Adhesion Gpcrs

Author : Simon Yona,Martin Stacey
Publisher : Springer Science & Business Media
Page : 216 pages
File Size : 45,9 Mb
Release : 2011-06-26
Category : Medical
ISBN : 9781441979131

Get Book

Adhesion‐GPCRs by Simon Yona,Martin Stacey Pdf

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

Author : Tobias Langenhan,Torsten Schöneberg
Publisher : Springer
Page : 403 pages
File Size : 50,7 Mb
Release : 2016-11-09
Category : Medical
ISBN : 9783319415239

Get Book

Adhesion G Protein-coupled Receptors by Tobias Langenhan,Torsten Schöneberg Pdf

Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.

Author : Beata Jastrzebska,Paul S.-H. Park
Publisher : Academic Press
Page : 500 pages
File Size : 49,8 Mb
Release : 2019-09-11
Category : Science
ISBN : 9780128167281

Get Book

GPCRs by Beata Jastrzebska,Paul S.-H. Park Pdf

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer’s disease, Parkinson’s disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth. Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology

Author : Sandra Siehler,Graeme Milligan
Publisher : Cambridge University Press
Page : 447 pages
File Size : 47,7 Mb
Release : 2010-09-30
Category : Medical
ISBN : 9781139491747

Get Book

G Protein-Coupled Receptors by Sandra Siehler,Graeme Milligan Pdf

Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.

Author : Anonim
Publisher : Elsevier
Page : 194 pages
File Size : 52,8 Mb
Release : 2023-01-25
Category : Science
ISBN : 9780323994354

Get Book

G Protein-Coupled Receptors - Part B by Anonim Pdf

G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more. Covers a broad range of topics related to GPCR activation and signaling Provides several receptor systems, with an emphasis on emerging paradigms Includes different processes and model systems, with a focus on GPCRs

Author : Anonim
Publisher : ScholarlyEditions
Page : 189 pages
File Size : 40,9 Mb
Release : 2013-06-21
Category : Science
ISBN : 9781481689724

Get Book

Membrane Proteins—Advances in Research and Application: 2013 Edition by Anonim Pdf

Membrane Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Membrane Transport Proteins. The editors have built Membrane Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Membrane Transport Proteins in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Membrane Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Siamon Gordon
Publisher : John Wiley & Sons
Page : 892 pages
File Size : 55,8 Mb
Release : 2020-07-10
Category : Science
ISBN : 9781555819194

Get Book

Myeloid Cells in Health and Disease by Siamon Gordon Pdf

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.

Author : Anonim
Publisher : Academic Press
Page : 192 pages
File Size : 41,6 Mb
Release : 2009-09-19
Category : Science
ISBN : 0080911943

Get Book

G Protein-Coupled Receptors in Health and Disease by Anonim Pdf

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field. * This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 45,8 Mb
Release : 19??
Category : Electronic
ISBN : 1461464382

Get Book

Encyclopedia of Signaling Molecules by Anonim Pdf

Author : Jackson Cioni Bittencourt,Giovanne B. Diniz,David Lovejoy,Herbert Herzog
Publisher : Frontiers Media SA
Page : 146 pages
File Size : 51,7 Mb
Release : 2021-08-25
Category : Science
ISBN : 9782889712229

Get Book

The Phylogenetic History of Hypothalamic Neuromodulators by Jackson Cioni Bittencourt,Giovanne B. Diniz,David Lovejoy,Herbert Herzog Pdf

Author : Zsolt Lele,Robert Hindges
Publisher : Frontiers Media SA
Page : 143 pages
File Size : 53,5 Mb
Release : 2023-02-09
Category : Science
ISBN : 9782832514214

Get Book

Cell adhesion molecules in neural development and disease by Zsolt Lele,Robert Hindges Pdf

Author : Krishna C. Persaud,Santiago Marco,Agustin Gutierrez-Galvez
Publisher : CRC Press
Page : 237 pages
File Size : 42,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439871720

Get Book

Neuromorphic Olfaction by Krishna C. Persaud,Santiago Marco,Agustin Gutierrez-Galvez Pdf

Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p

Author : Robert Laprairie
Publisher : Academic Press
Page : 214 pages
File Size : 42,9 Mb
Release : 2022-02-05
Category : Business & Economics
ISBN : 9780128197721

Get Book

Allosteric Modulation of G Protein-Coupled Receptors by Robert Laprairie Pdf

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not – as we once believed – unique to a few receptor subfamilies. Introduces background on core concepts of molecular pharmacology, including statistical analyses, non-linear regression, complex models and GPCR-dependent signal transduction as they relate to allosteric modulation Discusses critical advances and landmark studies, including discoveries in the area of GPCR allosteric modulation, which are reviewed for their importance in positive and negative regulation, protein-protein interactions, and small molecule drug discovery Includes key methodologies used to study allosteric modulation at the in silico, in vitro, and in vivo levels of drug discovery and characterization

Author : Anonim
Publisher : Academic Press
Page : 398 pages
File Size : 44,5 Mb
Release : 2017-09-23
Category : Medical
ISBN : 9780128124048

Get Book

G Protein-Coupled Receptors in Immune Response and Regulation by Anonim Pdf

G Protein-Coupled Receptors in Immune Response and Regulation, Volume 136 presents emerging concepts related to the role of GPCRs in immune response and regulation. Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G protein signaling (RGS) proteins in the immune system, information on Kinin receptors in immune response and pathogenic infections, and sections on GPCR signaling in C. elegans and its implications in immune response, GPCR Kinases in Inflammatory response and signaling, and GRK2 in Inflammation: Regulation of T cell receptors and IgE signaling. Chapters in this book discuss not only the well-known aspects of GPCR signaling in immunology, but also presents many emerging paradigms that have not yet been reported in classical textbooks. Each chapter presents a forward-looking discussion, providing a glimpse of the tremendous potential associated with the specific receptor systems discussed. Brings together contributions from leading experts in the area of GPCR biology Discusses current paradigms and the future potential of understanding GPCR signaling in immune response and regulation Presents the first of its kind book to focus on specific GPCR systems in various aspects of immunology, all brought together in one volume

Author : Anonim
Publisher : ScholarlyEditions
Page : 425 pages
File Size : 53,7 Mb
Release : 2012-12-26
Category : Science
ISBN : 9781464993732

Get Book

Advances in Extracellular Space Research and Application: 2012 Edition by Anonim Pdf

Advances in Extracellular Space Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Extracellular Space. The editors have built Advances in Extracellular Space Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Extracellular Space in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Extracellular Space Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.