Antimicrobial Peptides And Human Disease

Author : William Shafer
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 42,9 Mb
Release : 2006-10-05
Category : Medical
ISBN : 9783540299165

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Antimicrobial Peptides and Human Disease by William Shafer Pdf

Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.

Author : Jürgen Harder,Jens-M. Schröder
Publisher : Springer
Page : 158 pages
File Size : 53,7 Mb
Release : 2015-12-24
Category : Medical
ISBN : 9783319241999

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Antimicrobial Peptides by Jürgen Harder,Jens-M. Schröder Pdf

This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. The first chapters deal with several examples of the role of AMP in different epithelial organs (skin and wound healing, eye, lung, genito-urinary tract, gut), which are exposed to different kinds of infectious microorganisms and as a result produce different patterns of AMP. Examples of the dysregulation of AMP expression and function promoting infections are discussed. The capacity of AMP to restrict the availability of essential metals to bacteria as an efficient antibacterial strategy in nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin D, the sunshine vitamin, influences AMP-expression and how this can affect our health is also addressed. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity. AMP’s specific functions, including in fighting multi-resistant bacteria, suggest that they may offer therapeutic benefits – a question that is discussed in the final chapter.

Author : Richard L. Gallo
Publisher : Taylor & Francis
Page : 374 pages
File Size : 54,8 Mb
Release : 2005
Category : Medical
ISBN : 1904933106

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Antimicrobial Peptides in Human Health and Disease by Richard L. Gallo Pdf

This book represents a cutting edge summary of one of the most important fields in innate immunity. Antimicrobial peptides rapidly and directly inhibit infection by microbes and are of enormous importance in the body's natural defence against disease. In addition the role of antimicrobial peptides in the development of therapeutic agents for the prevention and treatment of disease is becoming increasingly important. Written by the leaders in the field this book provides an understanding of the implications of antimicrobial peptides in human disease. The volume is divided into sections containing reviews of specific families of antimicrobials, select organ systems that have demonstrated a relevance for antimicrobial peptides and, in addition, a more global discussion of these peptides and organs from distinct perspectives. Alternatively, each chapter can stand on its own, providing the reader with the ability to dive right into the subject of most interest. Topics covered include cathelicidins, alpha and beta defensins, granulysin, hepcidin, the role of antimicrobial peptides in blood, gut, skin, lung and in the oral environment. A recurring theme is the possibility of creating therapeutics that induce the expression of endogenous antimicrobial peptides for the prevention or treatment of disease.

Author : Pieter S. Hiemstra,Sebastian A. J. Zaat
Publisher : Springer Science & Business Media
Page : 384 pages
File Size : 47,6 Mb
Release : 2013-02-01
Category : Medical
ISBN : 9783034805414

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Antimicrobial Peptides and Innate Immunity by Pieter S. Hiemstra,Sebastian A. J. Zaat Pdf

Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.

Author : Joan Marsh,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 292 pages
File Size : 42,7 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470514665

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Antimicrobial Peptides by Joan Marsh,Jamie A. Goode Pdf

Describes the structure and function of important peptides from several different organisms. An exciting development is the use of these peptides or their analogues in the treatment and prevention of infectious diseases. Considers ways in which these peptides may be used to control the insect vectors of key pathogens including the malarial parasite. Discusses the role of antimicrobial peptides in the mammalian immune system and their interaction with other components of that system.

Author : K. Ajesh,K. Sreejith
Publisher : Academic Press
Page : 347 pages
File Size : 44,8 Mb
Release : 2022-11-23
Category : Medical
ISBN : 9780323903202

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Antimicrobial Peptides by K. Ajesh,K. Sreejith Pdf

Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development. Emphasizes antimicrobial peptides targeting various human viruses and multidrug resistant bacteria Written by internationally recognized experts who provide readers with a wide and useful perspective Provides in-depth resources for undertaking a research work in antimicrobial peptides with the inclusion of chapters on purification techniques and structural details Addresses the possibility and availability of peptide antibiotics in the global drug market Serves as a complete resource from the discovery to drug development of peptide antibiotics

Author : Andrea Giuliani,Andrea C. Rinaldi
Publisher : Methods in Molecular Biology
Page : 448 pages
File Size : 40,9 Mb
Release : 2010-03-23
Category : Medical
ISBN : STANFORD:36105211747592

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Antimicrobial Peptides by Andrea Giuliani,Andrea C. Rinaldi Pdf

In this book, leading investigators present a broad, up-to-date collection of current research and experimental methods for the isolation, characterization, production, and optimization of AMPs. The book covers a rapidly expanding field of research.

