Cellular Ageing And Replicative Senescence

Author : Suresh I.S. Rattan,Leonard Hayflick
Publisher : Springer
Page : 364 pages
File Size : 44,9 Mb
Release : 2016-05-09
Category : Medical
ISBN : 9783319262390

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Cellular Ageing and Replicative Senescence by Suresh I.S. Rattan,Leonard Hayflick Pdf

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Author : S. Kaul,Renu Wadwha
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 40,6 Mb
Release : 2013-03-14
Category : Science
ISBN : 9789401706698

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Aging of Cells in and Outside the Body by S. Kaul,Renu Wadwha Pdf

This book provides updated knowledge on the basic features and mechanisms of cellular aging established since its first manifestation at cellular level 40 years ago. Contributions of genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications determine the final lifespan of cells. This book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumor surveillance because of stringent controls on aging mechanisms. It also appraises the use of modern technology for aging studies and its intervention. This book serves as an excellent reading on cellular aging for undergraduate students, researchers and experts of this area.

Author : Valquiria Bueno
Publisher : Springer Nature
Page : 159 pages
File Size : 54,8 Mb
Release : 2024-06-15
Category : Electronic
ISBN : 9783031550225

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Cellular and Molecular Aspects of Ageing by Valquiria Bueno Pdf

Author : Thomas von Zglinicki
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 49,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9789401706674

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Aging at the Molecular Level by Thomas von Zglinicki Pdf

During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

Author : K. Lenhard Rudolph
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 51,9 Mb
Release : 2007-11-07
Category : Medical
ISBN : 9783540737094

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Telomeres and Telomerase in Aging, Disease, and Cancer by K. Lenhard Rudolph Pdf

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Author : Wang Zhiwei,Hiroyuki Inuzuka
Publisher : BoD – Books on Demand
Page : 162 pages
File Size : 55,5 Mb
Release : 2013-02-20
Category : Medical
ISBN : 9789535109976

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Senescence and Senescence-Related Disorders by Wang Zhiwei,Hiroyuki Inuzuka Pdf

Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions.

Author : Reginald B. Garvey
Publisher : Nova Publishers
Page : 202 pages
File Size : 44,8 Mb
Release : 2007
Category : Medical
ISBN : 1600214010

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New Research on Cell Aging by Reginald B. Garvey Pdf

This book presents research on cell growth and the ageing process. Emphasis is given to implications for cancer therapy, abnormal mitosis and aberrant nuclear morphology, neoplastic transformations, negative charges on various malignant cell types.

Author : Nikki J. Holbrook,George R. Martin,Richard A. Lockshin
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 46,6 Mb
Release : 1995-12-20
Category : Science
ISBN : 0471121231

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Cellular Aging and Cell Death by Nikki J. Holbrook,George R. Martin,Richard A. Lockshin Pdf

Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.

Author : Sana Loue,Martha Sajatovic
Publisher : Springer Science & Business Media
Page : 852 pages
File Size : 42,8 Mb
Release : 2008-01-16
Category : Medical
ISBN : 9780387337531

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Encyclopedia of Aging and Public Health by Sana Loue,Martha Sajatovic Pdf

Americans are living longer, and the elder population is growing larger. To meet the ongoing need for quality information on elder health, the Encyclopedia of Aging and Public Health combines multiple perspectives to offer readers a more accurate and complete picture of the aging process. The book takes a biopsychosocial approach to the complexities of its subject. In-depth introductory chapters include coverage on a historical and demographic overview of aging in America, a guide to biological changes accompanying aging, an analysis of the diversity of the U.S. elder population, legal issues commonly affecting older adults, and the ethics of using cognitively impaired elders in research. From there, over 425 entries cover the gamut of topics, trends, diseases, and phenomena: -Specific populations, including ethnic minorities, custodial grandparents, and centenarians -Core medical conditions associated with aging, from cardiac and pulmonary diseases to Parkinson’s and Alzheimer’s -Mental and emotional disorders -Drugs/vitamins/alternative medicine -Disorders of the eyes, feet, and skin -Insomnia and sleep disorders; malnutrition and eating disorders -Sexual and gender-related concerns -And a broad array of social and political issues, including access to care, abuse/neglect, veterans’ affairs, and assisted suicide Entries on not-quite-elders’ concerns (e.g., midlife crisis, menopause) are featured as well. And all chapters and entries include references and resource lists. The Encyclopedia has been developed for maximum utility to clinicians, social workers, researchers, and public health professionals working with older adults. Its multidisciplinary coverage and scope of topics make this volume an invaluable reference for academic and public libraries.

Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Page : 844 pages
File Size : 40,7 Mb
Release : 2008-02-03
Category : Science
ISBN : 9781597453615

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Biological Aging by Trygve O. Tollefsbol Pdf

This book investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions.

Author : Bernard Strihler
Publisher : Academic Press
Page : 510 pages
File Size : 45,8 Mb
Release : 1977-01-28
Category : Science
ISBN : UOM:39015004326321

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Times, Cells, and Aging by Bernard Strihler Pdf

Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

Author : Leonard Hayflick
Publisher : Unknown
Page : 0 pages
File Size : 49,9 Mb
Release : 1996
Category : Aging
ISBN : 0345401557

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How and why We Age by Leonard Hayflick Pdf

"How long can humans live? Is immortality possible? Just what is the aging process? The aging and inevitable death of the human body have inspired more myths and outrageous quackery than anything else subject to scientific inquiry. . . . Now comes a most fascinating book, insightful and scholarly, to provide what answers have emerged so far." --San Francisco Chronicle Here, at last, preeminent cell biologist Leonard Hayflick presents the truth about human aging. Based on more than thirty years of pioneering research in the field, How and Why We Age explores not only how our major biological systems change as we grow older, but also examines the intangible alterations in our modes of thinking and feeling, our moods and sexual desires, our personality traits and our memories. With the immediacy of the latest scientific discoveries, Dr. Hayflick explains how aging affects every part of the body, and dispels many of the most persistent aging myths, to show that: * Hearts do not naturally get weaker with age. * Regular exercise and a low-fat diet won't slow aging. * Curing cancer would only add two years to the average sixty-five-year-old American life. Curing heart disease, however would add fourteen years. * Only five percent of people over the age of sixty-five are in nursing homes * No human has lived--or probably can live--past 120 years. Gracefully written, clearly organized, and packed with essential facts and statistics, How and Why We Age is a landmark study of the aging process for readers of all ages. "Written in clear, nontechnical language, it is an excellent introduction to the scientific and demographic literature on this multifacetedsubject." --Nature

Author : Yuelin Zhang,Songyan Liao,Qingling Fu,Mark Hamrick
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 44,7 Mb
Release : 2022-01-18
Category : Science
ISBN : 9782889740635

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Mesenchymal Stem Cell Senescence and Rejuvenation by Yuelin Zhang,Songyan Liao,Qingling Fu,Mark Hamrick Pdf

Author : Michael Breitenbach,S. Michal Jazwinski,Peter Laun
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 40,6 Mb
Release : 2011-11-19
Category : Science
ISBN : 9789400725614

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Aging Research in Yeast by Michael Breitenbach,S. Michal Jazwinski,Peter Laun Pdf

This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

Author : Peter D. Adams,John M. Sedivy
Publisher : Springer Science & Business Media
Page : 272 pages
File Size : 40,7 Mb
Release : 2010-01-23
Category : Medical
ISBN : 9781441910752

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Cellular Senescence and Tumor Suppression by Peter D. Adams,John M. Sedivy Pdf

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.