Asymmetric Synthesis Ii

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Asymmetric Synthesis II

Mathias Christmann,Stefan Bräse
Asymmetric Synthesis II Book PDF

Author : Mathias Christmann,Stefan Bräse
Publisher : John Wiley & Sons
Page : 406 pages
File Size : 47,6 Mb
Release : 2013-03-19
Category : Science
ISBN : 9783527652259

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Asymmetric Synthesis II by Mathias Christmann,Stefan Bräse Pdf

After the overwhelming success of Asymmetric Synthesis - The Essentials, displaying a broad range of organic asymmetric syntheses, this is the second edition with latest subjects and authors. While the aim of the first edition was mainly to honor the achievements of the pioneers in asymmetric syntheses, the aim of this new edition was bringing the current developments, especially from younger colleagues, to the attention of students. The format of the book remained unchanged, i.e. short conceptual overviews by young leaders in their field including a short biography of the authors. The growing multidisciplinary research within chemistry is reflected in the selection of topics including metal catalysis, organocatalysis, physical organic chemistry, analytical chemistry, and its applications in total synthesis, materials research and industry. The prospective reader of this book is a graduate or undergraduate student of advanced organic chemistry as well as the industrial chemist who wants to get a brief update on the current developments in the field.

Asymmetric Synthesis II

Mathias Christmann,Stefan Bräse
Asymmetric Synthesis II Book PDF

Author : Mathias Christmann,Stefan Bräse
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 43,6 Mb
Release : 2013-04-12
Category : Science
ISBN : 9783527652266

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Asymmetric Synthesis II by Mathias Christmann,Stefan Bräse Pdf

After the overwhelming success of 'Asymmetric Synthesis - The Essentials', displaying a broad range of organic asymmetric syntheses, this is the second edition with latest subjects and authors. While the aim of the first edition was mainly to honor the achievements of the pioneers in asymmetric syntheses, the aim of this new edition was bringing the current developments, especially from younger colleagues, to the attention of students. The format of the book remained unchanged, i.e. short conceptual overviews by young leaders in their field including a short biography of the authors. The growing multidisciplinary research within chemistry is reflected in the selection of topics including metal catalysis, organocatalysis, physical organic chemistry, analytical chemistry, and its applications in total synthesis, materials research and industry. The prospective reader of this book is a graduate or undergraduate student of advanced organic chemistry as well as the industrial chemist who wants to get a brief update on the current developments in the field.

Principles of Asymmetric Synthesis

R.E. Gawley,J. Aubé
Principles of Asymmetric Synthesis Book PDF

Author : R.E. Gawley,J. Aubé
Publisher : Elsevier
Page : 394 pages
File Size : 52,5 Mb
Release : 1996-11-21
Category : Science
ISBN : 9780080514772

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Principles of Asymmetric Synthesis by R.E. Gawley,J. Aubé Pdf

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.

Catalysis in Asymmetric Synthesis

Vittorio Caprio,Jonathan M. J. Williams
Catalysis in Asymmetric Synthesis Book PDF

Author : Vittorio Caprio,Jonathan M. J. Williams
Publisher : John Wiley & Sons
Page : 409 pages
File Size : 45,6 Mb
Release : 2009-03-09
Category : Science
ISBN : 9781405190916

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Catalysis in Asymmetric Synthesis by Vittorio Caprio,Jonathan M. J. Williams Pdf

Asymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists. Written from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods. Topics covered include: Reduction of alkenes, ketones and imines Nucleophilic addition to carbonyl compounds Catalytic carbon-carbon bond forming reactions Catalytic reactions involving metal carbenoids Conjugate addition reactions Catalysis in Asymmetric Synthesis bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.

Axially Chiral Compounds

Bin Tan
Axially Chiral Compounds Book PDF

Author : Bin Tan
Publisher : John Wiley & Sons
Page : 338 pages
File Size : 41,7 Mb
Release : 2021-11-22
Category : Science
ISBN : 9783527347124

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Axially Chiral Compounds by Bin Tan Pdf

Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic chemist practicing today, the book follows the development history, research status, and applications of axial chirality. An introductory chapter familiarizes the reader with foundational material before the distinguished authors describe the different classes and the synthesis of axial chiral compounds used in asymmetric synthesis. The book concludes with a focus on the applications of chiral ligands, chiral catalysts, and materials. Readers will also benefit from the inclusion of: A thorough introduction to asymmetric synthesis, including biaryls atropisomers, heterobiaryls atropisomers, and non-biaryls atropisomers Explorations of chiral allene, spiro skeletons, and natural products Practical discussions of asymmetric transformation, chiral ligands, and chiral catalysts An examination of miscellaneous applications of axially chiral compounds Perfect for organic chemists, chemists working with or on organometallics, catalytic chemists, and materials scientists, Axially Chiral Compounds: Asymmetric Synthesis and Applications will also earn a place in the libraries of natural products chemists who seek a one-stop reference for compounds exhibiting axial chirality.

