Advances In Combinatorial Chemistry And High Throughput Screening

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Advances in Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu
Advances in Combinatorial Chemistry High Throughput Screening Book PDF

Author : Rathnam Chaguturu
Publisher : Bentham Science Publishers
Page : 274 pages
File Size : 45,9 Mb
Release : 2013-08-06
Category : Science
ISBN : 9781608057450

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Advances in Combinatorial Chemistry & High Throughput Screening by Rathnam Chaguturu Pdf

Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). A wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers – including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.

Advances in Combinatorial Chemistry and High Throughput Screening

Rathnam Chaguturu
Advances in Combinatorial Chemistry and High Throughput Screening Book PDF

Author : Rathnam Chaguturu
Publisher : Unknown
Page : 128 pages
File Size : 43,9 Mb
Release : 2024-07-01
Category : Electronic book
ISBN : OCLC:1066437906

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Advances in Combinatorial Chemistry and High Throughput Screening by Rathnam Chaguturu Pdf

Annotation Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). a wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers - including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.

Advances in Drug Discovery Techniques

Alan L. Harvey
Advances in Drug Discovery Techniques Book PDF

Author : Alan L. Harvey
Publisher : CRC Press
Page : 232 pages
File Size : 54,9 Mb
Release : 1998-08-15
Category : Medical
ISBN : 0471975095

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Advances in Drug Discovery Techniques by Alan L. Harvey Pdf

A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.

High-Throughput Synthesis

Irving Sucholeiki
High Throughput Synthesis Book PDF

Author : Irving Sucholeiki
Publisher : CRC Press
Page : 398 pages
File Size : 45,7 Mb
Release : 2001-02-22
Category : Science
ISBN : 1420056514

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High-Throughput Synthesis by Irving Sucholeiki Pdf

An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail.

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

Taosheng Chen
A Practical Guide to Assay Development and High Throughput Screening in Drug Discovery Book PDF

Author : Taosheng Chen
Publisher : CRC Press
Page : 291 pages
File Size : 41,5 Mb
Release : 2009-12-21
Category : Medical
ISBN : 9781420070514

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A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery by Taosheng Chen Pdf

The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P

Combinatorial Chemistry

Willi Bannwarth,Berthold Hinzen
Combinatorial Chemistry Book PDF

Author : Willi Bannwarth,Berthold Hinzen
Publisher : John Wiley & Sons
Page : 694 pages
File Size : 55,5 Mb
Release : 2006-05-12
Category : Science
ISBN : 9783527607389

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Combinatorial Chemistry by Willi Bannwarth,Berthold Hinzen Pdf

The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)

High Throughput Screening for Novel Anti-Inflammatories

Michael Kahn
High Throughput Screening for Novel Anti Inflammatories Book PDF

Author : Michael Kahn
Publisher : Birkhäuser
Page : 290 pages
File Size : 48,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034884624

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High Throughput Screening for Novel Anti-Inflammatories by Michael Kahn Pdf

Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.

Combinatorial Chemistry and Technology

Stanislav Miertus,Giorgio Fassina
Combinatorial Chemistry and Technology Book PDF

Author : Stanislav Miertus,Giorgio Fassina
Publisher : CRC Press
Page : 456 pages
File Size : 53,5 Mb
Release : 1999-07-01
Category : Science
ISBN : 142000056X

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Combinatorial Chemistry and Technology by Stanislav Miertus,Giorgio Fassina Pdf

"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

Analysis and Purification Methods in Combinatorial Chemistry

Bing Yan
Analysis and Purification Methods in Combinatorial Chemistry Book PDF

Author : Bing Yan
Publisher : John Wiley & Sons
Page : 482 pages
File Size : 41,5 Mb
Release : 2004-02-03
Category : Science
ISBN : 9780471531999

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Analysis and Purification Methods in Combinatorial Chemistry by Bing Yan Pdf

Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable." To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering: * Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis * High-throughput analytical methods used to analyze the quality of libraries * High-throughput purification techniques * Analytical methods applied in post-synthesis and post-purification stages Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques. This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

Taosheng Chen
A Practical Guide to Assay Development and High Throughput Screening in Drug Discovery Book PDF

Author : Taosheng Chen
Publisher : CRC Press
Page : 0 pages
File Size : 53,9 Mb
Release : 2009-12-21
Category : Medical
ISBN : 1420070509

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A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery by Taosheng Chen Pdf

The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations. The book first discusses assay developments for important target classes such as protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and heat shock proteins. It next examines assay developments for cell viability, apoptosis, and infectious diseases. The contributors explore the application of emerging technologies and systems, including image-based high content screening, RNA interference, and primary cells. Finally, they discuss the essential components of the integrated HTS process, such as screening automation, compound library management, the screening of natural products from botanical sources, and screening informatics. Designed to motivate researchers to bring further advances to the field, this volume provides practical guidance on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS, this is a resource that is both comprehensive and focused.