Author : David A. Phoenix,Sarah R. Dennison,Frederick Harris
Publisher : John Wiley & Sons
Page : 354 pages
File Size : 54,8 Mb
Release : 2012-12-27
Category : Science
ISBN : 9783527652877

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Antimicrobial Peptides by David A. Phoenix,Sarah R. Dennison,Frederick Harris Pdf

In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.

Author : Mark W. Robinson,Andrew T. Hutchinson,Sheila Donnelly
Publisher : Frontiers E-books
Page : 63 pages
File Size : 43,8 Mb
Release : 2024-06-16
Category : Electronic
ISBN : 9782889190775

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Antimicrobial Peptides: Utility Players in Innate Immunity by Mark W. Robinson,Andrew T. Hutchinson,Sheila Donnelly Pdf

Antimicrobial peptides (AMPs) represent an ancient group of molecules with diverse functions in innate immunity. To date, more than 1000 naturally-occurring AMPs have been identified which display considerable diversity in their primary sequences, lengths, structures and biological activities. Despite this variability, AMPs are broadly classified according to homologous secondary structures as cathelicidins (linear a-helical peptides), defensins (ß-strand peptides connected by disulfide bonds) and bactenecins (loop peptides). Most, but not all, AMPs are cationic with amphipathic faces. These biochemical properties bestow many peptides with potent antimicrobial activity by facilitating interactions with negatively charged microbial cell membrane components, thereby increasing membrane permeability and resulting in microbial death. Other indirect effects on microbial physiology have been reported including inhibition of DNA/RNA synthesis, impaired protein synthesis and folding, disruption of cell wall formation and inhibition of microbial cell metabolism. Thus, with the spread of antibiotic-resistant microbial pathogens, AMPs have emerged as exciting candidates for next generation anti-infective therapies. However, recent studies suggest that AMPs have evolved other mechanisms of pathogen clearance. Immunomodulation is a novel approach to antimicrobial therapy that centres on boosting host immunity rather than direct microbial killing. This is also an attractive means to treat sepsis and other immune-mediated diseases. Whilst several cationic peptides are under investigation as antimicrobial agents, a select few show a remarkable ability to protect against lethal endotoxaemia and clinically-relevant bacterial infections including methicillin-resistant Staphylococcus aureus (MRSA). The molecular mechanisms responsible for this protection are only beginning to emerge but include prevention of innate cell activation by targeting key stages of bacterial endotoxin-mediated cell signalling. In this research topic, hosted by Frontiers in Molecular Innate Immunity, we aim to highlight key areas of AMP research including peptide diversity, structure-function relationships, antimicrobial activity and mechanisms of immune-modulation. We also aim to stimulate discussion on the emerging therapeutic potential of AMPs including antifungal, antiviral and anticancer applications.

Author : Chi Hin Cho
Publisher : Academic Press
Page : 186 pages
File Size : 45,9 Mb
Release : 2018-06-06
Category : Medical
ISBN : 9780128143209

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Antimicrobial Peptides in Gastrointestinal Diseases by Chi Hin Cho Pdf

