Accelerated Path To Cures

Author : Josep Bassaganya-Riera
Publisher : Springer
Page : 82 pages
File Size : 46,6 Mb
Release : 2018-04-25
Category : Medical
ISBN : 9783319732381

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Accelerated Path to Cures by Josep Bassaganya-Riera Pdf

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

Author : Josep Bassaganya-Riera
Publisher : Unknown
Page : 128 pages
File Size : 41,8 Mb
Release : 2018
Category : Drug development
ISBN : 3319732390

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Accelerated Path to Cures by Josep Bassaganya-Riera Pdf

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

Author : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health
Publisher : Unknown
Page : 192 pages
File Size : 47,6 Mb
Release : 2015
Category : Drug development
ISBN : STANFORD:36105050680318

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21st Century Cures by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health Pdf

Author : Alain Vertes,Nathan J. Dowden,Devyn Smith,Nasib Qureshi
Publisher : Academic Press
Page : 846 pages
File Size : 53,5 Mb
Release : 2020-02-07
Category : Science
ISBN : 9780128120330

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Second Generation Cell and Gene-Based Therapies by Alain Vertes,Nathan J. Dowden,Devyn Smith,Nasib Qureshi Pdf

Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products. The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies

Author : Edward L Snyder,Eric A. Gehrie
Publisher : Elsevier Health Sciences
Page : 193 pages
File Size : 43,9 Mb
Release : 2019-09-03
Category : Medical
ISBN : 9780323709071

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Transfusion Medicine, An Issue of Hematology/Oncology Clinics of North America by Edward L Snyder,Eric A. Gehrie Pdf

This issue of Hematology/Oncology Clinics, Guest Edited by Drs. Edward Snyder and Eric A. Gehrie, with Consulting Editors George P. Canellos and H. Franklin Bunn, will focus on Transfusion Medicine. Topics include, but are not limited to, Pathogen Reduction, Transfusion Reactions-Infectious Complications, Txn Rxn-Non-Infectious Complications, Iron Deficiency and Teen Blood Donors, Advances in RBC Serology, Advances in Immunotherapy, Therapeutic Monoclonal Antibody Effect on RBC Compatibility Testing, Cell Therapy-New Regulations and Standards, Alternatives to Platelet and RBC Transfusions, New Hemostatic Agents, Tx Practices for Children with Cancer, and Relevance of Cold Platelets and WB to the Bleeding Oncology Patient.

Author : Antonio Giulietti
Publisher : Springer
Page : 320 pages
File Size : 54,8 Mb
Release : 2016-05-04
Category : Science
ISBN : 9783319315638

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Laser-Driven Particle Acceleration Towards Radiobiology and Medicine by Antonio Giulietti Pdf

This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.

Author : Alain A. Vertes,Nasib Qureshi,Arnold I. Caplan,Lee E. Babiss
Publisher : John Wiley & Sons
Page : 776 pages
File Size : 50,8 Mb
Release : 2015-09-14
Category : Science
ISBN : 9781118846216

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Stem Cells in Regenerative Medicine by Alain A. Vertes,Nasib Qureshi,Arnold I. Caplan,Lee E. Babiss Pdf

This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

Author : Emile R Mohler,Brian Annex
Publisher : Academic Press
Page : 178 pages
File Size : 49,5 Mb
Release : 2016-06-15
Category : Technology & Engineering
ISBN : 9780128014875

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Regenerative Medicine for Peripheral Artery Disease by Emile R Mohler,Brian Annex Pdf

Regenerative Medicine for Peripheral Artery Disease is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of peripheral arterial disease. This reference includes a general overview of regenerative medicine and covers important vascular topics, including intermittent claudication and critical limb ischemia, with important mechanisms clearly presented in full color images throughout the book. This important reference includes clear and concise information on both human clinical trials, as well as important and pertinent animal studies, and is a must-have reference for researchers and practitioners of peripheral artery disease. Compiles and explains the rationale and history of different regenerative treatment concepts for peripheral artery disease in one reference Presents pertinent animal studies and human clinical trials in the area of regenerative medicine for peripheral arterial disease, addressing both safety and efficacy of the clinical trials Provides full-color images that demonstrate covered mechanisms Includes access to a full-color website for further study

