A Practical Guide To Biomedical Research Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of A Practical Guide To Biomedical Research book. This book definitely worth reading, it is an incredibly well-written.
A Practical Guide to Biomedical Research by Peter Agger,Robert S. Stephenson,J. Michael Hasenkam Pdf
This book advises and supports novice researchers in taking their first steps into the world of scientific research. Through practical tips and tricks presented in a clear, concise and step-wise manner, the book describes the entire research process from idea to publication. It also gives the reader insight into the vast opportunities a research career can provide. The books target demographic is aspiring researchers within the biomedical professions, be it medical students, young doctors, nurses, engineers, physiotherapists etc. The book will help aspirational inexperienced researchers turn their intentions into actions, providing crucial guidance for successful entry into the field of biomedical research.
Description: In biomedical research, because of a dramatic increase in productivity, immunocytochemistry has emerged as a major technique. The proposed book will provide the first practical guide to planning, performing, and evaluating immunocytochemical experiments. In today’s graduate education the emphasis is on doing research and not on formal class work. Graduate students therefore lack the background in many essential techniques necessary to perform research in fields in which they were not trained. As director of a university core microscopy facility which sees students and faculty from dozens of laboratories each year, Dr. Burry has surmised the vast majority of these novice microscope users need considerable help. In an attempt to educate users, Dr. Burry has initiated immunocytochemistry seminars and workshops which serve to train people in this powerful research tool. The proposed book is an outgrowth of these presentations and conversations with, by now, hundreds of people who have asked for help. The philosophy which separates this book from other books in this field is that it is practical, rather than academic. In looking at other important immunocytochemistry titles, the predominant orientation is academic, with the author attempting to comprehensively discuss the topic. For example, one book with sample preparation lists ten fixatives which can be used; however, only two such fixatives are commonly used today. In this particular title, the detailed discussion of old methods might be seen as important in establishing the author as an expert. By contrast, the approach for Burry’s book would be to discuss methods based on what works in animal research laboratories today, and focus only on the most productive methods. An additional distinction with this proposed book is the focus on animal research and not human pathology. There is a certification program for pathology technicians which requires them to learn a set body of material based on processing human tissue for examination by a pathologist. Many of the books on immunocytochemistry aim at this large pathology user base. Due to historical reasons, pathology laboratories process human tissues in a specific way and embed the tissue in paraffin, as has been done for over a century. In the last ten years, the power of immunocytochemistry in clinical diagnosis has become clear and has accordingly been adapted to pathology. However, the extensive processing needed for paraffin sections is not needed if the tissues are from research animals. Processing for animal-based tissues takes about a third of the time and results in higher quality images. The focus of this book is on processing these animal research tissues for immunocytochemistry. Today, there are no technique books which are aimed at this user base. As a subject matter expert in the area of the proposed book, Dr. Burry will make recommendations and offer opinions. Because this field is new and is emerging, there are numerous advantages of specific methods over other, more generalized methods. The purpose of this book is to show a novice how to do immunocytochemistry without engaging in a discussion of possible advanced methods. For the advanced user, there are several good books which discuss the unusual methods, yet for the novice there are currently none. Main Author : Richard W. Burry, The Ohio State University (United States). The Outline of the Book : Each chapter supplies a set of important principals and steps necessary for good immunocytochemistry. The information is distilled down to include only the most important points and does not attempt to cover infrequently used procedures or reagents. At the end of most chapters is a section on trouble-shooting many of the common problems using the Sherlock Holmes method. Each chapter also includes specific protocols which can be used. The goal of each chapter is to present the reader with enough information to successfully design experiments and solve many of the problems one may encounter. Using immunocytochemical protocols without the understanding of their workings is not advised, as the user will need to evaluate his or her results to determine whether the results are reliable. Such evaluation is extremely important for users who need reliable images which will clearly answer important scientific questions. 