Alpha Herpesviruses

Author : Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publisher : Cambridge University Press
Page : 1325 pages
File Size : 44,8 Mb
Release : 2007-08-16
Category : Medical
ISBN : 9781139461641

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Human Herpesviruses by Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi Pdf

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author : Rozanne M. Sandri-Goldin
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 54,6 Mb
Release : 2006
Category : Science
ISBN : 1904455093

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Alpha Herpesviruses by Rozanne M. Sandri-Goldin Pdf

The alpha herpesviruses are an important group of viruses characterized by a short reproductive cycle, rapid destruction of the host cell, and the ability to replicate in a wide variety of host tissues. A key attribute of these viruses is the ability to establish lifelong latent infection in the peripheral nervous system of the natural host. Research into the molecular and cellular biology of the alpha herpesviruses has advanced greatly in recent years. Written by internationally recognized experts, this book highlights the more provocative and exciting findings in herpesvirus research. Each chapter is a review of a specific area with an emphasis on recent advances and the latest developments. The book examines multifunctional proteins, advances in DNA replication, new information on the regulation of gene expression, the emergence of new technologies, recent technological advances in fluorescent probes, the induction of apoptosis, the disruption of interferon, vaccine development, and drug design. With a specific focus on new and topical herpesvirus research, Alpha Herpesviruses is essential reading for everyone with an interest in herpesviruses and it is recommended reading for other scientists working in viral pathogenesis, viral genomics, and antiviral research.

Author : Nicola Pusterla,Jill Higgins
Publisher : John Wiley & Sons
Page : 444 pages
File Size : 45,8 Mb
Release : 2017-12-18
Category : Medical
ISBN : 9781118739792

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Interpretation of Equine Laboratory Diagnostics by Nicola Pusterla,Jill Higgins Pdf

Interpretation of Equine Laboratory Diagnostics offers a comprehensive approach to equine laboratory diagnostics, including hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics. Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to establish and new diagnostic procedures Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to established and new diagnostic procedures

Author : Sandra Knowles Weller
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 50,9 Mb
Release : 2011
Category : Science
ISBN : 190445576X

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Alphaherpesviruses by Sandra Knowles Weller Pdf

Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.

Author : Janos Minarovits,Eva Gonczol,Tibor Valyi-Nagy
Publisher : Springer Science & Business Media
Page : 309 pages
File Size : 46,9 Mb
Release : 2006-12-13
Category : Medical
ISBN : 9780387341279

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Latency Strategies of Herpesviruses by Janos Minarovits,Eva Gonczol,Tibor Valyi-Nagy Pdf

This volume provides an overview of the latency strategies developed during the estimated 200,000 year-long coevolution of Alpha-, Beta- and Gammaherpesvirinae and their host species. While the main emphasis is on herpesviruses infecting humans, relevant cases if herpesviruses infecting animals are covered as well. Special emphasis is given to results on molecular mechanisms regulating latent promoters of herpesvirus genomes and signals and molecular pathways resulting in reactivation of latent viral genomes.

Author : Ronaldo Luis Thomasini
Publisher : BoD – Books on Demand
Page : 130 pages
File Size : 53,5 Mb
Release : 2020-04-01
Category : Medical
ISBN : 9781838811587

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Human Herpesvirus Infection by Ronaldo Luis Thomasini Pdf

The relationship between herpesviruses and humans probably dates from thousands of years ago. In the last few decades, many aspects of herpesvirus infections have been understood, such as infections with a range of manifestations (severe, mild, or subclinical). Herpesvirus can remain latent during a lifetime and sometimes their reactivation can cause different clinical features in the patient. Several conditions have been related to herpesvirus reactivation such as complications in transplant organ recipients and immune regulatory modification in the elderly. Aspects of human herpesvirus simples, varicella-zoster virus, and cytomegalovirus are presented and discussed in this book.

Author : Michael G. Kaplitt,Arthur D. Loewy
Publisher : Academic Press
Page : 486 pages
File Size : 46,5 Mb
Release : 1995-08-14
Category : Science
ISBN : 9780080543574

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Viral Vectors by Michael G. Kaplitt,Arthur D. Loewy Pdf

Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells. Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers. This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience.

Author : Klaus Osterrieder
Publisher : Springer
Page : 224 pages
File Size : 48,8 Mb
Release : 2017-05-20
Category : Medical
ISBN : 9783319531687

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Cell Biology of Herpes Viruses by Klaus Osterrieder Pdf

Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences in the establishment and maintenance of virus persistence will be covered.

