Aging And Health A Systems Biology Perspective

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Aging and Health - A Systems Biology Perspective

A.I. Yashin,S.M. Jazwinski
Aging and Health A Systems Biology Perspective Book PDF

Author : A.I. Yashin,S.M. Jazwinski
Publisher : Karger Medical and Scientific Publishers
Page : 206 pages
File Size : 41,5 Mb
Release : 2014-10-09
Category : Science
ISBN : 9783318027303

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Aging and Health - A Systems Biology Perspective by A.I. Yashin,S.M. Jazwinski Pdf

Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.

Explaining Health Across the Sciences

Jonathan Sholl,Suresh I.S. Rattan
Explaining Health Across the Sciences Book PDF

Author : Jonathan Sholl,Suresh I.S. Rattan
Publisher : Springer Nature
Page : 551 pages
File Size : 46,6 Mb
Release : 2020-08-28
Category : Medical
ISBN : 9783030526634

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Explaining Health Across the Sciences by Jonathan Sholl,Suresh I.S. Rattan Pdf

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.

Health, Illness, and Optimal Aging

Carolyn M. Aldwin,Diane F. Gilmer
Health Illness and Optimal Aging Book PDF

Author : Carolyn M. Aldwin,Diane F. Gilmer
Publisher : SAGE
Page : 446 pages
File Size : 51,7 Mb
Release : 2004
Category : Social Science
ISBN : 0761922598

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Health, Illness, and Optimal Aging by Carolyn M. Aldwin,Diane F. Gilmer Pdf

The authors undertake the difficult task of assembling an objective and holistic picture of human aging, including the physical aspects of aging, chronic disease and health promotion in the later years, for students and professionals.

Biochemistry and Cell Biology of Ageing: Part II Clinical Science

J. Robin Harris,Viktor I. Korolchuk
Biochemistry and Cell Biology of Ageing Part II Clinical Science Book PDF

Author : J. Robin Harris,Viktor I. Korolchuk
Publisher : Springer
Page : 499 pages
File Size : 54,6 Mb
Release : 2019-03-19
Category : Medical
ISBN : 9789811336812

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Biochemistry and Cell Biology of Ageing: Part II Clinical Science by J. Robin Harris,Viktor I. Korolchuk Pdf

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Health, Illness, and Optimal Aging, Second Edition

Carolyn M. Aldwin, Ph.D.,Diane Fox Gilmer, Ph.D.
Health Illness and Optimal Aging Second Edition Book PDF

Author : Carolyn M. Aldwin, Ph.D.,Diane Fox Gilmer, Ph.D.
Publisher : Springer Publishing Company
Page : 416 pages
File Size : 47,5 Mb
Release : 2013-01-17
Category : Social Science
ISBN : 9780826193476

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Health, Illness, and Optimal Aging, Second Edition by Carolyn M. Aldwin, Ph.D.,Diane Fox Gilmer, Ph.D. Pdf

"Aldwin and Gilmer have supplied an interesting textual model for examining health, illness, and aging. Their homogenized approach to aging research is refreshing and insightful."--Anthropology and Aging Quarterly "Clearly written at a level for college students, this is an excellent resource on aging...Highly recommended.--Choice: Current Reviews for Academic Libraries Spanning the biological and psychosocial aspects of aging, this upper-level undergraduate and graduate text integrates current findings in biology, psychology, and the social sciences to provide comprehensive, multidisciplinary coverage of the aging process. This new edition incorporates the tremendous amount of research that has come to light since the first edition was published. From a physical perspective, the text examines age-related changes and disease-related processes, the demography of the aging population, aging theories, and how to promote optimal aging. Coverage of the psychosocial aspects of aging encompasses mental health, stress and coping, spirituality, and caregiving in later years. The authors address demographic, theoretical, and methodological issues on aging, including a worldwide overview of aging demographics. The book reviews biological and psychosocial theories and offers much-needed information on longitudinal design and statistics as they relate to aging research. It discusses the aging of the major organ systems, the brain and sensory systems, and the endocrine and immune systems; basic anatomy and physiology; normal, impaired, and optimal aging; and functional health. Psychosocial factors that affect health are addressed, including the interplay between physical health and mental health, stress, coping, and social support. The text also covers current issues in social gerontology, including such promising new trends as gerontechnology and Green Houses, and provides information on health promotion programs. New to the Second Edition: Information involving retirement, volunteer opportunities, housing, and adaptation to health changes Coverage of economics and aging, including information on social security and other retirement income and the future of Medicare and Medicaid Significant new information about the regulatory systems Revised and updated chapters on death and dying and optimal aging Discussions on two models of optimal aging and valuable tips for its promotion URLs to relevant websites for additional information

Human Aging

Augustine Gaspar DiGiovanna
Human Aging Book PDF

Author : Augustine Gaspar DiGiovanna
Publisher : McGraw-Hill Companies
Page : 356 pages
File Size : 49,7 Mb
Release : 1994
Category : Family & Relationships
ISBN : UOM:39015029979385

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Human Aging by Augustine Gaspar DiGiovanna Pdf

This text provides comprehensive coverage of biological aspects of human ageing at a level accessible to students with little or no science background. It is aimed at students pursuing a career working with, or for, the elderly. Each system is covered in its own chapter. Individual chapters present the structure and function of each body system, followed by natural age changes, and conclude with abnormal changes or diseased conditions of the elderly. Homeostasis is a unifying theme throughout the text: systems are presented relative to the body's ability to maintain homeostasis and good health is the main theme.

