Toward Connectomic Deep Brain Stimulation

Author : Andreas Horn
Publisher : Academic Press
Page : 602 pages
File Size : 50,5 Mb
Release : 2021-09-10
Category : Medical
ISBN : 9780128218624

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Connectomic Deep Brain Stimulation by Andreas Horn Pdf

Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) Presents references (key articles, books and protocols) for additional detailed study Provides data analysis boxes in each chapter to help with data interpretation

Author : Henry Kennedy,David C. Van Essen,Yves Christen
Publisher : Springer
Page : 173 pages
File Size : 49,5 Mb
Release : 2016-03-10
Category : Medical
ISBN : 9783319277776

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Micro-, Meso- and Macro-Connectomics of the Brain by Henry Kennedy,David C. Van Essen,Yves Christen Pdf

This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.

Author : Clement Hamani,Paul Holtzheimer,Andres M. Lozano,Helen Mayberg
Publisher : John Wiley & Sons
Page : 518 pages
File Size : 44,7 Mb
Release : 2016-01-26
Category : Medical
ISBN : 9781118801048

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Neuromodulation in Psychiatry by Clement Hamani,Paul Holtzheimer,Andres M. Lozano,Helen Mayberg Pdf

Edited by an expert multidisciplinary team, Neuromodulation in Psychiatry is the first reference guide to address both invasive and non-invasive neuromodulation strategies used in psychiatry. Covers basic principles, technical aspects, clinical applications and ethical considerations Presents up-to-date evidence in comprehensive summaries suitable for all levels of experience Each technique is clearly explained along with its implications for real-world clinical practice Allows psychiatrists to make informed decisions regarding neuromodulation for their patients

Author : Shilpa Chitnis MD, PhD,Pravin Khemani MD,Michael S. Okun MD
Publisher : Oxford University Press
Page : 256 pages
File Size : 52,6 Mb
Release : 2020-06-30
Category : Medical
ISBN : 9780190647216

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Deep Brain Stimulation by Shilpa Chitnis MD, PhD,Pravin Khemani MD,Michael S. Okun MD Pdf

Deep Brain Stimulation addresses the practical tips required to program and manage deep brain stimulation devices in the clinic. The number of deep brain stimulation devices worldwide will soon eclipse 200,000 and is an approved surgical treatment for medically refractory neurological movement disorders such as Parkinson disease, tremors, and dystonia. It is, therefore, inevitable that clinicians and nurses will require the necessary tools, and exemplary real-life cases, to manage these complex patients. This book offers a case-based approach to common and uncommon neurologic problems related to deep brain stimulator problems. Each case is a clinical pearl, accompanied by a discussion as well as practical tips to improve patient management.

Author : Nader Pouratian,Sameer A. Sheth
Publisher : Springer Nature
Page : 563 pages
File Size : 48,6 Mb
Release : 2020-02-28
Category : Medical
ISBN : 9783030349066

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Stereotactic and Functional Neurosurgery by Nader Pouratian,Sameer A. Sheth Pdf

This text presents a comprehensive and state-of the-art approach to stereotactic and functional neurosurgery. Overarching sections include achieving stereotactic precision, defining trajectories and targets, the biophysics of stereotactic therapies, diseases and targets, and the future of functional neurosurgery. Each section is designed to be inclusive of all relevant topics, serving as an unbiased resource to new clinicians in this field or established clinicians that are aiming to better understand complementary methods. Importantly, each section and the associated chapters can be used by basic and translational scientists as well as engineers and industry to better understand and deliver innovation to the field. Chapters within each section methodically analyze traditional and recently emerging concepts and techniques; address underlying principles with examples drawn from specific diseases and applications; and cover patient selection, target selection, available stereotactic methods, nuanced surgical methods, and clinical evidence across treatment options. Written by experts in each area, Stereotactic and Functional Neurosurgery is a definitive guide to the latest developments in stereotactic targeting, electrode implantation, surgical treatment of neurological and psychiatric disorders, the renaissance of stereotactic lesions, and the frontier of restorative neurosurgery for a variety of disorders that have no other therapeutic options.

