Aldosterone

Author : Brian Harvey,Frederic Jaisser
Publisher : BoD – Books on Demand
Page : 302 pages
File Size : 47,6 Mb
Release : 2019-09-25
Category : Medical
ISBN : 9781839621987

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Aldosterone-Mineralocorticoid Receptor by Brian Harvey,Frederic Jaisser Pdf

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 50,9 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Edith Gláz,Paul Vecsei
Publisher : Elsevier
Page : 645 pages
File Size : 49,7 Mb
Release : 2017-01-11
Category : Medical
ISBN : 9781483159973

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Aldosterone by Edith Gláz,Paul Vecsei Pdf

Aldosterone provides a comprehensive and detailed review of the problems that have arisen in the course of research on aldosterone, particularly with respect to their physiological roles and clinical implications. Topics covered include the biosynthesis, transport, and metabolism of aldosterone, as well as its biological activity and control of its secretion. A variety of pathological conditions, both acute and chronic, associated with aldosterone is also discussed. This volume is comprised of 10 chapters and opens with a historical background on aldosterone research, with emphasis on the discovery of the function of the adrenal cortex. The next chapter summarizes the methods suitable for the evaluation of aldosterone activity, from investigations of mineral metabolism to determination of the concentration of aldosterone or aldosterone metabolites; estimation of secretion of aldosterone; and examination of aldosterone metabolism. Subsequent chapters explore the biosynthesis, transport, and metabolism of aldosterone; secretion of aldosterone, factors affecting secretion, and how it can be controlled; pathological conditions caused by either an increase or a decrease in aldosterone secretion, including aldosteronism, Conn's syndrome, hypoaldosteronism, and hypomineralocorticism. The therapeutic uses of aldosterone are discussed in the last chapter. This book will appeal to biologists and biochemists.

Author : N. P. Christy
Publisher : HarperCollins Publishers
Page : 584 pages
File Size : 52,5 Mb
Release : 1971
Category : Medical
ISBN : UOM:39015004365840

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The Human Adrenal Cortex by N. P. Christy Pdf

Author : Jürg Müller
Publisher : Springer Science & Business Media
Page : 147 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642960628

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Regulation of Aldosterone Biosynthesis by Jürg Müller Pdf

Most of our knowledge of the physiological control of aldosterone secretion is based on animal experiments and clinical studies which were carried out in the 1950s and early 1960s by a large number of inspired, ingenious and meticulous researchers. Their work has been excellently reviewed by-among others-MULLER (1963), BLAIR WEST et al. (1963), LARAGH and KELLY (1964), GANONG et al. (1966), MULROW (1966), DAVIS (1967) and GROSS (1967). According to the majority of these investigators, aldosterone secretion is primarily regulated by the renin-angiotensin system, with plasma sodium and potassium levels and pituitary secretion of ACTH playing important secondary roles. During the last six years, this hypothesis has been generally accepted and has only occasionally been challenged. The following is an attempt to take-from the perspective of a relatively simple in vitro model-a new look at the efferent axis of the apparently very complex control system maintaining adequate aldosterone production in the mammalian organism. My views are based mainly on a series of experiments which I have performed in order to study more closely the interactions of adrenocortical tissue with substances capable of directly influencing aldosterone bio synthesis.

Author : Jürg Müller
Publisher : Springer Science & Business Media
Page : 364 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642831201

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Regulation of Aldosterone Biosynthesis by Jürg Müller Pdf

Sixteen years is a long time, not only in human life but also in the rapid history of contemporary endocrinology. Since the publication of the first edition of this monograph, numerous new lines of research and discoveries have greatly contrib uted to our knowledge of the physiological and pathological regulation of aldos terone biosynthesis in man and animals. The first reports about a sensitive ra dioimmunoassay for plasma aldosterone and about a preparation of dispersed zona glomerulosa cells were published in 1970 (Mayes et al. 1970; Haning et al. 1970). These two developments alone turned out to have a tremendous impact on research in aldosterone physiology (for reviews see Coghlan et al. 1979b; J.F. Tait et al. 1980b). In 1971, atrial natriuretic peptides, somatostatin, and the precursor molecule of ACTH had not yet been discovered. Angiotensin antagonists and con verting-enzyme inhibitors were not yet available. The clinical syndrome of hypo reninemic hypo aldosteronism was unknown. The possible roles of prostaglandins and dopamine in the control of aldosterone pwduction had not been considered. Cyclic AMP was then the only substance with a clearly established second-mes senger function.

Author : Per Hellman
Publisher : Springer Science & Business Media
Page : 242 pages
File Size : 40,8 Mb
Release : 2014-03-28
Category : Medical
ISBN : 9781493905096

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Primary Aldosteronism by Per Hellman Pdf

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene – KCNJ5 – in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.

