Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 45,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Molecular Biology of The Cell
Bruce Alberts
Gene Expression
Gene Expression Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Gene Expression book. This book definitely worth reading, it is an incredibly well-written.
Gene Expression Analysis
Nalini Raghavachari,Natàlia Garcia-Reyero
Author : Nalini Raghavachari,Natàlia Garcia-Reyero
Publisher : Humana
Page : 0 pages
File Size : 55,8 Mb
Release : 2018-05-17
Category : Medical
ISBN : 1493978330
Gene Expression Analysis by Nalini Raghavachari,Natàlia Garcia-Reyero Pdf
This volume provides experimental and bioinformatics approaches related to different aspects of gene expression analysis. Divided in three sections chapters detail wet-lab protocols, bioinformatics approaches, single-cell gene expression, highly multiplexed amplicon sequencing, multi-omics techniques, and targeted sequencing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Gene Expression Analysis: Methods and Protocols aims provide useful information to researchers worldwide.
Recombinant Gene Expression
Paulina Balbas,Argelia Lorence
Author : Paulina Balbas,Argelia Lorence
Publisher : Springer Science & Business Media
Page : 505 pages
File Size : 47,6 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592597741
Recombinant Gene Expression by Paulina Balbas,Argelia Lorence Pdf
Since newly created beings are often perceived as either wholly good or bad, the genetic alteration of living cells impacts directly on a symbolic meaning deeply imbedded in every culture. During the earlier years of gene expression research, te- nological applications were confined mainly to academic and industrial laboratories, and were perceived as highly beneficial since molecules that were previously unable to be separated or synthesized became accessible as therapeutic agents. Such were the success stories of hormones, antibodies, and vaccines produced in the bacterium Escherichia coli. Originally this bacterium gained fame among humans for being an unwanted host in the intestine, or worse yet, for being occasionally dangerous and pathogenic. H- ever, it was easily identified in contaminated waters during the 19th century, thus becoming a clear indicator of water pollution by human feces. Tamed, cultivated, and easily maintained in laboratories, its fast growth rate and metabolic capacity to adjust to changing environments fascinated the minds of scientists who studied and modeled such complex phenomena as growth, evolution, genetic exchange, infection, survival, adaptation, and further on—gene expression. Although at the lower end of the complexity scale, this microbe became a very successful model system and a key player in the fantastic revolution kindled by the birth of recombinant DNA technology.
Regulation of Gene Expression
Gary H. Perdew,Jack P. Vanden Heuvel,Jeffrey M. Peters
Author : Gary H. Perdew,Jack P. Vanden Heuvel,Jeffrey M. Peters
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 41,7 Mb
Release : 2008-08-17
Category : Science
ISBN : 9781597452281
Regulation of Gene Expression by Gary H. Perdew,Jack P. Vanden Heuvel,Jeffrey M. Peters Pdf
The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.
Gene Expression Programming
Candida Ferreira
Author : Candida Ferreira
Publisher : Springer
Page : 493 pages
File Size : 41,8 Mb
Release : 2006-08-29
Category : Computers
ISBN : 9783540328490
Gene Expression Programming by Candida Ferreira Pdf
This book describes the basic ideas of gene expression programming (GEP) and numerous modifications to this powerful new algorithm. It provides all the implementation details of GEP so that anyone with elementary programming skills will be able to implement it themselves. The book includes a self-contained introduction to this new exciting field of computational intelligence. This second edition has been revised and extended with five new chapters.
Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria
Frans J. de Bruijn
Author : Frans J. de Bruijn
Publisher : John Wiley & Sons
Page : 1472 pages
File Size : 47,6 Mb
Release : 2016-07-13
Category : Science
ISBN : 9781119004899
Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria by Frans J. de Bruijn Pdf
Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
Gene Structure and Expression
John D. Hawkins
Author : John D. Hawkins
Publisher : Cambridge University Press
Page : 236 pages
File Size : 50,8 Mb
Release : 1996-09-12
Category : Science
ISBN : 0521568668
Gene Structure and Expression by John D. Hawkins Pdf
This third edition of a successful textbook is a concise description of the structure and function of genes.
