Ageing The Biology Of Senescence

Author : Bernard Swynghedauw
Publisher : Springer
Page : 0 pages
File Size : 40,7 Mb
Release : 2020-08-15
Category : Medical
ISBN : 3030151131

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The Biology of Senescence by Bernard Swynghedauw Pdf

This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

Author : Alex Comfort
Publisher : Elsevier Publishing Company
Page : 432 pages
File Size : 46,7 Mb
Release : 1979
Category : Science
ISBN : UOM:39015003805994

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The Biology of Senescence by Alex Comfort Pdf

Author : Bernard Strihler
Publisher : Academic Press
Page : 510 pages
File Size : 47,5 Mb
Release : 1977-01-28
Category : Science
ISBN : UOM:39015004326321

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Times, Cells, and Aging by Bernard Strihler Pdf

Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

Author : John A. Behnke
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461339946

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The Biology of Aging by John A. Behnke Pdf

Egocentricity is characteristically human. It is natural for our prime in terest to be ourselves and for one of our major concerns to be what affects us personally. Aging and death - universal and inevitable have always been of compelling concern. Mystical explanations were invented when scientific answers were lacking. and gross physiologi As scientific knowledge developed, anatomy cal processes were explained, and the roles of the endocrine glands were revealed. Since the sex hormones obviously lose some of their potency with age, it was logical to assume that they played the major role in declining general well-being. The puzzle of aging would now be solved. The Ponce de Leon quest would soon be fulfilled. Pseudoscientists and quacks rushed in where most scientists feared to tread. By the time the glowing promises of perpetual youth through gland transplants and injections had proved illusory, serious study of the aging process had been set back for years. The field had lost "respect ability," and most capable scientists shunned it. Those who did con tinue to seek answers to its tough questions deserve special recognition.

Author : Bernard Swynghedauw
Publisher : Unknown
Page : 121 pages
File Size : 44,9 Mb
Release : 2019
Category : Family medicine
ISBN : 3030151123

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The Biology of Senescence by Bernard Swynghedauw Pdf

This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for "treating" it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related "chronic non-transmissible diseases"), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to "treat" or "prevent" the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

Author : Suresh I.S. Rattan,Leonard Hayflick
Publisher : Springer
Page : 364 pages
File Size : 51,9 Mb
Release : 2016-05-09
Category : Medical
ISBN : 9783319262390

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Cellular Ageing and Replicative Senescence by Suresh I.S. Rattan,Leonard Hayflick Pdf

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Author : J. Robin Harris,Viktor I. Korolchuk
Publisher : Springer
Page : 526 pages
File Size : 52,8 Mb
Release : 2019-02-18
Category : Medical
ISBN : 9789811328350

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Biochemistry and Cell Biology of Ageing: Part I Biomedical Science by J. Robin Harris,Viktor I. Korolchuk Pdf

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Author : Marion J. Lamb
Publisher : Unknown
Page : 200 pages
File Size : 44,9 Mb
Release : 1977
Category : Social Science
ISBN : UOM:39015000295660

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Biology of Ageing by Marion J. Lamb Pdf

Author : Caleb E. Finch
Publisher : University of Chicago Press
Page : 948 pages
File Size : 43,8 Mb
Release : 1994-05-16
Category : Health & Fitness
ISBN : 0226248895

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Longevity, Senescence, and the Genome by Caleb E. Finch Pdf

Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.

Author : L. Robert,T. Fulop
Publisher : Karger Medical and Scientific Publishers
Page : 226 pages
File Size : 51,9 Mb
Release : 2014-05-16
Category : Medical
ISBN : 9783318026535

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Aging by L. Robert,T. Fulop Pdf

Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.

Author : Nikki J. Holbrook,George R. Martin,Richard A. Lockshin
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 54,5 Mb
Release : 1995-12-20
Category : Science
ISBN : 0471121231

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Cellular Aging and Cell Death by Nikki J. Holbrook,George R. Martin,Richard A. Lockshin Pdf

Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.

Author : Valquiria Bueno
Publisher : Springer Nature
Page : 159 pages
File Size : 40,9 Mb
Release : 2024-06-15
Category : Electronic
ISBN : 9783031550225

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Cellular and Molecular Aspects of Ageing by Valquiria Bueno Pdf

Author : Robert Arking
Publisher : Unknown
Page : 440 pages
File Size : 41,9 Mb
Release : 1991
Category : Science
ISBN : UOM:39015025382295

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Biology of Aging by Robert Arking Pdf

Arking (Institute of Gerontology, Wayne State U.) presents an overview of the biological processes underlying aging at the cellular, organism, and population levels. A textbook for the college or graduate level. Annotation copyright Book News, Inc. Portland, Or.

Author : Leonard Hayflick
Publisher : Unknown
Page : 408 pages
File Size : 44,7 Mb
Release : 1994
Category : Family & Relationships
ISBN : UOM:39015031854113

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How and why We Age by Leonard Hayflick Pdf

Preeminent cell biologist Leonard Hayflick reveals the results of more than thirty years of pioneering research in the field of aging. Gracefully written, clearly organized, and packed with essential facts and statistics, "How and Why We Age" is a landmark study of the aging process for readers of all ages.

Author : Ian Stuart-Hamilton
Publisher : Cambridge University Press
Page : 459 pages
File Size : 41,5 Mb
Release : 2011-03-31
Category : Psychology
ISBN : 9781139500173

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An Introduction to Gerontology by Ian Stuart-Hamilton Pdf

With the world's population getting increasingly older, there has never been a more pressing need for the study of old age and ageing. An Introduction to Gerontology provides a wide-ranging introduction to this important topic. By assuming no prior expert knowledge and avoiding jargon, this book will guide students through all the main subjects in gerontology, covering both traditional areas, such as biological and social ageing, and more contemporary areas, such as technology, the arts and sexuality. An Introduction to Gerontology is written by a team of international authors with multidisciplinary backgrounds who draw evidence from a variety of different perspectives and traditions.