Asymmetric Synthesis of Natural Products

Ari M. P. Koskinen
Asymmetric Synthesis of Natural Products Book PDF

Author : Ari M. P. Koskinen
Publisher : John Wiley & Sons
Page : 388 pages
File Size : 41,8 Mb
Release : 2022-11-30
Category : Science
ISBN : 9781119707028

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Asymmetric Synthesis of Natural Products by Ari M. P. Koskinen Pdf

Asymmetric Synthesis of Natural Products Fully updated learning resource covering the concept of using natural product chemistry for strategies in asymmetric synthesis The third edition of Asymmetric Synthesis of Natural Products introduces students to the rapidly growing field of natural products in organic chemistry, discussing the practical, mainly pharmacological, importance of selected compounds and emphasizing the target-oriented approach of organic synthesis which is key in industrial strategies. To aid in reader comprehension, the text includes key references and an Index of Compounds. The textbook is based on two lecture courses (Asymmetric Synthesis & Asymmetric Synthesis of Natural Products), which the author has delivered more than 50 times over the past 20 years in Finland, the UK, Italy, and Greece. This third edition is fully updated from the earlier versions (published by Wiley in 1993 and 2012). The importance of natural products as truly renewable raw materials in sustainable chemistry and circular economy is illustrated through applications of e.g. organocatalysis, organometallic catalysis, and biocatalysis. The contents consist of traditional text supplemented with illustrations (such as chemical drawings and structural formulae). Three dimensional aspects are also discussed with the use of 3D renderings of structures for both reaction mechanisms (molecular modeling) and crystallographic data. Sample topics covered in the textbook include: The foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions Sustainable development, the circular economy, and use of renewable raw materials that have become prominent in many fields of science and technology Various natural product classes, including carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, and polyketides The properties of these natural product classes, including their structures, biosynthesis, and interrelationships, as well as examples of asymmetric syntheses and the practical value of these compounds Asymmetric Synthesis of Natural Products is a comprehensive, authoritative, and up-to-date learning resource on the subject for advanced level undergraduate or early-stage graduate students. It is also useful for specialists already working in synthesis who wish to learn about asymmetric synthesis.

Asymmetric Synthesis of Nitrogen Heterocycles

Jacques Royer
Asymmetric Synthesis of Nitrogen Heterocycles Book PDF

Author : Jacques Royer
Publisher : John Wiley & Sons
Page : 425 pages
File Size : 52,7 Mb
Release : 2009-08-04
Category : Science
ISBN : 9783527625512

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Asymmetric Synthesis of Nitrogen Heterocycles by Jacques Royer Pdf

Here, all aspects of the topic are presented in a compact manner. The book is clearly structured, and divided into two sections -- asymmetric synthesis of heterocycles containing only one nitrogen and that of those with more than one nitrogen as a heteroatom -- such that the necessary information may be found at a glance. The international team of authors provides important experimental procedures, including industrial applications. Essential for synthetic chemists in pharmaceutical and agrochemical chemistry.

The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers

James D. Morrison,John W. Scott
The Chiral Carbon Pool and Chiral Sulfur Nitrogen Phosphorus and Silicon Centers Book PDF

Author : James D. Morrison,John W. Scott
Publisher : Unknown
Page : 400 pages
File Size : 40,8 Mb
Release : 1984
Category : Addisiereaksies
ISBN : UCLA:L0065425001

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The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers by James D. Morrison,John W. Scott Pdf

Asymmetric Synthesis, Volume 4: The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers describes the practical methods of obtaining chiral fragments. Divided into five chapters, this book specifically examines initial chiral transmission and extension. The opening chapter describes the so-called chiral carbon pool, the readily available chiral carbon fragments used as building blocks in synthesis. This chapter also provides a list of 375 chiral building blocks, along with their commercial sources, approximate prices, and methods of synthesis. Schemes involving almo ...

Principles and Applications of Asymmetric Synthesis

Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan
Principles and Applications of Asymmetric Synthesis Book PDF

Author : Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan
Publisher : John Wiley & Sons
Page : 536 pages
File Size : 46,6 Mb
Release : 2003-05-29
Category : Science
ISBN : 9780471465249

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Principles and Applications of Asymmetric Synthesis by Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan Pdf

Asymmetric synthesis remains a challenge to practicing scientistsas the need for enantiomerically pure or enriched compoundscontinues to increase. Over the last decade, a large amount ofliterature has been published in this field. Principles andApplications of Asymmetric Synthesis consolidates and evaluates themost useful methodologies into a one-volume resource for theconvenience of practicing scientists and students. Authored by internationally renowned scientists in the field, thisreliable reference covers more than 450 reactions and includesimportant stoichiometric as well as catalytic asymmetric reactions.The first chapter reviews the basic principles, commonnomenclature, and analytical methods, and the remainder of the bookis organized according to reaction type. The text examines suchtopics as: Carbon-carbon bond formations involving carbonyls, enamines,imines, and enolates Asymmetric C-O bond formations including epoxidation,dihydroxylation, and aminohydroxylation Asymmetric synthesis using the Diels-Alder reaction and othercyclizations Applications to the total synthesis of natural products Use of enzymes in asymmetric synthesis Practicing chemists in the pharmaceutical, fine chemical, andagricultural professions as well as graduate students will findthat Principles and Applications of Asymmetric Synthesis affordscomprehensive and current coverage.

