Ecm 99

Author : Marina Colombi ,Marco Ritelli
Publisher : MDPI
Page : 218 pages
File Size : 44,6 Mb
Release : 2020-12-14
Category : Science
ISBN : 9783039363223

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Molecular Genetics and Pathogenesis of Ehlers–Danlos Syndrome and Related Connective Tissue Disorders by Marina Colombi ,Marco Ritelli Pdf

Ehlers–Danlos syndromes (EDS) are a group of heritable connective tissue disorders (HCTDs) characterized by a variable degree of skin hyperextensibility, joint hypermobility and tissue fragility. The current EDS classification distinguishes 13 subtypes and 19 different causal genes mainly involved in collagen and extracellular matrix synthesis and maintenance. EDS need to be differentiated from other HCTDs with a variable clinical overlap, including Marfan syndrome and related disorders, some types of skeletal dysplasia and cutis laxa. The clinical recognition of EDS is not always straightforward, and, for a definite diagnosis, molecular testing can be of great assistance, especially in patients with an uncertain phenotype. Currently, the major challenging task in EDS is to unravel the molecular basis of the hypermobile EDS that is the most frequent form, and for which the diagnosis is only clinical in the absence of any definite laboratory test. This EDS subtype, as well as other EDS-reminiscent phenotypes, are currently investigated worldwide to unravel the primary genetic defect and related pathomechanisms. The research articles, case report, and reviews published in the Special Issue entitled “Molecular Genetics and Pathogenesis of Ehlers–Danlos Syndrome and Related Connective Tissue Disorders” focus on different clinical, genetic and molecular aspects of several EDS subtypes and some related disorders, offering novel findings and future research and nosological perspectives.

Author : Bela Suki
Publisher : Academic Press
Page : 284 pages
File Size : 55,8 Mb
Release : 2021-11-27
Category : Technology & Engineering
ISBN : 9780128226056

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Structure and Function of the Extracellular Matrix by Bela Suki Pdf

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. Examines the evolutionary origins and consequences of the extracellular matrix Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning Provides an introduction to the properties and organization of the extracellular matrix components

Author : Ashutosh Tiwari,Bora Garipcan,Lokman Uzun
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 52,9 Mb
Release : 2016-11-29
Category : Technology & Engineering
ISBN : 9781119242826

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Advanced Surfaces for Stem Cell Research by Ashutosh Tiwari,Bora Garipcan,Lokman Uzun Pdf

The book outlines first the importance of Extra Cellular Matrix (ECM), which is a natural surface for most of cells. In the following chapters the influence of biological, chemical, mechanical, and physical properties of surfaces in micro and nano-scale on stem cell behavior are discussed including the mechanotransduction. Biomimetic and bioinspired approaches are highlighted for developing microenvironment of several tissues, and surface engineering applications are discussed in tissue engineering, regenerative medicine and different type of biomaterials in various chapters of the book. This book brings together innovative methodologies and strategies adopted in the research and development of Advanced Surfaces in Stem Cell Research. Well-known worldwide researchers deliberate subjects including: Extracellular matrix proteins for stem cell fate The superficial mechanical and physical properties of matrix microenvironment as stem cell fate regulator Effects of mechanotransduction on stem cell behavior Modulation of stem cells behavior through bioactive surfaces Influence of controlled micro and nanoengineered surfaces on stem cell fate Nanostructured polymeric surfaces for stem cells Laser surface modification techniques and stem cells applications Plasma polymer deposition: a versatile tool for stem cell research Application of bioreactor concept and modeling techniques in bone regeneration and augmentation treatments Substrates and surfaces for control of pluripotent stem cell fate and function Application of biopolymer-based, surface modified devices in transplant medicine and tissue engineering Silk as a natural biopolymer for tissue engineering

Author : Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Page : 4865 pages
File Size : 55,5 Mb
Release : 2017-05-18
Category : Technology & Engineering
ISBN : 9780081006924

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Comprehensive Biomaterials II by Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick Pdf

Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Author : Anthony B. Brennan,Chelsea M. Kirschner
Publisher : John Wiley & Sons
Page : 414 pages
File Size : 48,8 Mb
Release : 2014-03-19
Category : Science
ISBN : 9781118843437

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Bio-inspired Materials for Biomedical Engineering by Anthony B. Brennan,Chelsea M. Kirschner Pdf

