Synthetic Applications

Author : Huimin Zhao
Publisher : Academic Press
Page : 352 pages
File Size : 47,6 Mb
Release : 2013-03-21
Category : Science
ISBN : 9780123978202

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Synthetic Biology by Huimin Zhao Pdf

Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomes Highlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development

Author : Hannah Minges
Publisher : Springer
Page : 116 pages
File Size : 50,6 Mb
Release : 2017-05-11
Category : Science
ISBN : 9783658184100

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Engineering of Halogenases towards Synthetic Applications by Hannah Minges Pdf

Hannah Minges focuses on the investigation of two different FAD-dependent halogenases in order to analyze and improve their applicability for chemoenzymatic approaches in chemistry. Owing to beneficial features, like high selectivity and benign reaction conditions, nature’s toolkit for halogenation provides several advantages, whereas conventional chemical strategies require hazardous reagents and suffer from low selectivity. Therefore, enzymatic halogenation arises as promising alternative in the synthesis of valuable chemicals. One project focuses on the generation of a thermostable variant of the tryptophan halogenase Thal by means of directed evolution. The second project deals with the investigation of the marine halogenase Bmp5. This enzyme is of synthetic interest because it preferably introduces bromine into phenol compounds, whereas chlorination cannot take place.

Author : Weiwen Zhang,David Nielsen
Publisher : Frontiers E-books
Page : 130 pages
File Size : 54,7 Mb
Release : 2014-12-03
Category : Bioengineering
ISBN : 9782889193424

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Synthetic biology applications in industrial microbiology by Weiwen Zhang,David Nielsen Pdf

Exponentially increasing information on biological organisms coupled with increasing computational power in the past decade have broadened the perspective of fundamental biological research, bringing about considerable promise and unprecedented potential for practical applications in biotechnology. As one emergent discipline, synthetic biology aims to design and engineer novel biologically-based parts, devices, and systems, in addition to redesigning existing, natural biological systems. Although previously relegated to demonstration studies, more recent research in synthetic biology has focused on the rational engineering of industrial microorganisms with the potential to address many of society’s critical challenges. Within the realm of industrial microbiology, progress in the field of synthetic biology has enabled the development of, for example, new biosynthetic pathways for the production of renewable fuels and chemicals, programmable logic controls to regulate and optimize cell function, and robust microbes for the destruction of harmful environmental contaminants. Some of the exciting examples included producing anti-malarial drug, anti- cancer taxol precursor and various biofuel molecules in E. coli and yeast. In addition, these researches have also greatly enhanced our understanding of the cellular machinery and its regulation in some of the industry important microbes, laying an important foundation for further design and engineering of biological function for even greater application. For these reasons, we present here a collection of articles from the leading edge of the field of synthetic biology, with a specific focus on the development in industrial microorganisms. It is the intent of this collection to reach a wide audience whose interests and expertise spans from development of novel synthetic biology methodologies and theories (both experimental and computational) to practical applications seeking to address issues facing the world today.

Author : Albert Padwa,William H. Pearson
Publisher : John Wiley & Sons
Page : 952 pages
File Size : 55,6 Mb
Release : 2003-04-14
Category : Science
ISBN : 9780471461364

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Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products, Volume 59 by Albert Padwa,William H. Pearson Pdf

Dipolar cycloaddition reactions have found many useful applications in chemistry, particularly with respect to the synthesis of compounds with new chiral centers. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products updates the popular 1984 edition, featuring the advances made over the past twenty years and focusing on synthetic applications.

Author : Bradley D. Smith
Publisher : Royal Society of Chemistry
Page : 466 pages
File Size : 46,9 Mb
Release : 2015-07-10
Category : Science
ISBN : 9781849739719

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Synthetic Receptors for Biomolecules by Bradley D. Smith Pdf

Synthetic receptor molecules, molecules that mimic antibody recognition, are widely used for developing drug leads; drug delivery vehicles; imaging agents; sensing agents; capture agents and separation systems. Synthetic Receptors for Biomolecules covers the most effective synthetic receptors for each major class of biomolecules within the context of specific applications. The book starts with an introduction to the applications of synthetic receptors for biomolecules and their design and synthesis for biomolecule recognition. Dedicated chapters then cover synthetic receptors for the key biomolecules including inorganic cations; small organic and inorganic anions; carbohydrates; nucleosides/nucleotides; oligonucleotides; amino acids and peptides; protein surfaces as well as non-polar and polar lipids; Each chapter follows the same systematic format of (a) chemical structures and physical properties of the biomolecule, (b) biological recognition of the biomolecule, (c) synthetic receptors for the biomolecule, (d) future directions and challenges. Edited by a leader in the field, the book is written in an accessible style for readers new to supramolecular chemistry or for those looking for synthetic receptors.