Molecular Diversity and Combinatorial Chemistry

Irwin M. Chaiken,Kim D. Janda
Molecular Diversity and Combinatorial Chemistry Book PDF

Author : Irwin M. Chaiken,Kim D. Janda
Publisher : Unknown
Page : 346 pages
File Size : 53,5 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015037805408

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Molecular Diversity and Combinatorial Chemistry by Irwin M. Chaiken,Kim D. Janda Pdf

Reports progress on chemical, enzymatic, phage, and cell-derived libra ries. Discusses synergy between structure-based design and combinatori al libraries. Presents applications of combinatorial libraries to drug discovery and new synthetic catalysis. Reports library screening appr oaches, including the use of NMR. Presents recent advances in solid-ph ase organic synthesis, liquid-phase organic synthesis, and high-throug hput combinatorial organic synthesis. Discusses automation of organic synthesis as well as new methodologies for monitoring solid-phase orga nic synthesis.

Exploiting Chemical Diversity for Drug Discovery

Paul A Bartlett,Michael Entzeroth
Exploiting Chemical Diversity for Drug Discovery Book PDF

Author : Paul A Bartlett,Michael Entzeroth
Publisher : Royal Society of Chemistry
Page : 444 pages
File Size : 42,7 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847552556

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Exploiting Chemical Diversity for Drug Discovery by Paul A Bartlett,Michael Entzeroth Pdf

Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays that provide the most useful biological information, this book provides a comprehensive overview of modern approaches to lead identification. Beginning with an introductory overview, subsequent chapters address topics that include the design of chemical libraries and methods for optimizing their diversity; automated and accelerated chemistry; high throughput assay design and detection techniques; and strategies for data analysis and property optimization. Written by experts in the field, both academic and industrial, and illustrated in full colour, this book provides an excellent overview for current practitioners and will also serve as a stimulating resource for future generations. Researchers in organic and medicinal chemistry, the biological and pharmacological sciences, as well as those interested in allied computational and engineering disciplines will value the comprehensive and up-to-date coverage.

Combinatorial Methods for Chemical and Biological Sensors

Radislav A. Potyrailo,Vladimir M. Mirsky
Combinatorial Methods for Chemical and Biological Sensors Book PDF

Author : Radislav A. Potyrailo,Vladimir M. Mirsky
Publisher : Springer Science & Business Media
Page : 495 pages
File Size : 48,5 Mb
Release : 2009-03-21
Category : Science
ISBN : 9780387737133

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Combinatorial Methods for Chemical and Biological Sensors by Radislav A. Potyrailo,Vladimir M. Mirsky Pdf

Chemical sensors are in high demand for applications as varied as water pollution detection, medical diagnostics, and battlefield air analysis. Designing the next generation of sensors requires an interdisciplinary approach. The book provides a critical analysis of new opportunities in sensor materials research that have been opened up with the use of combinatorial and high-throughput technologies, with emphasis on experimental techniques. For a view of component selection with a more computational perspective, readers may refer to the complementary volume of Integrated Analytical Systems edited by M. Ryan et al., entitled “Computational Methods for Sensor Material Selection”.

Molecular Diversity in Drug Design

P.M. Dean,R.A. Lewis
Molecular Diversity in Drug Design Book PDF

Author : P.M. Dean,R.A. Lewis
Publisher : Springer Science & Business Media
Page : 261 pages
File Size : 55,5 Mb
Release : 2007-05-08
Category : Science
ISBN : 9780306468735

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Molecular Diversity in Drug Design by P.M. Dean,R.A. Lewis Pdf

High-throughput screening and combinatorial chemistry are two of the most potent weapons ever to have been used in the discovery of new drugs. At a stroke, it seems to be possible to synthesise more molecules in a month than have previously been made in the whole of the distinguished history of organic chemistry, Furthermore, all the molecules can be screened in the same short period. However, like any weapons of immense power, these techniques must be used with care, to achieve maximum impact. The costs of implementing and running high-throughput screening and combinatorial chemistry are high, as large dedicated facilities must be built and staffed. In addition, the sheer number of chemical leads generated may overwhelm the lead optimisation teams in a hail of friendly fire. Mother nature has not entirely surrendered, as the number of building blocks that could be used to build libraries would require more atoms than there are in the universe. In addition, the progress made by the Human Genome Project has uncovered many proteins with different functions but related binding sites, creating issues of selectivity. Advances in the new field of pharmacogenomics will produce more of these challenges. There is a real need to make hi- throughput screening and combinatorial chemistry into 'smart' weapons, so that their power is not dissipated. That is the challenge for modellers, computational chemists, cheminformaticians and IT experts. In this book, we have broken down this grand challenge into key tasks.

Combinatorial Chemistry and Technologies

Stanislav Miertus,Giorgio Fassina
Combinatorial Chemistry and Technologies Book PDF

Author : Stanislav Miertus,Giorgio Fassina
Publisher : CRC Press
Page : 616 pages
File Size : 55,5 Mb
Release : 2005-04-12
Category : Medical
ISBN : 9780824758370

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Combinatorial Chemistry and Technologies by Stanislav Miertus,Giorgio Fassina Pdf

Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.