Aldosterone Mineralocorticoid Receptor Cell Biology To Translational Medicine

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Aldosterone-Mineralocorticoid Receptor

Brian Harvey,Frederic Jaisser
Aldosterone Mineralocorticoid Receptor Book PDF

Author : Brian Harvey,Frederic Jaisser
Publisher : BoD – Books on Demand
Page : 302 pages
File Size : 53,9 Mb
Release : 2019-09-25
Category : Medical
ISBN : 9781839621987

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Aldosterone-Mineralocorticoid Receptor by Brian Harvey,Frederic Jaisser Pdf

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Aldosterone-Mineralocorticoid Receptor - Cell Biology to Translational Medicine

Frederic Jaisser,Brian Harvey
Aldosterone Mineralocorticoid Receptor Cell Biology to Translational Medicine Book PDF

Author : Frederic Jaisser,Brian Harvey
Publisher : Unknown
Page : 300 pages
File Size : 52,6 Mb
Release : 2019
Category : Diseases of the endocrine glands. Clinical endocrinology
ISBN : 1839621990

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Aldosterone-Mineralocorticoid Receptor - Cell Biology to Translational Medicine by Frederic Jaisser,Brian Harvey Pdf

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Primary Aldosteronism

Per Hellman
Primary Aldosteronism Book PDF

Author : Per Hellman
Publisher : Springer Science & Business Media
Page : 242 pages
File Size : 43,7 Mb
Release : 2014-03-28
Category : Medical
ISBN : 9781493905096

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Primary Aldosteronism by Per Hellman Pdf

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene – KCNJ5 – in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.

Textbook of Nephro-Endocrinology

Ajay K. Singh,Gordon H. Williams
Textbook of Nephro Endocrinology Book PDF

Author : Ajay K. Singh,Gordon H. Williams
Publisher : Academic Press
Page : 534 pages
File Size : 53,8 Mb
Release : 2009-01-12
Category : Medical
ISBN : 9780080920467

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Textbook of Nephro-Endocrinology by Ajay K. Singh,Gordon H. Williams Pdf

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Stress and Mental Disorders

Richard McCarty
Stress and Mental Disorders Book PDF

Author : Richard McCarty
Publisher : Oxford University Press, USA
Page : 673 pages
File Size : 45,7 Mb
Release : 2020
Category : Medical
ISBN : 9780190697266

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Stress and Mental Disorders by Richard McCarty Pdf

Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.

Endocrine Hypertension

Christian A Koch,George P Chrousos
Endocrine Hypertension Book PDF

Author : Christian A Koch,George P Chrousos
Publisher : Springer Science & Business Media
Page : 367 pages
File Size : 52,6 Mb
Release : 2012-08-30
Category : Medical
ISBN : 9781607615484

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Endocrine Hypertension by Christian A Koch,George P Chrousos Pdf

The prevalence of hypertension is almost three times as high as that of diabetes mellitus type 2, with both conditions being major risk factors for stroke, ischemic heart disease, cardiac arrhythmias, and heart failure. The exact prevalence of hypertension related to hormonal derangements (endocrine hypertension) is not known but estimated to affect less than 15% of hypertensive patients. Recent scientific discoveries have increased the understanding of the pathophysiologic mechanisms of hypertension. In Endocrine Hypertension, a renowned panel of experts provides a comprehensive, state-of-the-art overview of this disorder, discussing when to assign an endocrine cause in one of many conditions that may present with hypertension. The first part of Endocrine Hypertension is dedicated to adrenal causes. The second part of the volume concerns potential nonadrenal causes of hypertension, such as growth hormone excess or deficiency, primary hyperparathyroidism, vitamin D deficiency, testosterone deficiency, insulin resistance, obesity-associated hypertension, and the role of central mineralocorticoid receptors and cardiovascular disease. An important contribution to the literature, Endocrine Hypertension is an indispensable reference not only for endocrinologists, diabetologists, and adrenal investigators, but also for translational scientists and clinicians from cardiology, internal medicine, pediatrics, family medicine, geriatrics, urology, and reproductive medicine / gynecology.

Glucocorticoid Signaling

Jen-Chywan Wang,Charles Harris
Glucocorticoid Signaling Book PDF

Author : Jen-Chywan Wang,Charles Harris
Publisher : Springer
Page : 385 pages
File Size : 50,7 Mb
Release : 2015-07-27
Category : Science
ISBN : 9781493928958

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Glucocorticoid Signaling by Jen-Chywan Wang,Charles Harris Pdf

This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.