Author : Laszlo Kurti,Barbara Czako
Publisher : Elsevier
Page : 808 pages
File Size : 54,8 Mb
Release : 2005-04-29
Category : Science
ISBN : 9780080575414

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Strategic Applications of Named Reactions in Organic Synthesis by Laszlo Kurti,Barbara Czako Pdf

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples* An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools* Extensive index quickly locates information using words found in text and drawings

Author : Chris Nadovich
Publisher : Elsevier
Page : 256 pages
File Size : 46,8 Mb
Release : 2004-09-09
Category : Technology & Engineering
ISBN : 0080481299

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Synthetic Instruments: Concepts and Applications by Chris Nadovich Pdf

The way electronic instruments are built is changing in a deeply fundamental way. It is making an evolutionary leap to a new method of design that is being called synthetic instruments. This new method promises to be the most significant advance in electronic test and instrumentation since the introduction of automated test equipment (ATE). The switch to synthetic instruments is beginning now, and it will profoundly affect all test and measurement equipment that will be developed in the future. Synthetic instruments are like ordinary instruments in that they are specific to a particular measurement or test. They might be a voltmeter that measures voltage, or a spectrum analyzer that measures spectra. The key, defining difference is this: synthetic instruments are implemented purely in software that runs on general purpose, non-specific measurement hardware with a high speed A/D and D/A at its core. In a synthetic instrument, the software is specific; the hardware is generic. Therefore, the "personality" of a synthetic instrument can be changed in an instant. A voltmeter may be a spectrum analyzer a few seconds later, and then become a power meter, or network analyzer, or oscilloscope. Totally different instruments are implemented on the same hardware and can be switched back and forth in the blink of an eye. This book explains the basics of synthetic instrumentation for the many people that will need to quickly learn about this revolutionary way to design test equipment. This book attempts to demystify the topic, cutting through, commercial hype, and obscure, vague jargon, to get to the heart of the technique. It reveals the important basic underlying concepts, showing people how the synthetic instrument design approach, properly executed, is so effective in creating nstrumentation that out performs traditional approaches to T&M and ATE being used today. provides an overview and complete introduction to this revolutionary new technology enables equipment designers and manufacturers to produce vastly more functional and flexible instrumentation; it's not your father's multimeter!

Author : P.M. Bungay,H.K. Lonsdale,M.N. de Pinho
Publisher : Springer Science & Business Media
Page : 735 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400947122

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Synthetic Membranes: by P.M. Bungay,H.K. Lonsdale,M.N. de Pinho Pdf

The chapters in this book are based upon lectures given at the NATO Advanced Study Institute on Synthetic Membranes (June 26-July 8, 1983, Alcabideche, Portugal), which provided an integrated presentation of syn thetic membrane science and technology in three broad areas. Currently available membrane formation mechanisms are reviewed, as well as the manner in which synthesis conditions can be controlled to achieve desired membrane structures. Membrane performance in a specific separa tionprocess involves complex phenomena, the understanding of which re quires a multidisciplinary approach encompassing polymer chemistry, phys ical chemistry, and chemical engineering. Progress toward a global understanding of membrane phenomena is described in chapters on the principles of membrane transport. The chapters on membrane processes and applications highlight both established and emerging membrane processes, and elucidate their myriad applications. It is our hope that this book will be an enduring, comprehensive compen dium of the state of knowledge in the field of synthetic membranes. We have been encouraged in that hope by numerous expressions of interest in the book, coming from a variety of potential users.

Author : Shailza Singh
Publisher : Springer
Page : 160 pages
File Size : 52,6 Mb
Release : 2016-09-08
Category : Science
ISBN : 9788132228097

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Systems Biology Application in Synthetic Biology by Shailza Singh Pdf

This book introduces students to methods that will help them understand behaviour in terms of cellular components and their interactions in non-intuitive ways, which calls for an interdisciplinary approach combining mathematical, chemical, computational and biological strategies. Tibor Ganti was one of the early pioneers who proposed a theoretical framework to understand living principles in terms of chemical transformation cycles and their coupling. The twenty-first century then brought with it a novel ‘systems’ paradigm, which shone new light on all previous work and was accompanied by numerous implications for the way we conceive of chemical and biological complexity today. This book seeks to equip students to take advantage of any field that investigates living systems. Based on a conceptualisation of science-oriented branches, engineering-oriented branches and biology as astoundingly complex fields, those structures laden with biochemical detail encompass a deeper theory unifying our knowledge of designed systems. Readers will be pleasantly surprised at how lucidly the topics are presented. The book offers an indispensable resource for students and professionals working in systems and synthetic biology or any of the various related fields of research.

