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The Autoimmune Diseases by Noel R. Rose,Ian R. Mackay Pdf
The Autoimmune Diseases comprehensively describes the clinical expressions of all known autoimmune diseases, as well as the experimental bases of autoimmunity and failure of tolerance. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and diseases of the blood, skin, eye, kidney, and liver.
Vaccines and Autoimmunity by Yehuda Shoenfeld,Nancy Agmon-Levin,Lucija Tomljenovic Pdf
In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.
B Cell Receptor Signaling by Tomohiro Kurosaki,Jürgen Wienands Pdf
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Mosaic of Autoimmunity by Carlo Perricone,Yehuda Shoenfeld Pdf
The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications
Idiotypes in Medicine: Autoimmunity, Infection and Cancer by R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld Pdf
This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.
Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Human Autoimmunity and Associated Diseases by Kenan Demir,Selim Görgün Pdf
The collection of essays reviews, explores, and reports state-of-the-art autoimmunity issues with a cause and effect relationship. It provides a comprehensive presentation of immunity and autoimmunity and their connection to related diseases, current trends, data and possible future developments in health sciences. As such, it represents a unique resource for medical educators, medical practitioners and academics.
Polymyositis and Dermatomyositis by Marinos C Dalakas Pdf
Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.
Autoimmune by Annesse Brockley,Kristin Urdiales Pdf
"This book identifies the cause and the cure for: Chronic Fatigue Syndrome, Fibromyalgia, Lupus, Sjögren's, Rheumatoid Arthritis, Raynaud's, Rosacea, Myasthenia Gravis, Hashimoto's, Type 2 Diabetes, Multiple Sclerosis and more."
Pediatric Autoimmunity and Transplantation by Farzaneh Rahmani,Nima Rezaei Pdf
This book is a collection of case-based questions, directed towards and meticulously selected to cover the most common and important aspects of pediatric autoimmune disorders. Autoimmune disorders of infancy and childhood, rheumatological disorders, dermatologic autoimmune disorders, autoinflammatory disorders, and clinical immunology in solid organ and hematopoietic stem cell transplantation are among the topics covered. Each chapter starts with a case description followed by a series of 5-6 multiple choice questions (MCQ), presenting the flow from diagnosis to treatment in a step-wise, logical manner. The text guides the reader through the stream of real clinical practice from initial presentation, differential diagnosis, next best step, lab data, and definitive diagnosis to management and adverse effects of therapy. This MCQ format along with precise, yet detailed answer ensure a quick, reality learning to the reader. The book provides a quick guide and hands-on learning experience for pediatricians, hematologists, immunologists, transplant specialists, pulmonologists, as well as PhD and post-graduate researchers around the world.
Vaccines, Autoimmunity, and the Changing Nature of Childhood Illness by Thomas Cowan Pdf
Over the past 50 years, rates of chronic illness, learning disabilities, and allergies in children have exploded--1 in 6 children has a diagnosed learning disorder, 1 in 50 has autism, and 1 in 13 has severe food allergies. Instead of blaming genetics or increased awareness and diagnosis, author Thomas Cowan, MD, attributes these rising numbers to our current vaccination policy. In Vaccines, Auto-Immunity, and the Assault on Childhood, Cowan combines his years of experience as a medical practitioner with his research into the history and science of vaccines to show how childhood illnesses, which help children to develop a robust immune system, are now eschewed by conventional medicine in favor of an increasing array of vaccinations that do more harm than good. Invoking philosopher Rudolph Steiner's vision of vaccines as inspired by "spirits of darkness," Cowan brings to light the various ways in which scientists and government officials work to promote a vaccine program that only increases suffering. Along the way he questions commonly held views of cell biology, the role of water in the body, and the spatial and spiritual components of autism. Additionally, he provides hope of recovery in the form of a nontoxic course of treatment for those suffering chronic inflammation and other averse immune responses to vaccines. Cowan's thoughtfully bold writing takes us on a journey into the history of illness, questioning the true origins of diseases such as polio, and asking important questions, such as: why did paralytic polio make a sudden appearance in the US in the years between 1916-1918? The answers lie far beyond what conventional medicine would have us believe. Vaccines, Auto-Immunity, and the Assault on Childhood asks that we re-examine not only our modern health system but our relationship with the spiritual world. Only then will we find true health.
Autoimmune Disease by Duncan Dartrey Adams,Christopher Dartrey Adams Pdf
This book describes how the Jerne-Burnet Forbidden Clone Theory and the Adams-Knight H Gene Theory, solved the pathogenesis and genetics of the autoimmune diseases showing how specific immunotherapy and prophylaxis can be developed. Furthermore, Ebringer's discovery of two microbial triggers of autoimmune diseases is described and the conclusion drawn that all autoimmune diseases have microbial triggers, so will be preventable by the finding of the triggers and vaccination against them.
Chronic Illness, Vulnerability and Social Work by Liz Price,Liz Walker Pdf
Whilst the body has recently assumed greater sociological significance, there has been less engagement in social work and social care on the bodily experience of health, illness and disease. This innovative volume redresses the balance by exploring chronic illness and social work, through the specific lens of autoimmunity, engaging in wider debates around vulnerability, resistance and the lived experience of ongoing ill-health. Moving beyond existing conceptualisations of vulnerability as an issue of mental distress, ageing, child protection and poverty, Price and Walker demonstrate the role that society has to play in actively engaging the physical body, rather than working around and through it. The book focuses on auto-immune conditions such as lupus, multiple sclerosis, rheumatoid arthritis and scleroderma. Conditions like these allow for an exploration of the materiality of illness which exacerbates social and economic vulnerability and may precipitate personal and social crises, requiring a variety of interventions and support. The risks and challenges associated with chronic illness include disruptions to a sense of self and identity, altered relationships and the renegotiation of roles and responsibilities in a variety of relationships in addition to an economic impact, with the potential for disruption to employment status and financial insecurity. This text opens up a range of debates around some of the central concerns of the social work profession, including vulnerability, ill-health, and independence. It will be of interest to scholars and students of social work, nursing, disability studies, medicine and the social sciences.
An Epidemic of Absence by Moises Velasquez-Manoff Pdf
A controversial, revisionist approach to autoimmune and allergic disorders considers the perspective that the human immune system has been disabled by twentieth-century hygiene and medical practices.
Textbook of the Autoimmune Diseases by Robert George Lahita,Nicholas Chiorazzi,Westley H. Reeves Pdf
The Textbook of the Autoimmune Diseases is the definitive reference work about the mechanisms autoimmune diseases employ against the body and the conditions in which they thrive. Whether it's where and how autoimmune diseases disable organs from functioning, or the first symptoms of disease, this book blends both the clinical and the scientific to explain autoimmune diseases' phenomena. The only source for information on heavy metals' and silicone implants' effects on autoimmunity, this book compiles contributions from world-renowned faculty to cut across all fields of medicine, from surgery to internal medicine.