Computational Systems Biology

Andres Kriete,Mathieu Cloutier
Computational Systems Biology Book PDF

Author : Andres Kriete,Mathieu Cloutier
Publisher : Elsevier Inc. Chapters
Page : 548 pages
File Size : 40,6 Mb
Release : 2013-11-26
Category : Medical
ISBN : 9780128070185

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Computational Systems Biology by Andres Kriete,Mathieu Cloutier Pdf

What makes the study of aging particularly challenging is the wide spectrum of phenotypical changes that can be observed during its progression. While initial attention was paid to damage accumulation, dysfunction, and failure, it is now realized that aging, and associated diseases including dementias, are influenced by a multitude of interacting factors. Proximal mechanisms beyond passive accumulation of damage include regulatory mechanisms, stress responses, changes in networks, as well as genetic and stochastic effects. The application of computational systems biology in aging, which is in line with other attempts to overcome the study of isolated or compartmentalized mechanisms, has made initial progress allowing us to simulate partial aspects of the aging dynamics and to make new hypotheses about how these aging mechanism shape disease progression. Here we provide examples for analysis of networks, regulatory mechanisms, and spatiotemporal effects in the study of proximal mechanisms of aging and Parkinson’s Disease. In addition, we introduce complexity theories that may contribute to explain the ultimate causes of aging with an evolutionary view.

Health Aspects of Aging

Gari Lesnoff-Caravaglia
Health Aspects of Aging Book PDF

Author : Gari Lesnoff-Caravaglia
Publisher : Charles C Thomas Publisher
Page : 199 pages
File Size : 49,5 Mb
Release : 2007
Category : Social Science
ISBN : 9780398076962

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Health Aspects of Aging by Gari Lesnoff-Caravaglia Pdf

This second edition of Health Aspects of Aging serves to broaden the perspectives of societal change due to increases in life expectancy, as well as the effects of age-related changes as they impinge upon the provision of health care for older persons. The growing presence of a large number of persons aged 65 and older worldwide has propelled a re-evaluation of the nature of life that is protracted to 100 years and beyond. The emphasis in this second edition is to replace the prevailing problem approach to aging by a problem-solving approach. The problem-solving approach of this volume has allowed for the incorporation of the concept of new social structures and the development of intervention and prevention strategies along with new technologies. Such new products and health care measures include those that are deliberately aimed to offset debilities due to normal age changes, the onslaught of diseases, incongruous environments, and altered social states. Such a multi-disciplinary perspective underscores the fact that aging permeates not only biological systems, but clinical medicine, economics, ethics, and the very fabric of society. The chapters in this volume address these issues from the standpoints of diverse disciplines and professional positions. Since biological changes are primary issues, the aging process is largely described from the perspective of biological changes related to age and to particular dysfunctions. The environmental features and the potential introduction of technological interventions are interspersed within chapters, as well as finding primary focus in particular chapters. The maturity of the technology described in the chapters varies, from devices and systems that are nearly ready to be marketed to concepts and prototypes that are still in the design and developmental stages in the laboratory. The relationship between the provision of appropriate health care and the responsible utilization of technologies as described in this volume will serve to enhance the nature of life extension.

Aging

James L McGaugh,Sara B. Kiesler
Aging Book PDF

Author : James L McGaugh,Sara B. Kiesler
Publisher : Elsevier
Page : 428 pages
File Size : 51,5 Mb
Release : 2013-09-17
Category : Medical
ISBN : 9781483260051

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Aging by James L McGaugh,Sara B. Kiesler Pdf

Aging: Biology and Behavior addresses behavioral changes in aging related to biological processes, focusing on the nature of changes in brain plasticity, factors influencing life-span, and environmental and social influences on health in the elderly. This book is divided into four main topics—longevity, aging, and mortality; aging brain and behavior; cognitive and social functioning; and health. In these topics, this publication specifically discusses the longevity in primates, life-span extension, environment and biology in aging, and some economic implications of life-span extension. The neurobiological basis of age-related changes in neuronal connectivity, aging and brain plasticity, and cognitive functioning in the elderly are also elaborated. This text likewise covers the life changes and disease in elderly populations, social stress and mental disorders in the elderly, and perspective of social epidemiology. This volume is a useful source to clinicians and students examining possible social and behavioral science research perspectives on aging.

