Atrophy

Author : Junjie Xiao
Publisher : Springer
Page : 624 pages
File Size : 43,5 Mb
Release : 2018-11-02
Category : Science
ISBN : 9789811314353

Get Book

Muscle Atrophy by Junjie Xiao Pdf

The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.

Author : Charlotte J Sumner,Sergey Paushkin,Chien-Ping Ko
Publisher : Academic Press
Page : 506 pages
File Size : 50,8 Mb
Release : 2016-10-24
Category : Medical
ISBN : 9780128036860

Get Book

Spinal Muscular Atrophy by Charlotte J Sumner,Sergey Paushkin,Chien-Ping Ko Pdf

Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA Includes outstanding questions and perspectives for future investigations and key references for additional detailed study

Author : Jackson Burgess
Publisher : SCB Distributors
Page : 102 pages
File Size : 51,8 Mb
Release : 2018-09-21
Category : Psychology
ISBN : 9781949342062

Get Book

Atrophy by Jackson Burgess Pdf

Dive bars, gas stations, bedrooms, and snowfields comprise the setting as the speaker asks: What do we feel? What should we feel? Who gets to feel what? In his moving debut collection, Jackson Burgess examines heartbreak, depression, and empathy through a lens of rigorous introspection. Atrophy’s poems vary in location, mostly between Los Angeles and Iowa City, with reoccurring characters serving as touchstones, forming the book’s narrative. Much of the collection is about or directly addresses an ex-lover, Lily. In the wake of that failed relationship, Atrophy wrestles with loneliness, substance abuse, and dissociation, utilizing lists, letters, prose poems, and free verse. These poems celebrate the past while mourning it, armed with the advantage of retrospect. Prescription drugs, dog fights, dance parties, love letters, and ghosts—the world depicted is at times dark, at times humorous, but always human. Atrophy is vulnerable and cinematic, a series of manic meditations exploring what it means to love and be loved, to hurt and be hurt.

Author : Dan Haga
Publisher : Schiffer Publishing Limited
Page : 0 pages
File Size : 54,5 Mb
Release : 2011
Category : Architecture
ISBN : 0764337386

Get Book

Urban Atrophy by Dan Haga Pdf

Take an adventure into the abandoned structures of the American mid-Atlantic region through 560 startling photos and compelling text. These surreal images were captured in abandoned power plants, mental asylums, military bases, prisons, hospitals, schools, and cathedrals. Explore St. Elizabeth's Hospital in Washington, D.C.; Baltimore's Westport Power Plant and American Brewery; St. Mary's College in Ilchester, Maryland; Pittsburgh's Saints Peter and Paul Church; the Maryland Point Observatory military installation; Lorton Prison in Virginia; and the Enchanted Forest amusement park in Ellicott City, Maryland. Anyone who has ever wondered what happens to buildings when an organization closes its doors and turns out the lights for the last time will be fascinated by these images. Exploring these forgotten locations, according to the author, is like "being in another world, a surreal dream where people just disappeared and left everything behind."

Author : William Roberts
Publisher : Unknown
Page : 284 pages
File Size : 41,7 Mb
Release : 1858
Category : Electronic
ISBN : BSB:BSB10474303

Get Book

An Essay on Wasting Palsy, (Cruveilhier's Atrophy.) by William Roberts Pdf

Author : Julianna Cseri
Publisher : BoD – Books on Demand
Page : 190 pages
File Size : 42,9 Mb
Release : 2021-03-03
Category : Medical
ISBN : 9781838807245

Get Book

Background and Management of Muscular Atrophy by Julianna Cseri Pdf

A healthy skeletal musculature is necessary for a good quality of life and is important in sports. The loss of skeletal muscle mass leads to severe clinical complications and alters daily functioning. The aim of this book is to give an overview of skeletal muscle atrophy including pathomechanism, clinical characters, and the tools for prevention and treatment. Skeletal muscle atrophy can develop due to neurogenic or myogenic reasons, and frequently appears as an age-dependent disorder (sarcopenia). The studies of theoretical background give promising perspectives to prevent and treat muscle atrophy. The book is recommended to scientists, practitioners, students, sportsmen, and everybody who is interested in the normal and impaired function of the skeletal muscle.

Author : David L Shambaugh
Publisher : Univ of California Press
Page : 260 pages
File Size : 40,6 Mb
Release : 2008-04-02
Category : History
ISBN : 0520934695

Get Book

China's Communist Party by David L Shambaugh Pdf

Few issues affect the future of China--and hence all the nations that interact with China--more than the nature of its ruling party and government. In this timely study, David Shambaugh assesses the strengths and weaknesses, durability, adaptability, and potential longevity of China's Communist Party (CCP). He argues that although the CCP has been in a protracted state of atrophy, it has undertaken a number of adaptive measures aimed at reinventing itself and strengthening its rule. Shambaugh's investigation draws on a unique set of inner-Party documents and interviews, and he finds that China's Communist Party is resilient and will continue to retain its grip on power. Copub: Woodrow Wilson Center Press

Author : Sir James Paget
Publisher : Unknown
Page : 62 pages
File Size : 49,6 Mb
Release : 1847
Category : Hypertrophy
ISBN : NWU:35558005364902

