Posttranscriptional Gene Regulation

Author : Erik Dassi
Publisher : Humana
Page : 0 pages
File Size : 44,5 Mb
Release : 2022-11-09
Category : Science
ISBN : 1071618539

Get Book

Post-Transcriptional Gene Regulation by Erik Dassi Pdf

This volume presents the most recent advances in techniques for studying the post-transcriptional regulation of gene expression (PTR). With sections on bioinformatics approaches, expression profiling, the protein and RNA interactome, the mRNA lifecycle, and RNA modifications, the book guides molecular biologists toward harnessing the power of this new generation of techniques, while also introducing the data analysis skills that these high-throughput techniques require. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Post-Transcriptional Gene Regulation, Third Edition serves as a versatile resource for researchers studying post-transcriptional regulation by both introducing the most recent techniques and providing a comprehensive guide to their implementation. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 46,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Jeffrey Wilusz
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 52,6 Mb
Release : 2008
Category : Business & Economics
ISBN : 9781588297839

Get Book

Post-Transcriptional Gene Regulation by Jeffrey Wilusz Pdf

Step-by-step instructions that ensure successful results.

Author : Joe B. Harford,David R. Morris
Publisher : John Wiley & Sons
Page : 372 pages
File Size : 52,9 Mb
Release : 1997-03-28
Category : Science
ISBN : 0471142069

Get Book

mRNA Metabolism & Post-Transcriptional Gene Regulation by Joe B. Harford,David R. Morris Pdf

mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted. mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions. Topics covered include: * RNA structure * Mammalian RNA editing * RNA export from the nucleus * The fundamentals of translation initiation * Control of mRNA decay in plants * mRNA metabolism and cancer * Control of mRNA stability during herpes simplex virus infection * Regulation of mRNA expression in HIV-1 and other complexretroviruses * Nucleases * RNA localization A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries.

Author : Ghedira Kais
Publisher : BoD – Books on Demand
Page : 136 pages
File Size : 44,6 Mb
Release : 2018-10-10
Category : Medical
ISBN : 9781789237917

Get Book

Transcriptional and Post-transcriptional Regulation by Ghedira Kais Pdf

This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.

Author : John E.G. McCarthy,Mick F. Tuite
Publisher : Springer Science & Business Media
Page : 650 pages
File Size : 41,5 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642751394

Get Book

Post-Transcriptional Control of Gene Expression by John E.G. McCarthy,Mick F. Tuite Pdf

The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression. In particular, the development of recombinant DNA techniques that began in the 1970s provided powerful new tools with which to study the molecular basis of control and regulation at all levels. The resulting investigations revealed a diversity of post-transcriptional mechanisms in both prokaryotes and eukaryotes. Scientists working on translation, mRNA stability, transcriptional (anti)termination or other aspects of gene expression will often have met at specialist meetings for their own research area. However, only rarely do workers in different areas of post-transcriptional control/ regulation have the opportunity to meet under one roof. We therefore thought it was time to bring together leading representatives of most of the relevant areas in a small workshop intended to encourage interaction across the usual borders of research, both in terms of the processes studied, and with respect to the evolutionary division prokaryotes/eukaryotes. Given the breadth of topics covered and the restrictions in size imposed by the NATO workshop format, it was an extraordinarily difficult task to choose the participants. However, we regarded this first attempt as an experiment on a small scale, intended to explore the possibilities of a meeting of this kind. Judging by the response of the participants during and after the workshop, the effort had been worthwhile.

Author : Buddhi Prakash Jain,Shyamal K Goswami,Tapan Sharma
Publisher : Academic Press
Page : 396 pages
File Size : 40,8 Mb
Release : 2022-08-12
Category : Medical
ISBN : 9780323914246

Get Book

Post-transcriptional Gene Regulation in Human Disease by Buddhi Prakash Jain,Shyamal K Goswami,Tapan Sharma Pdf

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail. Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats Features a summary and conclusion at the end of each chapter

Author : Fumiaki Uchiumi
Publisher : BoD – Books on Demand
Page : 374 pages
File Size : 54,5 Mb
Release : 2018-02-28
Category : Medical
ISBN : 9789535138679

Get Book

Gene Expression and Regulation in Mammalian Cells by Fumiaki Uchiumi Pdf

Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.

Author : Jane Wu
Publisher : John Wiley & Sons
Page : 280 pages
File Size : 46,7 Mb
Release : 2013-04-24
Category : Science
ISBN : 9783527665419

Get Book

Post-Transcriptional Gene Regulation by Jane Wu Pdf

Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.

Author : Paolo Sassone-Corsi,Yves Christen
Publisher : Springer
Page : 132 pages
File Size : 43,6 Mb
Release : 2016-04-04
Category : Medical
ISBN : 9783319270692

Get Book

A Time for Metabolism and Hormones by Paolo Sassone-Corsi,Yves Christen Pdf

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Author : Altuna Akalin
Publisher : CRC Press
Page : 462 pages
File Size : 48,8 Mb
Release : 2020-12-16
Category : Mathematics
ISBN : 9781498781862

Get Book

Computational Genomics with R by Altuna Akalin Pdf

Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.

Author : Daniel L. Kiss,Neva Caliskan,Kiong Ho,Deepika Vasudevan,Kristin S. Koutmou
Publisher : Frontiers Media SA
Page : 135 pages
File Size : 53,6 Mb
Release : 2022-07-25
Category : Science
ISBN : 9782889765904

Get Book

mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation by Daniel L. Kiss,Neva Caliskan,Kiong Ho,Deepika Vasudevan,Kristin S. Koutmou Pdf

Author : Narendra Wajapeyee,Romi Gupta
Publisher : Humana
Page : 278 pages
File Size : 41,5 Mb
Release : 2018-06-08
Category : Medical
ISBN : 1493982230

Get Book

Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation by Narendra Wajapeyee,Romi Gupta Pdf

This volume describes a variety of protocols that will allow the readers to study different aspects of transcriptional and posttranscriptional gene expression regulation in eukaryotic cells. Chapters focus on the latest use of CRISPRi and RNAi technologies for studying various aspects of transcriptional and posttranscriptional regulation and tools to navigate protocols on key bioinformatics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, Eukaryotic Transcription and Post-Transcription Gene Expression Regulation aims to ensure successful results in the further study of this vital field.

Author : Jun Ma
Publisher : Springer
Page : 0 pages
File Size : 51,9 Mb
Release : 2010-12-24
Category : Science
ISBN : 1441922032

Get Book

Gene Expression and Regulation by Jun Ma Pdf

This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.

Author : K.M.J. Menon, PhD,Aaron Goldstrohm, PhD
Publisher : Springer
Page : 347 pages
File Size : 48,5 Mb
Release : 2015-12-30
Category : Medical
ISBN : 9783319251240

Get Book

Post-transcriptional Mechanisms in Endocrine Regulation by K.M.J. Menon, PhD,Aaron Goldstrohm, PhD Pdf

This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.