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Author : Harry A. Milman
Publisher : Springer Science & Business Media
Page : 505 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461337904
Author : Harry A Milman
Publisher : Unknown
Page : 532 pages
File Size : 41,8 Mb
Release : 1983-11-01
Category : Electronic
ISBN : 1461337917
Author : Institute of Medicine,Committee on Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment
Publisher : National Academies Press
Page : 250 pages
File Size : 41,5 Mb
Release : 2007-03-27
Category : Medical
ISBN : 9780309133999
Many cancer patients are diagnosed at a stage in which the cancer is too far advanced to be cured, and most cancer treatments are effective in only a minority of patients undergoing therapy. Thus, there is tremendous opportunity to improve the outcome for people with cancer by enhancing detection and treatment approaches. Biomarkers will be instrumental in making that transition. Advances in biotechnology and genomics have given scientists new hope that biomarkers can be used to improve cancer screening and detection, to improve the drug development process, and to enhance the effectiveness and safety of cancer care by allowing physicians to tailor treatment for individual patients—an approach known as personalized medicine. However, progress overall has been slow, despite considerable effort and investment, and there are still many challenges and obstacles to overcome before this paradigm shift in oncology can become a reality.
Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 51,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : P. Toniolo
Publisher : Unknown
Page : 340 pages
File Size : 41,8 Mb
Release : 1997
Category : Medical
ISBN : UCSD:31822023126550
This publication originates from an international workshop which addresses a range of methodological issues underlying the use of biological markers of exposure, biological effects and individual susceptibility in cancer epidemiology. It includes a report of the workshop, with a general discussion and recommendation on epidemiology. a series of peer-reviewed authored contributors provide a more personal view on the most important aspects by key researchers.
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Comparative Toxicity of Naturally Occurring Carcinogens
Publisher : National Academies Press
Page : 433 pages
File Size : 49,5 Mb
Release : 1996-02-12
Category : Nature
ISBN : 9780309175715
Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
Author : Mu Wang,Frank Witzmann
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 45,6 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9789535125051
The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.
Author : Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease
Publisher : National Academies Press
Page : 335 pages
File Size : 46,6 Mb
Release : 2010-06-25
Category : Medical
ISBN : 9780309157278
Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Author : James G. Ravenel
Publisher : Springer Science & Business Media
Page : 205 pages
File Size : 50,7 Mb
Release : 2013-06-22
Category : Medical
ISBN : 9781607616207
While specialists often guide the care to lung cancer patients, it is often a general radiologist who is left to interpret studies that impact patient care and management. Lung Cancer Imaging provides a comprehensive guide to the diagnosis, staging and overview of the management of lung cancer relevant to practicing radiologists so that they can better understand the decision making issues and provide more directed and useful communication to the treating physicians. It Primary Care physicians will also find this book valuable to understand the relevant issues that they face when one of their patients is being treated for lung cancer.
Author : Roberto Scatena
Publisher : Unknown
Page : 128 pages
File Size : 40,5 Mb
Release : 2015
Category : Electronic
ISBN : 9401772169
At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes. Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers tested. Often the physician who should utilize these biomarker does not entirely know their limits and the total potential applications as well and sometimes this knowledge is influenced by economical and marketing strategies. This limited and "polluted" knowledge may have dramatic consequences for patient. The aim of this book is to diffuse all aspects of cancer biomarkers, from their biochemical peculiarities to all clinical implications by passing through their physiology and pathophysiology. This critical approach towards old and new cancer biomarkers should foster a deepened and useful understanding of the diagnostic and prognostic index of these fundamental parameters of laboratory medicine and in the same time facilitating the research of new and more sensitive-specific signals of the cancer cell proliferation.
Author : Anonim
Publisher : Unknown
Page : 608 pages
File Size : 42,5 Mb
Release : 1983
Category : Carcinogenesis
ISBN : MINN:30000001805302
Author : Giampietro Gasparini,Daniel F. Hayes
Publisher : Springer Science & Business Media
Page : 335 pages
File Size : 46,9 Mb
Release : 2008-01-17
Category : Medical
ISBN : 9781592599158
Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Author : National Academy of Engineering
Publisher : National Academies Press
Page : 125 pages
File Size : 52,7 Mb
Release : 2019-02-28
Category : Technology & Engineering
ISBN : 9780309487504
This volume presents papers on the topics covered at the National Academy of Engineering's 2018 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2018 symposium was held September 5-7 and hosted by MIT Lincoln Laboratory in Lexington, Massachusetts. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.
Author : Anonim
Publisher : Unknown
Page : 686 pages
File Size : 46,8 Mb
Release : 1986
Category : Toxicology
ISBN : UOM:39015014050408
Includes notices of research projects submitted to the Smithsonian Science Information Exchange concerning toxicological testing.
Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 46,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401106771
It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.