1. Introduction Definitions (immunocytochemistry and immunohistochemistry) Scope: animal research and not human pathology, paraffin sections, epitope retrieval, or immunohistochemistry Focus: fluorescence and enzyme detection Why do immunocytochemistry? Immunocytochemistry "individual study" rather than "population study" Example of a two-label experiment What is included in these chapters? Overview of the theory Background with enough information to help solve common problems. Advantages and disadvantages of different options Opinions and suggestions 2. Fixation and Sectioning Chemistry of fixation Denaturing vs cross-linking fixatives Application of fixative Perfusion, drop-in, cultures, fresh-frozen Selection of sample section type Sectioning tissue Rapid freezing, cryostat, freezing microtome, vibratome Storage of tissue Protocols 3. Antibodies Introduction Isoforms, structure, reactivity Generation Polyclonal vs monoclonal Antibodies as reagents Antibody specificity and sources Storage and handling 4. Labels for antibodies Fluorescence, enzymes and particulates Fluorescence theory Fluorescent labels - four generations Enzymes theory Selecting enzymes vs. fluorescence Selecting a label- advantages and disadvantages Protocols 5. Methods of applying antibodies Direct method Indirect method Antibody amplification methods ABC TSA Protocols 6. Blocking and Permeability Theory of blocking Theory of detergents Protocols 7. Procedure- Single primary antibody Planning steps Sample, fixation, sectioning Vehicle Antibody dilutions Controls Protocols 8. Multiple primary antibodies - primary antibodies of different species Procedure Controls Protocols 9. Multiple primary antibodies-primary antibodies of same species Block-between Zenon HRP-chromogen development High-titer incubations Controls Protocols 10. Microscopy Wide-field fluorescence microscope Confocal microscope Bright field—enzyme chromogen Choice Problems 11. Images Size, intensity, and pixels Manipulation—what is ethical? Manuscript Figures 11. Planning and Troubleshooting Scheme for discussion-making in planning experiments Case studies with Sherlock Holmes detective work 12. So you want to do electron microscopic ICC? Criteria in decision-making Summary of the two techniques
Practical Guide for Biomedical Signals Analysis Using Machine Learning Techniques by Abdulhamit Subasi Pdf
Practical Guide for Biomedical Signals Analysis Using Machine Learning Techniques: A MATLAB Based Approach presents how machine learning and biomedical signal processing methods can be used in biomedical signal analysis. Different machine learning applications in biomedical signal analysis, including those for electrocardiogram, electroencephalogram and electromyogram are described in a practical and comprehensive way, helping readers with limited knowledge. Sections cover biomedical signals and machine learning techniques, biomedical signals, such as electroencephalogram (EEG), electromyogram (EMG) and electrocardiogram (ECG), different signal-processing techniques, signal de-noising, feature extraction and dimension reduction techniques, such as PCA, ICA, KPCA, MSPCA, entropy measures, and other statistical measures, and more. This book is a valuable source for bioinformaticians, medical doctors and other members of the biomedical field who need a cogent resource on the most recent and promising machine learning techniques for biomedical signals analysis. Provides comprehensive knowledge in the application of machine learning tools in biomedical signal analysis for medical diagnostics, brain computer interface and man/machine interaction Explains how to apply machine learning techniques to EEG, ECG and EMG signals Gives basic knowledge on predictive modeling in biomedical time series and advanced knowledge in machine learning for biomedical time series
An Introduction to Biomedical Science in Professional and Clinical Practice by Sarah J. Pitt,Jim Cunningham Pdf
Biomedical Science in Professional and Clinical Practice is essential reading for all trainee biomedical scientists looking for an introduction to the biomedical science profession whether they are undergraduates following an accredited biomedical sciences BSc, graduate trainees or experienced staff with overseas qualifications. This book guides trainees through the subjects, which they need to understand to meet the standards required by the Health Professions Council for state registration. These include professional topics, laws and guidelines governing clinical pathology, basic laboratory techniques and an overview of each pathology discipline. It helps trainees at any stage of training and in any pathology discipline(s) to think creatively about how to gather evidence of their understanding and professional competence. By referring to specialist sources of information in each area, it helps students to explore particular topics in more depth and to keep up to date with professional and legal changes. It is also of value to any Training Officers who are looking for ideas while planning a programme of training for a trainee biomedical scientist. The book includes basic principles of working in the pathology laboratory including laws and regulations, which must be observed, such as health and safety, data protection and equal opportunities laws and guidelines. Practical exercises are included throughout the book with examples of coursework, suggestions for further exercises and self -assessment. Summary boxes of key facts are clearly set out in each chapter and ideas for group/tutorial discussions are also provided to enhance student understanding.
