Alzheimer S Disease Biology Biophysics And Computational Models

Author : Don Kulasiri,Jingyi Liang
Publisher : World Scientific
Page : 416 pages
File Size : 55,8 Mb
Release : 2022-01-06
Category : Medical
ISBN : 9781800610132

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Alzheimer's Disease: Biology, Biophysics And Computational Models by Don Kulasiri,Jingyi Liang Pdf

Alzheimer's disease (AD) is the leading cause of dementia and, unfortunately, remains incurable. The social, emotional and financial implications of AD are immeasurable, and about 47 million people worldwide are affected by AD or other forms of dementia. As lifespans are improved by healthcare systems worldwide, age-associated neurodegenerative diseases are imposing an increasing challenge to science. It is becoming imperative for us to understand the causes of these diseases, AD in particular, at molecular and cellular levels. Starting with the broader picture from a biological perspective, this book takes the reader through fascinating dynamics within and outside of neurons in the brain.Alzheimer's Disease: Biology, Biophysics and Computational Models helps the reader to understand AD from mechanistic and biochemical perspectives at intra- and inter-cellular levels. It focuses on biochemical pathways and modeling associated with AD. Some of the recent research on biophysics and computational models related to AD are explained using context-driven computational and mathematical modeling and essential biology is discussed to understand the modeling research.

Author : Kulasiri Don,He Yao
Publisher : #N/A
Page : 364 pages
File Size : 50,8 Mb
Release : 2017-06-09
Category : Computers
ISBN : 9781786343390

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Computational Systems Biology Of Synaptic Plasticity: Modelling Of Biochemical Pathways Related To Memory Formation And Impairement by Kulasiri Don,He Yao Pdf

This book demonstrates the power of mathematical thinking in understanding the biological complexity that exists within the brain. It looks at the latest research on modelling of biochemical pathways within synapses, and provides a clear background for the study of mathematical models related to systems biology. Discussion then focusses on developments in computational models based on networks linked to synaptic plasticity. The models are used to understand memory formation and impairment and they provide a mathematical basis for memory research. Computational Systems Biology of Synaptic Plasticity is a valuable source of knowledge to postgraduate students and researchers in computational systems biology, and as a reference book for various techniques that are needed in modelling biological processes.

Author : Lubica Benuskova,Nikola K. Kasabov
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 52,9 Mb
Release : 2010-05-05
Category : Technology & Engineering
ISBN : 9780387483559

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Computational Neurogenetic Modeling by Lubica Benuskova,Nikola K. Kasabov Pdf

This is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines.

Author : Yuan Jian-min,Zhou Huan-xiang
Publisher : World Scientific
Page : 328 pages
File Size : 45,6 Mb
Release : 2017-06-02
Category : Science
ISBN : 9789813202399

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Biophysics And Biochemistry Of Protein Aggregation: Experimental And Theoretical Studies On Folding, Misfolding, And Self-assembly Of Amyloidogenic Peptides by Yuan Jian-min,Zhou Huan-xiang Pdf

This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.

Author : Rubem Mondaini,Rui Dil?o
Publisher : World Scientific
Page : 409 pages
File Size : 50,9 Mb
Release : 2006
Category : Science
ISBN : 9789812567970

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BIOMAT 2005 by Rubem Mondaini,Rui Dil?o Pdf

This volume contains the contributions of the keynote speakers to the BIOMAT 2005 symposium, as well as a collection of selected papers by pioneering researchers. It provides a comprehensive review of the mathematical modeling of cancer development, Alzheimer's disease, malaria, and aneurysm development. Various models for the immune system and epidemiological issues are analyzed and reviewed. The book also explores protein structure prediction by optimization and combinatorial techniques (Steiner trees). The coverage includes bioinformatics issues, regulation of gene expression, evolution, development, DNA and array modeling, and small world networks.

