A Paradigm Shift To Prevent And Treat Alzheimer S Disease

Author : Howard Friel,Sally A. Frautschy
Publisher : Academic Press
Page : 290 pages
File Size : 50,8 Mb
Release : 2017-07-18
Category : Medical
ISBN : 9780128122792

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A Paradigm Shift to Prevent and Treat Alzheimer's Disease by Howard Friel,Sally A. Frautschy Pdf

A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth. This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model. A Paradigm Shift to Prevent and Treat Alzheimer’s Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers. Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer’s disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer’s disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols

Author : Dale Bredesen
Publisher : Penguin
Page : 322 pages
File Size : 40,8 Mb
Release : 2017-08-22
Category : Health & Fitness
ISBN : 9780735216204

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The End of Alzheimer's by Dale Bredesen Pdf

The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene. The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.

Author : Annette Leibing,Silke Schicktanz
Publisher : Berghahn Books
Page : 268 pages
File Size : 48,6 Mb
Release : 2020-10-06
Category : Medical
ISBN : 9781789209105

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Preventing Dementia? by Annette Leibing,Silke Schicktanz Pdf

The conceptualization of dementia has changed dramatically in recent years with the claim that, through early detection and by controlling several risk factors, a prevention of dementia is possible. Although encouraging and providing hope against this feared condition, this claim is open to scrutiny. This volume looks at how this new conceptualization ignores many of the factors which influence a dementia sufferers’ prognosis, including their history with education, food and exercise as well as their living in different epistemic cultures. The central aim is to question the concept of prevention and analyze its impact on aging people and aging societies.

Author : Hyun Kook Lim,Howard Aizenstein
Publisher : Frontiers Media SA
Page : 99 pages
File Size : 53,9 Mb
Release : 2020-08-05
Category : Electronic
ISBN : 9782889639175

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Prevention of Alzheimer’s Disease: From Cognitive Reserve to Precision Medicine by Hyun Kook Lim,Howard Aizenstein Pdf

Author : Anonim
Publisher : Unknown
Page : 12 pages
File Size : 53,8 Mb
Release : 1987
Category : Dementia
ISBN : MINN:31951D01951424R

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Differential Diagnosis of Dementing Diseases by Anonim Pdf

Author : Dale Bredesen
Publisher : Penguin
Page : 273 pages
File Size : 41,6 Mb
Release : 2021-08-17
Category : Health & Fitness
ISBN : 9780593192436

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The First Survivors of Alzheimer's by Dale Bredesen Pdf

First person stories of patients who recovered from Alzheimer's Disease--and how they did it. It has been said that everyone knows a cancer survivor, but no one has met an Alzheimer's survivor – until now. In his first two books, Dr. Dale Bredesen outlined the revolutionary treatments that are changing what had previously seemed like the inevitable outcome of cognitive decline and dementia. And in these moving narratives, you can hear directly from the first survivors of Alzheimer’s themselves--their own amazing stories of hope told in their own words. These first person accounts honestly detail the fear, struggle, and ultimate victory of each patient's journey. They vividly describe what it is like to have Alzheimer's. They also drill down on how each of these patients made the program work for them--the challenges, the workarounds, the encouraging results that are so motivating. Dr. Bredesen includes commentary following each story to help point readers to the tips and tricks that might help them as well. Dr. Bredesen's patients have not just survived; they have thrived to rediscover fulfilling lives, rewarding relationships, and meaningful work. This book will give unprecedented hope to patients and their families.

Author : Timothy J. Dickey
Publisher : Emerald Group Publishing
Page : 121 pages
File Size : 55,8 Mb
Release : 2020-02-28
Category : Language Arts & Disciplines
ISBN : 9781838676933

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Library Dementia Services by Timothy J. Dickey Pdf

There are 50 million people globally living with Alzheimer’s disease and related dementias, and tens of millions of their caregivers. Library and information professionals must learn to assist those with dementia. This book explores best practice guidelines and concrete ideas for serving those with dementia and their caregivers.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Preventing Dementia and Cognitive Impairment
Publisher : National Academies Press
Page : 181 pages
File Size : 44,9 Mb
Release : 2017-10-05
Category : Medical
ISBN : 9780309459594

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Preventing Cognitive Decline and Dementia by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Preventing Dementia and Cognitive Impairment Pdf

Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or delay these conditions has been limited at best, despite the many claims of success made in popular media and advertising. Today, however, a growing body of prevention research is emerging. Preventing Cognitive Decline and Dementia: A Way Forward assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. This report provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging.

Author : A.D. Roses,K.H. Weisgraber,Y. Christen
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642801099

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Apolipoprotein E and Alzheimer’s Disease by A.D. Roses,K.H. Weisgraber,Y. Christen Pdf

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Author : Amar Kapoor M.D.
Publisher : Xlibris Corporation
Page : 187 pages
File Size : 43,8 Mb
Release : 2024-01-07
Category : Fiction
ISBN : 9798369414217

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PROBRAIN MINDSET for PERFECT HEALTH SPAN and PREVENTION OF ALZHEIMER’S DEMENTIA by Amar Kapoor M.D. Pdf

THIS BOOK HELPS YOU TO HARNESS YOUR FULL POTENTIAL TO OPTIMIZE YOUR BRAINPOWER Dr. Amar Kapoor presents a comprehensive approach to transforming your fixed mindset into a ProBrain Mindset. This can help you lead a healthy life and prevent Alzheimer's disease. This is the first book that addresses evidence-based studies on the civilization's curse of sugar and the endless epidemics of degenerative diseases, dietary indiscretions, the epidemic of diabetes, heart disease, obesity, metabolic syndrome, and the dreaded Alzheimer's disease, along with all cancers of all sorts. The central focus of this literature is not centered on weight loss but rather on identifying and comprehending the sole underlying cause of the various degenerative ailments affecting the modern age. It provides exceptional insights into inner cellular intelligence by assimilating information and knowledge gained from extensive medical and research studies. This publication is a valuable resource for individuals seeking to enhance their cognitive capacities and achieve higher levels of personal and professional success. It also offers current research on anti-aging and longevity therapies, which can aid in mitigating the prevalence. Of degenerative diseases and increasing one's life health span. The information provided in this publication is essential for those in the business in an academic setting seeking to improve their cognitive abilities and optimize their Health Span.