Author : Petr Ptáček
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 55,5 Mb
Release : 2016-04-13
Category : Science
ISBN : 9789535122654

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Apatites and their Synthetic Analogues by Petr Ptáček Pdf

Apatite-type minerals and their synthetic analogues are of interest of many industrial branches and scientific disciplines including material sciences, chemical industry, agriculture, geology, medicine and dentistry. This book provides a basic overview of general knowledges of this topic in order to provide the comprehensive survey from a scientific and technological perspective. The book is divided into 10 chapters, which are devoted to the structure and properties of minerals from the supergroup of apatite, experimental techniques of preparation and characterization of synthetic analogues of apatite minerals, substitution in the structure of apatite as well as utilization of these materials in wide range of common and special advanced applications in industry, material sciences and research. Additionally, the phosphate rocks, their classification, geological role, mining and beneficiation of phosphate ore, production of elemental phosphorus, phosphoric acid and fertilizers are also described. Although this book is meant for chemist, material scientist and research engineers, the individual chapters contain theoretical background, historical aspects as well as examples of synthetic and analytical methods which may be also interesting for students and non-expert readers as well.

Author : Feng Shi
Publisher : Unknown
Page : 658 pages
File Size : 43,5 Mb
Release : 2007
Category : Chemical bonds
ISBN : MSU:31293028458549

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Synthetic Applications of Iridium-catalyzed Aromatic C-H Borylation by Feng Shi Pdf

Author : Eric Joseph Lewis
Publisher : Unknown
Page : 520 pages
File Size : 50,5 Mb
Release : 1990
Category : Electronic
ISBN : UCAL:X42974

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The Chemistry and Synthetic Applications of Some Electrophilic and Nucleophilic Organozinc Reagents Derived from 1,1-dihaloalkanes by Eric Joseph Lewis Pdf

Author : Raj K. Bansal
Publisher : Jones & Bartlett Learning
Page : 436 pages
File Size : 52,9 Mb
Release : 1996
Category : Science
ISBN : 0763706655

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Synthetic Approaches in Organic Chemistry by Raj K. Bansal Pdf

Designed for undergraduate and beginning graduate courses in organic synthesis.

Author : Anonim
Publisher : World Scientific
Page : 196 pages
File Size : 40,5 Mb
Release : 2015-08-24
Category : Science
ISBN : 9781783268818

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Synthetic Biology — A Primer by Anonim Pdf

Synthetic Biology — A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made. The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems. Examples of cutting-edge applications designed using synthetic biology principles are presented, including: the production of novel, microbial synthesis of pharmaceuticals and fine chemicalsthe design and implementation of biosensors to detect infections and environmental waste. The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research. Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology. Contents:List of ContributorsPrefaceIntroduction to BiologyBasic Concepts in Engineering BiologyFoundational TechnologiesMinimal Cells and Synthetic LifeParts, Devices and SystemsModelling Synthetic Biology SystemsApplications of Designed Biological SystemsiGEMThe Societal Impact of Synthetic BiologyAppendices:Proforma of Common Laboratory TechniquesGlossaryIndex Readership: Students, professionals, researchers in biotechnology and bioengineering. Keywords:Synthetic Biology;Engineering Principles;Biosociety;Biological Engineering;BiotechnologyKey Features:The book is written in a way that is accessible to students and researchers from different disciplinesThe authors are part of the internationally recognised Centre for Synthetic Biology and Innovation and are among the leaders in this field

Author : Rolf Scheffold
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 43,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642837586

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Modern Synthetic Methods 1989 by Rolf Scheffold Pdf

This paperback is the conference documentation of the fifth Seminar on MODERN SYNTHETIC METHODS 1989. It is the aim of these triennial Interlaken-Seminars to provide a proper, concine and "ready for use" acceos to important and rapidly developing areas of synthetic organic chemistry. Usefu.l synthetic methods have to combine economic and ecological aspects. The search for such methods is a continuous scientific challenge. It implies a solid knowledge a~d updated information on current prospects in biochemistry, organic as well as inorganic chemiotry. The main themes of the 1989-Seminar are "Biotransformations in Organic Synthesis", "Enantioselective Catalyois with Metal Complexes" and "Aluminosilicates in Organic Synthesis". These topics have been chosen, since they reflect the enormous progress in experience and understanding of catalysis in organic syntheGis. This book if' the compilation of the contributions provided by the lecturers of the Seminar. The reviews are written by leading experts and describe not only the basic concepts, their application in oynthesis but also contain representative experimental procedures. The purpose of this volume is twofold. It should aid participants and students in followi~g the lectures. The main reason, however, is to serve ao an updated guide for chemists interested in catalyois applied to organic synthesis.