Author : Panayiotis Vlamos
Publisher : Springer Nature
Page : 288 pages
File Size : 45,8 Mb
Release : 2022-01-01
Category : Science
ISBN : 9783030787752

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GeNeDis 2020 by Panayiotis Vlamos Pdf

The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. Computational methodologies for implementation on the discovery of biomarkers for neurodegenerative diseases are extensively discussed. This volume focuses on the sessions from the conference regarding computational biology and bioinformatics.

Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
Publisher : Cambridge University Press
Page : 575 pages
File Size : 48,7 Mb
Release : 2022-03-31
Category : Business & Economics
ISBN : 9781108838665

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Alzheimer's Disease Drug Development by Jeffrey Cummings,Jefferson Kinney,Howard Fillit Pdf

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Author : Thomas Wisniewski
Publisher : Frontiers Media SA
Page : 143 pages
File Size : 54,8 Mb
Release : 2021-08-03
Category : Science
ISBN : 9782889711376

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Frontiers in Aging Neuroscience Editor’s Pick 2021 by Thomas Wisniewski Pdf

Author : Lubica Benuskova,Nikola Kasabov
Publisher : Springer
Page : 0 pages
File Size : 48,5 Mb
Release : 2008-10-17
Category : Technology & Engineering
ISBN : 0387564497

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Computational Neurogenetic Modeling by Lubica Benuskova,Nikola Kasabov Pdf

This is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines.

Author : Péter Érdi,Basabdatta Sen Bhattacharya,Amy L. Cochran
Publisher : Springer
Page : 448 pages
File Size : 54,9 Mb
Release : 2017-01-25
Category : Technology & Engineering
ISBN : 9783319499598

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Computational Neurology and Psychiatry by Péter Érdi,Basabdatta Sen Bhattacharya,Amy L. Cochran Pdf

This book presents the latest research in computational methods for modeling and simulating brain disorders. In particular, it shows how mathematical models can be used to study the relationship between a given disorder and the specific brain structure associated with that disorder. It also describes the emerging field of computational psychiatry, including the study of pathological behavior due to impaired functional connectivity, pathophysiological activity, and/or aberrant decision-making. Further, it discusses the data analysis techniques that will be required to analyze the increasing amount of data being generated about the brain. Lastly, the book offers some tips on the application of computational models in the field of quantitative systems pharmacology. Mainly written for computational scientists eager to discover new application fields for their model, this book also benefits neurologists and psychiatrists wanting to learn about new methods.

Author : Michael J. Dinneen,Bakhadyr Khoussainov,Prof. Andre Nies
Publisher : Springer
Page : 427 pages
File Size : 43,6 Mb
Release : 2012-02-15
Category : Computers
ISBN : 9783642276545

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Computation, Physics and Beyond by Michael J. Dinneen,Bakhadyr Khoussainov,Prof. Andre Nies Pdf

This Festschrift volume has been published in honor of Cristian Calude on the occasion of his 60th birthday and contains contributions from invited speakers and regular papers presented at the International Workshop on Theoretical Computer Science, WTCS 2012, held in Auckland, New Zealand, in February 2012. Cristian Calude has made a significant contribution to research in computer science theory. Along with early work by Chaitin, Kučera, Kurtz, Solovay, and Terwijn his papers published in the mid-1990s jointly with Khoussainov, Hertling, and Wang laid the foundation for the development of modern theory of algorithmic randomness. His work was essential for establishing the leading role of New Zealand in this area. The research interests of Cristian Calude are reflected in the topics covered by the 32 papers included in this book, namely: algorithmic information theory, algorithms, automata and formal languages, computing and natural sciences, computability and applications, logic and applications, philosophy of computation, physics and computation, and unconventional models of computation. They have been organized into four parts. The first part consists of papers discussing his life achievements. This is followed by papers in the three general areas of complexity, computability, and randomness; physics, philosophy (and logic), and computation; and algorithms, automata, and formal models (including unconventional computing).

