Adenosine And Adenine Nucleotides From Molecular Biology To Integrative Physiology

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Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology

Luiz Belardinelli,A. Pelleg
Adenosine and Adenine Nucleotides From Molecular Biology to Integrative Physiology Book PDF

Author : Luiz Belardinelli,A. Pelleg
Publisher : Springer Science & Business Media
Page : 515 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461520115

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Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology by Luiz Belardinelli,A. Pelleg Pdf

This book contains a selection of lectures given during the 5th International Symposium on Adenosine and Adenine Nucleotides, recently held in Philadelphia, Pennsylvania. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology covers a wide range of subjects from molecular and cellular biology to clinical applications. A great emphasis has been placed on cutting edge information derived from studies using molecular and cellular biology techniques applied to the field of adenosine and adenine nucleotide research. The book also includes information on potentially promising developments in the therapeutic applications of adenosine related drugs and ATP. The tradition of past meetings is also maintained by including in the program presentations of new research in the areas of purine metabolism and physiology, and pharmacology of adenosine and adenine nucleotides. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology is an excellent, up-to-date reference book for basic and clinical scientists in the field of adenosine and adenine nucleotides.

Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Morris Karmazyn
Myocardial Ischemia Mechanisms Reperfusion Protection Book PDF

Author : Morris Karmazyn
Publisher : Springer Science & Business Media
Page : 538 pages
File Size : 43,7 Mb
Release : 1996-08-28
Category : Medical
ISBN : 3764352698

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Myocardial Ischemia: Mechanisms, Reperfusion, Protection by Morris Karmazyn Pdf

Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.

New Concepts in Cerebral Ischemia

Rick C. S. Lin
New Concepts in Cerebral Ischemia Book PDF

Author : Rick C. S. Lin
Publisher : CRC Press
Page : 328 pages
File Size : 54,7 Mb
Release : 2001-12-21
Category : Medical
ISBN : 9781420042184

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New Concepts in Cerebral Ischemia by Rick C. S. Lin Pdf

Approximately half a million Americans suffer brain ischemic episodes every year. These brain strokes are the third leading cause of death in the United States and the number-one cause of permanent disability. Over the past decade, we have made extensive attempts to understand the biological mechanisms that underlie stroke-induced neuronal injury.

Cardiovascular Biology of Purines

Geoffrey Burnstock,James G. Dobson Jr.,Bruce T. Liang,Joel Linden
Cardiovascular Biology of Purines Book PDF

Author : Geoffrey Burnstock,James G. Dobson Jr.,Bruce T. Liang,Joel Linden
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461556039

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Cardiovascular Biology of Purines by Geoffrey Burnstock,James G. Dobson Jr.,Bruce T. Liang,Joel Linden Pdf

Following many years when a great deal of attention was directed towards the intracellular roles of purines, there is expanding interest in the field of extracellular purinergic signalling. In this book we focus on the actions of purines in cardiovascular biology, where it is clear that they play major roles in both normal and pathophysiological conditions. Activation of different purinoceptor subtypes by purines can regulate cardiac contractility and electrical activity, modulate catecholamine-mediated responses both pre- and post-junctionally, trigger and mediate ischaemic preconditioning, cause vasodilation and vasoconstriction and enhance endothelial proliferation and apoptosis as well as inhibit platelet and neutrophil function. This book covers the cardiovascular actions mediated by the major P1 and P2 subclasses of purinoceptors and emphasizes the interactions between these two signalling systems. Cardiovascular Biology of Purines covers topics ranging from molecular and cellular to systemic and clinical. It also aims to highlight how basic advances have led to the identification of novel targets for cardiovascular therapeutic developments. We hope that our book will prove to be timely and helpful.

P2 Purinoceptors

Derek J. Chadwick,Jamie A. Goode
P2 Purinoceptors Book PDF

Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 346 pages
File Size : 47,9 Mb
Release : 2008-04-30
Category : Nature
ISBN : 9780470514917

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P2 Purinoceptors by Derek J. Chadwick,Jamie A. Goode Pdf

Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.