Epigenetic Gene Expression and Regulation
Suming Huang,Michael D Litt,C. Ann Blakey
Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Page : 482 pages
File Size : 44,9 Mb
Release : 2015-10-19
Category : Science
ISBN : 9780128004715
Epigenetic Gene Expression and Regulation by Suming Huang,Michael D Litt,C. Ann Blakey Pdf
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science
Measuring Gene Expression
Matthew Avison
Author : Matthew Avison
Publisher : Taylor & Francis
Page : 328 pages
File Size : 44,5 Mb
Release : 2008-04-18
Category : Science
ISBN : 9781134189182
Measuring Gene Expression by Matthew Avison Pdf
In the post-genomic age, much biomedical research looks at when, where, and at what level genes are expressed. Measuring Gene Expression is an all-in-one introduction to the main methods of measuring gene expression, including RT-PCR, differential display, RNA interference, reporter genes, microarrays, and proteomics, as well as a section on RNA isolation and analysis. There is an overview of each method: its pros and cons, sample preparation, sources of error, and data interpretation.
Epigenetic Mechanisms of Gene Regulation
Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Page : 716 pages
File Size : 50,8 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015047449171
Epigenetic Mechanisms of Gene Regulation by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs Pdf
Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
Gene Expression and Regulation
Jun Ma
Author : Jun Ma
Publisher : Springer
Page : 0 pages
File Size : 43,9 Mb
Release : 2010-12-24
Category : Science
ISBN : 1441922032
Gene Expression and Regulation by Jun Ma Pdf
This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.
Gene Expression Systems
Joseph M. Fernandez,James P. Hoeffler
Author : Joseph M. Fernandez,James P. Hoeffler
Publisher : Elsevier
Page : 493 pages
File Size : 47,5 Mb
Release : 1998-12-21
Category : Science
ISBN : 9780080532356
Gene Expression Systems by Joseph M. Fernandez,James P. Hoeffler Pdf
Gene Expression Systems: Using Nature for the Art of Expression offers detailed information on a wide variety of gene expression systems from an array of organisms. It describes several different types of expression systems including transient, stable, viral, and transgenic systems. Each chapter is written by a leader in the field. The book includes timelines and examples for each expression system, and provides an overview of the future of recombinant protein expression. Provides detailed information on expression systems Covers a variety of promoters and host organisms enabling researchers to tailor protocols to their specific needs Includes timelines and examples Compares pros and cons of each method
Cell-Free Gene Expression
Ashty S. Karim,Michael C. Jewett
Author : Ashty S. Karim,Michael C. Jewett
Publisher : Unknown
Page : 435 pages
File Size : 46,5 Mb
Release : 2022
Category : Biology
ISBN : 1071619985
Cell-Free Gene Expression by Ashty S. Karim,Michael C. Jewett Pdf
This detailed volume explores perspectives and methods using cell-free expression (CFE) to enable next-generation synthetic biology applications. The first section focuses on tools for CFE systems, including a primer on DNA handling and reproducibility, as well as methods for cell extract preparation from diverse organisms and enabling high-throughput cell-free experimentation. The second section provides an array of applications for CFE systems, such as metabolic engineering, membrane-based and encapsulated CFE, cell-free sensing and detection, and educational kits. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cell‐Free Gene Expression: Methods and Protocols serves as an ideal guide for researchers seeking technical methods to current aspects of CFE and related applications.
Recoding: Expansion of Decoding Rules Enriches Gene Expression
John F. Atkins,Raymond F. Gesteland
Author : John F. Atkins,Raymond F. Gesteland
Publisher : Springer Science & Business Media
Page : 473 pages
File Size : 49,6 Mb
Release : 2010-03-10
Category : Science
ISBN : 9780387893822
Recoding: Expansion of Decoding Rules Enriches Gene Expression by John F. Atkins,Raymond F. Gesteland Pdf
The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solved by encoding information in DNA and retrieving the information for each new generation, for it is easier to make a new organism than it is to repair an aging, malfunctioning one. Subsequently, small modi?cations of the standard genetic code were found in certain organisms and in mitochondria. Mitochondrial DNA only encodes about 10–13 proteins, so some modi?cations of the genetic code are tolerated that pr- ably would be lethal if applied to the thousands of kinds of proteins encoded by genomic DNA.
Mechanisms of Gene Regulation
Carsten Carlberg,Ferdinand Molnár
Author : Carsten Carlberg,Ferdinand Molnár
Publisher : Springer
Page : 211 pages
File Size : 46,8 Mb
Release : 2016-06-06
Category : Medical
ISBN : 9789401777414
Mechanisms of Gene Regulation by Carsten Carlberg,Ferdinand Molnár Pdf
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