This book covers the latest bio-inspired materials synthesis techniques and biomedical applications that are advancing the field of tissue engineering. Bio-inspired concepts for biomedical engineering are at the forefront of tissue engineering and regenerative medicine. Scientists, engineers and physicians are working together to replicate the sophisticated hierarchical organization and adaptability found in nature and selected by evolution to recapitulate the cellular microenvironment. This book demonstrates the dramatic clinical breakthroughs that have been made in engineering all four of the major tissue types and modulating the immune system. Part I (Engineering Bio-inspired Material Microenvironments) covers Bio-inspired Presentation of Chemical Cues, Bio-inspired Presentation of Physical Cues, and Bio-inspired Integration of Natural Materials. Part II (Bio-inspired Tissue Engineering) addresses tissue engineering in epithelial tissue, muscle tissue, connective tissue, and the immune system.

Author : Jason White,Gayle Smythe
Publisher : Springer
Page : 192 pages
File Size : 41,6 Mb
Release : 2016-03-22
Category : Science
ISBN : 9783319275116

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Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease by Jason White,Gayle Smythe Pdf

This book describes the diverse roles that growth factors and cytokines play in skeletal muscle. The extracellular environment has profound effects on the biology of skeletal muscle. The soluble portion of this environment includes a rich milieu of growth factors and cytokines which have been shown to regulate virtually all facets of the response of skeletal muscle to external stimuli, whether it be exercise induced metabolic shifts, remodeling in response to trauma or loading of the ongoing pathology associated with neuromuscular disease. The chapters included in this work illustrate growth factors that directly affect skeletal muscle cells and those which influence non-muscle cells that contribute to the biology of skeletal muscle as a whole tissue. The current state of the art, with the advent of systems biology, allows for the delineation of signaling networks which are regulated by suites of growth factors. This is in stark contrast to early more traditional studies, which only examined the effects of isolated growth factors on the activity of skeletal muscle precursor cells in tissue culture. The work presented in this volume ranges from reviewing and analyzing the roles of individual growth factors in detail, to the complex interplay of multiple soluble factors in the control of muscle functional, and dysfunctional states. The material covered in this volume will particularly suit readers from a range of research fields spanning general muscle biology and physiology, and those working on diseases and conditions affecting skeletal muscle both directly and indirectly.

Author : Isao Okazaki
Publisher : Academic Press
Page : 508 pages
File Size : 48,9 Mb
Release : 2003-02-06
Category : Medical
ISBN : 012525251X

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Extracellular Matrix and The Liver by Isao Okazaki Pdf

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology.

Author : Alexander V. Sirotkin,Adriana Kolesarova
Publisher : Academic Press
Page : 438 pages
File Size : 41,6 Mb
Release : 2022-02-08
Category : Medical
ISBN : 9780323860123

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Environmental Contaminants and Medicinal Plants Action on Female Reproduction by Alexander V. Sirotkin,Adriana Kolesarova Pdf

Environmental Contaminants and Medicinal Plants Action on Female Reproduction discusses the problem of environmental pollution, medicinal and food plants, and their impact on reproduction. The book describes the mechanisms of environmental contaminants' action, outlines the key causes of their harmful impact on reproduction, and explores what regulatory substances and processes should be targeted due to the negative effect of pollutants on reproduction. Furthermore, it describes the provenance, properties, physiological and therapeutic effects, and possible areas of application of the known medicinal and functional food plants and their constituents with a focus on female reproductive processes. This book will be a useful resource for reproductive biologists, specialists in assisted reproduction, animal production and phytotherapy, toxicologists, pharmacologists, pharmaceutical scientists, endocrinologists, medicinal and natural product chemists, nutritionists and others engaged in the study of environmental contaminants and medicinal and functional food plants. Discusses common environmental contaminants that affect female reproductive processes and the mechanisms of their effects Covers plants and their active substances as potential protectives to environmental contaminants Examines how medicinal plants affect female reproductive processes, the mechanisms of their effects, and what plant molecules are responsible for the positive effects

Author : Tom Clancy,Chuck Horner,Tony Koltz
Publisher : Penguin
Page : 588 pages
File Size : 48,5 Mb
Release : 2008-01-02
Category : History
ISBN : 0425219135

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Every Man a Tiger by Tom Clancy,Chuck Horner,Tony Koltz Pdf

The #1 New York Times bestseller-updated with additional information on the current Iraq War-now in trade paperback. General Chuck Horner commanded the U.S. and allied air assets-the forces of a dozen nations- during Desert Shield and Desert Storm, and was responsible for the design and execution of one of the most devastating air campaigns in history. Never before has the Gulf air war planning, a process filled with controversy and stormy personalities, been revealed in such rich, provocative detail. In this edition of Every Man a Tiger, General Horner looks at the current Gulf conflict and comments on the use of air power in Iraq.