Get Book

Lectures on Nutrition, Hypertrophy, and Atrophy by Sir James Paget Pdf

Author : Julien Cohen-Adad,Claudia Wheeler-Kingshott
Publisher : Academic Press
Page : 330 pages
File Size : 48,6 Mb
Release : 2014-01-16
Category : Medical
ISBN : 9780123972828

Get Book

Quantitative MRI of the Spinal Cord by Julien Cohen-Adad,Claudia Wheeler-Kingshott Pdf

Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord. Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory’s applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord. Chapters authored by international experts in the field of MRI of the spinal cord Contains “cooking recipes —examples of imaging parameters for each quantitative technique—designed to aid researchers and clinicians in using them in practice Ideal for clinical settings

Author : Robert Zivadinov
Publisher : Nova Publishers
Page : 220 pages
File Size : 51,9 Mb
Release : 2005
Category : Atrophy
ISBN : 1594541604

Get Book

Brain and Spinal Cord Atrophy in Multiple Sclerosis by Robert Zivadinov Pdf

Intended for general neurologists as well as specialists in multiple sclerosis (MS) and imaging, this book provides comprehensive discussion of central nervous system (CNS) atrophy involving the brain and spinal cord, and both the chapter authors and topics have been selected to provide state-of-the-art reviews. Key issues covered in the book include pathogenesis and its mechanisms, technical aspects of MRI measurement, the relationship between CNS atrophy and other MRI metrics, clinical relevance, the association with neurobehavioral and genetic-immunologic components of MS, and the effects of disease-modifying therapies on tissue atrophy. Pros and cons of different technical approaches are discussed critically. Special attention is devoted to CNS atrophy as a clinically relevant biologic marker of the MS disease process.

Author : Giuseppe Querques,Eric Souied
Publisher : Springer
Page : 120 pages
File Size : 51,9 Mb
Release : 2016-02-15
Category : Medical
ISBN : 9783319266213

Get Book

Macular Dystrophies by Giuseppe Querques,Eric Souied Pdf

​This book provides the ophthalmologist with the most recently available data on the macular dystrophies, a group of many different inherited or sporadic eye conditions linked by a problem with photoreceptors or other structures of the central retina. Internationally recognized experts in the field present the latest evidence and discuss their own personal experiences with regard to each of the principal dystrophies as well as some very rare entities. Topics covered include molecular biology, state-of-the-art diagnostic techniques, and the newest treatment options, including still experimental therapies. Attention is also devoted to a range of issues that continue to be debated. The editors have taken care to ensure that chapters are of a uniformly high standard while not sacrificing the originality of the individual authors. Macular Dystrophies will fully acquaint the reader with both the latest research findings and the current and emerging approaches to diagnosis and treatment.

Author : Gregor K. Wenning,Alessandra Fanciulli
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 45,6 Mb
Release : 2013-09-14
Category : Medical
ISBN : 9783709106877

Get Book

Multiple System Atrophy by Gregor K. Wenning,Alessandra Fanciulli Pdf

This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson`s disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.

Author : Josef F. Bille
Publisher : Springer
Page : 407 pages
File Size : 51,6 Mb
Release : 2019-08-13
Category : Medical
ISBN : 9783030166380

Get Book

High Resolution Imaging in Microscopy and Ophthalmology by Josef F. Bille Pdf

This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Author : Colin Atrophy Hagendorf
Publisher : Simon and Schuster
Page : 224 pages
File Size : 55,9 Mb
Release : 2016-11-08
Category : Biography & Autobiography
ISBN : 9781476790541

Get Book

Slice Harvester by Colin Atrophy Hagendorf Pdf

"Over the course of two years, a twenty-something punk rocker eats a cheese slice from every pizzeria in New York City, gets sober, falls in love, and starts a blog that captures headlines around the world--he is the Slice Harvester, and this is his story. Since its arrival on US shores in 1905, pizza has risen from an obscure ethnic food to an iconic symbol of American culture. It has visited us in our dorm rooms and apartments, sometimes before we'd even unpacked or painted. It has nourished us during our jobs, consoled us during break-ups, and celebrated our triumphs right alongside us. In August 2009, Colin Hagendorf set out to review every regular slice of pizza in Manhattan, and his blog, Slice Harvester, was born. Two years and nearly 400 slices later, he'd been featured in The Wall Street Journal, the Daily News (New York), and on radio shows all over the country. Suddenly, this self-proclaimed punk who was barely making a living doing burrito delivery and selling handmade zines had a following. But at the same time Colin was stepping up his game for the masses (grabbing slices with Phoebe Cates and her teenage daughter, reviewing kosher pizza so you don't have to), his personal life was falling apart. A problem drinker and chronic bad boyfriend, he started out using the blog as a way to escape--the hangovers, the midnight arguments, the hangovers again--until finally realizing that by taking steps to reach a goal day by day, he'd actually put himself in a place to finally take control of his life for good"--

Author : Anonim
Publisher : Unknown
Page : 1024 pages
File Size : 52,8 Mb
Release : 2013
Category : Gynecology
ISBN : 0071742670

Get Book

Current Diagnosis & Treatment by Anonim Pdf

This 11th edition is a concise, yet comprehensive textbook on the medical and surgical management of obstetrics and gynecology. It succinctly covers more than 1,000 diseases and disorders, the latest screening guidelines, and underlying pathophysiology when relevant. The eleventh edition is enriched by contributions from more than 85 world-renowned contributors.