It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosisand 565,650individualswould die of cancer (Jemal et al. 2008).Since the vast majority of patients dying of cancer will have had anticancer therapy, both c- ventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of m- tidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger de?nition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original de?nition of multidrug resistance as simply the res- tance to multipleagents that occurs in the course of normalcancer progression.This resistance is likely to be mediated by many factors.

Breast Cancer Metastasis and Drug Resistance

Aamir Ahmad
Breast Cancer Metastasis and Drug Resistance Book PDF

Author : Aamir Ahmad
Publisher : Springer Nature
Page : 427 pages
File Size : 49,8 Mb
Release : 2019-08-27
Category : Medical
ISBN : 9783030203016

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Breast Cancer Metastasis and Drug Resistance by Aamir Ahmad Pdf

Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Cancer Drug Resistance

Beverly A. Teicher
Cancer Drug Resistance Book PDF

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 50,6 Mb
Release : 2007-11-09
Category : Medical
ISBN : 9781597450355

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Cancer Drug Resistance by Beverly A. Teicher Pdf

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Cancer Drug Resistance Research Perspectives

Liman S. Torres
Cancer Drug Resistance Research Perspectives Book PDF

Author : Liman S. Torres
Publisher : Nova Publishers
Page : 242 pages
File Size : 50,5 Mb
Release : 2007
Category : Drug resistance in cancer cells
ISBN : 1600215726

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Cancer Drug Resistance Research Perspectives by Liman S. Torres Pdf

One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.

Multi-Drug Resistance in Cancer

Jun Zhou
Multi Drug Resistance in Cancer Book PDF

Author : Jun Zhou
Publisher : Humana Press
Page : 492 pages
File Size : 48,7 Mb
Release : 2012-08-09
Category : Medical
ISBN : 1617796646

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Multi-Drug Resistance in Cancer by Jun Zhou Pdf

Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .

Drug Resistance in the Treatment of Cancer

Herbert M. Pinedo,Giuseppe Giaccone
Drug Resistance in the Treatment of Cancer Book PDF

Author : Herbert M. Pinedo,Giuseppe Giaccone
Publisher : Cambridge University Press
Page : 344 pages
File Size : 54,6 Mb
Release : 1998-03-26
Category : Medical
ISBN : 0521473217

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Drug Resistance in the Treatment of Cancer by Herbert M. Pinedo,Giuseppe Giaccone Pdf

International authorities review the mechanisms and clinical implications of drug resistance in cancer.

Progress in Cancer Drug Resistance Research

Robert A. Parsons
Progress in Cancer Drug Resistance Research Book PDF

Author : Robert A. Parsons
Publisher : Nova Publishers
Page : 240 pages
File Size : 47,8 Mb
Release : 2007
Category : Medical
ISBN : 1600218229

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Progress in Cancer Drug Resistance Research by Robert A. Parsons Pdf

One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100 percent effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common.The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information on how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs.

Mechanisms of Drug Resistance in Cancer Therapy

Mario Mandalà,Emanuela Romano
Mechanisms of Drug Resistance in Cancer Therapy Book PDF

Author : Mario Mandalà,Emanuela Romano
Publisher : Springer
Page : 297 pages
File Size : 44,6 Mb
Release : 2019-01-10
Category : Medical
ISBN : 9783030105075

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Mechanisms of Drug Resistance in Cancer Therapy by Mario Mandalà,Emanuela Romano Pdf

A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.

Drug Resistance

William N. Hait
Drug Resistance Book PDF

Author : William N. Hait
Publisher : Springer Science & Business Media
Page : 421 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461312673

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Drug Resistance by William N. Hait Pdf

Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.

Drug Resistance in Oncology

S. Bernal
Drug Resistance in Oncology Book PDF

Author : S. Bernal
Publisher : CRC Press
Page : 416 pages
File Size : 52,5 Mb
Release : 1997-08-21
Category : Medical
ISBN : 9781420002096

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Drug Resistance in Oncology by S. Bernal Pdf

This timely new reference integrates the latest clinical results and laboratory studies on the resistance of specific cancers to chemotherapeutic drugs-covering drug resistance in lung, breast, ovary, and colon cancer as well as hematological malignancies.