Experimental Neurochemistry

Abel Lajtha
Experimental Neurochemistry Book PDF

Author : Abel Lajtha
Publisher : Springer
Page : 516 pages
File Size : 52,8 Mb
Release : 1982-12-01
Category : Science
ISBN : 0306409720

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Experimental Neurochemistry by Abel Lajtha Pdf

The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.

Textbook of Vascular Medicine

Rhian M. Touyz,Christian Delles
Textbook of Vascular Medicine Book PDF

Author : Rhian M. Touyz,Christian Delles
Publisher : Springer
Page : 503 pages
File Size : 52,8 Mb
Release : 2019-08-02
Category : Medical
ISBN : 9783030164812

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Textbook of Vascular Medicine by Rhian M. Touyz,Christian Delles Pdf

This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Nuclear Receptors

Mostafa Z. Badr
Nuclear Receptors Book PDF

Author : Mostafa Z. Badr
Publisher : Springer Nature
Page : 676 pages
File Size : 53,7 Mb
Release : 2021-09-28
Category : Medical
ISBN : 9783030783150

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Nuclear Receptors by Mostafa Z. Badr Pdf

Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.

Metabolic Cardiomyopathy

H. Böhles,A. C. Sewell
Metabolic Cardiomyopathy Book PDF

Author : H. Böhles,A. C. Sewell
Publisher : CRC Press
Page : 188 pages
File Size : 42,8 Mb
Release : 2004
Category : Cardiomyopathy
ISBN : 3887631048

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Metabolic Cardiomyopathy by H. Böhles,A. C. Sewell Pdf

During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.

Heart Failure

Roy S. Gardner,Theresa A. McDonagh,Niki L. Walker
Heart Failure Book PDF

Author : Roy S. Gardner,Theresa A. McDonagh,Niki L. Walker
Publisher : Oxford University Press
Page : 512 pages
File Size : 40,5 Mb
Release : 2014-09-04
Category : Medical
ISBN : 9780191034145

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Heart Failure by Roy S. Gardner,Theresa A. McDonagh,Niki L. Walker Pdf

Heart failure is an important and ever expanding sub-speciality of cardiology. Many health care professional bodies are now developing specialist expertise in heart failure. This is true for cardiologists in training, consultant cardiologists, care of the elderly and general physicians, cardiothoracic surgeons, primary care doctors, pharmacists and specialist nurses. With advances in medical therapy, the prognosis of the condition has improved dramatically. Whereas once heart failure was a pre-terminal diagnosis, now for many it is treatable. However, some patients remain symptomatic and at high risk of death despite maximal medical therapy. These patients can benefit from a range of novel device therapies. For those who remain symptomatic despite optimal treatment cardiac transplantation remains an option. This updated book comprehensively covers all aspects necessary to manage a patient with heart failure. It gives simple, clear advice on the diagnosis, investigation and treatment options available highlighting the current evidence-base. The chapters provide concise and objective information to guide all health care professionals involved in the modern day multi-disciplinary management of the syndrome. The book is set out logically to mirror the patient journey in heart failure. An updated edition of the first practical manual of heart failure management.

Principles of Endocrinology and Hormone Action

Antonino Belfiore,Derek LeRoith
Principles of Endocrinology and Hormone Action Book PDF

Author : Antonino Belfiore,Derek LeRoith
Publisher : Springer
Page : 0 pages
File Size : 40,6 Mb
Release : 2018-02-08
Category : Medical
ISBN : 3319446746

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Principles of Endocrinology and Hormone Action by Antonino Belfiore,Derek LeRoith Pdf

This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

Pediatric Hypertension

Joseph Flynn,Julie R. Ingelfinger,Ronald J. Portman
Pediatric Hypertension Book PDF

Author : Joseph Flynn,Julie R. Ingelfinger,Ronald J. Portman
Publisher : Springer Science & Business Media
Page : 597 pages
File Size : 55,5 Mb
Release : 2013-06-26
Category : Medical
ISBN : 9781627034906

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Pediatric Hypertension by Joseph Flynn,Julie R. Ingelfinger,Ronald J. Portman Pdf

The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.

Amyloid Diseases

Dmitry Kurouski
Amyloid Diseases Book PDF

Author : Dmitry Kurouski
Publisher : BoD – Books on Demand
Page : 244 pages
File Size : 41,8 Mb
Release : 2019-08-07
Category : Medical
ISBN : 9781789853810

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Amyloid Diseases by Dmitry Kurouski Pdf

Neurodegenerative diseases are severe, rapidly developing, and currently incurable conditions that result in progressive degeneration and the death of neurons. This causes dementia, movement problems, and essentially loss of personal identity. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiological changes are observed upon development and progression of these diseases? and (3) how can we treat amyloid-associated diseases?