Acute Lung Injury And Repair

Author : Lynn M. Schnapp,Carol Feghali-Bostwick
Publisher : Humana Press
Page : 185 pages
File Size : 55,8 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9783319465272

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Acute Lung Injury and Repair by Lynn M. Schnapp,Carol Feghali-Bostwick Pdf

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. ​

Author : Geoffrey J. Bellingan,Geoffrey J. Laurent
Publisher : Unknown
Page : 143 pages
File Size : 40,7 Mb
Release : 2000
Category : Lungs
ISBN : OCLC:1164836663

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Acute Lung Injury by Geoffrey J. Bellingan,Geoffrey J. Laurent Pdf

Author : Sadis Matalon,Jacob Iasha Sznajder
Publisher : IOS Press
Page : 320 pages
File Size : 55,5 Mb
Release : 2001
Category : Lungs
ISBN : 158603183X

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Etiology and Treatment of Acute Lung Injury by Sadis Matalon,Jacob Iasha Sznajder Pdf

This book contains contributions of internationally known basic scientists and clinicians with expertise in various aspects of lung injury and repair. This monogram on the pathophysiology and treatment of Acute Lung Injury contains five different sections, each one with contributions from both basic and clinical scientists, outlining existing controversies, an how they can be resolved by future multidisciplinary studies. The various sections discuss: sodium transport and fluid clearance across the normal and injured lungs, the role of the pulmonary surfactant in the pathogenesis and treatment of ARDS, mechanisms and modification of acute and chronic lung injury, ventilatory strategies for the management of acute respiratory distress syndrome and nitric oxide: friend or foe.

Author : Didier Dreyfuss,Georges Saumon,Rolf Hubmayr
Publisher : CRC Press
Page : 776 pages
File Size : 55,9 Mb
Release : 2006-03-21
Category : Medical
ISBN : 9781420019261

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Ventilator-Induced Lung Injury by Didier Dreyfuss,Georges Saumon,Rolf Hubmayr Pdf

This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Cons

Author : Ronald G. Crystal,John Burnard West
Publisher : Lippincott Williams & Wilkins
Page : 424 pages
File Size : 55,7 Mb
Release : 1992
Category : Interventional radiology
ISBN : UOM:39015024778956

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Lung Injury by Ronald G. Crystal,John Burnard West Pdf

A comprehensive review of lung injury, defence and repair and therapeutic interventions. The text focuses on clinically relevant issues such as infections and host defences, immune injury, airborne contaminants, acute lung injury, injury from drugs, fibrotic processes and genetic modulation.

Author : Robert H. Notter,Jacob Finkelstein,Bruce Holm
Publisher : CRC Press
Page : 888 pages
File Size : 50,8 Mb
Release : 2005-04-20
Category : Medical
ISBN : 0824757939

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Lung Injury by Robert H. Notter,Jacob Finkelstein,Bruce Holm Pdf

Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and other subacute and chronic conditions. Additional chapters also address vascular dysfunction, surfactant dysfunction, reactive oxygen/nitrogen species, and cell and animal models of acute and chronic lung injury.

Author : J.J. Marini,Timothy W. Evans
Publisher : Springer Science & Business Media
Page : 466 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642607332

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Acute Lung Injury by J.J. Marini,Timothy W. Evans Pdf

To integrate current knowledge in terms of basic and clinical science and to highlight problems, thirty world-renowned experts in the field of acute lung injury describe the state of up to date knowledge regarding the epidemiology, pathophysiology, and clinical management of acute lung injury. Novel techniques for the clinical support of these difficult patients are discussed in full. Prospects for successful pharmacological intervention are also outlined. This book is aimed at those practising within the field of critical care and is likely to become an indispensable aid to all concerned with the investigation and management of patients with severe respiratory failure.

Author : Michael Kasper,Christian Mühlfeld
Publisher : Unknown
Page : 222 pages
File Size : 55,5 Mb
Release : 2020
Category : Electronic
ISBN : 3039431676

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The Alveolar Epithelium by Michael Kasper,Christian Mühlfeld Pdf

Alveolar epithelial cells (AECs) of the lung are important contributors to pulmonary immune functions and to pulmonary development and alveolar repair mechanisms following lung injury. AECI, together with the capillary endothelium, form the extremely thin barrier between alveolar air and blood. AECII produce and metabolize the surface-tension lowering and immune-modulating surfactant and are the progentiors of AECI. A great variety of processes rely on their normal functioning, including maintenance of the alveolar barrier; innate immune defense; and processes of differentiation, senescence, apoptosis, and autophagy. The wide range of AEC functions is nicely reflected by the diversity of topics addressed by the four review and eight original articles contained in this Special Issue of the International Journal of Molecular Sciences. Beyond the broad spectrum of topics, the authors of this issue also made use of an impressive variety of analytical methods, thus further illustrating the fascinating diversity of aspects related to AEC biology.

