10 Years Of Frontiers In Genetics Past Discoveries Current Challenges And Future Perspectives
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10 Years of frontiers in genetics: Past discoveries, current challenges and future perspectives by William C. Cho,Jordi Pérez-Tur,Rosalba Giugno,Mehdi Pirooznia,Kathleen Boris-Lawrie,Dov Greenbaum,Blanka Rogina,Mojgan Rastegar,Rui Henrique,Peng Xu,Joao Batista Teixeira da Rocha Pdf
Precision medicine: recent advances, current challenges and future perspectives by Oriana Awwad,Mamoun Ahram,Mariam Abdel Jalil ,Francesca Coperchini Pdf
Personalized medicine (precision medicine) is an evolving field that comprises medical interventions tailored to individuals or groups of patients. It is designed to facilitate enhanced screening and earlier disease detection, more precise disease diagnosis, and improved treatment. Personalized medicine allows patients to receive specific therapies that work best for them aiming for more effective treatment, better outcomes, safer clinical managements and more efficient health systems.
National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on Genetically Engineered Crops: Past Experience and Future Prospects
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on Genetically Engineered Crops: Past Experience and Future Prospects Publisher : National Academies Press Page : 607 pages File Size : 40,9 Mb Release : 2017-01-28 Category : Science ISBN : 9780309437387
Genetically Engineered Crops by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on Genetically Engineered Crops: Past Experience and Future Prospects Pdf
Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.
Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies by Ciria Hernandez,Luis Eduardo Diaz Gimenez,Jean-Marc Taymans,Tim Strassmaier ,Marc Rogers Pdf
Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell membrane allowing ion flow from one side of the membrane to the other. They are ubiquitously expressed in human tissues and consist of one of the largest and best understood functional groups of proteins, with more than 400 members spanning nearly 1% of the human genome. They are involved in a variety of fundamental physiological processes, and their malfunction causes numerous diseases. In terms of the challenges faced in the effort to discover specific drugs in ancient and emerging diseases, ion channels are the third-largest class of target proteins after G-protein-coupled receptors (GPCRs) and kinases. 15% of small molecule drug targets have been reported to be voltage- or ligand-gated ion channels, resulting in approximately 150 new drug candidates in preclinical and clinical studies. Of the ion channel targeting drugs found on the market, these were identified more than a decade ago, and many of the current studies are at various stages of scientific approval. Overcoming these challenges has led the field of ion channel drug discovery to transform over the past 15 years through major advancements in genetic target detection, validation, structure-based drug design, and drug modeling of cell-based diseases.
Author : Peter P. Nanasi,László Virág,Esther Pueyo Publisher : Frontiers Media SA Page : 241 pages File Size : 49,9 Mb Release : 2020-09-08 Category : Medical ISBN : 9782889639960
Perspectives on Antiarrhythmic Drug Therapy: Disappointing Past, Current Efforts and Faint Hopes by Peter P. Nanasi,László Virág,Esther Pueyo Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Global Trends 2040 by National Intelligence Council Pdf
"The ongoing COVID-19 pandemic marks the most significant, singular global disruption since World War II, with health, economic, political, and security implications that will ripple for years to come." -Global Trends 2040 (2021) Global Trends 2040-A More Contested World (2021), released by the US National Intelligence Council, is the latest report in its series of reports starting in 1997 about megatrends and the world's future. This report, strongly influenced by the COVID-19 pandemic, paints a bleak picture of the future and describes a contested, fragmented and turbulent world. It specifically discusses the four main trends that will shape tomorrow's world: - Demographics-by 2040, 1.4 billion people will be added mostly in Africa and South Asia. - Economics-increased government debt and concentrated economic power will escalate problems for the poor and middleclass. - Climate-a hotter world will increase water, food, and health insecurity. - Technology-the emergence of new technologies could both solve and cause problems for human life. Students of trends, policymakers, entrepreneurs, academics, journalists and anyone eager for a glimpse into the next decades, will find this report, with colored graphs, essential reading.
