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Prostate cancer is the second leading cause of death in men and its progression is highly dependent on androgens and androgen receptors. However, even with treatment, eventually most prostate cancers progress. Studies of the mechanisms behind this progression leads to advances in treatments for androgen-related diseases.
Psoriasis: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf
Psoriasis: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Genetics. The editors have built Psoriasis: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Psoriasis: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
This comprehensive and easy-to-read monograph is an authoritative update on clinical prostate cancer. It has been prepared by an international, multidisciplinary team at the invitation of the International Prostate Health Council think tank. A particular strength of the book is its presentation of the therapeutic options for patients with localized and advanced disease, including hormonal treatment.
Cancer-Leading Proteases by Satya Prakash Gupta Pdf
Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples
Devolution, Port Governance and Port Performance by Mary R Brooks,Kevin Cullinane Pdf
The relationship between ports and governments has changed profoundly over the past quarter of a century. Many governments have sought to extract themselves from the business of port operations and, in many cases, the provision of port services has devolved to local governments, communities or private management and administration. As such devolution implies a change in governance model, this trend raises questions about consequent performance. This issue examines the changed port management environment, focusing particularly on government policies such as devolution, regulatory reform and newly imposed governance models, all of which have exerted a significant influence over the nature of that changed environment. The issue is structured so as to first explore the devolution and port reform approaches for 14 countries or regions, before examining how ports are governed and what the choice of governance might mean for their performance. Part I introduces the issue, and provides a framework for defining the basic concepts involved in devolution; it paints a picture of the current port environment, its likely future evolution and the expected impact this will have on the functioning of ports. Part II examines the port industry in 14 countries or administrations, and presents the thinking behind any devolution programs that have been implemented. Part III focuses on port governance and devolution generally, and examines governance from both strategic management and economics perspectives, including topics such as governance models, supranational governance and stakeholder conflict. Part IV examines the measurement of port performance and closes by providing conclusions and a future research agenda. This issue will be of interest to port managers, government officials and academics alike. *Examines the relationship between ports and governments with a focus on devolution *Divided into sections that provide an overview, evaluate the port industry, disucss port governance, and suggest new measures of port performance *14 countries or regions are addressed
The discovery of adult neurogenesis and of stem cells in the brain has changed our view of the mature brain. Though we now know that the adult brain can make new neurons, it normally does so only in two privileged regions, the olfactory bulb and the hippocampus. Yet stem cells, which have the potential to produce new neurons, can be found throughout the adult brain. So why does the brain not make wider use of its potential for neurogenesis? And what is the function of new neurons and of neural stem cells in areas where they occur? After all, the brain regenerates poorly and many neurological and psychiatric disorders are chronic because cell replacement has not taken place. This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience. It begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. For graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research, this book is a unique resource that sifts through the evidence for exciting scientific ideas and fosters a realistic view of the therapeutic possibilities for the use of stem cells in the adult brain.
Adverse Events with Biomedicines by Giuseppe Tridente Pdf
This monograph gathers and evaluates data on adverse events (AEs) associated specifically with those “biomedicines” – monoclonal antibodies, fusion proteins, and cytokines – that have recently entered therapeutic use in humans. All AEs observed when using each member of this new drug class are covered, with a view to improving understanding of pathogenesis, facilitating prevention, monitoring, and control, and contributing to the development of better drugs that provide benefits while minimizing risk. Further aspects here examined include the role of drug mechanisms of action and immunogenicity in relation to AEs outcome and induction of systemic syndromes. Additional data on AEs in off-label treatments are also considered. Electronic data sheets, downloadable from Springer Extra Materials platform, include more detailed safety data as well as additional basic information on product characteristics, pre- and post-marketing AEs classified according to frequency, and system/organ targeting. Data on excipients and selected information on drug interactions and associations are also provided. Adverse Events with Biomedicines: Prevention Through Understanding will serve as a detailed, practical guideline to this important new area, which demands the attention of clinicians, immunologists, oncologists, allergologists, public health professionals, and drug companies.