Author : Michael A. Matthay
Publisher : CRC Press
Page : 592 pages
File Size : 44,6 Mb
Release : 2003-07-11
Category : Medical
ISBN : 9780203912034

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Acute Respiratory Distress Syndrome by Michael A. Matthay Pdf

Forty-seven international specialists contribute 23 chapters documenting recent progress made in the research of the acute respiratory distress syndrome (ARDS) and clinical acute lung injury (ALI) at the molecular, cellular, and physiological levels, and current pharmacological and ventilatory appro

Author : Robert H. Notter,Jacob Finkelstein,Bruce Holm
Publisher : CRC Press
Page : 888 pages
File Size : 49,5 Mb
Release : 2005-04-20
Category : Medical
ISBN : 1135521980

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Lung Injury by Robert H. Notter,Jacob Finkelstein,Bruce Holm Pdf

Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and other subacute and chronic conditions. Additional chapters also address vascular dysfunction, surfactant dysfunction, reactive oxygen/nitrogen species, and cell and animal models of acute and chronic lung injury.

Author : Augustine M.K. Choi
Publisher : CRC Press
Page : 478 pages
File Size : 54,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420088410

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Acute Respiratory Distress Syndrome by Augustine M.K. Choi Pdf

The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS).Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS.Highlights include:the definition,

Author : Timothy W. Evans,C. Haslett
Publisher : Springer
Page : 537 pages
File Size : 53,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489934307

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ARDS Acute Respiratory Distress in Adults by Timothy W. Evans,C. Haslett Pdf

Great progress has been made since the first description of the acute respiratory distress syndrome by the Denver group in 1967 (Lancet). Although we introduced the term 'adult respiratory distress syndrome' in our second and more detailed description of the syndrome (ehest, 1971), this was probably amistake for the simple reason that children also suffer the same syndrome fo11owing acute lung insults. Today, the syndrome of acute respiratory distress in adults (ARDS) is recognized as a worldwide problem, but the prevalence of disease varies in different parts of the world. A huge amount of research has focused on the mechanisms of acute lung injury and yet the exact sequence of events and media tors in inflammatory cascade, which result in acute respiratory failure from ARDS, is not known but many possibilities exist. The definition of ARDS has been gradua11y modified in recent years and investigators around the world are now co11aborating in order to establish more uniform concepts in identification, risk factors and mechanisms of lung injury, which someday will result in improved approaches to management. Already, at least some centers are showing improved outcomes in ARDS, achieving an approximate 60% survival rate. In the past, most large series documented only about a 40% survivability taking a11 causes of ARDS. This apparent progress is likely attributable to more meticulous and disciplined care than any specific pharmacologic attack on the basic mechanism resulting in ARDS.

Author : Ian McConachie
Publisher : Cambridge University Press
Page : 453 pages
File Size : 46,8 Mb
Release : 2006-01-12
Category : Medical
ISBN : 9780521678575

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Handbook of ICU Therapy by Ian McConachie Pdf

Handbook of ICU Therapy provides rapid access to important information on the treatment of the critically ill patient. It comprises a series of 'cutting edge' reviews of the most advanced treatment concepts available in the modern ICU. Whilst assuming a basic knowledge of underlying conditions, it nonetheless outlines key physiological principles where necessary, and critically reviews current literature and best practice. The heart of the book is aimed at providing key practical information on treatment techniques to the busy clinician in an easily accessible style. In addition to conventional drug therapy, ventilator, fluid and physical therapies are also discussed in detail. All of the authors are directly involved in ICU research and practice and are familiar with all of the latest developments in this fast-moving field of medicine.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 48,6 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Violet Murphy
Publisher : American Medical Publishers
Page : 0 pages
File Size : 42,7 Mb
Release : 2023-09-19
Category : Medical
ISBN : 9798887405681

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Acute Lung Injury: Pathophysiology, Prevention and Treatment by Violet Murphy Pdf

Acute lung injury (ALI) is a form of acute respiratory failure that causes disruption of epithelial and endothelial barriers in the lungs. The severe form of acute lung injury manifests as adult respiratory distress syndrome (ARDS). Some common symptoms of acute lung injury are severe dyspnoea, tachypnoea, and resistant hypoxaemia, bowel perforation, and sepsis syndrome. Appropriate diagnostic tests such as blood or urine cultures, and bronchoalveolar lavage are performed for examining a patient for underlying conditions, particularly pneumonia, sepsis, pancreatitis or transfusion related lung injury. Treatment strategy for acute lung injury consists of treatment of the underlying disease, mechanical ventilation for elimination of carbon dioxide and securing oxygenation, and adjunctive procedures for treating specific pulmonary pathologies. This book outlines the pathophysiology, prevention and treatment of acute lung injury in detail. A number of latest researches have been included to keep the readers up-to-date with the global concepts in this area of medicine. Students, researchers, experts and all associated with the study of this medical condition will benefit alike from this book.