Fundamentals of Asymmetric Catalysis

Patrick J. Walsh,Marisa C. Kozlowski
Fundamentals of Asymmetric Catalysis Book PDF

Author : Patrick J. Walsh,Marisa C. Kozlowski
Publisher : University Science Books
Page : 692 pages
File Size : 54,5 Mb
Release : 2009-01-02
Category : Science
ISBN : 1891389548

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Fundamentals of Asymmetric Catalysis by Patrick J. Walsh,Marisa C. Kozlowski Pdf

This work describes the essential aspects of enantioselective catalysis, with chapters organised by concept rather than by reaction type. Each concept is supported by examples to give the reader broad exposure to a wide range of catalysts, reactions and reaction mechanisms.

Asymmetric Catalysis on Industrial Scale

Hans Ulrich Blaser,Elke Schmidt
Asymmetric Catalysis on Industrial Scale Book PDF

Author : Hans Ulrich Blaser,Elke Schmidt
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 46,7 Mb
Release : 2007-02-27
Category : Science
ISBN : 9783527605774

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Asymmetric Catalysis on Industrial Scale by Hans Ulrich Blaser,Elke Schmidt Pdf

Edited by two of the experts in the field, the central aim is to show organic chemists working in process development that enantioselective catalysis is suitable for the large-scale production of enantioenriched intermediates. In so doing, it is equally a source of information and inspiration for academic research, and, with its contribution by Noble prizewinner W. S. Knowles, will also heighten the status of industrial catalyst specialists working in the exciting field of enantioselective catalysis. Some 25 contributions from top industrial researchers around the world present case studies on the development of the widest possible range of large-scale enantioselective processes, featuring stereoselective production processes of fine-chemicals, agrochemicals and pharmaceuticals. Clearly structured according to the nature of the task, this handbook adopts a problem-driven approach such that readers can easily find how colleagues have dealt with a similar situation.

Asymmetric Synthesis of Natural Products

Ari M. P. Koskinen
Asymmetric Synthesis of Natural Products Book PDF

Author : Ari M. P. Koskinen
Publisher : John Wiley & Sons
Page : 415 pages
File Size : 52,9 Mb
Release : 2012-06-15
Category : Science
ISBN : 9781118347331

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Asymmetric Synthesis of Natural Products by Ari M. P. Koskinen Pdf

Asymmetric Synthesis of Natural Products, 2nd Edition introduces students to this rapidly growing field of organic chemistry. The initial chapters present the foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions. This is followed by chapters on each of the major individual classes of natural products; their structures, biosynthesis and interrelationships as well as examples of asymmetric syntheses and the practical value of these compounds. Natural product classes covered include carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, polyketides, isoprenoids, shikamic acid derivatives and alkaloids. For this second edition the text has been thoroughly updated and expanded, and includes new discussions and examples covering atom and redox economies, practical aspects and environmental awareness. Organocatalysis has emerged completely in the last ten years, and has been fully integrated into this new edition.

Principles of Asymmetric Synthesis

Robert E. Gawley,Jeffrey Aube
Principles of Asymmetric Synthesis Book PDF

Author : Robert E. Gawley,Jeffrey Aube
Publisher : Elsevier
Page : 569 pages
File Size : 42,6 Mb
Release : 2012-07-16
Category : Science
ISBN : 9780080448602

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Principles of Asymmetric Synthesis by Robert E. Gawley,Jeffrey Aube Pdf

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. The aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions.

Asymmetric Catalysis on Industrial Scale

Hans Ulrich Blaser,Hans-Jürgen Federsel
Asymmetric Catalysis on Industrial Scale Book PDF

Author : Hans Ulrich Blaser,Hans-Jürgen Federsel
Publisher : John Wiley & Sons
Page : 517 pages
File Size : 41,5 Mb
Release : 2011-08-04
Category : Science
ISBN : 9783527642168

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Asymmetric Catalysis on Industrial Scale by Hans Ulrich Blaser,Hans-Jürgen Federsel Pdf

This second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found. The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the catalytic step fits into the overall synthesis, or competition with other synthetic approaches, as well as the typical problems encountered in the various phases, including finding/developing the catalyst and optimization of the process or choice of equipment. Both successful and unsuccessful approaches to solve these problems are described.

Catalytic Asymmetric Synthesis

Takahiko Akiyama,Iwao Ojima
Catalytic Asymmetric Synthesis Book PDF

Author : Takahiko Akiyama,Iwao Ojima
Publisher : John Wiley & Sons
Page : 798 pages
File Size : 53,5 Mb
Release : 2022-06-15
Category : Science
ISBN : 9781119736394

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Catalytic Asymmetric Synthesis by Takahiko Akiyama,Iwao Ojima Pdf

Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.