Adp Ribosylating Toxins

Author : Klaus Aktories
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642769665

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ADP-Ribosylating Toxins by Klaus Aktories Pdf

ADP-ribosylating toxins have been the focus of intensive research for more than 30 years. Researchers from diverse fields of science have taken an interest in these bacterial toxins; they are studied, for example, by microbiologists, biochemists, cell biologists, and pharmacologists. There are two principal reasons for the broad and still growing interest in ADP ribosylating toxins. First, insights into the structure and functions of the toxins might be the key to prevention and treatment of diseases caused by the toxin-producing infectious micro organisms. Second, the ADP-ribosylating toxins provide potent and often unique pharmacological tools for the study of the physiological functions of their target proteins. The latter is especially the case with cholera and pertussis toxins, which both modify the IX-subunits of heterotrimeric G-proteins involved in signal transduction pathways. These toxins have proved invaluable in extending our basic understanding of the regulation of hormone-controlled signal transduction. This volume provides a review and an update of recent studies on the basic properties of bacterial ADP-ribosylating tbxins and/or exoenzymes. Our current knowledge of the cel lular entry mechanisms of ADP-ribosylating toxins is reviewed by MADSHUS and STENMARK. WILSON and COLLIER then deal with recent insights into the enzyme mechanism and active site structure of diphtheria toxin and Pseudomonas aeruginosa exotoxin A, which modify elongation factor 2. Toxins which ADP-ribosylate heterotrimeric G-proteins involved in trans membrane signal transduction are the subject of the next two chapters.

Author : Joel Moss,Martha Vaughan
Publisher : ASM Press
Page : 594 pages
File Size : 54,9 Mb
Release : 1990
Category : ADP-ribosylation
ISBN : UOM:39015024999255

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ADP-ribosylating Toxins and G Proteins by Joel Moss,Martha Vaughan Pdf

Twenty-eight contributions topics and authors spanning the disciplines of microbiology, biochemistry, molecular biology, and medicine present what is known in an area that has important implications for aspects of biomedical research. Investigations of the mechanisms of action of the ADP-ribosylatin

Author : Klaus Aktories
Publisher : Unknown
Page : 164 pages
File Size : 40,9 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 3642769675

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Adp-Ribosylating Toxins by Klaus Aktories Pdf

Author : Friedrich Koch-Nolte
Publisher : Springer
Page : 213 pages
File Size : 44,8 Mb
Release : 2014-10-29
Category : Medical
ISBN : 3319107720

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Endogenous ADP-Ribosylation by Friedrich Koch-Nolte Pdf

This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections: · Evolution and detection of endogenous ADP-ribosylation · ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs) · ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs) The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.

Author : Otto Holst
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 44,6 Mb
Release : 2008-02-05
Category : Science
ISBN : 9781592590520

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Bacterial Toxins by Otto Holst Pdf

The interest of investigators across a broad spectrum of scientific dis- plines has been steadily stimulated by the field of bacterial toxin research, an area that makes use of a large variety of biological, chemical, physicochemical, and medically oriented approaches. Researchers studying bacterial toxins need to be acquainted with all these disciplines in order to work effectively in the field. To date, there has been no published collection offering detailed descr- tions of the techniques and methods needed by researchers operating across the field’sdiverse areas. The present volume Bacterial Toxins: Methods and Pro- cols, is intended to fill this gap. Bacterial Toxins: Methods and Protocols consists of two sections: one on protein toxins (15 chapters) and one on endotoxins (5 chapters). Each s- tion is introduced by an overview article (Chapters 1 and 16). The protocols collected represent state-of-the-art techniques that each have high impact on future bacterial toxin research. All methods are described by authors who have regularly been using the protocol in their own laboratories. Included in each chapter is a brief introduction to the method being described.

Author : Yehuda Gutman,Philip Lazarovici
Publisher : CRC Press
Page : 520 pages
File Size : 49,9 Mb
Release : 1997-05-22
Category : Science
ISBN : 9057020785

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Toxins and Signal Transduction by Yehuda Gutman,Philip Lazarovici Pdf

Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters, growth factors, and other mediators). Up-to-date information is provided by outstanding experts, who discuss the molecular mechanisms involved in the action of many toxins, as well as the use of toxins as informative tools with which to study signal transduction and their potential therapeutic usage. This volume contains useful information for the experimentalist interested in toxins or in signal transduction, as well as for the reader interested in gaining a comprehensive overview of the field. The Cellular and Molecular Mechanisms of Toxin Action series will include monographs on signal transduction, secretory systems, cytoskeleton, selective neurotoxicity of natural, recombinant and chimeric toxins giving a broader emphasis on the mechanism of action, structure-function relationship, and use of toxins as research tools and their therapeutic applications.

Author : Klaus Aktories
Publisher : John Wiley & Sons
Page : 334 pages
File Size : 45,5 Mb
Release : 2008-09-26
Category : Science
ISBN : 9783527614608

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Bacterial Toxins by Klaus Aktories Pdf

This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.