Author : Dewen Hu,Ling-Li Zeng
Publisher : Springer Nature
Page : 258 pages
File Size : 54,9 Mb
Release : 2019-11-12
Category : Medical
ISBN : 9789813295230

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Pattern Analysis of the Human Connectome by Dewen Hu,Ling-Li Zeng Pdf

This book presents recent advances in pattern analysis of the human connectome. The human connectome, measured by magnetic resonance imaging at the macroscale, provides a comprehensive description of how brain regions are connected. Based on machine learning methods, multiviarate pattern analysis can directly decode psychological or cognitive states from brain connectivity patterns. Although there are a number of works with chapters on conventional human connectome encoding (brain-mapping), there are few resources on human connectome decoding (brain-reading). Focusing mainly on advances made over the past decade in the field of manifold learning, sparse coding, multi-task learning, and deep learning of the human connectome and applications, this book helps students and researchers gain an overall picture of pattern analysis of the human connectome. It also offers valuable insights for clinicians involved in the clinical diagnosis and treatment evaluation of neuropsychiatric disorders.

Author : Anonim
Publisher : Elsevier
Page : 490 pages
File Size : 46,7 Mb
Release : 2022-03-02
Category : Psychology
ISBN : 9780323901659

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Cognition in Parkinson's Disease by Anonim Pdf

Cognition in Parkinson's Disease, Volume 269 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cognition in Prodromal Parkinson’s disease, The epidemiology of cognitive function in Parkinson's disease, Real-life consequences of cognitive dysfunction in Parkinson’s disease, Animal models of cognition in Parkinson’s disease, Functional neuroanatomy of cognition in Parkinson’s disease, Neuroimaging approaches to cognition in Parkinson’s disease, Cognitive dysfunction and neuropsychiatric aspects of Parkinson’s disease, Neuropsychology of Parkinson’s disease, Cholinergic Systems, Attentional-Motor Integration, and Cognitive Control in Parkinson Disease, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research series Updated release includes the latest information on Cognition in Parkinson's Disease

Author : Anonim
Publisher : Unknown
Page : 708 pages
File Size : 45,8 Mb
Release : 1993
Category : Nervous system
ISBN : NWU:35558003413412

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Stereotactic and Functional Neurosurgery by Anonim Pdf

Author : Hagai Bergman
Publisher : MIT Press
Page : 333 pages
File Size : 41,8 Mb
Release : 2021-10-12
Category : Science
ISBN : 9780262367295

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The Hidden Life of the Basal Ganglia by Hagai Bergman Pdf

The anatomy and physiology of the basal ganglia and their relation to brain and behavior, disorders and therapies, and philosophy of mind and moral values. The main task of the basal ganglia—a group of subcortical nuclei, located at the base of the brain—is to optimize and execute our automatic behavior. In this book, Hagai Bergman analyzes the anatomy and physiology of the basal ganglia, discussing their relation to brain and behavior, to disorders and therapies, and even to moral values. Drawing on his forty years of studying the basal ganglia, Bergman presents new information on physiology and computational models, Parkinson’s disease and other ganglia-related disorders, and such therapies as deep brain stimulation. Focusing on studies of nonhuman primates and human basal ganglia and relying on system physiology and in vivo extra-cellular recording techniques, Bergman first describes the major brain structures that constitute the basal ganglia, the morphology of their cellular elements, their synaptic connectivity and their physiological function in health and disease. He discusses the computational physiology of the healthy basal ganglia, describing four generations of computational models, and then traces the computational physiology of basal ganglia–related disorders and their treatments, including Parkinson’s disease and its pharmacological and surgical therapies. Finally, Bergman considers the implications of these findings for such moral concerns as free will. Explaining this leap into domains rarely explored in neuroscientific accounts, Bergman writes that the longer he studies the basal ganglia, the more he is convinced that they are truly the base of both brain and mind.

Author : Helena Knotkova,Michael A. Nitsche,Marom Bikson,Adam J. Woods
Publisher : Springer
Page : 651 pages
File Size : 50,7 Mb
Release : 2019-01-23
Category : Medical
ISBN : 9783319959481

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Practical Guide to Transcranial Direct Current Stimulation by Helena Knotkova,Michael A. Nitsche,Marom Bikson,Adam J. Woods Pdf

This book provides a comprehensive overview on Transcranial Direct Current Stimulation (tDCS) and the clinical applications of this promising technique. Separated into three parts, the book begins with basic principles, mechanisms and approaches of tDCS. This is followed by a step-by-step practicum, methodological considerations and ethics and professional conduct pertaining to this novel technique. Chapters are authored by renowned experts who also direct and plan tDCS educational events worldwide. Bridging the existing gap in instructional materials for tDCS while addressing growing interest in education in this field, professionals within a broad range of medical disciplines will find this text to be an invaluable guide.