Antimicrobial peptides (AMPs), including cathelicidins and defensins are host defence peptides that carry out multiple roles in the gastrointestinal (GI) tract. Antimicrobial Peptides in Gastrointestinal Diseases presents knowledge about the physiological functions and pharmacological actions of AMPs in inflammation, cancer, and further infection of the GI tract. The book provides coverage from the basic research to clinical application for GI diseases. Current research and development of AMPs is presented, opening the way for further work on these peptides, not only in the context of GI diseases, but also for similar pathologies in other organs. AMPs are key to the regulation of human microbiome and second line defence in the GI mucosa, prevent colonization of pathogens and modulation of innate response to invading pathogens, and modify immunological reactions during inflammatory processes and oncogenic development in the GI mucosa. More importantly, AMPs possess diversified anti-microbial actions against various infectious diseases in the GI tract. With these physiological functions and pharmacological actions, AMPs have significant potential as therapeutic agents for the treatment of inflammation, cancer and further infection in the GI tract. Provides an overview of AMPs, particularly cathelicidin and defensin, in different diseases Covers inflammation and ulcer repair in the stomach and colon and carcinogenesis in the GI tract Presents AMP information and knowledge in a concise manner Gives useful information on all aspects of AMPs Promotes research on AMPs and their development as drugs, from bench, to clinical application

Author : Katsumi Matsuzaki
Publisher : Springer
Page : 304 pages
File Size : 45,8 Mb
Release : 2019-04-12
Category : Medical
ISBN : 9789811335884

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Antimicrobial Peptides by Katsumi Matsuzaki Pdf

This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

Author : Mark Hulett,Charles Lee Bevins,Thanh Kha Phan
Publisher : Frontiers Media SA
Page : 399 pages
File Size : 42,7 Mb
Release : 2021-04-07
Category : Medical
ISBN : 9782889666676

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Advances in The Immunology of Host Defense Peptide: Mechanisms and Applications of Antimicrobial Functions and Beyond by Mark Hulett,Charles Lee Bevins,Thanh Kha Phan Pdf

Author : Guangshun Wang
Publisher : Cabi
Page : 230 pages
File Size : 43,7 Mb
Release : 2010
Category : Medical
ISBN : 1845936574

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Antimicrobial Peptides by Guangshun Wang Pdf

Antimicrobial Peptides (AMPs) are an organism's built-in defence molecules that have attracted extensive research attention worldwide. Covering the advances in AMP research, this volume examines technologies such as bioinformatics, combinatorial libraries, high-throughput screening, peptidomimetics, biophysics, and structural biology.

Author : Peter R. Donald,Paul D. Van Helden
Publisher : Karger Medical and Scientific Publishers
Page : 262 pages
File Size : 40,6 Mb
Release : 2011
Category : Medical
ISBN : 9783805596275

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Antituberculosis Chemotherapy by Peter R. Donald,Paul D. Van Helden Pdf

Tuberculosis (TB) remains one of the major infectious diseases of mankind although drugs for its treatment have been available for nearly 60 years. The standard short-course 6-month regimen used since about 1980 has helped to save millions of lives, but co-infection with HIV has had a devastating effect on the epidemic, and multidrug-resistant TB is a growing problem, particularly in communities with a high incidence of HIV. Following the declaration by the WHO in the early 1990s that TB was a 'global health emergency', interest in TB research and the development of new drugs has increased significantly. This volume reviews anti-TB chemotherapy with the emphasis on the actions and pharmacology of existing drugs and the development and evaluation of new agents. A close look is taken at new research regarding our existing drugs by some of the best-known specialists in the field, and historical aspects of these agents are reviewed from a modern perspective. The prospects for the introduction of new drugs and different approaches of how to assess them in adults and in children are discussed in detail. Several papers address the problems associated with drug resistance, its spread and diagnosis. Compiled by two editors from Cape Town, which has a particularly high incidence of TB and is a centre of tuberculosis research, this publication is an indispensable reference for anyone involved in the management of TB either as a researcher, clinician or administrator, and those working in drug development.

Author : Michael Zasloff
Publisher : Wiley-Interscience
Page : 300 pages
File Size : 44,6 Mb
Release : 2013-03-19
Category : Science
ISBN : 0470227230

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Antimicrobial Peptides by Michael Zasloff Pdf

Written by a pioneer in the field of antimicrobial peptides, who has been involved in discovery, drug development, and the study of the role played by AMPs in human health and disease, Antimicrobial Peptides is the first comprehensive overview of the field of innate immunity. Exploring this "hard wired" system of host defense that has emerged over the past decade as an important system in health and disease, author Michael Zasloff explains why AMPs are of such interest, what has been accomplished commercially to date, the problems, potential solutions, and what the future holds.