Attempts To Understand Metastasis Formation Ii

Author : Ursula Günthert,Walter Birchmeier
Publisher : Springer Science & Business Media
Page : 297 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642611094

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Attempts to Understand Metastasis Formation II by Ursula Günthert,Walter Birchmeier Pdf

Within the last decade the molecular biology of tumor models has revealed the identification of several metastasis- related molecules. These volumes attempt to review the most recent approaches of their mechanisms, regulation and way to treat their malignant alterations. The first volume covers the presentation of proteases and inhibitors and their role in invasion of tumor cells, also cell adhesion molecules and their interaction with the extracellular matrix. In the second volume the regulation of tumor progression and angiogenesis by cytokines, growth factors and motility factors is outlined. The third volume deals with detection of micrometastases and therapeutic approaches, such as immunotherapy, gene therapy, chemotherapy and surgical strategies to combat metastatic spread.

Author : Ursula Günthert,Walter Birchmeier
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 48,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642611070

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Attempts to Understand Metastasis Formation I by Ursula Günthert,Walter Birchmeier Pdf

In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The pu-rpose of these three volumes is to review the recent progress in molecular metas tasis research and to attempt to further understand the biol ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno logy compile the most recent developments on these meta stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.

Author : Ursula Günthert,Walter Birchmeier,Peter M. Schlag
Publisher : Unknown
Page : 262 pages
File Size : 46,9 Mb
Release : 1996
Category : Electronic
ISBN : OCLC:1123602276

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Attempts to Understand Metastasis Formation by Ursula Günthert,Walter Birchmeier,Peter M. Schlag Pdf

Author : Ursula Günthert,Peter M. Schlag,Walter Birchmeier
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642800719

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Attempts to Understand Metastasis Formation III by Ursula Günthert,Peter M. Schlag,Walter Birchmeier Pdf

In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The purpose of these three volumes is to review the recent progress in molecular metas tasis research and to attempt to further understand the biol ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno logy compile the most recent developments on these meta stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.

Author : Ursula Günthert,Walter Birchmeier
Publisher : Unknown
Page : 316 pages
File Size : 47,5 Mb
Release : 1996
Category : Metastasis
ISBN : WISC:89057151896

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Attempts to Understand Metastasis Formation by Ursula Günthert,Walter Birchmeier Pdf

Author : Kenneth L. Tyler,Michael B.A. Oldstone
Publisher : Springer Science & Business Media
Page : 195 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642720956

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Reoviruses II by Kenneth L. Tyler,Michael B.A. Oldstone Pdf

Reoviruses are one of the most important viral groups for understanding the molecular and genetic basis for viral pathogenesis. These two volumes cover virtually all aspects of reovirus biology. Volume I begins with a review of reovirus structure; further chapters deal with functions of the reovirus structural proteins, the assembly of the genome, and reovirus mutants. Volume II reviews general mechanisms of reovirus persistent infection and cytopathic effects, and then discusses reovirus-induced disease in specific organ systems including the heart, nervous and endocrine systems, liver and biliary system, and intestine. Together, these two volumes provide a current and comprehensive review of the mammalian reoviruses.

Author : Robert L. Coffman,Sergio Romagnani
Publisher : Springer Science & Business Media
Page : 158 pages
File Size : 45,9 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9783662097090

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Redirection of Th1 and Th2 Responses by Robert L. Coffman,Sergio Romagnani Pdf

The two major subsets of CD4+ helper T cells, designated Th1 and Th2, have quite different patterns of cytokine production and, as a consequence, have very different roles in immune responses. The articles in this volume review both basic and clinical studies of T cell heterogeneity, including: the mechanisms by which Th1 and Th2 cells develop and maintain their differences in cytokine production; the different roles of Th1 and Th2 cells in allergy, autoimmunity and infectious diseases; the prospects and strategies for therapeutic manipulation of Th1 and Th2 cells; and the control of Th1 and Th2 responses by regulatory T cell subsets. The volume should give the reader a view of the development and function of Th1 and Th2 cells and the attempts to treat immunological diseases with therapies directed towards altering the Th1/Th2 balance.