The Oncobiology of the Prostate by D.P. Wood,K.V. Honn Pdf
Prostate cancer (PCa) is the most common newly diagnosed cancer among men in the United States today. With the advent of the prostate-specific antigen (PSA) test, the number of newly diagnosed cases has increased tremendously. The rates of PCa have increased so dramatically over the last decade that the age-adjusted incidence rate of PCa is no greater than that for any other cancer among men in the United States. Although PCa rates have risen steadily since 1973, there has been a dramatic acceleration in the late 1980s which has been associated with the introduction and use of PSA for screening and early detection. There is now some evidence that the rates may be levelling off and even decreasing in some areas. After lung cancer, PCa is the leading cause of death due to cancer in men in the United States. Although PCa can occur in younger men, it is essentially a cancer of elderly men. The highest rates of PCa in the world occur among African-American men in the United States. African-Americans have higher rates than Caucasians at all age levels in the United States, and adjusting for social-economic status does not appear to account for this difference to any appreciable extent. There is no clear reason why PCa rates are so much greater among African-Americans compared with Caucasians in the United States. The reported rates in Africans are substantially lower than those of an African-American, suggesting that environmental factors have an influence on PCa. In spite of this substantial impact on our society. PCa remains a relatively understudied disease, with an essentially unknown etiology. The reviews contained in this book are by no means exhaustive. We have, however, attempted to provide information regarding the pathology of prostate cancer, the status of diagnostic and prognostic markers, as well as a discussion of our understanding of the molecular basis for the disease. The biology of prostate cancer is covered with a discussion on the role of apoptosis in prostate cancer and the suggestion of it being the target for new therapeutic development, as well as the role played by integrins and angiogenesis. The status of current therapies, both hormonal and chemotherapy, are also discussed. This volume should provide a useful background for individuals wishing to commence an in-depth understanding of prostate cancer.
Robert M. Nakamura,Wayne W. Grody,James T. Wu,Raymond B. Nagle
Author : Robert M. Nakamura,Wayne W. Grody,James T. Wu,Raymond B. Nagle Publisher : Springer Science & Business Media Page : 505 pages File Size : 45,6 Mb Release : 2004-07-16 Category : Medical ISBN : 9781592597918
Cancer Diagnostics by Robert M. Nakamura,Wayne W. Grody,James T. Wu,Raymond B. Nagle Pdf
Reviews recent and emerging clinical laboratory tests that can help in the early detection, evaluation, and prediction of human tumors. Emphasizing the importance of molecular and genetic RNA/DNA tets that detect persons at high risk for specific cancers, the authors explore these novel serological assays, cellular assays useful for anatomic pathology, and molecular and genetic assays.
United States. Advisory Council on Social Security (1994-1996)
Author : United States. Advisory Council on Social Security (1994-1996) Publisher : Unknown Page : 270 pages File Size : 40,9 Mb Release : 1997 Category : Social security ISBN : PURD:32754066706494
Report of the 1994-1996 Advisory Council on Social Security: Findings and recommendations by United States. Advisory Council on Social Security (1994-1996) Pdf
Crossing Boundaries in Public Management and Policy by Janine O'Flynn,Deborah Blackman,John Halligan Pdf
In the 21st century governments are increasingly focusing on designing ways and means of connecting across boundaries to achieve goals. Whether issues are complex and challenging – climate change, international terrorism, intergenerational poverty– or more straightforward - provision of a single point of entry to government or delivering integrated public services - practitioners and scholars increasingly advocate the use of approaches which require connections across various boundaries, be they organizational, jurisdictional or sectorial. Governments around the world continue to experiment with various approaches but still confront barriers, leading to a general view that there is considerable promise in cross boundary working, but that this is often unfulfilled. This book explores a variety of topics in order to create a rich survey of the international experience of cross-boundary working. The book asks fundamental questions such as: What do we mean by the notion of crossing boundaries? Why has this emerged? What does cross boundary working involve? What are the critical enablers and barriers? By scrutinizing these questions, the contributing authors examine: the promise; the barriers; the enablers; the enduring tensions; and the potential solutions to cross-boundary working. As such, this will be an essential read for all those involved with public administration, management and policy.
Androgens and Androgen Receptor by Chawnshang Chang Pdf
Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications. Key topics covered include: -The discovery and cloning of the androgen receptor; -Androgen receptor coregulators; -Androgen related genes and their consensus DNA response elements; -Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies; -Cross-talk to other signal transduction systems; -The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer. This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.