Animal Models Of Depression

Author : KOOB,EHLERS,KUPFER
Publisher : Springer Science & Business Media
Page : 303 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468467628

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Animal Models of Depression by KOOB,EHLERS,KUPFER Pdf

Animal models represent experimental investigations developed in one species for the purpose of studying phenomena in another species and provide numerous advantages for preclinical research. They allow scientists greater control and isolation of important experimental variables. Animal models are safe, reproducible strategies by which to evaluate and design new pharma cological treatment strategies, while also allowing direct central nervous system intervention to alter the course of the aberrant behavior. Animal models have been developed for a number of mental illnesses; in this particular domain, they hold the promise to shed light on the still obscure etiologies of these illnesses and ultimately to facilitate the development and testing of "cures. " Yet, true models of mental illness are difficult to develop, because mental illness may be a uniquely human phenomenon. It was based on these considerations that the MacArthur Foundation Research Network on the Psychobiology of Depression set out to sponsor a conference to review the status, problems, promises, and relevance of animal models to the clinical conditions of affective disorders. The conference was held in September 1986 and included participants from both within the Network as well as scientists and scholars from various disciplines relevant to the concerns of the conference. After the conference was held, it became clear to the organizers that the material presented could be helpful to a broader field of investigators, since a significant portion of the information has not been presented elsewhere or in the unified context of a monograph.

Author : Jerry J. Buccafusco
Publisher : CRC Press
Page : 341 pages
File Size : 45,7 Mb
Release : 2000-08-29
Category : Medical
ISBN : 9781420041811

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Methods of Behavior Analysis in Neuroscience by Jerry J. Buccafusco Pdf

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Author : Olivier,Slangen,Mos
Publisher : Birkhäuser
Page : 447 pages
File Size : 47,7 Mb
Release : 2013-11-21
Category : Science
ISBN : 9783034864190

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Animal Models in Psychopharmacology by Olivier,Slangen,Mos Pdf

Author : Jim J. Hagan
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 40,6 Mb
Release : 2011-04-02
Category : Medical
ISBN : 9783642197031

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Molecular and Functional Models in Neuropsychiatry by Jim J. Hagan Pdf

The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.

Author : Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo
Publisher : Cambridge University Press
Page : 361 pages
File Size : 46,9 Mb
Release : 2013-04-25
Category : Science
ISBN : 9781107355576

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Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes by Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo Pdf

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Author : Puneet Kumar Bansal,Rahul Deshmukh
Publisher : Springer
Page : 343 pages
File Size : 40,5 Mb
Release : 2018-01-17
Category : Medical
ISBN : 9789811059810

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Animal Models of Neurological Disorders by Puneet Kumar Bansal,Rahul Deshmukh Pdf

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Author : Pascual Ángel Gargiulo,Humberto Luis Mesones Arroyo
Publisher : Springer
Page : 465 pages
File Size : 54,7 Mb
Release : 2018-11-28
Category : Medical
ISBN : 9783319953601

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Psychiatry and Neuroscience Update by Pascual Ángel Gargiulo,Humberto Luis Mesones Arroyo Pdf

This broad and thought-provoking volume provides an overview of recent intellectual and scientific advances that bridge the gap between psychiatry and neuroscience, offering a wide range of penetrating insights in both disciplines. The third volume on the topic in the last several years from a varying panel of international experts, this title identifies the borders, trends and implications in both fields today and goes beyond that into related disciplines to seek out connections and influences. Similar to its two Update book predecessors, Psychiatry and Neuroscience – Volume III presents the current state-of-the-art in the main disciplines – psychiatry and neuroscience – and attempts to provide deeper comprehension or explication of the normal and diseased human mind, its biological correlates and its biographical and existential implications. This engaging volume continues the previous style of exploring different disciplines and trying to integrate disciplinary evidence from varying points of view in an organic manner. Developed for clinicians and researchers in the fields of medicine, psychiatry, psychology and biology, this third volume also will be of great interest to students and university professors of diverse disciplines.

Author : Kurt Leroy Hoffman
Publisher : Woodhead Publishing
Page : 324 pages
File Size : 46,7 Mb
Release : 2015-08-28
Category : Medical
ISBN : 9780081001066

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Modeling Neuropsychiatric Disorders in Laboratory Animals by Kurt Leroy Hoffman Pdf

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders

Author : Kathrin Herrmann,Kimberley Jayne
Publisher : BRILL
Page : 749 pages
File Size : 53,9 Mb
Release : 2019-04-30
Category : Philosophy
ISBN : 9789004391192

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Animal Experimentation: Working Towards a Paradigm Change by Kathrin Herrmann,Kimberley Jayne Pdf

Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Author : George F. Koob
Publisher : Unknown
Page : 295 pages
File Size : 41,5 Mb
Release : 1989-01-01
Category : Depression, Mental
ISBN : 376433407X

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Animal Models of Depression by George F. Koob Pdf

Animal models represent experimental investigations developed in one species for the purpose of studying phenomena in another species and provide numerous advantages for preclinical research. They allow scientists greater control and isolation of important experimental variables. Animal models are safe, reproducible strategies by which to evaluate and design new pharma cological treatment strategies, while also allowing direct central nervous system intervention to alter the course of the aberrant behavior. Animal models have been developed for a number of mental illnesses; in this particular domain, they hold the promise to shed light on the still obscure etiologies of these illnesses and ultimately to facilitate the development and testing of "cures. " Yet, true models of mental illness are difficult to develop, because mental illness may be a uniquely human phenomenon. It was based on these considerations that the MacArthur Foundation Research Network on the Psychobiology of Depression set out to sponsor a conference to review the status, problems, promises, and relevance of animal models to the clinical conditions of affective disorders. The conference was held in September 1986 and included participants from both within the Network as well as scientists and scholars from various disciplines relevant to the concerns of the conference. After the conference was held, it became clear to the organizers that the material presented could be helpful to a broader field of investigators, since a significant portion of the information has not been presented elsewhere or in the unified context of a monograph."

Author : Laura B. Tucker,Mario G. Oyola,Nikolaos Kokras,Deborah Suchecki
Publisher : Frontiers Media SA
Page : 141 pages
File Size : 51,9 Mb
Release : 2022-08-12
Category : Science
ISBN : 9782889767731

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Animal Models of Anxiety and Depression: Exploring the Underlying Mechanisms of Sex Differences by Laura B. Tucker,Mario G. Oyola,Nikolaos Kokras,Deborah Suchecki Pdf

Author : Paul Willner
Publisher : Cambridge University Press
Page : 564 pages
File Size : 53,8 Mb
Release : 1991-02-21
Category : Medical
ISBN : 052139192X

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Behavioural Models in Psychopharmacology by Paul Willner Pdf

Behavioural models in psychopharmacology are used for different purposes. The main concern of industrial psychopharmacologists is specifically to develop new and improved drugs for the treatment of mental disorders, while basic scientists use animal models to investigate the underlying nature of such conditions. The important distinction between these different perspectives is made explicit for the first time in this book. By considering such conditions as anxiety, depression, mania and schizophrenia, feeding disorders, dementia, and drug dependence, this book provides a comprehensive and critical review of the adequacy of the behavioural procedures used by psychopharmacologists to model psychiatric disorders. Graduate students and research workers in pscyhopharmacology, from both academic and industrial spheres, as well as clinicians, will find this book of considerable interest.

Author : Eva Tvrdá,Sarat Chandra Yenisetti
Publisher : BoD – Books on Demand
Page : 248 pages
File Size : 46,7 Mb
Release : 2020-04-08
Category : Science
ISBN : 9781838800116

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Animal Models in Medicine and Biology by Eva Tvrdá,Sarat Chandra Yenisetti Pdf

Thanks to animal models, our knowledge of biology and medicine has increased enormously over the past decades, leading to significant breakthroughs that have had a direct impact on the prevention, management and treatment of a wide array of diseases.This book presents a comprehensive reference that reflects the latest scientific research being done in a variety of medical and biological fields utilizing animal models. Chapters on Drosophila, rat, pig, rabbit, and other animal models reflect frontier research in neurology, psychiatry, cardiology, musculoskeletal disorders, reproduction, chronic diseases, epidemiology, and pain and inflammation management. Animal Models in Medicine and Biology offers scientists, clinicians, researchers and students invaluable insights into a wide range of issues at the forefront of medical and biological progress.

Author : Todd D. Gould
Publisher : Unknown
Page : 128 pages
File Size : 43,5 Mb
Release : 2009
Category : Affective disorders
ISBN : 1617793132

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Mood and Anxiety Related Phenotypes in Mice by Todd D. Gould Pdf

Author : Allan V. Kalueff
Publisher : Nova Publishers
Page : 236 pages
File Size : 40,7 Mb
Release : 2006
Category : Animal models in research
ISBN : 1594548145

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Animal Models in Biological Psychiatry by Allan V. Kalueff Pdf

In this book, experts from academia introduce the reader to some of the recent new developments in the field of experimental modelling of various brain disorders. Covering data from neuroethology to neurogenetics and psychopharmacology, this book collects a number of outstanding state-of-the-art papers on the topic, collected by the Russian Society for BioPsychiatry. They will give us a brief, but sound, resume of the reasons why it is so important to study biological markers of brain pathology, and in so doing, discuss the various challenges and available opportunities.