Drug Resistance in Cancer Cells

Kapil Mehta,Zahid H. Siddik
Drug Resistance in Cancer Cells Book PDF

Author : Kapil Mehta,Zahid H. Siddik
Publisher : Springer
Page : 363 pages
File Size : 42,6 Mb
Release : 2009-05-27
Category : Medical
ISBN : 0387894446

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Drug Resistance in Cancer Cells by Kapil Mehta,Zahid H. Siddik Pdf

It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosisand 565,650individualswould die of cancer (Jemal et al. 2008).Since the vast majority of patients dying of cancer will have had anticancer therapy, both c- ventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of m- tidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger de?nition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original de?nition of multidrug resistance as simply the res- tance to multipleagents that occurs in the course of normalcancer progression.This resistance is likely to be mediated by many factors.

Alternative Mechanisms of Multidrug Resistance in Cancer

John A. Kellen
Alternative Mechanisms of Multidrug Resistance in Cancer Book PDF

Author : John A. Kellen
Publisher : Springer Science & Business Media
Page : 288 pages
File Size : 43,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461598527

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Alternative Mechanisms of Multidrug Resistance in Cancer by John A. Kellen Pdf

Nullius in verba. . . Truth will be tested not by words. Horace (Epistles) Few read introductions except for book reviewers, who want to take a shortcut and avoid reading the book itself. However, tradition requires that the preface make public why the book was written at all (this is not supposed to include powerful reasons such as augmenting the ego of the editor and authors). Frequently, the inflationary tendency to publish in verbose length is in conflict with market forces and interest. No doubt, multidrug resistance is a "fashionable" topic, but there are many fashions displayed on the cat-walk of scientific literature. One can rationalize that the forces driving our concern with multi drug resistance reflect the frustration of pharmaceutical companies and oncologists alike: as soon as a new anticancer drug enters clinical trials, cancer cells start eluding extinction with their elaborate and successful mechanisms. Many grants have been awarded and spent, only to confirm the futility of our efforts to defeat this cellular Darwinism. Our medical and scientific training makes it hard, if not impossible, to accept that the survival of a malignant cell, alone or as part of a tissue, is part of the continuance of life. Since exposure to noxious and lethal substances is unavoidable, cells have been forced to develop a multitude of mechanisms to prevent entry or accelerate exit of such materials from intracellular space.

Clinically Relevant Resistance in Cancer Chemotherapy

Borje Andersson,David Murray
Clinically Relevant Resistance in Cancer Chemotherapy Book PDF

Author : Borje Andersson,David Murray
Publisher : Springer Science & Business Media
Page : 391 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461511731

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Clinically Relevant Resistance in Cancer Chemotherapy by Borje Andersson,David Murray Pdf

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.

Multi-Drug Resistance in Cancer

Rishabha Malviya,Arun Kumar Singh,Deepika Yadav
Multi Drug Resistance in Cancer Book PDF

Author : Rishabha Malviya,Arun Kumar Singh,Deepika Yadav
Publisher : John Wiley & Sons
Page : 228 pages
File Size : 44,9 Mb
Release : 2023-07-18
Category : Medical
ISBN : 9781394209842

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Multi-Drug Resistance in Cancer by Rishabha Malviya,Arun Kumar Singh,Deepika Yadav Pdf

MULTI-DRUG RESISTANCE IN CANCER The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents. Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases. Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming of cancer drug resistance. The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment. Audience This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer’s multi-drug resistance.

Multiple Drug Resistance in Cancer 2

Martin Clynes
Multiple Drug Resistance in Cancer 2 Book PDF

Author : Martin Clynes
Publisher : Springer Science & Business Media
Page : 343 pages
File Size : 46,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9789401723749

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Multiple Drug Resistance in Cancer 2 by Martin Clynes Pdf

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.