Author : Bernard Roizman,Richard J. Whitley,Carlos Lopez
Publisher : Raven Press (ID)
Page : 458 pages
File Size : 49,8 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015026820756

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The Human Herpesviruses by Bernard Roizman,Richard J. Whitley,Carlos Lopez Pdf

Author : Ekaterina E Heldwein,Gregory A Smith
Publisher : Unknown
Page : 640 pages
File Size : 52,7 Mb
Release : 2020-07-24
Category : Science
ISBN : 1913652556

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Alphaherpesviruses by Ekaterina E Heldwein,Gregory A Smith Pdf

Author : Yasushi Kawaguchi,Yasuko Mori,Hiroshi Kimura
Publisher : Springer
Page : 501 pages
File Size : 49,5 Mb
Release : 2018-06-12
Category : Medical
ISBN : 9789811072307

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Human Herpesviruses by Yasushi Kawaguchi,Yasuko Mori,Hiroshi Kimura Pdf

This book introduces and reviews several topics for each human herpesvirus. One of the most important features of the book is that it covers aspects of both basic research and clinical medicine. Herpesviridae, a family of double-strand DNA viruses, has unique biological features by which these viruses establish latency after primary infection and reactivate in later life. Nine human herpesviruses are known so far, and each of them causes a variety of diseases in both primary infection and reactivation. Since the discovery of each human herpesvirus, an abundance of findings related to them has accumulated in basic research and clinical medicine. However, the vast majority of biological features is still masked in mystery. Furthermore, a strategy of treatment and prevention has not yet been established for most human herpesviruses. A wide range of readers will be interested in this volume with its treatment of problematic points and latest findings in the field.

Author : Heide Schatten
Publisher : Cambridge University Press
Page : 275 pages
File Size : 45,5 Mb
Release : 2013
Category : Science
ISBN : 9780521195997

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Scanning Electron Microscopy for the Life Sciences by Heide Schatten Pdf

A guide to modern scanning electron microscopy instrumentation, methodology and techniques, highlighting novel applications to cell and molecular biology.

Author : Benedikt B. Kaufer,Louis Flamand,Randall J. Cohrs,Benjamin G. Dewals,Benoit Muylkens
Publisher : Frontiers Media SA
Page : 169 pages
File Size : 45,9 Mb
Release : 2020-09-14
Category : Medical
ISBN : 9782889660018

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Herpesvirus Latency by Benedikt B. Kaufer,Louis Flamand,Randall J. Cohrs,Benjamin G. Dewals,Benoit Muylkens Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : G. Wittmann,R.M. Gaskell,H.J. Rziha
Publisher : Springer Science & Business Media
Page : 503 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400956629

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Latent Herpes Virus Infections in Veterinary Medicine by G. Wittmann,R.M. Gaskell,H.J. Rziha Pdf

This seminar referred to latent herpes virus infections in veterinary medicine, with emphasis on the domestic animals. The phenomenon of latency is of particular importance in veterinary medicine because it can jeopardize the successful control and eradication of diseases such as Aujeszky's disease and infectious bovine rhinotracheitis, diseases which are often the cause of great economic losses. For this reason, the Commission of the European Communities (CEC) realized the importance of summarizing the present state of knowledge on latent herpes virus infections in veterinary medicine. A seminar was therefore organized by the Federal Research Institute for Animal Virus Diseases in Ttibingen, Federal Republic of Germany, from September 21 to 23, 1982, as a part of the 'Animal Pathology Programme' of the CEC. The seminar was attended by 50 participants not only from the countries of the CEC, and 38 papers were selected for presentation. In veterinary medicine, more intensive investigations on the latency of animal herpes viruses have only relatively recently been initiated. In contrast, great efforts have been made for many years to elucidate latency in human and primate herpes viruses, and consequently the most considerable advances have been made in this field. Some of the most experienced scientists working on both systems were therefore invited. As a result, this seminar was the first occasion on which scientists from different countries and faculties investigating herpes virus latency had the opportunity to present and exchange their latest results. The.

Author : Susmit Suvas,Richard D. Dix
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 49,6 Mb
Release : 2020-01-20
Category : Electronic
ISBN : 9782889634552

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Immunity and Immunopathogenesis to Herpesviruses by Susmit Suvas,Richard D. Dix Pdf

Herpesviruses are a large group of double-stranded DNA viruses, which have evolved strategies to persist and disseminate widely throughout the human population. Unlike RNA viruses which have the ability to alter their antigenic expression profile to evade host immune responses, herpesviruses can establish life-long latency in the infected host. Herpesviruses are divided into alpha, beta and gamma herpesviruses sub-families. The human members of the alpha-herpesvirinae subfamily is comprised of herpes simplex virus-1 and 2 (HSV-1 and HSV-2) and of varicella-zoster virus (VZV). These viruses are considered neurotropic, as they can (i) infect nerve endings; (ii) traffic via neuronal axons and (iii) establish latency in neuronal nuclei. On the other hand, the members of the beta-herpesvirinae subfamily such as human cytomegalovirus (HCMV), human herpesviruses 6 and 7 (HHV-6 and HHV-7) are known to establish latent infections in immune cell types such as monocytes and T cells. Epstein-Barr Virus (EBV) is a member of gamma-herpesvirinae subfamily that establishes latency in B lymphocytes. Additionally, HHV-8 also known as Kaposi’s Sarcoma-Associated Herpes virus (KSHV) is a γ-herpes virus which establishes latency in monocytes, dendritic cells, B lymphocytes and endothelial cells of the host.