Abc Proteins

Author : I Barry Holland,Susan P. C. Cole,Karl Kuchler,Christopher F. Higgins
Publisher : Elsevier
Page : 530 pages
File Size : 45,9 Mb
Release : 2003-01-07
Category : Science
ISBN : 9780080481876

Get Book

ABC Proteins by I Barry Holland,Susan P. C. Cole,Karl Kuchler,Christopher F. Higgins Pdf

ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Phylogeny and Evoloution of ABC Transporters Fundamental Aspects of the Mechanism of Action of ABC Transporters Prokaryote ABC Transporters Non-Mammalian Transporters Multidrug Transporters ABC Transporters, Physiological Roles and Human Disease Full color throughout

Author : Michael Carlton Dean
Publisher : Unknown
Page : 0 pages
File Size : 55,9 Mb
Release : 2002
Category : Electronic
ISBN : OCLC:505330606

Get Book

The Human ATP-binding Cassette (ABC) Transporter Superfamily by Michael Carlton Dean Pdf

Author : Markus Geisler
Publisher : Springer
Page : 331 pages
File Size : 53,6 Mb
Release : 2014-09-06
Category : Science
ISBN : 9783319065113

Get Book

Plant ABC Transporters by Markus Geisler Pdf

This book is devoted to the fascinating superfamily of plant ATP-binding cassette (ABC) transporters and their variety of transported substrates. It highlights their exciting biological functions, covering aspects ranging from cellular detoxification, through development, to symbiosis and defense. Moreover, it also includes a number of chapters that center on ABC transporters from non-Arabidopsis species. ABC proteins are ubiquitous, membrane-intrinsic transporters that catalyze the primary (ATP-dependent) movement of their substrates through biological membranes. Initially identified as an essential aspect of a vacuolar detoxification process, genetic work in the last decade has revealed an unexpectedly diverse variety of ABC transporter substrates, which include not only xenobiotic conjugates, but also heavy metals, lipids, terpenoids, lignols, alkaloids and organic acids. The discovery that members of the ABCB and ABCG family are involved in the movement of phytohormones has further sparked their exploration and provided a new understanding of the whole family. Accordingly, the trafficking, regulation and structure-function of ABCB-type auxin transporters are especially emphasized in this book.

Author : Anthony M. George
Publisher : Springer
Page : 376 pages
File Size : 45,9 Mb
Release : 2015-12-16
Category : Science
ISBN : 9783319234762

Get Book

ABC Transporters - 40 Years on by Anthony M. George Pdf

This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 42,5 Mb
Release : 2024-06-02
Category : Electronic
ISBN : 9789814467353

Get Book

The ABC Transporters of Human Physiology and Disease by Anonim Pdf

Author : Kenneth J. Linton,Barry I. Holland
Publisher : World Scientific
Page : 478 pages
File Size : 54,6 Mb
Release : 2011
Category : Science
ISBN : 9789814280075

Get Book

The ABC Transporters of Human Physiology and Disease by Kenneth J. Linton,Barry I. Holland Pdf

ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins present in all cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport across cellular membranes of molecules ranging from small ions to drugs, lipids and proteins. The human genome encodes 48 ABC transporter genes and mutations in most have been linked to disease. This book OCo that brings together state-of-the-art knowledge on ABC proteins in one volume OCo will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to disease. Each of the 14 chapters is written by a leading researcher in the field. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.

Author : Ahcène Boumendjel,Jean Boutonnat,Jacques Robert
Publisher : John Wiley & Sons
Page : 475 pages
File Size : 42,7 Mb
Release : 2009-06-17
Category : Medical
ISBN : 9780470495124

Get Book

ABC Transporters and Multidrug Resistance by Ahcène Boumendjel,Jean Boutonnat,Jacques Robert Pdf

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Author : Suresh V. Ambudkar,Michael M. Gottesman
Publisher : Gulf Professional Publishing
Page : 902 pages
File Size : 53,5 Mb
Release : 1998-07-31
Category : Medical
ISBN : 0121821935

Get Book

ABC Transporters: Biochemical, Cellular, and Molecular Aspects by Suresh V. Ambudkar,Michael M. Gottesman Pdf

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchersin all fields of life sciences. Prokaryotic ABC Transporters Eukaryotic ABC Transporters Nonmammalian ABC Transport Systems Mammalian P-Glycoproteins Multidrug Resistance Associated Protein Cystic Fibrosis Transmembrane Conductance Regulator Sulfonylurea Receptor Intracellular ABC Transporters

Author : Karobi Moitra
Publisher : Morgan & Claypool Publishers
Page : 87 pages
File Size : 41,9 Mb
Release : 2012-04-20
Category : Medical
ISBN : 9781615043781