Author : Gordon H. Baltuch,Matthew B. Stern
Publisher : CRC Press
Page : 372 pages
File Size : 41,5 Mb
Release : 2007-03-19
Category : Medical
ISBN : 9781420019759

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Deep Brain Stimulation for Parkinson's Disease by Gordon H. Baltuch,Matthew B. Stern Pdf

Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's

Author : Yasin Temel,Albert F.G. Leentjens,Rob M.A. de Bie,Stephan Chabardes,Alfonso Fasano
Publisher : Springer
Page : 307 pages
File Size : 47,8 Mb
Release : 2021-04-08
Category : Medical
ISBN : 3030363481

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Fundamentals and Clinics of Deep Brain Stimulation by Yasin Temel,Albert F.G. Leentjens,Rob M.A. de Bie,Stephan Chabardes,Alfonso Fasano Pdf

This book provides a state-of-the-art overview of our current understanding of deep brain stimulation (DBS) for the treatment of neurological and psychiatric disorders. With a broad multidisciplinary scope, it presents contributions from leading experts in the field from Europe and America, who share not only their knowledge, but their experience as well. The book focuses both on basic and theoretical aspects of DBS, as well as clinical and practical aspects. It follows an evidence-based approach, and where possible offers clinical recommendations based on published guidelines. It starts with a general section, which discusses basic principles and general considerations. This is followed a sections dedicated to neurological disorders, and psychiatric disorders, in which only accepted indications are discussed. All experimental indications are discussed in the final chapter. The text is supplemented with numerous illustrations. Intended for medical specialists and residents involved in the treatment of patients with DBS, it also appeals to other professionals working with DBS patients, such as psychologists, nurses, physiotherapists, as well as basic and clinical neuroscientists.

Author : Sergey N. Makarov
Publisher : Springer Nature
Page : 395 pages
File Size : 46,6 Mb
Release : 2021
Category : Biomedical engineering
ISBN : 9783030456238

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Brain and Human Body Modeling 2020 by Sergey N. Makarov Pdf

The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.

Author : Mark Humphries
Publisher : Princeton University Press
Page : 232 pages
File Size : 54,7 Mb
Release : 2023-01-24
Category : Psychology
ISBN : 9780691241487

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The Spike by Mark Humphries Pdf

The story of a neural impulse and what it reveals about how our brains work We see the last cookie in the box and think, can I take that? We reach a hand out. In the 2.1 seconds that this impulse travels through our brain, billions of neurons communicate with one another, sending blips of voltage through our sensory and motor regions. Neuroscientists call these blips “spikes.” Spikes enable us to do everything: talk, eat, run, see, plan, and decide. In The Spike, Mark Humphries takes readers on the epic journey of a spike through a single, brief reaction. In vivid language, Humphries tells the story of what happens in our brain, what we know about spikes, and what we still have left to understand about them. Drawing on decades of research in neuroscience, Humphries explores how spikes are born, how they are transmitted, and how they lead us to action. He dives into previously unanswered mysteries: Why are most neurons silent? What causes neurons to fire spikes spontaneously, without input from other neurons or the outside world? Why do most spikes fail to reach any destination? Humphries presents a new vision of the brain, one where fundamental computations are carried out by spontaneous spikes that predict what will happen in the world, helping us to perceive, decide, and react quickly enough for our survival. Traversing neuroscience’s expansive terrain, The Spike follows a single electrical response to illuminate how our extraordinary brains work.

Author : Rudi A.J.O. Dierckx,Andreas Otte,Erik F.J. de Vries,Aren van Waarde,Klaus L. Leenders
Publisher : Springer
Page : 1103 pages
File Size : 47,5 Mb
Release : 2014-06-02
Category : Medical
ISBN : 9783642543074

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PET and SPECT in Neurology by Rudi A.J.O. Dierckx,Andreas Otte,Erik F.J. de Vries,Aren van Waarde,Klaus L. Leenders Pdf

PET and SPECT in Neurology highlight the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable not only to neurologists and radiologists/nuclear medicine specialists but also to interested general practitioners and geriatricians. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.