Pan-genomics: Applications, Challenges, and Future Prospects by Debmalya Barh,Siomar C. Soares,Sandeep Tiwari,Vasco Ariston De Car Azevedo Pdf
Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an "overview of pan-genomics and common approaches, brings the main concepts and current approaches on pan-genomics research; the second, “case studies in pan-genomics, thoroughly discusses twelve case, and the last, “current approaches and future prospects in pan-multiomics , encompasses the developments on omics studies to be applied on bacteria related studies. This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relationship to human health. Covers the entire spectrum of pangenomics, highlighting the use of specific approaches, case studies and future perspectives Discusses current bioinformatics tools and strategies for exploiting pangenomics data Presents twelve case studies with different organisms in order to provide the audience with real examples of pangenomics applicability
Omics Approaches for Sugarcane Crop Improvement by Rajarshi Kumar Gaur Pdf
In this book, the information encompasses various researchable biotechnology aspects of sugarcane, its genomic structure, diversity, comparative and structural genomics, data mining, etc. This book explores both the theoretical and practical aspects of sugarcane crops, focusing on innovative processes. This book argues in favor of developing an integrated research and development system to strengthen the research and development capabilities of all the areas of sugarcane. Further, it covers the recent trends of sugarcane biotechnology, especially in the next-generation sequencing (NGS) era. This book will be very useful for professors and scientists who are working in the area of sugarcane crops by using molecular biology and bioinformatics. It is also useful for students to use as a reference for their classes or thesis projects. Key features: • Discusses an integral part of molecular biology and pivotal tools for molecular breeding; enables breeders to design cost-effective and efficient breeding strategies for sugarcane • Discusses the harnessing genomics technologies for genetic engineering and pathogen characterization and diagnosis of sugarcane • Provides new examples and problems, added where needed • Provides insight from contributors drawn from around the globe
Predictive Analytics for Toxicology by Luis G. Valerio, Jr. Pdf
Predictive data science is already in use in many fields, but its application in toxicology is new and sought after by non-animal alternative testing initiatives. Predictive Analytics for Toxicology: Applications in Discovery Science provides a comprehensive overview of the application of predictive analytics in the field of toxicology, highlighting its role and applications in discovery science. This book addresses the challenges of accurately predicting high-level endpoints of toxicity and explores the use of computational and artificial intelligence research to automate predictive toxicology. It underscores the importance of predictive toxicology in proposing and explaining adverse outcomes resulting from human exposures to specific toxicants, especially when experimental and observational data on the toxicant are incomplete or unavailable. Key features: Includes a plain language description of predictive analytics in toxicology adding an overview of the wide range of applications Examines the science of prediction, computational models as an automated science and comprehensive discussions on concepts of machine learning Opens the hood on AI and its applications in toxicology Features coverage on how in silico toxicity predictions are translational science tools The book integrates strategies and practices of predictive toxicology and offers practical information that students and professionals of the toxicology, chemical, and pharmaceutical industries will find essential. It fulfills the expectations of student researchers seeking to learn predictive analytics in toxicology. This book will energize scientists to conduct predictive toxicology modeling using artificial intelligence and machine learning, and inspire students and seasoned scientists interested in automated science to pick up new research using predictive in silico models to evaluate chemical-induced toxicity. With its focus on practical applications and real-world examples, this book serves as a guide for navigating the complex issues and practices of discovery toxicology. It is an essential resource for those interested in computer-based methods in toxicology, providing valuable insights into the use of predictive analytics.
Digital Transformation in Healthcare 5.0 by Rishabha Malviya,Sonali Sundram,Rajesh Kumar Dhanaraj,Seifedine Kadry Pdf
"Digital Transformation in Healthcare 5.0: IoT, AI, and Digital Twin" provides a comprehensive overview of the integration of cutting-edge technology with healthcare, from the Fourth Industrial Revolution (4IR) to the introduction of IoT, AI, and Digital Twin technologies. This in-depth discussion of the digital revolution expanding the healthcare industry covers a wide range of topics, including digital disruption in healthcare delivery, the impact of 4IR and Health 4.0, e-health services and applications, virtual reality's impact on accessible healthcare delivery, digital twins and dietary health technologies, big data analytics in healthcare systems, machine learning models for cost-effective healthcare delivery systems, affordable healthcare with machine learning, enhanced biomedical signal processing with machine learning, and data-driven AI for information retrieval of biomedical images.
Autism Spectrum Disorder: New Insights Into Molecular Pathophysiology and Therapeutic Development by Junyu Xu,Lei Shi,João Peça Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Jews and Genes by Elliot N. Dorff,Laurie Zoloth Pdf
Well aware of Jews having once been the victims of Nazi eugenics policies, many Jews today have an ambivalent attitude toward new genetics and are understandably wary of genetic forms of identity and intervention. At the same time, the Jewish tradition is strongly committed to medical research designed to prevent or cure diseases. Jews and Genes explores this tension against the backdrop of various important developments in genetics and bioethics--new advances in stem cell research; genetic mapping, identity, testing, and intervention; and the role of religion and ethics in shaping public policy. Jews and Genes brings together leaders in their fields, from all walks of Judaism, to explore these most timely and intriguing topics--the intricacies of the genetic code and the wonders of life, along with cutting-edge science and the ethical issues it raises.