Author : Hamdam Alghamdi,John Jansen
Publisher : Woodhead Publishing
Page : 368 pages
File Size : 43,9 Mb
Release : 2019-10-15
Category : Technology & Engineering
ISBN : 9780081024782

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Dental Implants and Bone Grafts Materials and Biological Issues by Hamdam Alghamdi,John Jansen Pdf

Dental Implants and Bone Grafts: Materials and Biological Issues brings together cutting-edge research to provide detailed coverage of biomaterials for alveolar bone replacement and reconstruction, enabling scientists and clinicians to gain a thorough knowledge of advances and applications in this field. As tooth loss and alveolar bony defects are common and pose a significant health problem in dental clinics, this book deals with timely topics, including alveolar bone structures and properties, mechanical function, pathological changes, material issues, reviews of biomaterials and tissue engineering for dental implants, design and surface modification, biological interaction and biocompatibility of dental implants, and new frontiers. This book is a highly valuable resource for scientists, clinicians and implantologists interested in the complex alveolar bone system and biomaterial and regenerative strategies for its reconstruction. Focuses on the structure, function and pathology of alveolar bone system Considers the issues involved in selecting alveolar bone biomaterials (dental implants and bone grafts) Discusses the requirements for optimal dental implant osseointegration and alveolar bone replacements/reconstruction Explains the biological basis of interactions between alveolar bone and biomaterials

Author : María Luisa Rivero,Angela Ralli
Publisher : Oxford University Press, USA
Page : 241 pages
File Size : 40,8 Mb
Release : 2001
Category : Balkan Peninsula
ISBN : 9780195129526

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Comparative Syntax of Balkan Languages by María Luisa Rivero,Angela Ralli Pdf

This collection of seven papers studies important aspects of the syntax of Albanian, Bulgarian, Greek, and Rumanian from a comparative perspective based on current linguistic frameworks, including the Minimalist Program. Topics addressed include control, raising, and obviation, negation, noun phrase structure, clitic pronouns, and verb movement.

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 153 pages
File Size : 47,6 Mb
Release : 2020-02-08
Category : Science
ISBN : 9783030357238

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Tumor Microenvironment by Alexander Birbrair Pdf

Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include neutrophils, basophils, T helper cells, cytotoxic lymphocytes, fibrocytes, and myeloid-derived suppressor cells, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Hematopoietic Cells – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Author : United States. Congress. Senate. Committee on Appropriations. Subcommittee on Department of Defense
Publisher : Unknown
Page : 1024 pages
File Size : 50,5 Mb
Release : 1972
Category : Electronic
ISBN : UFL:31262084980316

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Department of Defense Appropriations for Fiscal Year 1973 by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Department of Defense Pdf

Author : Rajan Ambat,Kamila Piotrowska
Publisher : Woodhead Publishing
Page : 399 pages
File Size : 44,9 Mb
Release : 2021-11-30
Category : Technology & Engineering
ISBN : 9780323908542

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Humidity and Electronics by Rajan Ambat,Kamila Piotrowska Pdf

Humidity and Electronics: Corrosion Reliability Issues and Preventive Measures provides comprehensive information on humidity related corrosion reliability issues surrounding electronics and how to tackle potential issues from a pro-active-design-prevention perspective. The book contains a mix of academic and industrial relevance, making it suitable for a detailed understanding on humidity issues on electronics, both for materials and corrosion experts and electronics and electrical experts. It will be useful for researchers, academics, and industrial personals involved in materials, corrosion, and electronics reliability aspects. Provides basic and applied knowledge surrounding corrosion in electronics Combines electronics/electrical and electrochemical aspects related to failure modes and mechanisms Presents knowledge on influencing factors and how they can be used as preventive measures at the material, component, device and system level

Author : British Columbia
Publisher : Unknown
Page : 1278 pages
File Size : 51,7 Mb
Release : 1896
Category : British Columbia
ISBN : UCAL:C2626505

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The British Columbia Gazette by British Columbia Pdf