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Endotoxin in Health and Disease by Helmut Brade Pdf
Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.
Bacterial Endotoxic Lipopolysaccharides by David C. Morrison,John L. Ryan Pdf
Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.
Anticarbohydrate Antibodies by Paul Kosma,Sven Müller-Loennies Pdf
Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. “Anticarbohydrate Antibodies – from molecular basis to clinical application” compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.
Surface Structures of Microorganisms and Their Interactions with the Mammalian Host by E. Schrinner,M. H. Richmond,G. Seibert,U. Schwarz Pdf
Surface Structures of Microorganisms and Their Interactions with the Mammalian Host Edited by E. Schrinner, M. H. Richmond, G. Seibert, U. Schwarz This book discusses the interactions that occur between the surface layers of microorganisms and the mammalian "host". Particular emphasis is placed on the field of microbial infection and pathogenicity, whereby yeasts, fungi and protozoa are considered in addition to bacteria. Other topics treated include bacterial endotoxins and cell wall degradation products. The twenty contributions to this book were written by a wide range of specialists from different countries. They offer an international and interdisciplinary compilation of current knowledge in this field.
Meggs' History of Graphic Design by Philip B. Meggs,Alston W. Purvis Pdf
Note from the publisher: The Interactive Resource Center is an online learning environment where instructors and students can access the tools they need to make efficient use of their time, while reinforcing and assessing their understanding of key concepts for successful understanding of the course. An access card with redemption code for the online Interactive Resource Center is included with all new, print copies or can be purchased separately. (***If you rent or purchase a used book with an access code, the access code may have been redeemed previously and you may have to purchase a new access code - ISBN: 9781118922248). The online Interactive Resource Center contains resources tied to the book, such as: Interactive Resources: Flashcards featuring images from book for image identification self-study Self-test assessment by chapter Image Gallery featuring key designers and their work Downloadable Resources: Indices of key terms and people ***Winner of the First-Ever QED (Quality, Excellence, Design) award by Digital Book World*** This is the unrivaled, comprehensive, and award-winning reference tool on graphic design recognized for publishing excellence by the Association of American Publishers. Now, this Fifth Edition of Meggs' History of Graphic Design offers even more detail and breadth of content than its heralded predecessors, revealing a saga of creative innovators, breakthrough technologies, and important developments responsible for paving the historic paths that define the graphic design experience. In addition to classic topics such as the invention of writing and alphabets, the origins of printing and typography, and postmodern design, this new Fifth Edition presents new information on current trends and technologies sweeping the graphic design landscape—such as the web, multimedia, interactive design, and private presses, thus adding new layers of depth to an already rich resource. With more than 1,400 high-quality images throughout—many new or newly updated—Meggs' History of Graphic Design, Fifth Edition provides a wealth of visual markers for inspiration and emulation. For professionals, students, and everyone who works with or loves the world of graphic design, this landmark text will quickly become an invaluable guide that they will turn to again and again.
Microbial Surface Components and Toxins in Relation to Pathogenesis by Eliora Z. Ron,Shlomo Rottem Pdf
The meeting on "Microbial Surface Components and Toxins in Relation to Pathogenesis" was held on May 15-19, 1989, in the Mitzpe Rachel guesthouse of Kibbutz Ramat Rachel in Israel. Four major topics formed the basis for the meeting: adhesion and colonization; cell invasion and intracellular multipli cation; evasion of host defenses; toxins and systemic effects. The presentations clearly show that our understanding of the pathology, pathogenesis and bacteria-host cell inter-action has greatly advanced over the last few years. The contributions to our knowledge on the biogenesis of adhesins and their molecular organization, as well as on the mechanism of adherence to infected target tissue by pathogenic bacteria, have been particularly impressive. significant progress has been made in defining the nature of pathogenic and cytotoxic factors produced by bacteria, and much has been learned about the biochemical and antigenic modifications occurring in diverse types of host cells upon infection. The discussions of poly saccharide capsules, bacterial endotoxins and secreted toxins illustrated the challenge and the possibilities for vaccine development.
Endotoxins: Structure, Function and Recognition by Xiaoyuan Wang,Peter J. Quinn Pdf
Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.
Immunological Adjuvants and Vaccines by Gregory Gregoriadis,Anthony C. Allison,George Poste Pdf
Vaccination, chiefly responsible for the eradication of smallpox and the control of poliomyelitis and German measles in man and of foot-and mouth, Marek's and Newcastle disease in domestic animals, remains the best answer to infectious diseases. Early vaccines were live wild type organ isms but these have been largely replaced by attenuated or killed organisms or by purified components (subunits) thereof. More recently, developments in recombinant DNA techniques, the advent of monoclonal antibodies and progress in our understanding of the immunological structure of proteins, have laid the foundations for a new generation of vaccines. For instance, subuni t vaccines have been produced through gene cloning and a number of peptides mimicking small regions of proteins on the outer coat of viruses and capable of eliciting virus neutralizing antibodies, have been synthes ized. Such vaccines are defined at the molecular level, can elicit immune responses controlling specific infectious organisms and are, thus, potent ially free of the problems inherent in conventional ones. However, because subunit and peptide vaccines are only weakly or non-immunogenic, they re quire the presence of immunological adjuvants. These are a diverse array of agents that promote specific humoural and/or cell-mediated immunity responses to antigens. This book contains the proceedings of the 1st NATO Advanced Studies Institute "Immunological Adjuvants and Vaccines" held in Cape Sounion Beach, Greece during 24 June-5 July, 1988.
Victor Vaughan's career at the University of Michigan spanned more than four decades, beginning with his graduate studies in physiological chemistry during the 1870s and ending in 1921 with his retirement after three decades as dean of the medical school. Not only was he instrumental in modernizing medical training at Michigan, his work in areas of hygiene, epidemiology and the study of toxins and infectious disease was highly regarded on the national scene. Twice he was called upon to serve his country in times of crisis. During the Spanish-American War he was a key member of the Typhoid Commission which investigated the outbreak of the life-threatening fever among army recruits in southern camps. During World War I, he was a member of the medical board within the Council of National Defense which contended with an unprecedented influenza outbreak. Vaughan's professional work included more than 250 published papers and some 17 books, many outlining laboratory techniques that modernized the newly evolving field of bacteriology.
Advances in Carbohydrate Chemistry and Biochemistry by Anonim Pdf
Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. High quality comprehensive reviews covering all aspects of carbohydrate chemistry
Based on the International Symposium on Immunotherapy of Infections held recently at the Robert Koch Institute, Berlin, Germany, this work discusses cytokines as well as synthetic and natural immunomodulators and their applications in the immunotherapy of bacterial, viral, parasitic and fungal infections.;The contributors describe innovative treatment concepts that act as adjuncts to established therapies for the control of both existing and newly emerging infectious diseases.
Offers histories of music drama beginning with Wagner's Parsifal and then looking at works by Arnold Schoenberg, Richard Strauss, Luigi Dallapiccola, Luigi Nono and Hans Werner Henze.
Environmental Sampling for Unknowns by Kathleen Hess-Kosa Pdf
Environmental Sampling for Unknowns covers modern approaches to indoor and outdoor environmental sampling, with an emphasis on identifying unknown substances.