Author : Richard A. Smith,Brian K. Kaspar,Clive N. Svendsen
Publisher : Academic Press
Page : 520 pages
File Size : 51,7 Mb
Release : 2020-11-28
Category : Medical
ISBN : 9780128172742

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Neurotherapeutics in the Era of Translational Medicine by Richard A. Smith,Brian K. Kaspar,Clive N. Svendsen Pdf

For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis?, spinal muscular atrophy, multiple sclerosis, Parkinson’s disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it. Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disorders Discusses important issues in clinical trials such as design and ethical issues Written for neuroscientists, neurologists and pharmacologists

Author : Peter W. Huber
Publisher : Basic Books
Page : 304 pages
File Size : 46,5 Mb
Release : 2013-11-12
Category : Law
ISBN : 9780465069811

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The Cure in the Code by Peter W. Huber Pdf

Never before have two revolutions with so much potential to save and prolong human life occurred simultaneously. The converging, synergistic power of the biochemical and digital revolutions now allows us to read every letter of life's code, create precisely targeted drugs to control it, and tailor their use to individual patients. Cancer, diabetes, Alzheimer's and countless other killers can be vanquished—if we make full use of the tools of modern drug design and allow doctors the use of modern data gathering and analytical tools when prescribing drugs to their patients. But Washington stands in the way, clinging to outdated drug-approval protocols developed decades ago during medicine's long battle with the infectious epidemics of the past. Peter Huber, an expert in science, technology, and public policy, demonstrates why Washington's one-size-fits-all drug policies can't deal with diseases rooted in the complex molecular diversity of human bodies. Washington is ill-equipped to handle the torrents of data that now propel the advance of molecular medicine and is reluctant to embrace the statistical methods of the digital age that can. Obsolete economic policies, often rationalized as cost-saving measures, stifle innovation and suppress investment in the medicine that can provide the best cures at the lowest cost. In the 1980s, an AIDS diagnosis was a death sentence, until the FDA loosened its throttling grip and began streamlining and accelerating approval of life-saving drugs. The Cure in the Code shows patients, doctors, investors, and policy makers what we must now do to capture the full life-saving and cost-saving potential of the revolution in molecular medicine. America has to choose. At stake for America is the power to lead the world in mastering the most free, fecund, competitive, dynamic, and intelligent natural resource on the planet—the molecular code that spawns human life and controls our health.

Author : Adam D.K. Abelkop,Lucas Bergkamp,Lynn L. Bergeson ,Bethami Auerbach
Publisher : Edward Elgar Publishing
Page : 651 pages
File Size : 53,8 Mb
Release : 2023-03-20
Category : Law
ISBN : 9781785360367

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Chemical Risk Governance by Adam D.K. Abelkop,Lucas Bergkamp,Lynn L. Bergeson ,Bethami Auerbach Pdf

This incisive volume of the Elgar Encyclopedia of Environmental Law offers a broad analysis of the foundations, main concepts, and substantive and procedural requirements of selected chemical law regimes as they pertain to the environment. Featuring contributions from more than 40 expert scholars and practitioners in the field, the volume focuses on chemical regulatory systems from representative jurisdictions, including the EU and the US, to provide a coherent overview of this expansive and often fragmented area of law. Divided into five thematic parts, the volume first examines the fundamental concepts of chemical law, addressing topics including risk assessment, nomenclature, environmental justice and animal testing. Entries then discuss types of chemicals and exposures, regulation of chemicals in products and manufacturing, and waste and contamination, as well as covering liability rules as they apply to chemicals. This volume will be an essential resource for scholars and students looking for a clear understanding of chemicals regulation and governance from environmental and public health perspectives at both national and international levels. Its insights into policy developments and liability issues will also be of interest to policymakers and practitioners.