Author : Han Yu
Publisher : Columbia University Press
Page : 487 pages
File Size : 44,5 Mb
Release : 2021-03-02
Category : Science
ISBN : 9780231552769

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Mind Thief by Han Yu Pdf

Alzheimer’s disease, a haunting and harrowing ailment, is one of the world’s most common causes of death. Alzheimer’s lingers for years, with patients’ outward appearance unaffected while their cognitive functions fade away. Patients lose the ability to work and live independently, to remember and recognize. There is still no proven way to treat Alzheimer’s because its causes remain unknown. Mind Thief is a comprehensive and engaging history of Alzheimer’s that demystifies efforts to understand the disease. Beginning with the discovery of “presenile dementia” in the early twentieth century, Han Yu examines over a century of research and controversy. She presents the leading hypotheses for what causes Alzheimer’s; discusses each hypothesis’s tangled origins, merits, and gaps; and details their successes and failures. Yu synthesizes a vast amount of medical literature, historical studies, and media interviews, telling the gripping stories of researchers’ struggles while situating science in its historical, social, and cultural contexts. Her chronicling of the trajectory of Alzheimer’s research deftly balances rich scientific detail with attention to the wider implications. In narrating the attempts to find a treatment, Yu also offers a critical account of research and drug development and a consideration of the philosophy of aging. Wide-ranging and accessible, Mind Thief is an important book for all readers interested in the challenge of Alzheimer’s.

Author : Dale Bredesen
Publisher : Penguin
Page : 354 pages
File Size : 47,7 Mb
Release : 2020-08-18
Category : Health & Fitness
ISBN : 9780525538509

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The End of Alzheimer's Program by Dale Bredesen Pdf

The instant New York Times bestseller The New York Times Best Selling author of The End of Alzheimer's lays out a specific plan to help everyone prevent and reverse cognitive decline or simply maximize brainpower. In The End of Alzheimer's Dale Bredesen laid out the science behind his revolutionary new program that is the first to both prevent and reverse symptoms of Alzheimer's disease. Now he lays out the detailed program he uses with his own patients. Accessible and detailed, it can be tailored to anyone's needs and will enhance cognitive ability at any age. What we call Alzheimer's disease is actually a protective response to a wide variety of insults to the brain: inflammation, insulin resistance, toxins, infections, and inadequate levels of nutrients, hormones, and growth factors. Bredesen starts by having us figure out which of these insults we need to address and continues by laying out a personalized lifestyle plan. Focusing on the Ketoflex 12/3 Diet, which triggers ketosis and lets the brain restore itself with a minimum 12-hour fast, Dr. Bredesen drills down on restorative sleep, targeted supplementation, exercise, and brain training. He also examines the tricky question of toxic exposure and provides workarounds for many difficult problems. The takeaway is that we do not need to do the program perfectly but will see tremendous results if we can do it well enough. With inspiring stories from patients who have reversed cognitive decline and are now thriving, this book shifts the treatment paradigm and offers a new and effective way to enhance cognition as well as unprecedented hope to sufferers of this now no longer deadly disease.

Author : Christian Behl
Publisher : Springer Nature
Page : 661 pages
File Size : 52,8 Mb
Release : 2023-08-14
Category : Medical
ISBN : 9783031315701

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Alzheimer’s Disease Research by Christian Behl Pdf

This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.

Author : Santo Davide Ferrara
Publisher : Springer
Page : 635 pages
File Size : 54,9 Mb
Release : 2018-03-27
Category : Medical
ISBN : 9783319670928

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P5 Medicine and Justice by Santo Davide Ferrara Pdf

This book describes the state of the art and future prospects of the most important bio-medicolegal subdisciplines in the post-genomic framework of personalized medicine. Focusing on the three main themes Innovation, Unitariness and Evidence, the book addresses a wide range of topics, including: Bio-Medicolegal and Criminological Sciences, Forensic Pathology and Anthropology, Clinical and Forensic Medicine in Living Persons (from Interpersonal Violence to Personal Injury and Damage, Malpractice, Personal Identification and Age Estimation), Forensic Genetics and Genomics, and Toxicology and Imaging. The unitariness of the “Bio-Medicolegal Sciences”, historically founded on the accuracy and rigor of the methods of ascertainment and criteria of evaluation, should be re-established on the basis of molecular evidence, and used to promote Personalized Justice. Taken together, the book’s conclusions and future perspectives outline a vision of transdisciplinary innovation and future evidence in the framework of personalized justice.

Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
Publisher : Cambridge University Press
Page : 575 pages
File Size : 41,7 Mb
Release : 2022-03-31
Category : Business & Economics
ISBN : 9781108838665

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Alzheimer's Disease Drug Development by Jeffrey Cummings,Jefferson Kinney,Howard Fillit Pdf

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.