A Practical Guide for Medical Teachers by John Dent,Ronald M Harden,Dan Hunt Pdf
The Fifth Edition of the highly praised Practical Guide for Medical Teachers provides a bridge between the theoretical aspects of medical education and the delivery of enthusiastic and effective teaching in basic science and clinical medicine. Healthcare professionals are committed teachers and this book is an essential guide to help them maximise their performance. This highly regarded book recognises the importance of educational skills in the delivery of quality teaching in medicine. The contents offer valuable insights into all important aspects of medical education today. A leading educationalist from the USA joins the book’s editorial team. The continual emergence of new topics is recognised in this new edition with nine new chapters: The role of patients as teachers and assessors; Medical humanities; Decision-making; Alternative medicine; Global awareness; Education at a time of ubiquitous information; Programmative assessment; Student engagement; and Social accountability. An enlarged group of authors from more than 15 countries provides both an international perspective and a multi-professional approach to topics of interest to all healthcare teachers.
How to Succeed in Medical Research by Robert Foley,Robert Maweni,Shahram Shirazi,Hussein Jaafar Pdf
How to Succeed in Medical Research is a practical resource for medical students and junior doctors across all specialties. Designed for busy readers seeking to distinguish themselves in a highly competitive environment, this concise yet comprehensive guide provides step-by-step advice on selecting a project, finding a mentor, conducting a study, analysing results, publishing a paper, communicating findings, and much more. Presented in an accessible and conversational style, 14 succinct chapters walk readers through the essential stages of their research journey, from the initial steps to getting involved in research as a medical student, to effectively balancing clinical work, scientific research, and other academic pursuits early in your career as a healthcare professional. The book is packed with real-world case studies and expert tips to help readers apply the content directly in their own studies and careers. Straightforward and easy-to-use, this valuable guide: Covers a variety of clinical research and presentation skills using clear and engaging language Provides detailed guidance on writing a paper, conducting a clinical audit, creating a CV and portfolio, and other key proficiencies Develops writing skills for literature reviews, critical appraisals, and case reports Discusses how to further medical careers through research electives, PhD studies, teaching, and quality improvement projects Offers a range of helpful learning features including objectives, key points, case studies, review questions, and links to references and further readings Includes PowerPoint templates for oral presentations and posters via a companion website How to Succeed in Medical Research: A Practical Guide is an ideal resource for medical students, junior doctors and other early career medical professionals.
Essential Guide to Reading Biomedical Papers by Philip D. Langton Pdf
Essential Guide to Reading Biomedical Papers: Recognising and Interpreting Best Practice is an indispensable companion to the biomedical literature. This concise, easy-to-follow text gives an insight into core techniques and practices in biomedical research and how, when and why a technique should be used and presented in the literature. Readers are alerted to common failures and misinterpretations that may evade peer review and are equipped with the judgment necessary to be properly critical of the findings claimed by research articles. This unique book will be an invaluable resource for students, technicians and researchers in all areas of biomedicine. Allows the reader to develop the necessary skills to properly evaluate research articles Coverage of over 30 commonly-used techniques in the biomedical sciences Global approach and application, with contributions from leading experts in diverse fields
A Practical Guide for Health Researchers by M. F. Fathalla,Mahmoud F. Fathalla Pdf
Health researchers, the intended audience of this book, are not limited to scientists pursuing a research career. They include health professionals, administrators, policymakers and non-governmental organizations, among others, who can and should use the scientific method to guide their work for improving the health of individuals and communities. Even if they do not pursue much research themselves, they need to grasp the principles of the scientific method, to understand the value and also the limitations of science, and to be able to assess and evaluate results of research before applying them. This book includes the following chapters: Introduction and overview; ethics in health research; what research to do; planning the research; writing the research protocol; submitting a research proposal; implementing the research project; describing and analysing the research results; communicating research; guidelines on writing a scientific paper; publishing a scientific paper; guidelines on making a scientific presentation; assessing and evaluating research.
An Introduction to Health Services Research by Dawn-Marie Walker Pdf
This is a primary, comprehensive textbook for people who are considering undertaking a piece of health-related research. It is an accessible companion with the aim of getting the reader to think broadly about all of the issues that need to be considered when embarking on a project. This is a pragmatic book, a step-by-step guide to research which mirrors the structure of a research project, taking you through the thought process for designing and conducting your study from formulating the right research question at idea inception, ascertaining what methodologies and analysis can answer what type of questions, right through to dissemination, all presented in an easy, digestible style. The book is full of case study illustrations and practical tips such as how to work out a research budget and obtaining funding for your project, discussion of what permissions need to obtained when conducting research with people, and how to involve public and patients. The authors are all experienced researchers and so this book is an accumulation of collective wisdom on common research challenges and issues.