Whole Organ Approaches to Cellular Metabolism

James Bassingthwaighte,Carl A. Goresky,John H. Linehan
Whole Organ Approaches to Cellular Metabolism Book PDF

Author : James Bassingthwaighte,Carl A. Goresky,John H. Linehan
Publisher : Springer Science & Business Media
Page : 576 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461221845

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Whole Organ Approaches to Cellular Metabolism by James Bassingthwaighte,Carl A. Goresky,John H. Linehan Pdf

The field of capillary-tissue exchange physiology has been galvanized twice in the past 25 years. A 1969 conference at the National Academy of Sciences in Copenhagen resulted in the book Capillary Permeability: The Transfer of Mole cules and Ions Between the Capillary Blood and the Tissue (Crone and Lassen, 1970). It focused on the physiochemical aspects of transcapillary water and solute transport. The field has matured considerably since. This volume was designed as the successor to the 1970 book, and was created at a gathering of the authors at McGill University. It too captures the breadth of a field that has been dramatically enriched by numerous technical and conceptual advances. In 1970 it was already known that the capillary wall was not merely a "cellophane bag" exerting steric hindrances on solute particles. Instead, the endothelial surface was recognized as the site of binding reactions and permeation by passive or carrier-mediated trans port. Furthermore, the cells of the blood could traverse evanescent wide openings in the "zippered" clefts. Today, research priorities have turned more to cell-cell interactions, toward understanding the utility of the gap junctional connections between endothelial cells and neighboring smooth muscle cells, neuronal twigs, and the parenchymal cells of organs. New discoveries in the past few years have revealed the critical importance of the close relationships between the endothelial cells and the parenchymal cells.

Purine and Pyrimidine Metabolism in Man X

Esther Zoref-Shani,Oded Sperling
Purine and Pyrimidine Metabolism in Man X Book PDF

Author : Esther Zoref-Shani,Oded Sperling
Publisher : Springer Science & Business Media
Page : 406 pages
File Size : 46,7 Mb
Release : 2001-01-31
Category : Science
ISBN : 9780306465154

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Purine and Pyrimidine Metabolism in Man X by Esther Zoref-Shani,Oded Sperling Pdf

th This volume contains articles presented at the X International Symposium on Purines and Pyrimidines in Man, held on May 14 19, 2000 in Tel Aviv, Israel. The first symposium in this series took place in Tel Aviv in 1973. Since then, the symposium has been held every three years in different parts of the world, including Europe, USA and Japan. The participants, in this series of symposia, are characterised by a wide interest in the various aspects of purines and pyrimidines in man, which include biochemistry, genetics, pharmacology, physiology, clinics, etc. Presentations in the symposia include clarification of metabolic pathways, characterisation of enzyme structure and kinetics and discoveries of new inborn errors of metabolism and suggestions for new therapeutic approaches for these inborn errors. In addition, development of new purine and pyrimidine derivatives for the treatment of cancer and viral diseases, and many more subjects of mutual interest were brought to the fore. With the development of therapeutic means and of new research tools, we have witnessed changes in the areas of interest. The interest in gout and uric acid urolithiasis has lessened, whereas molecular aspects, the role of purine and pyrimidine substances in neurotransmission and in purinergic signaling appear to gain greater interest. The articles, included in this volume, contain new data pertaining to the various aspects detailed above.

Nucleotides and their Receptors in the Nervous System

P. Illes,H. Zimmermann
Nucleotides and their Receptors in the Nervous System Book PDF

Author : P. Illes,H. Zimmermann
Publisher : Elsevier
Page : 429 pages
File Size : 43,8 Mb
Release : 1999-08-31
Category : Science
ISBN : 0080862454

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Nucleotides and their Receptors in the Nervous System by P. Illes,H. Zimmermann Pdf

The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated. Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metabolizing ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides. At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide. An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.