Author : John Middlebrook
Publisher : Elsevier
Page : 389 pages
File Size : 50,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323141338

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Receptor-Mediated Binding and Internalization of Toxins and Hormones by John Middlebrook Pdf

Receptor-Mediated Binding and Internalization of Toxins and Hormones presents the proceedings of a conference conducted for the purpose of exploring relationships between hormones and toxins, specifically, receptor-mediated internalization of toxins and hormones and the role of this internalization in message transmission and biodegradatory processes. This book is divided into three sections, with the first focusing on model systems of internalization. It presents pictorial illustrations of the receptor-mediated endocytosis of low-density lipoprotein via coated regions of membrane and discusses the receptor for lysosomal enzymes on the surface of cultured fibroblasts. The second section focuses on toxins and hormones and discusses such topics as receptor-mediated internalization of diphtheria toxin, diphtheria toxin interactions with an inhibitory activity from plasma membranes, and uptake mechanisms for ADP-ribosylating toxins. The third and final section focuses on hybrids and discusses such topics as chimeric toxins containing fragment A from diphtheria toxin, directed entry of hybrid proteins into cells via alternate receptors, and a hybrid protein of monoclonal anti-THY 1.2 and diphtheria toxin fragment A. This book will be of interest to practitioners in the fields of endocrinology, cell biology, and molecular genetics.

Author : Moss
Publisher : CRC Press
Page : 660 pages
File Size : 47,8 Mb
Release : 1995-03-21
Category : Medical
ISBN : 0824793811

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Handbook of Natural Toxins by Moss Pdf

This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria, cholera, pertussis, shigellosis, tetanus, botulism and anthrax, are discussed.;The work is aimed at microbiologists, biochemists, endocrinologists, toxicologists, infectious disease specialists, pathologists, public health officials, and upper-level undergraduate and graduate students in these disciplines.

Author : Holger Barth
Publisher : Springer
Page : 256 pages
File Size : 51,7 Mb
Release : 2017-12-01
Category : Medical
ISBN : 9783319588933

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Uptake and Trafficking of Protein Toxins by Holger Barth Pdf

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

Author : K. Aktories,I. Just
Publisher : Springer Science & Business Media
Page : 713 pages
File Size : 51,6 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783662059715

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Bacterial Protein Toxins by K. Aktories,I. Just Pdf

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Author : P. Cohen,S. Van Heyningen
Publisher : Elsevier
Page : 387 pages
File Size : 53,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780444600974

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Molecular Action of Toxins and Viruses by P. Cohen,S. Van Heyningen Pdf

Molecular Action of Toxins and Viruses investigates the molecular action of bacterial toxins and viruses and its striking similarity to the mechanisms by which many neural and hormonal stimuli control normal cell functions. Topics covered include the biological activity of diphteria toxin; the role of cholera toxin in the regulation of hormone-sensitive adenylate cyclase; toxic lectins and related proteins; and bacterial cytolysins (membrane-damaging toxins). Comprised of nine chapters, this volume begins with a discussion on the biosynthesis and biological activity of diphtheria toxin, toxin-resistant mutant cells, and the entry of toxin into cells and fragment A in the cytoplasm of living cells. The reader is then systematically introduced to the use of cholera toxin as a probe to study the regulation and interaction of adenylate cyclase components; the toxic action of lectins and related proteins such as abrin, ricin, and modeccin; and the ability of bacterial cytolysins to damage cell membranes. The remaining chapters focus on the mechanism of action of colicin E2, colicin E3, and cloacin DF13; similarities in the action of different bacterial toxins; the role of cell membranes in infection with bacterial viruses and colicins; and the life cycle and infection mechanisms of bacteriophage T4. The book concludes with an analysis of the involvement of protein kinases in viral transformation. This monograph will be of interest to students, practitioners, and researchers in fields ranging from molecular biology and biochemistry to cell biology, bacteriology, and physiology.

Author : Rino Rappuoli,Cesare Montecucco
Publisher : OUP Oxford
Page : 278 pages
File Size : 43,8 Mb
Release : 1997-05-29
Category : Medical
ISBN : 9780191547287

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Guidebook to Protein Toxins and Their Use in Cell Biology by Rino Rappuoli,Cesare Montecucco Pdf

Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.

Author : Friedrich Haag,Friedrich Koch-Nolte
Publisher : Springer Science & Business Media
Page : 463 pages
File Size : 54,8 Mb
Release : 2012-02-02
Category : Science
ISBN : 9781441986320

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ADP-Ribosylation in Animal Tissues by Friedrich Haag,Friedrich Koch-Nolte Pdf

Proceedings of an international workshop held in Hamburg, Germany, May 19-23, 1996

Author : Klaus Aktories,Ingo Just
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 50,5 Mb
Release : 2007-05-02
Category : Medical
ISBN : 9783540271154

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Special Issue on Emerging Bacterial Toxins by Klaus Aktories,Ingo Just Pdf

With contributions by numerous experts