Author : Kristen M. Waterstram-Rich,David Gilmore
Publisher : Elsevier Health Sciences
Page : 696 pages
File Size : 43,5 Mb
Release : 2016-07-30
Category : Medical
ISBN : 9780323400350

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Nuclear Medicine and PET/CT - E-Book by Kristen M. Waterstram-Rich,David Gilmore Pdf

Master the latest imaging procedures and technologies in Nuclear Medicine! Medicine and PET/CT: Technology and Techniques, 8th Edition provides comprehensive, state-of-the-art information on all aspects of nuclear medicine. Coverage of body systems includes anatomy and physiology along with details on how to perform and interpret related diagnostic procedures. The leading technologies — SPECT, PET, CT, MRI, and PET/CT — are presented, and radiation safety and patient care are emphasized. Edited by nuclear imaging and PET/CT educator Kristen M. Waterstram-Rich and written by a team of expert contributors, this reference features new information on conducting research and managing clinical trials. Complete coverage of nuclear medicine eliminates the need to search for information in other sources. Foundations chapters cover basic math, statistics, physics and instrumentation, computers, lab science, radiochemistry, and pharmacology, allowing you to understand how and why procedures are performed. PET/CT focus with hybrid PET/CT studies provides information that is especially beneficial to working technologists. Accessible writing style and approach to basic science subjects simplifies topics, first introducing fundamentals and progressing to more complex concepts. Procedure boxes provide step-by-step instructions for clinical procedures and protocols, so you can perform each with confidence. CT Physics and Instrumentation chapter provides the knowledge needed for clinical success by introducing CT as it is applied to PET imaging for combined PET/CT studies. Key terms, chapter outlines, learning objectives, and suggested readings help you organize your study. Table of Radionuclides used in nuclear medicine and PET is provided in the appendix for quick reference. More than 50 practice problems in the Mathematic and Statistics chapter let you brush up on basic math skills, with answers provided in the back of the book. 12-page, full-color insert includes clear PET/CT scans showing realistic scans found in practice. A glossary provides definitions of key terms and important concepts. UPDATED content reflects the latest advances and provides the information you need to pass the boards. NEW information on conducting research and managing clinical trials prepares you more fully for clinical success. New information on administrative procedures includes coverage of coding and reimbursement. NEW practice tests on the Evolve companion website help you apply your knowledge. NEW! A second color in the design highlights the most important material for easier study and understanding.

Author : Lei Yang,Sarit Bhaduri,Thomas J. Webster
Publisher : Academic Press
Page : 358 pages
File Size : 48,6 Mb
Release : 2018-11-30
Category : Technology & Engineering
ISBN : 9780128134788

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Biomaterials in Translational Medicine by Lei Yang,Sarit Bhaduri,Thomas J. Webster Pdf

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

Author : Institute of Medicine,Committee on Research Capabilities of AcademicDepartments of Obstetrics and Gynecology
Publisher : National Academies Press
Page : 320 pages
File Size : 52,9 Mb
Release : 1992-02-01
Category : Medical
ISBN : 9780309046978

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Strengthening Research in Academic OB/GYN Departments by Institute of Medicine,Committee on Research Capabilities of AcademicDepartments of Obstetrics and Gynecology Pdf

Research conducted in academic departments of obstetrics and gynecology could result in substantial improvements in the health of women and the outcomes of pregnancy. Strengthening Research in Academic OB/GYN Departments determines whether such departments are capable of fulfilling this promise. The committee finds that these departments have a poor track record in their ability to compete for research funds and in the extent to which their faculty contribute to research. Adding to the problem are factors that deter OB/GYNs from a research career and a dearth of dynamic research leaders in the profession. The volume explores reasons for this situation and makes recommendations to counteract them. Also included is an agenda of needed research.

Author : Anonim
Publisher : Nordic Council of Ministers
Page : 126 pages
File Size : 46,5 Mb
Release : 2002
Category : Adhesives
ISBN : 9289308087

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Adhesives in Food Contact Materials and Articles by Anonim Pdf