Author : Eric John Ross
Publisher : Unknown
Page : 524 pages
File Size : 42,5 Mb
Release : 1975
Category : Aldosterone
ISBN : UCAL:B4979671

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Aldosterone and Aldosteronism by Eric John Ross Pdf

Author : Anonim
Publisher : Academic Press
Page : 449 pages
File Size : 47,8 Mb
Release : 2019-02-01
Category : Science
ISBN : 9780128177839

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Aldosterone by Anonim Pdf

Aldosterone, Volume 109, the latest release in the Vitamins and Hormones series first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics relating to Aldosterone Research, Aldosterone and Micrornas, the Evolution of the Mineralocorticoid Receptor, Aldosterone and Kidney Micrornas, Adipocyte Mineralocorticoid Receptor, Regulation of Aldosterone Secretion, Leptin and Aldosterone, Cell- and Ligand-Specific Interactions in Mineralocorticoid Receptor Signaling, Primary Aldosteronism, Present and Future, Aldosterone-Producing Adenomas, Overexpression of the Mineralocorticoid Receptor, Aldosterone and Myocardial Pathology, and much more. Focuses on the newest aspects of hormone action in connection with diseases, with this update focusing on aldosterone Lays the groundwork for the focus of new chemotherapeutic targets Represents reviews on emerging areas in hormone action, cellular regulators and signaling pathways

Author : Ajay K. Singh,Gordon H. Williams
Publisher : Academic Press
Page : 534 pages
File Size : 45,9 Mb
Release : 2009-01-12
Category : Medical
ISBN : 9780080920467

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Textbook of Nephro-Endocrinology by Ajay K. Singh,Gordon H. Williams Pdf

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Author : Dimitrios A. Linos,Jon A. van Heerden
Publisher : Springer Science & Business Media
Page : 396 pages
File Size : 52,9 Mb
Release : 2004-12-07
Category : Medical
ISBN : 3540410996

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Adrenal Glands by Dimitrios A. Linos,Jon A. van Heerden Pdf

- Over 200 exquisite illustrations, ranging from intraoperative photographs, line drawings, diagnostic images, pathology slides, tables and graphs are available to make each case discussed comprehensible and easy to follow. - Traditional and novel therapeutic recommendations are introduced and the latest developments in minimal-access operative techniques are discussed and reviewed. - Focuses on a teamwork oriented approach that identifies the necessary communications amongst the many medical disciplines when dealing with adrenal disorders.

Author : Eric John Ross
Publisher : Unknown
Page : 162 pages
File Size : 53,6 Mb
Release : 1959
Category : Aldosterone
ISBN : UOM:39015052067884

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Aldosterone in Clinical and Experimental Medicine by Eric John Ross Pdf

Author : Karel Pacak,Graeme Eisenhofer
Publisher : Unknown
Page : 0 pages
File Size : 51,8 Mb
Release : 2002
Category : Adrenal Gland Neoplasms
ISBN : 1573314188

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Endocrine Hypertension by Karel Pacak,Graeme Eisenhofer Pdf

Several genetic, biochemical and radiologic discoveries have impacted the management of endocrine hypertension, while surgical procedures have revolutionized treatment of patients with endocrine hypertension. This text contains the proceedings of a 2001 workshop on the topic.

Author : Alan S. L. Yu,Glenn M. Chertow,Valerie Luyckx,Philip A. Marsden,Karl Skorecki,Maarten W. Taal
Publisher : Elsevier Health Sciences
Page : 3585 pages
File Size : 50,7 Mb
Release : 2015-10-25
Category : Medical
ISBN : 9780323262590

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Brenner and Rector's The Kidney E-Book by Alan S. L. Yu,Glenn M. Chertow,Valerie Luyckx,Philip A. Marsden,Karl Skorecki,Maarten W. Taal Pdf

Overcome the toughest clinical challenges in nephrology with Brenner & Rector’s The Kidney -- the most well-known nephrology resource in the world. A diverse team of more than 200 international contributors brings you the latest knowledge and best practices on every front in nephrology worldwide. From basic science and pathophysiology to clinical best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career. Review of the basic science that underpins clinical nephrology, comprehensive selection of the most important bibliographical sources in nephrology, and Board Review-style questions help you prepare for certification or recertification. Coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and into old age. Expanded sections and chapter on global perspective and ethical considerations. Uniform terminology and nomenclature in line with emerging consensus in world kidney community. More than 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making provide a visual grasp and better understanding of critical information. Internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors . An editorial team headed by Dr. Skorecki and handpicked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. All chapters have been extensively updated or entirely rewritten by authorities in their respective fields. The latest clinical information including recent clinical trials, genetic causes of kidney disease, cardiovascular and renal risk prediction in chronic kidney disease, new paradigms in fluid and electrolyte management, and pediatric kidney disease, keep you current with the rapid development of care and research worldwide.

Author : Anonim
Publisher : Unknown
Page : 1440 pages
File Size : 55,6 Mb
Release : 1990
Category : Medicine
ISBN : OSU:32436011073523

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Cumulated Index Medicus by Anonim Pdf