Get Book

ABC Transporters in Human Disease by Karobi Moitra Pdf

The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all vertebrates so far studied. The human ABC transporter superfamily contains 48 genes, subdivided into 7 subfamilies ranging from A to G (based on sequence homology of their nucleotide binding domains). The ABC proteins encoded by these genes are ATP-driven transmembrane pumps, some of which possess the capacity to efflux harmful toxic substances and therefore play a key role in xenobiotic defense. ABC proteins have been evolutionarily conserved from bacteria to humans and multiple gene duplication and deletion events in the ABC genes indicate that the process of gene evolution is still ongoing. Polymorphisms and variations in these genes are linked to variations in expression, function, drug disposition, and drug response. Single nucleotide polymorphisms (SNPs) in these genes could be markers of individual risk for adverse drug reactions or susceptibility to complex diseases. The pharmacogenetics of this unique family of transporters is still under study; however, in the context of human health, it is a well-known fact that variations in these transporters are the underlying cause for several human diseases including cystic fibrosis, Pseudoxanthoma elasticum (PXE), and X-linked adenoleukodystrophy (X-ALD). Table of Contents: Introduction to the Human ATP-Binding Cassette (ABC) Transporter Superfamily / Evolution of ABC Transporters / Overview of ABC Transporters in Human Disease / The Cystic Fibrosis Transmembrane Conductance Regulator-ABCC7 / PXE / X-linked Adrenoleukodystrophy / ABC Proteins: A Global Perspective / References / Titles of Related Interest

Author : Michael Carlton Dean
Publisher : Unknown
Page : 128 pages
File Size : 40,7 Mb
Release : 2002
Category : ATP-binding cassette transporters
ISBN : OCLC:505330606

Get Book

The Human ATP-binding Cassette (ABC) Transporter Superfamily by Michael Carlton Dean Pdf

Author : Gerhard F. Ecker,Rasmus P. Clausen,Harald H. Sitte
Publisher : John Wiley & Sons
Page : 354 pages
File Size : 53,8 Mb
Release : 2017-04-10
Category : Medical
ISBN : 9783527333844

Get Book

Transporters as Drug Targets by Gerhard F. Ecker,Rasmus P. Clausen,Harald H. Sitte Pdf

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

Author : S.S. Rothman
Publisher : Elsevier
Page : 270 pages
File Size : 44,6 Mb
Release : 1996-04-16
Category : Science
ISBN : 008053614X

Get Book

Membrane Protein Transport by S.S. Rothman Pdf

This is the second volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.

Author : Stefan Offermanns,W. Rosenthal
Publisher : Springer Science & Business Media
Page : 1515 pages
File Size : 41,8 Mb
Release : 2008-08-14
Category : Medical
ISBN : 9783540389163

Get Book

Encyclopedia of Molecular Pharmacology by Stefan Offermanns,W. Rosenthal Pdf

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Author : Asim K. Duttaroy,Friedrich Spener
Publisher : John Wiley & Sons
Page : 478 pages
File Size : 54,8 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605286

Get Book

Cellular Proteins and Their Fatty Acids in Health and Disease by Asim K. Duttaroy,Friedrich Spener Pdf

In light of the increasing importance of these proteins and their ligands for our understanding of cellular growth, differentiation, and development, as well as of diseases such as obesity, insulin resistance, atherosclerosis, cancer, and inflammation, a team of internationally renowned editors and authors have compiled here the very first comprehensive book on these topics. They describe fatty acid-activated transcription factors as well as membrane and soluble fatty acid transporters, covering such aspects as structure and function, lipid-protein interaction, delivery of ligands, and the roles of these proteins in gene expression pertaining to the homeostatic and diseased states of cells and organs. Incorporating recent findings, this is indispensable for basic scientists, health professionals in industry and clinics as well as postgraduate students. Contributors among others: N.A. Abumrad, J.E. Schaffer, G. Schmitz, N.J. Brunskill, J. Storch, U. Seedorf, S. Mandrup, C.N.A. Palmer, T. Perlmann, H.I. Nebb, J. Bar-Tana, H. Kondo, C. Wolfrum, C. Kerkhoff , S. Farmer, E.J. Murphy, J.F.C. Glatz, P. Besnard, J.M. Stewart, A. Meirhaeghe, J. Plutzky, W. Wahli, R.A. Roberts

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 3307 pages
File Size : 45,7 Mb
Release : 2008-09-23
Category : Medical
ISBN : 9783540368472

Get Book

Encyclopedia of Cancer by Manfred Schwab Pdf

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.