Author : Albert Y. Zomaya
Publisher : John Wiley & Sons
Page : 1000 pages
File Size : 50,7 Mb
Release : 2006-04-14
Category : Computers
ISBN : 9780471756491

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Parallel Computing for Bioinformatics and Computational Biology by Albert Y. Zomaya Pdf

Discover how to streamline complex bioinformatics applications withparallel computing This publication enables readers to handle more complexbioinformatics applications and larger and richer data sets. As theeditor clearly shows, using powerful parallel computing tools canlead to significant breakthroughs in deciphering genomes,understanding genetic disease, designing customized drug therapies,and understanding evolution. A broad range of bioinformatics applications is covered withdemonstrations on how each one can be parallelized to improveperformance and gain faster rates of computation. Current parallelcomputing techniques and technologies are examined, includingdistributed computing and grid computing. Readers are provided witha mixture of algorithms, experiments, and simulations that providenot only qualitative but also quantitative insights into thedynamic field of bioinformatics. Parallel Computing for Bioinformatics and Computational Biology isa contributed work that serves as a repository of case studies,collectively demonstrating how parallel computing streamlinesdifficult problems in bioinformatics and produces better results.Each of the chapters is authored by an established expert in thefield and carefully edited to ensure a consistent approach and highstandard throughout the publication. The work is organized into five parts: * Algorithms and models * Sequence analysis and microarrays * Phylogenetics * Protein folding * Platforms and enabling technologies Researchers, educators, and students in the field of bioinformaticswill discover how high-performance computing can enable them tohandle more complex data sets, gain deeper insights, and make newdiscoveries.

Author : Mary T. Newport
Publisher : Turner Publishing Company
Page : 423 pages
File Size : 49,9 Mb
Release : 2023-09-19
Category : Health & Fitness
ISBN : 9781684429264

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Alzheimer's Disease: What If There Was a Cure (3rd Edition) by Mary T. Newport Pdf

Third Edition, Fully Updated and Expanded There is hope, there is relief, there is another way to treat Alzheimer’s disease! More than 6.5 million people in the United States suffer from Alzheimer’s and other neurodegenerative diseases. Dr. Mary T. Newport’s husband, Steve, was one of them. In Alzheimer’s Disease: What If There Was a Cure?, Dr. Newport shares Steve’s story—how he fell into the abyss that is Alzheimer’s disease and was able to climb back out to enjoy a nearly four-year reprieve from the disease, thanks to a dietary intervention with coconut oil and MCT (medium-chain triglyceride) oil. Since Steve’s remarkable turnaround from early-onset Alzheimer’s in 2008, Dr. Newport has communicated with hundreds of people and their caregivers dealing with neurodegenerative diseases. In addition to detailing the most recent research on the links between Alzheimer’s and many common medications, Dr. Newport illustrates how infection, inflammation, and genetic makeup may affect an individual’s response to fatty-acid therapy. She also covers the recent advances in imaging technologies, which have made it possible to detect subtle changes in the brain a decade or more before a person develops obvious symptoms, giving at-risk individuals the opportunity to take preventive measures. While the cause of Alzheimer’s disease is not known, Dr. Newport’s research offers a message of hope and shows how adopting certain lifestyle changes could prevent, delay, or otherwise alter the course of the disease.

Author : James E. Barrett,Joseph T. Coyle,Michael Williams
Publisher : Cambridge University Press
Page : 128 pages
File Size : 50,6 Mb
Release : 2012-06-28
Category : Medical
ISBN : 9781139510301

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Translational Neuroscience by James E. Barrett,Joseph T. Coyle,Michael Williams Pdf

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Author : Nancy J. Woolf,Avner Priel
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 40,8 Mb
Release : 2009-12-04
Category : Technology & Engineering
ISBN : 9783642035845

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Nanoneuroscience by Nancy J. Woolf,Avner Priel Pdf

Nanoneuroscience is the study of computationally relevant biomolecules found inside neurons. Because of recent technological advances at the nanometer scale, scientists have at their disposal increasingly better ways to study the brain and the biophysics of its molecules. This book describes how biomolecules contribute to the operations of synapses and perform other computationally relevant functions inside dendrites. These biomolecular operations considerably expand the brain-computer analogy - endowing each neuron with the processing power of a silicon-based multiprocessor. Amazingly, the brain contains hundreds of billions of neurons.