A Practical Guide to Human Research and Clinical Trials by M. U. R. Naidu,P. Usha Rani Pdf
Regulatory bodies such as the European Medicine Agency have done tremendous work in collaboration with experts from the field to develop Good Clinical Practices that apply not only in Europe but also in emerging countries. Designed to be a teaching aid and reference guide, A Practical Guide to Human Research and Clinical focuses on ethics, regulations, and guidelines. Conducting a successful clinical trial requires not only a strong basic knowledge, but also hands-on practical training. The book explains the intricate details of the subject to readers by citing concrete cases, exercises, and templates along with the theoretical aspects. Prof. M.U.R Naidu and his co-authors address all aspects of clinical trials from clinical research, drug development, and quality to methodology, biostatistics, and pharmacovigilance.
Healthcare Simulation Research by Debra Nestel,Joshua Hui,Kevin Kunkler,Mark W. Scerbo,Aaron W. Calhoun Pdf
This book provides readers with a detailed orientation to healthcare simulation research, aiming to provide descriptive and illustrative accounts of healthcare simulation research (HSR). Written by leaders in the field, chapter discussions draw on the experiences of the editors and their international network of research colleagues. This seven-section practical guide begins with an introduction to the field by relaying the key components of HSR. Sections two, three, four, and five then cover various topics relating to research literature, methods for data integration, and qualitative and quantitative approaches. Finally, the book closes with discussions of professional practices in HSR, as well as helpful tips and case studies.Healthcare Simulation Research: A Practical Guide is an indispensable reference for scholars, medical professionals and anyone interested in undertaking HSR.
Doing Real Research by Eric Jensen,Charles Laurie Pdf
Challenging the formality and idealized settings of conventional methods teaching and opting instead for a real world approach to social research, this book offers frank, practical advice designed to empower students and researchers alike. Theoretically robust and with an exhaustive coverage of key methodologies and methods the title establishes the cornerstones of social research. Examples reflect research conducted inside and outside formal university settings and range from the extremes of war torn countries to the complexities of school classrooms. Supported by a wealth of learning features and tools the textbook and website include: Video top tips Podcasts Full text journal articles Interviews with researchers conducting field research Links to external websites and blogs Student exercises Real world case studies
David H. Peters,Nhan T. Tran,Taghreed Adam,World Health Organization
Author : David H. Peters,Nhan T. Tran,Taghreed Adam,World Health Organization Publisher : World Health Organization Page : 69 pages File Size : 49,7 Mb Release : 2013 Category : Medical ISBN : 9789241506212
Implementation Research in Health by David H. Peters,Nhan T. Tran,Taghreed Adam,World Health Organization Pdf
Interest in implementation research is growing, largely in recognition of the contribution it can make to maximizing the beneficial impact of health interventions. As a relatively new and, until recently, rather neglected field within the health sector, implementation research is something of an unknown quantity for many. There is therefore a need for greater clarity about what exactly implementation research is, and what it can offer. This Guide is designed to provide that clarity. Intended to support those conducting implementation research, those with responsibility for implementing programs, and those who have an interest in both, the Guide provides an introduction to basic implementation research concepts and language, briefly outlines what it involves, and describes the many opportunities that it presents. The main aim of the Guide is to boost implementation research capacity as well as demand for implementation research that is aligned with need, and that is of particular relevance to health systems in low- and middle-income countries (LMICs). Research on implementation requires the engagement of diverse stakeholders and multiple disciplines in order to address the complex implementation challenges they face. For this reason, the Guide is intended for a variety of actors who contribute to and/or are impacted by implementation research. This includes the decision-makers responsible for designing policies and managing programs whose decisions shape implementation and scale-up processes, as well as the practitioners and front-line workers who ultimately implement these decisions along with researchers from different disciplines who bring expertise in systematically collecting and analyzing information to inform implementation questions. The opening chapters (1-4) make the case for why implementation research is important to decision-making. They offer a workable definition of implementation research and illustrate the relevance of research to problems that are often considered to be simply administrative and provide examples of how such problems can be framed as implementation research questions. The early chapters also deal with the conduct of implementation research, emphasizing the importance of collaboration and discussing the role of implementers in the planning and designing of studies, the collection and analysis of data, as well as in the dissemination and use of results. The second half of the Guide (5-7) detail the various methods and study designs that can be used to carry out implementation research, and, using examples, illustrates the application of quantitative, qualitative, and mixed-method designs to answer complex questions related to implementation and scale-up. It offers guidance on conceptualizing an implementation research study from the identification of the problem, development of research questions, identification of implementation outcomes and variables, as well as the selection of the study design and methods while also addressing important questions of rigor.