Perspectives in Receptor Research

Dario Giardina,Alessandro Piergentili,Maria Pigini
Perspectives in Receptor Research Book PDF

Author : Dario Giardina,Alessandro Piergentili,Maria Pigini
Publisher : Elsevier
Page : 422 pages
File Size : 51,6 Mb
Release : 1996-06-07
Category : Electronic
ISBN : 0080545017

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Perspectives in Receptor Research by Dario Giardina,Alessandro Piergentili,Maria Pigini Pdf

Perspectives in Receptor Research

The P2 Nucleotide Receptors

John T. Turner,Gary A. Weisman,Jeffrey S. Fedan
The P2 Nucleotide Receptors Book PDF

Author : John T. Turner,Gary A. Weisman,Jeffrey S. Fedan
Publisher : Springer Science & Business Media
Page : 439 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461218005

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The P2 Nucleotide Receptors by John T. Turner,Gary A. Weisman,Jeffrey S. Fedan Pdf

A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.

Purinergic Signalling and the Nervous System

Geoffrey Burnstock,Verkhratsky Alexei
Purinergic Signalling and the Nervous System Book PDF

Author : Geoffrey Burnstock,Verkhratsky Alexei
Publisher : Springer Science & Business Media
Page : 724 pages
File Size : 49,8 Mb
Release : 2012-06-05
Category : Medical
ISBN : 9783642288630

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Purinergic Signalling and the Nervous System by Geoffrey Burnstock,Verkhratsky Alexei Pdf

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

Adenosine Receptors in Health and Disease

Constance N. Wilson,S. Jamal Mustafa
Adenosine Receptors in Health and Disease Book PDF

Author : Constance N. Wilson,S. Jamal Mustafa
Publisher : Springer Science & Business Media
Page : 656 pages
File Size : 46,7 Mb
Release : 2009-07-28
Category : Medical
ISBN : 9783540896159

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Adenosine Receptors in Health and Disease by Constance N. Wilson,S. Jamal Mustafa Pdf

Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Purinergic and Pyrimidinergic Signalling II

Maria P. Abracchio,Michael Williams
Purinergic and Pyrimidinergic Signalling II Book PDF

Author : Maria P. Abracchio,Michael Williams
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642569210

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Purinergic and Pyrimidinergic Signalling II by Maria P. Abracchio,Michael Williams Pdf

Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.

Purinergic and Pyrimidinergic Signalling

Maria P. Abracchio,Michael Williams
Purinergic and Pyrimidinergic Signalling Book PDF

Author : Maria P. Abracchio,Michael Williams
Publisher : Springer Science & Business Media
Page : 544 pages
File Size : 49,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662096048

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Purinergic and Pyrimidinergic Signalling by Maria P. Abracchio,Michael Williams Pdf

Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.

Cardiac Electrophysiology

Milind G. Parikh
Cardiac Electrophysiology Book PDF

Author : Milind G. Parikh
Publisher : Springer Nature
Page : 335 pages
File Size : 46,6 Mb
Release : 2022-02-17
Category : Medical
ISBN : 9783030753269

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Cardiac Electrophysiology by Milind G. Parikh Pdf

This book offers a comprehensive review of clinical cardiac electrophysiology in a question and answer format. Chapters contain over 200 questions divided into 9 chapters, each organized by cardiac electrophysiology topic. Each question is followed by the correct answer with a detailed explanation along with references for further reading. Important concepts are highlighted and supported by over 200 illustrations and high resolution images. The book addresses a broad range of topics that are important when studying for the initial certification or recertification of the clinical cardiac electrophysiology board examination. It is also highly relevant for daily clinical practice in cardiology and cardiac electrophysiology. Topics covered in the book include: Review of basic and clinical cardiac electrophysiology principles associated with cardiac arrhythmias The evaluation and management of patients with cardiac rhythm disorders Review of pharmacologic and nonpharmacologic therapies for the treatment of arrhythmias Clinical indications, fundamental principles and electrical characteristics of implantable cardiac electronic devices such as pacemakers and defibrillators Clinical, electrocardiographic, and electrophysiologic characteristics of specific cardiac arrhythmia syndromes Cardiac Electrophysiology Board Review is a must-have resource for cardiology and cardiac electrophysiology trainees as well as attending physicians preparing for the certification or recertification examination. It may also be a useful guide for cardiologists, cardiac electrophysiologists and all clinicians who wish to further their understanding of heart rhythm disorders.