Author : Kenneth I. Berns,Catherine Giraud
Publisher : Springer Science & Business Media
Page : 179 pages
File Size : 48,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642802072

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Adeno-Associated Virus (AAV) Vectors in Gene Therapy by Kenneth I. Berns,Catherine Giraud Pdf

Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good copy of the affected gene must be available. For a vector to be of use several attributes are highly desirable: these include ability to carry the intact gene (although this may be either the genomic or the cDNA form) in a stable form, ability to introduce the gene into the desired cell type, ability to express the introduced gene in an appropriately regulated manner for an extended period of time, and a lack of toxicity for the recipient. Also of concern is the frequency of cell transformation and, in some cases, the ability to introduce the gene into nondividing stem cells. Sev eral animal viruses have been tested as potential vectors, but none has proven to have all the desired properties described above. For example, retroviruses are difficult to propagate in sufficient titers, do not integrate into nondividing cells, and are of concern because of their oncogenic properties in some hosts and because they integrate at many sites in the genome and, thus, are potentially insertional mutagens. Additionally, genes introduced by retroviral vectors are frequently expressed for relatively short periods of time. A second virus used as a vector in model systems has been adenovirus (Ad).

Author : Uwe Gross
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642510144

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Toxoplasma gondii by Uwe Gross Pdf

For years, toxoplasmosis has been known as disease mostly affecting newborns. Since immunocompromised patients (AIDS) present a high risk of reactivation of chronic toxoplasmosis this parasitic disease has gained increasing interest. Besides presenting clinical and therapeutical concepts, this volume provides current knowledge about genetics and immunology of T. gondii and the interaction with its 'host'. Since in vivo and in vitro models of toxoplasmosis exist, and genetic manipulation has become possible, this protozoan parasite has recently been accepted as a model for understanding the pathogenesis and persistance of other intracellular parasites. The articles of the book compromise both reviewing current concepts and reporting on yet unpublished results of leading scientists in this field.

Author : Michael B. Kastan
Publisher : Springer Science & Business Media
Page : 189 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642605055

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Genetic Instability and Tumorigenesis by Michael B. Kastan Pdf

M. B. KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast, in the majority of cancers, no such inherited gene abnormalities can be identified (which does not mean that they do not exist) and there is no obvious family history suggesting an inherited disease. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual. Thus, the critical question which arises is "how do these genetic changes occur in somatic cells?". Epidemiologic data suggest that exposure to environmental carcinogens con tributes to the genesis of at least 80% of all human cancers (DOLL and PETO 1981). Thus, it is natural to suspect that the genetic changes in somatic cells which con tribute to the transformed phenotype arise from DNA damage caused by such exposures. Therefore, understanding how cells respond to DNA-damaging agents is likely to be an important component of our understanding of the genesis of human tumors.

Author : Klas Kärre,Marco Colonna
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642468599

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Specificity, Function, and Development of NK Cells by Klas Kärre,Marco Colonna Pdf

Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.

Author : Anthony J. Pawson
Publisher : Springer Science & Business Media
Page : 375 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642804816

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Protein Modules in Signal Transduction by Anthony J. Pawson Pdf

This volume in the series Current Topics in Microbiology and Immunology focuses on protein modules in signal transduction. Topics covered include: functions of SH2 and SH3 domains; structure and function of LIM domains; and the IRS-signalling system.

Author : C.H. Hagedorn,C.M. Rice
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642596056

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The Hepatitis C Viruses by C.H. Hagedorn,C.M. Rice Pdf

Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.

Author : Steven Tracy,Nora M. Chapman,Brian W.J. Mahy
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 49,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783642606878

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The Coxsackie B Viruses by Steven Tracy,Nora M. Chapman,Brian W.J. Mahy Pdf

S. TRACY Late in the 1940s, a virus was isolated from a young patient with a flaccid par alysis in the sleepy Hudson River town of Coxsackie in the state of New York. Within the next few years, it was apparent that this and other similar viruses were not polioviruses but were indeed a new group of viruses, viruses that by the mid- 1950s had been found to be commonly associated with pediatric inflammatory heart disease. Two groups of coxsackieviruses (A and B) were differentiated on the basis of the type of paralysis induced in suckling mice by these viruses. Group B coxsackieviruses, because of their primacy as etiologic agents of human acute viral myocarditis and its relatively common sequela, dilated cardiomyopathy, are the focus of this volume. of the century approaches, the massive international effort to eradi As the end cate polioviruses through vaccination as causes of human disease has been success ful in the Western Hemisphere and in many parts of Europe, and it is expected that worldwide eradication may be achieved within the near future. While this is wonderful news, there are sadly no similar efforts being planned to combat the numerous other human enteroviruses that daily incur widespread morbidity and mortality throughout the world. While this is due in part to the lack of specific know ledge about the other human enteroviruses, it is also due to the perceptions of industry that there is insufficient profit to be made by developing these vaccines.

Author : H. Wagner
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642596728

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Immunobiology of Bacterial CpG-DNA by H. Wagner Pdf

Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.