Biological Anthropology and Aging

Douglas E. Crews,Ralph M. Garruto
Biological Anthropology and Aging Book PDF

Author : Douglas E. Crews,Ralph M. Garruto
Publisher : Unknown
Page : 482 pages
File Size : 41,9 Mb
Release : 1994
Category : Aging
ISBN : UOM:39015032436670

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Biological Anthropology and Aging by Douglas E. Crews,Ralph M. Garruto Pdf

This timely volume explores evolutionary, cross-cultural, physiological, environmental, and pathological influences on variation in human biological aging. Chapters by leading experts use models traditionally unique to anthropological research in order to illuminate human biological aging asa heterogeneous and variable process. By explicitly emphasizing evolutionary biology and human variation, the book presents the fascinating perspective of human biological aging as the end result of a set of co-adapted genetic complexes associated with successful growth, development, reproduction,and parenting of offspring. While examining human life span and life-history parameters as population-level phenomena, the book also emphasizes human phenotypic plasticity as key to understanding aging. This broad evolutionary perspective is unique in biological gerontology, a field that is oftenreductionist in method and theory. The book is sure to appeal to students, teachers, and researchers of geriatrics, gerontology, biology and anthropology of aging, and human population biology.

Epigenetics of Aging

Trygve O. Tollefsbol
Epigenetics of Aging Book PDF

Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 46,5 Mb
Release : 2009-11-11
Category : Medical
ISBN : 9781441906397

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Epigenetics of Aging by Trygve O. Tollefsbol Pdf

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Biology of Aging

Robert Arking
Biology of Aging Book PDF

Author : Robert Arking
Publisher : Oxford University Press
Page : 624 pages
File Size : 50,5 Mb
Release : 2006-02-02
Category : Science
ISBN : 0199727627

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Biology of Aging by Robert Arking Pdf

Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: ? Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. ? A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. ? Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. ? Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. ? Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. ? Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.

The Aging Immune System and Health

Valquiria Bueno,Rafael Solana,Annemieke Boots
The Aging Immune System and Health Book PDF

Author : Valquiria Bueno,Rafael Solana,Annemieke Boots
Publisher : Frontiers Media SA
Page : 314 pages
File Size : 44,7 Mb
Release : 2020-01-15
Category : Electronic
ISBN : 9782889633616

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The Aging Immune System and Health by Valquiria Bueno,Rafael Solana,Annemieke Boots Pdf

The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens are increased in the aging population mainly due to pneumonia and influenza whereas Cytomegalovirus, Epstein-Barr virus, among other viruses seem to contribute to the low-grade inflammatory process observed (inflammaging). Aging is a complex and multifactorial process in which functions of the organism are adjusted (remodelled) in order to deal with damaging events during life. One of the most important changes in aging individuals occurs in the immune system (innate and adaptive responses) with consequences such as poor response to new infections and vaccinations; increased susceptibility to cancer development and autoimmune diseases; frailty, and organ dysfunction. In addition, it has been proposed that immunosenescence not only reflects the aging of the organism but also contributes to this process. Bone marrow presents decreased hematopoiesis, the thymus undergoes involution and lymphoid organs (lymph nodes, spleen) also present reduced functionality. Therefore, cells derived, matured, or residing in these tissues decline in number and function. These changes have been identified in experimental models, in vitro conditions, peripheral blood, and biopsies via biomarkers such as cell phenotype, stimulus-induced proliferation, cytokines and antibodies levels. Telomere length and telomerase activity also decline in bone marrow-derived and peripheral blood cells and have been shown to play a role in immunosenescence. More recently, the investigation of short non-coding RNA molecules (microRNAs; miRNAs) pointed to this system as a possible control of aging-related mechanisms. Data obtained on these markers for aging individuals could lead to the generation of a marker panel for pathology prediction, to indicate interventions, and to evaluate the efficacy of interventions. Interventions such as nutrition supplements, exercise, vaccination (different dose, concentration of antigen, adjuvants) have been proposed to circumvent age-related diseases. Considering the heterogeneity in the aging process, further investigation is vital before the indication of interventions for aging individuals. As the extension of life expectancy is a reality, it is a challenge to understand how the aging population copes with the remodelling of the organism and how interventions could provide longevity in good health.

The Gerontological Imagination

Kenneth F. Ferraro
The Gerontological Imagination Book PDF

Author : Kenneth F. Ferraro
Publisher : Oxford University Press
Page : 225 pages
File Size : 51,9 Mb
Release : 2018
Category : Medical
ISBN : 9780190665340

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The Gerontological Imagination by Kenneth F. Ferraro Pdf

The power of the gerontological imagination -- Causality -- Life course analysis -- Multifaceted change -- Heterogeneity -- Accumulation process -- Ageism -- The gerontological imagination at work in scientific communities

Handbook of the Biology of Aging

Matt Kaeberlein,George Martin
Handbook of the Biology of Aging Book PDF

Author : Matt Kaeberlein,George Martin
Publisher : Academic Press
Page : 576 pages
File Size : 50,7 Mb
Release : 2015-08-20
Category : Medical
ISBN : 9780124116207

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Handbook of the Biology of Aging by Matt Kaeberlein,George Martin Pdf

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions